{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:22:02Z","timestamp":1791836522361,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.aohep.2020.09.005","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T19:13:01Z","timestamp":1601406781000},"page":"100261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["The histone variant H3.3 regulates the transcription of the hepatitis B virus"],"prefix":"10.1016","volume":"21","author":[{"given":"Francisca","family":"Alvarez-Astudillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Varas-Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Leonardo","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A.","family":"Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Loyola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.aohep.2020.09.005_bib0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mcna.2013.08.004","article-title":"Chronic hepatitis B virus infection","volume":"98","author":"McMahon","year":"2014","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.aohep.2020.09.005_bib0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1743-422X-10-239","article-title":"Medical virology of hepatitis B: how it began and where we are now","volume":"10","author":"Gerlich","year":"2013","journal-title":"Virol J"},{"key":"10.1016\/j.aohep.2020.09.005_bib0015","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00049","article-title":"Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus","volume":"1","author":"Yan","year":"2012","journal-title":"Elife"},{"key":"10.1016\/j.aohep.2020.09.005_bib0020","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.virol.2015.02.031","article-title":"Molecular biology of hepatitis B virus infection","volume":"479\u2013480","author":"Seeger","year":"2015","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.aohep.2020.09.005_bib0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01703079","article-title":"Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell","volume":"8","author":"Bock","year":"1994","journal-title":"Virus Genes"},{"issue":"6","key":"10.1016\/j.aohep.2020.09.005_bib0030","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1128\/jvi.69.6.3350-3357.1995","article-title":"The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes","volume":"69","author":"Newbold","year":"1995","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.aohep.2020.09.005_bib0035","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/j.gastro.2006.01.001","article-title":"Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones","volume":"130","author":"Pollicino","year":"2006","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.aohep.2020.09.005_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003613","article-title":"Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes","volume":"9","author":"Liu","year":"2013","journal-title":"PLoS Pathog"},{"issue":"47","key":"10.1016\/j.aohep.2020.09.005_bib0045","doi-asserted-by":"crossref","first-page":"19975","DOI":"10.1073\/pnas.0908365106","article-title":"Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function","volume":"106","author":"Belloni","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.aohep.2020.09.005_bib0050","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI58847","article-title":"IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome","volume":"122","author":"Belloni","year":"2012","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.aohep.2020.09.005_bib0055","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1128\/JVI.02574-12","article-title":"Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription","volume":"87","author":"Benhenda","year":"2013","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.aohep.2020.09.005_bib0060","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00705-015-2702-x","article-title":"Replication of a chronic hepatitis B virus genotype F1b construct","volume":"161","author":"Hernandez","year":"2016","journal-title":"Arch Virol"},{"key":"10.1016\/j.aohep.2020.09.005_bib0065","doi-asserted-by":"crossref","first-page":"25901","DOI":"10.1038\/srep25901","article-title":"The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state","volume":"6","author":"Alarcon","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.aohep.2020.09.005_bib0070","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jhep.2015.06.023","article-title":"HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase","volume":"63","author":"Riviere","year":"2015","journal-title":"J Hepatol"},{"issue":"42","key":"10.1016\/j.aohep.2020.09.005_bib0075","doi-asserted-by":"crossref","first-page":"E5715","DOI":"10.1073\/pnas.1518090112","article-title":"Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation","volume":"112","author":"Tropberger","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.aohep.2020.09.005_bib0080","doi-asserted-by":"crossref","DOI":"10.1002\/hep.29912","article-title":"SIRT3 restricts HBV transcription and replication via epigenetic regulation of cccDNA involving SUV39H1 and SETD1A histone methyltransferases","author":"Ren","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2020.09.005_bib0085","series-title":"Cold Spring Harbor symposia on quantitative biology","article-title":"Shaping chromatin in the nucleus: the bricks and the architects","author":"Sitbon","year":"2017"},{"issue":"2","key":"10.1016\/j.aohep.2020.09.005_bib0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrm.2016.148","article-title":"Histone variants on the move: substrates for chromatin dynamics","volume":"18","author":"Talbert","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.aohep.2020.09.005_bib0095","series-title":"Gene regulation, epigenetics and hormone signaling. 1","first-page":"209","article-title":"Histone variants: structure, function, and implication in diseases","author":"Alvarez","year":"2017"},{"issue":"1","key":"10.1016\/j.aohep.2020.09.005_bib0100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0092-8674(03)01064-X","article-title":"Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis","volume":"116","author":"Tagami","year":"2004","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.aohep.2020.09.005_bib0105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.tibs.2007.08.004","article-title":"Marking histone H3 variants: how, when and why?","volume":"32","author":"Loyola","year":"2007","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"10.1016\/j.aohep.2020.09.005_bib0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.molcel.2006.08.019","article-title":"PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state","volume":"24","author":"Loyola","year":"2006","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.aohep.2020.09.005_bib0115","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1073\/pnas.0308092100","article-title":"Histone H3.3 is enriched in covalent modifications associated with active chromatin","volume":"101","author":"McKittrick","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.aohep.2020.09.005_bib0120","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cell.2010.01.003","article-title":"Distinct factors control histone variant H3.3 localization at specific genomic regions","volume":"140","author":"Goldberg","year":"2010","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.aohep.2020.09.005_bib0125","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1101\/gad.566910","article-title":"The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3","volume":"24","author":"Drane","year":"2010","journal-title":"Genes Dev"},{"issue":"9","key":"10.1016\/j.aohep.2020.09.005_bib0130","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/ncb2089","article-title":"Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3","volume":"12","author":"Santenard","year":"2010","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.aohep.2020.09.005_bib0135","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1101\/gr.084947.108","article-title":"Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells","volume":"19","author":"Wong","year":"2009","journal-title":"Genome Res"},{"issue":"1","key":"10.1016\/j.aohep.2020.09.005_bib0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2013.08.061","article-title":"Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells","volume":"155","author":"Banaszynski","year":"2013","journal-title":"Cell"},{"issue":"7555","key":"10.1016\/j.aohep.2020.09.005_bib0145","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nature14345","article-title":"Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells","volume":"522","author":"Elsasser","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.aohep.2020.09.005_bib0150","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01075-14","article-title":"Full-genome sequence of a hepatitis B virus genotype f1b clone from a chronically infected chilean patient","volume":"2","author":"Hernandez","year":"2014","journal-title":"Genome Announc"},{"issue":"19","key":"10.1016\/j.aohep.2020.09.005_bib0155","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1093\/nar\/gkr529","article-title":"Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1gamma","volume":"39","author":"Kim","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1016\/j.aohep.2020.09.005_bib0160","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nrm.2017.47","article-title":"Understanding nucleosome dynamics and their links to gene expression and DNA replication","volume":"18","author":"Lai","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.aohep.2020.09.005_bib0165","doi-asserted-by":"crossref","DOI":"10.3390\/genes9040207","article-title":"Gene therapy for chronic HBV-can we eliminate cccDNA?","volume":"9","author":"Bloom","year":"2018","journal-title":"Genes (Basel)"},{"issue":"10","key":"10.1016\/j.aohep.2020.09.005_bib0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110442","article-title":"Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.aohep.2020.09.005_bib0175","doi-asserted-by":"crossref","first-page":"10309","DOI":"10.1128\/JVI.01220-16","article-title":"Canonical and variant forms of histone H3 are deposited onto the human cytomegalovirus genome during lytic and latent infections","volume":"90","author":"Albright","year":"2016","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.aohep.2020.09.005_bib0180","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1128\/JVI.01276-08","article-title":"The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1","volume":"83","author":"Placek","year":"2009","journal-title":"J Virol"},{"issue":"7","key":"10.1016\/j.aohep.2020.09.005_bib0185","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.3390\/v5071758","article-title":"Chromatin dynamics during lytic infection with herpes simplex virus 1","volume":"5","author":"Conn","year":"2013","journal-title":"Viruses"},{"issue":"11","key":"10.1016\/j.aohep.2020.09.005_bib0190","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00705-008-0231-6","article-title":"Prevalence of hepatitis B virus genotypes in chronic carriers in Santiago, Chile","volume":"153","author":"Venegas","year":"2008","journal-title":"Arch Virol"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268120301769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268120301769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:41:52Z","timestamp":1761648112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268120301769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":38,"alternative-id":["S1665268120301769"],"URL":"https:\/\/doi.org\/10.1016\/j.aohep.2020.09.005","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The histone variant H3.3 regulates the transcription of the hepatitis B virus","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aohep.2020.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100261"}}