{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:56:58Z","timestamp":1780657018124,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2016YFC1302303"],"award-info":[{"award-number":["2016YFC1302303"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672345"],"award-info":[{"award-number":["81672345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972657"],"award-info":[{"award-number":["81972657"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.aohep.2021.100538","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T21:01:37Z","timestamp":1632171697000},"page":"100538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma"],"prefix":"10.1016","volume":"25","author":[{"given":"Yue-fan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-mei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-zan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-peng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.aohep.2021.100538_bib0001","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ccell.2020.02.004","article-title":"mA Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer[J]","volume":"37","author":"Huang","year":"2020","journal-title":"Cancer Cell"},{"issue":"10127","key":"10.1016\/j.aohep.2021.100538_bib0002","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma[J]","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet (London, England)"},{"issue":"7642","key":"10.1016\/j.aohep.2021.100538_bib0003","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature21355","article-title":"mA-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition[J]","volume":"542","author":"Zhao","year":"2017","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.aohep.2021.100538_bib0004","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jhep.2019.12.016","article-title":"IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease[J]","volume":"72","author":"Ma","year":"2020","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12943-018-0847-4","article-title":"Novel insights on mA RNA methylation in tumorigenesis: a double-edged sword[J]","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Cancer"},{"issue":"10","key":"10.1016\/j.aohep.2021.100538_bib0006","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells[J]","volume":"71","author":"DESROSIERS","year":"1974","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0007","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41419-017-0129-x","article-title":"N6-methyladenosine links RNA METABOLISM TO CANCER progression[J]","volume":"9","author":"Dai","year":"2018","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0008","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.gpb.2018.03.001","article-title":"Structural Insights into N-methyladenosine (mA) Modification in the Transcriptome[J]","volume":"16","author":"Huang","year":"2018","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"9","key":"10.1016\/j.aohep.2021.100538_bib0009","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.celrep.2017.08.027","article-title":"Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs[J]","volume":"20","author":"Zhou","year":"2017","journal-title":"Cell Rep"},{"issue":"19","key":"10.1016\/j.aohep.2021.100538_bib0010","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1101\/gad.269415.115","article-title":"A majority of m6A residues are in the last exons, allowing the potential for 3\u2032 UTR regulation[J]","volume":"29","author":"Ke","year":"2015","journal-title":"Genes Dev"},{"issue":"6","key":"10.1016\/j.aohep.2021.100538_bib0011","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.tig.2017.04.003","article-title":"mA in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression[J]","volume":"33","author":"Roignant","year":"2017","journal-title":"Trends Genet"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0012","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation[J]","volume":"10","author":"Liu","year":"2014","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0013","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12943-020-01204-7","article-title":"The potential role of RNA N6-methyladenosine in Cancer progression[J]","volume":"19","author":"Wang","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.aohep.2021.100538_bib0014","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1101\/gad.309146.117","article-title":"Zc3h13\/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15\/Spenito to the mA machinery component Wtap\/Fl(2)d[J]","volume":"32","author":"Knuckles","year":"2018","journal-title":"Genes Dev"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0015","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.celrep.2014.05.048","article-title":"Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5\u2032 sites[J]","volume":"8","author":"Schwartz","year":"2014","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0016","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility[J]","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol Cell"},{"issue":"12","key":"10.1016\/j.aohep.2021.100538_bib0017","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis[J]","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res"},{"key":"10.1016\/j.aohep.2021.100538_bib0018","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/ncomms2822","article-title":"FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA[J]","volume":"4","author":"Fu","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.aohep.2021.100538_bib0019","doi-asserted-by":"crossref","first-page":"42271","DOI":"10.1038\/srep42271","article-title":"AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells[J]","volume":"7","author":"Ueda","year":"2017","journal-title":"Sci Rep"},{"issue":"7481","key":"10.1016\/j.aohep.2021.100538_bib0020","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability[J]","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.aohep.2021.100538_bib0021","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency[J]","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.aohep.2021.100538_bib0022","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5\u2032 UTR m(6)A Promotes Cap-Independent Translation[J]","volume":"163","author":"Meyer","year":"2015","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.aohep.2021.100538_bib0023","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N-methyladenosine-modified RNA[J]","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2017.09.021","article-title":"Regulation of mA Transcripts by the 3\u2032\u21925\u2032 RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline[J]","volume":"68","author":"Wojtas","year":"2017","journal-title":"Mol Cell"},{"issue":"5","key":"10.1016\/j.aohep.2021.100538_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007412","article-title":"Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development[J]","volume":"14","author":"Kasowitz","year":"2018","journal-title":"PLos Genet"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0026","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13045-020-00872-8","article-title":"mA-binding proteins: the emerging crucial performers in epigenetics[J]","volume":"13","author":"Zhao","year":"2020","journal-title":"J Hematol Oncol"},{"issue":"6","key":"10.1016\/j.aohep.2021.100538_bib0027","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/ng.2256","article-title":"Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma[J]","volume":"44","author":"Guichard","year":"2012","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.aohep.2021.100538_bib0028","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2015.08.011","article-title":"HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events[J]","volume":"162","author":"Alarc\u00f3n","year":"2015","journal-title":"Cell"},{"issue":"15","key":"10.1016\/j.aohep.2021.100538_bib0029","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s00018-012-1186-z","article-title":"Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?[J]","volume":"70","author":"Bell","year":"2013","journal-title":"Cellular and molecular life sciences: CMLS"},{"issue":"3","key":"10.1016\/j.aohep.2021.100538_bib0030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation[J]","volume":"20","author":"HUANG","year":"2018","journal-title":"Nat Cell Biol"},{"issue":"8","key":"10.1016\/j.aohep.2021.100538_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007874","article-title":"Human apolipoprotein E promotes hepatitis B virus infection and production[J]","volume":"15","author":"Qiao","year":"2019","journal-title":"PLoS Pathog"},{"issue":"9","key":"10.1016\/j.aohep.2021.100538_bib0032","first-page":"e56","article-title":"Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention[J]","volume":"2","author":"Jones","year":"2013","journal-title":"Emerging microbes & infections"},{"issue":"35","key":"10.1016\/j.aohep.2021.100538_bib0033","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1073\/pnas.1808319115","article-title":"N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle[J]","volume":"115","author":"Imam","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.aohep.2021.100538_bib0034","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ab.2019.05.005","article-title":"Role of identified RNA N6-methyladenosine methylation in liver[J]","volume":"578","author":"Xu","year":"2019","journal-title":"Anal Biochem"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.gtc.2020.01.012","article-title":"Extrahepatic Manifestations of Chronic Viral C Hepatitis[J]","volume":"49","author":"Petta","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"issue":"4","key":"10.1016\/j.aohep.2021.100538_bib0036","doi-asserted-by":"crossref","first-page":"e1983","DOI":"10.1002\/rmv.1983","article-title":"RNA epitranscriptomics: Regulation of infection of RNA and DNA viruses by N -methyladenosine (m A)[J]","volume":"28","author":"Tan","year":"2018","journal-title":"Rev Med Virol"},{"issue":"5","key":"10.1016\/j.aohep.2021.100538_bib0037","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.chom.2016.09.015","article-title":"N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection[J]","volume":"20","author":"Gokhale","year":"2016","journal-title":"Cell host & microbe"},{"issue":"5","key":"10.1016\/j.aohep.2021.100538_bib0038","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00833-16","article-title":"RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling[J]","volume":"7","author":"Durbin","year":"2016","journal-title":"mBio"},{"issue":"6","key":"10.1016\/j.aohep.2021.100538_bib0039","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/gutjnl-2019-318841","article-title":"Quantifying and monitoring fibrosis in non-alcoholic fatty liver disease using dual-photon microscopy[J]","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12943-020-01172-y","article-title":"The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis[J]","volume":"19","author":"Chen","year":"2020","journal-title":"Mol Cancer"},{"issue":"4","key":"10.1016\/j.aohep.2021.100538_bib0041","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/10495398.2016.1273835","article-title":"FTO Promotes Adipogenesis through Inhibition of the Wnt\/\u03b2-catenin Signaling Pathway in Porcine Intramuscular Preadipocytes[J]","volume":"28","author":"Chen","year":"2017","journal-title":"Anim Biotechnol"},{"key":"10.1016\/j.aohep.2021.100538_bib0042","doi-asserted-by":"crossref","first-page":"6792","DOI":"10.1038\/ncomms7792","article-title":"FTO influences adipogenesis by regulating mitotic clonal expansion[J]","volume":"6","author":"Merkestein","year":"2015","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.aohep.2021.100538_bib0043","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.bbalip.2018.08.008","article-title":"FTO regulates adipogenesis by controlling cell cycle progression via mA-YTHDF2 dependent mechanism[J]","volume":"1863","author":"Wu","year":"2018","journal-title":"Biochimica et biophysica acta. Molecular and cell biology of lipids"},{"issue":"7","key":"10.1016\/j.aohep.2021.100538_bib0044","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1080\/15476286.2020.1736868","article-title":"GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m(6)A on lipogenic mRNAs[J]","volume":"17","author":"HU","year":"2020","journal-title":"RNA Biol"},{"key":"10.1016\/j.aohep.2021.100538_bib0045","article-title":"N -methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes[J]","author":"Zhou","year":"2020","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0046","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/hep.28885","article-title":"METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6) -methyladenosine-dependent primary MicroRNA processing[J]","volume":"65","author":"MA","year":"2017","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.aohep.2021.100538_bib0047","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/hep.29683","article-title":"RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2[J]","volume":"67","author":"Chen","year":"2018","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0048","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12943-019-1109-9","article-title":"Functions of N6-methyladenosine and its role in cancer[J]","volume":"18","author":"He","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.aohep.2021.100538_bib0049","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3389\/fonc.2019.01407","article-title":"A Novel RNA Imprint in Human Cancer[J]","volume":"9","author":"Yu","year":"2019","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020296","article-title":"N6-Methyladenosine Regulates the Expression and Secretion of TGF\u03b21 to Affect the Epithelial-Mesenchymal Transition of Cancer Cells[J]","volume":"9","author":"Li","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.aohep.2021.100538_bib0051","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103181","article-title":"RNA m A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy[J]","author":"Lin","year":"2020","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0052","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12943-019-1053-8","article-title":"WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1[J]","volume":"18","author":"CHEN","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.aohep.2021.100538_bib0053","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.2147\/OTT.S180954","article-title":"KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA[J]","volume":"12","author":"Cheng","year":"2019","journal-title":"OncoTargets and therapy"},{"issue":"9","key":"10.1016\/j.aohep.2021.100538_bib0054","first-page":"6084","article-title":"m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation[J]","volume":"11","author":"LI","year":"2019","journal-title":"Am J Transl Res"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12943-020-01239-w","article-title":"ALKBH5 suppresses malignancy of hepatocellular carcinoma via m(6)A-guided epigenetic inhibition of LYPD1[J]","volume":"19","author":"CHEN","year":"2020","journal-title":"Mol Cancer"},{"issue":"4","key":"10.1016\/j.aohep.2021.100538_bib0056","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3233\/CBM-170791","article-title":"Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma[J]","volume":"21","author":"Zhao","year":"2018","journal-title":"Cancer biomarkers: section A of Disease markers"},{"key":"10.1016\/j.aohep.2021.100538_bib0057","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.omtn.2020.09.036","article-title":"YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner[J]","volume":"22","author":"LIU","year":"2020","journal-title":"Molecular therapy. Nucleic acids"},{"key":"10.1016\/j.aohep.2021.100538_bib0058","doi-asserted-by":"crossref","first-page":"12626","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex[J]","volume":"7","author":"Du","year":"2016","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.aohep.2021.100538_bib0059","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1074\/jbc.M116.749689","article-title":"NMicroRNA-145 Modulates -Methyladenosine Levels by Targeting the 3\u2032-Untranslated mRNA Region of the -Methyladenosine Binding YTH Domain Family 2 Protein[J]","volume":"292","author":"Yang","year":"2017","journal-title":"J Biol Chem"},{"issue":"23","key":"10.1016\/j.aohep.2021.100538_bib0060","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1038\/s41388-020-1303-7","article-title":"YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation[J]","volume":"39","author":"ZHANG","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.aohep.2021.100538_bib0061","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.canlet.2018.11.006","article-title":"YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma[J]","volume":"442","author":"ZHONG","year":"2019","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0062","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12943-019-1082-3","article-title":"YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma[J]","volume":"18","author":"HOU","year":"2019","journal-title":"Mol Cancer"},{"issue":"3","key":"10.1016\/j.aohep.2021.100538_bib0063","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N-methyladenosine by IGF2BP proteins enhances mRNA stability and translation[J]","volume":"20","author":"Huang","year":"2018","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0064","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12885-020-6638-5","article-title":"Multiple mA RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis[J]","volume":"20","author":"Qu","year":"2020","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.aohep.2021.100538_bib0065","first-page":"621","article-title":"The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells[J]","volume":"52","author":"Taketo","year":"2018","journal-title":"Int J Oncol"},{"issue":"4","key":"10.1016\/j.aohep.2021.100538_bib0066","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/onc.2017.351","article-title":"Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance[J]","volume":"37","author":"Visvanathan","year":"2018","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0067","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1038\/s41467-019-10669-0","article-title":"mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade[J]","volume":"10","author":"Yang","year":"2019","journal-title":"Nat Commun"},{"issue":"7743","key":"10.1016\/j.aohep.2021.100538_bib0068","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-0916-x","article-title":"Anti-tumour immunity controlled through mRNA mA methylation and YTHDF1 in dendritic cells[J]","volume":"566","author":"Han","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.aohep.2021.100538_bib0069","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/nar\/gku1276","article-title":"Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5[J]","volume":"43","author":"Huang","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.aohep.2021.100538_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.11.031","article-title":"R-2HG Exhibits Anti-tumor Activity by Targeting FTO\/mA\/MYC\/CEBPA Signaling[J]","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.aohep.2021.100538_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2019.03.006","article-title":"Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia[J]","volume":"35","author":"Huang","year":"2019","journal-title":"Cancer Cell"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268121002374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268121002374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:43:39Z","timestamp":1761648219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268121002374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":71,"alternative-id":["S1665268121002374"],"URL":"https:\/\/doi.org\/10.1016\/j.aohep.2021.100538","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aohep.2021.100538","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100538"}}