{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:36:31Z","timestamp":1793208991166,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.aohep.2026.102431","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:28:46Z","timestamp":1788622126000},"page":"102431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sleep disorders in primary biliary cholangitis: A prospective analysis of clinical and patient-reported outcomes"],"prefix":"10.1016","volume":"32","author":[{"given":"Ana","family":"Marenco-Flores","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Rojas-Amaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Abadi-Ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Garita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Polo-Ibarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Munguia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romelia","family":"Barba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Goyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esli Medina","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam","family":"Saberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilas R.","family":"Patwardhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Bonder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.aohep.2026.102431_bib0001","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5152\/tjg.2023.22239","article-title":"Management of primary biliary cholangitis: current treatment and future perspectives","volume":"34","author":"Barba Bernal","year":"2023","journal-title":"Turk J Gastroenterol"},{"issue":"11","key":"10.1016\/j.aohep.2026.102431_bib0002","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1136\/gut.2005.065862","article-title":"Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis","volume":"54","author":"Jacoby","year":"2005","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.aohep.2026.102431_bib0003","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.advms.2024.08.002","article-title":"Associations between sleep disorders and clinical outcomes of patients with primary biliary cholangitis","volume":"69","author":"Dong","year":"2024","journal-title":"Adv Med Sci"},{"issue":"10","key":"10.1016\/j.aohep.2026.102431_bib0004","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1007\/s10620-019-06009-3","article-title":"Symptom burden and treatment response in patients with primary biliary cholangitis (PBC)","volume":"65","author":"Kaps","year":"2020","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.aohep.2026.102431_bib0005","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/hep4.1567","article-title":"A systematic review of patient-reported outcomes in primary biliary cholangitis and primary sclerosing cholangitis","volume":"4","author":"Kim","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.aohep.2026.102431_bib0006","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.21953","article-title":"Quality of life and everyday activities in patients with primary biliary cirrhosis","volume":"46","author":"Selmi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2026.102431_bib0007","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11901-018-0390-1","article-title":"Assessment and management of sleep disturbance in cirrhosis","volume":"17","author":"Formentin","year":"2018","journal-title":"Curr Hepatol Rep"},{"key":"10.1016\/j.aohep.2026.102431_bib0008","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/liv.12026","article-title":"Sleep-wake profiles in patients with primary biliary cirrhosis","volume":"33","author":"Montagnese","year":"2013","journal-title":"Liver Int"},{"key":"10.1016\/j.aohep.2026.102431_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01530","article-title":"Morning bright light treatment for sleep-wake disturbances in primary biliary cholangitis: a pilot study","volume":"9","author":"Turco","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.aohep.2026.102431_bib0010","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(54)91874-7","article-title":"Portal-systemic encephalopathy: neurological complications of liver disease","volume":"264","author":"Sherlock","year":"1954","journal-title":"Lancet"},{"key":"10.1016\/j.aohep.2026.102431_bib0011","article-title":"Psychological factors and biochemical indicators influencing sleep disturbance of patients with primary biliary cholangitis in China: a cross-sectional survey analysis","volume":"11","author":"Zhao","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.aohep.2026.102431_bib0012","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/S2468-1253(21)00169-2","article-title":"Sleep and liver disease: a bidirectional relationship","volume":"6","author":"Marjot","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2026.102431_bib0013","doi-asserted-by":"crossref","DOI":"10.5334\/jcr.aa","article-title":"Prevalence of insomnia and sleep patterns among liver cirrhosis patients","volume":"12","author":"AL-Jahdali","year":"2014","journal-title":"J Circadian Rhythms"},{"key":"10.1016\/j.aohep.2026.102431_bib0014","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/poh2.61","article-title":"Sleep disturbances in patients with cirrhosis: pursuing just right","volume":"2","author":"Hui","year":"2023","journal-title":"Portal Hypertens Circ"},{"key":"10.1016\/j.aohep.2026.102431_bib0015","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/liv.12485","article-title":"Sleep disorders in cirrhotics; how can we detect?","volume":"34","author":"Gencdal","year":"2014","journal-title":"Liver Int"},{"issue":"1","key":"10.1016\/j.aohep.2026.102431_bib0016","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2021-000857","article-title":"Disease burden of primary biliary cholangitis and associated pruritus based on a cross-sectional US claims analysis","volume":"9","author":"Gungabissoon","year":"2022","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1016\/j.aohep.2026.102431_bib0017","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/apt.13794","article-title":"The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis","volume":"44","author":"Dyson","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.aohep.2026.102431_bib0018","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.cgh.2022.10.032","article-title":"Glimmer: a randomized phase 2b dose-ranging trial of linerixibat in primary biliary cholangitis patients with pruritus","volume":"21","author":"Levy","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2026.102431_bib0019","doi-asserted-by":"crossref","DOI":"10.1186\/s41687-024-00722-y","article-title":"Relationship between pruritus and sleep in participants with primary biliary cholangitis in the phase 2b glimmer trial","volume":"8","author":"von Maltzahn","year":"2024","journal-title":"J Patient Rep Outcomes"},{"key":"10.1016\/j.aohep.2026.102431_bib0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/hep.21230","article-title":"Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence","volume":"44","author":"Newton","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.aohep.2026.102431_bib0021","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/apt.70630","article-title":"Seladelpar improved itch, itch-related sleep disturbance and measures of fatigue in patients with primary biliary cholangitis and pruritus in the phase 3 RESPONSE trial","volume":"64","author":"Levy","year":"2026","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268126002516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268126002516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:23:39Z","timestamp":1793208219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268126002516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S1665268126002516"],"URL":"https:\/\/doi.org\/10.1016\/j.aohep.2026.102431","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep disorders in primary biliary cholangitis: A prospective analysis of clinical and patient-reported outcomes","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aohep.2026.102431","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C.","name":"copyright","label":"Copyright"}],"article-number":"102431"}}