{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:20:51Z","timestamp":1788837651139,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500455"],"award-info":[{"award-number":["81500455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974079"],"award-info":[{"award-number":["81974079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070646"],"award-info":[{"award-number":["82070646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFE0190800"],"award-info":[{"award-number":["2019YFE0190800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.aohep.2022.100700","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T19:52:49Z","timestamp":1648065169000},"page":"100700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["microRNA-122 inhibits hepatic stellate cell proliferation and activation in vitro and represses carbon tetrachloride-induced liver cirrhosis in mice"],"prefix":"10.1016","volume":"27","author":[{"given":"Jing","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aohep.2022.100700_bib0001","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Disease","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.aohep.2022.100700_bib0002","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00535-016-1258-1","article-title":"Status of and candidates for cell therapy in liver cirrhosis: overcoming the \"point of no return\" in advanced liver cirrhosis","volume":"52","author":"Terai","year":"2017","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.aohep.2022.100700_bib0003","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1111\/jcmm.14987","article-title":"Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway","volume":"24","author":"Yang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.aohep.2022.100700_bib0004","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2022.100700_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19071889","article-title":"The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis","volume":"19","author":"Huang","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.aohep.2022.100700_bib0006","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9856538","article-title":"Identification of a novel lincRNA-p21-miR-181b-PTEN signaling cascade in liver fibrosis","author":"Yu","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.aohep.2022.100700_bib0007","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1111\/jcmm.13208","article-title":"MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis","volume":"21","author":"Lou","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.aohep.2022.100700_bib0008","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.molimm.2017.10.006","article-title":"Leptin reduces microRNA-122 level in hepatic stellate cells in vitro and in vivo","volume":"92","author":"Zhai","year":"2017","journal-title":"Mol Immunol"},{"key":"10.1016\/j.aohep.2022.100700_bib0009","first-page":"9","article-title":"Role of B cell lymphoma 2 in the regulation of liver fibrosis in miR-122 knockout mice","author":"Teng","year":"2020","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.aohep.2022.100700_bib0010","first-page":"22","article-title":"The clinical impact of the EPH\/Ephrin system in cancer: unwinding the thread","author":"Pergaris","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.aohep.2022.100700_bib0011","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/cns.13641","article-title":"EphB2 knockdown decreases the formation of astroglial-fibrotic scars to promote nerve regeneration after spinal cord injury in rats","volume":"27","author":"Wu","year":"2021","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.aohep.2022.100700_bib0012","doi-asserted-by":"crossref","first-page":"eaba1983","DOI":"10.1126\/sciadv.aba1983","article-title":"Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis","volume":"6","author":"Adams","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.aohep.2022.100700_bib0013","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1038\/s41598-018-20926-9","article-title":"EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells","volume":"8","author":"Mimche","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.aohep.2022.100700_bib0014","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41419-020-2613-y","article-title":"Synergistic antifibrotic effects of miR-451 with miR-185 partly by co-targeting EphB2 on hepatic stellate cells","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.aohep.2022.100700_bib0015","article-title":"LncRNA FGD5-AS1 facilitates the radioresistance of breast cancer cells by enhancing MACC1 expression through competitively sponging miR-497-5p","volume":"11","author":"Li","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.aohep.2022.100700_bib0016","first-page":"99","article-title":"Isolation and culture of hepatic stellate cells","volume":"117","author":"Weiskirchen","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.aohep.2022.100700_bib0017","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.1111\/jcmm.16766","article-title":"miRNA-130b-5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression","volume":"25","author":"Wang","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.aohep.2022.100700_bib0018","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2016.01.035","article-title":"The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis","volume":"64","author":"Bala","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2022.100700_bib0019","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s10020-020-00207-w","article-title":"Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy","volume":"26","author":"Wang","year":"2020","journal-title":"Mol Med"},{"key":"10.1016\/j.aohep.2022.100700_bib0020","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.taap.2017.12.007","article-title":"Leptin suppresses microRNA-122 promoter activity by phosphorylation of foxO1 in hepatic stellate cell contributing to leptin promotion of mouse liver fibrosis","volume":"339","author":"Cao","year":"2018","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.aohep.2022.100700_bib0021","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/jvh.12696","article-title":"Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients","volume":"24","author":"Shaker","year":"2017","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.aohep.2022.100700_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135915","article-title":"Imidacloprid-induced liver fibrosis in quails via activation of the TGF-beta1\/Smad pathway","volume":"705","author":"Lv","year":"2020","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.aohep.2022.100700_bib0023","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/14728214.2021.1918099","article-title":"Emerging synthetic drugs for the treatment of liver cirrhosis","volume":"26","author":"Fallowfield","year":"2021","journal-title":"Expert Opin Emerg Drugs"},{"key":"10.1016\/j.aohep.2022.100700_bib0024","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00109-017-1586-5","article-title":"NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6","volume":"95","author":"Yu","year":"2017","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.aohep.2022.100700_bib0025","first-page":"284","article-title":"MicroRNA-122 inhibits epithelial-mesenchymal transition of hepatic stellate cells induced by the TGF-beta1\/Smad signaling pathway","volume":"17","author":"Cheng","year":"2019","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.aohep.2022.100700_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118293","article-title":"Effect of atorvastatin, curcumin, and quercetin on miR-21 and miR-122 and their correlation with TGFbeta1 expression in experimental liver fibrosis","volume":"259","author":"Nozari","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.aohep.2022.100700_bib0027","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jhep.2012.11.011","article-title":"miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression","volume":"58","author":"Li","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2022.100700_bib0028","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BST20170037","article-title":"MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target","volume":"46","author":"Mellis","year":"2018","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.aohep.2022.100700_bib0029","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/hep.27792","article-title":"The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice","volume":"62","author":"Mimche","year":"2015","journal-title":"Hepatology"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268122000424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268122000424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:44:16Z","timestamp":1761648256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268122000424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1665268122000424"],"URL":"https:\/\/doi.org\/10.1016\/j.aohep.2022.100700","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"microRNA-122 inhibits hepatic stellate cell proliferation and activation in vitro and represses carbon tetrachloride-induced liver cirrhosis in mice","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aohep.2022.100700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100700"}}