{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T07:40:01Z","timestamp":1755934801073,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Ophthalmology Practice and Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.aopr.2025.04.001","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T04:11:25Z","timestamp":1743912685000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification: A double-blind crossover non-inferiority clinical trial (BEKEF study)"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-2600","authenticated-orcid":false,"given":"Adriano Cypriano","family":"Faneli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Danilo","family":"Chagas Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Amado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F.","family":"Marback","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Amaral","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Fernandes","family":"Marback","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larrie","family":"Laporte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-8696","authenticated-orcid":false,"given":"Caio Vinicius","family":"Saito Regatieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Muccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aopr.2025.04.001_bib1","series-title":"StatPearls Publishing Copyright \u00a9 2025","article-title":"Cataract. StatPearls","author":"Nizami","year":"2025"},{"key":"10.1016\/j.aopr.2025.04.001_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.14","article-title":"Cataract","volume":"1","author":"Lam","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.aopr.2025.04.001_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF03020350","article-title":"Regional anaesthesia for 12,000 cataract extraction and intraocular lens implantation procedures","volume":"35","author":"Hamilton","year":"1988","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.aopr.2025.04.001_bib4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ophtha.2011.09.056","article-title":"Topical anesthesia versus regional anesthesia for cataract surgery: a meta-analysis of randomized controlled trials","volume":"119","author":"Zhao","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.aopr.2025.04.001_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4274\/tjo.13914","article-title":"Pain perception in phacoemulsification with topical anesthesia and evaluation of factors related with pain","volume":"46","author":"Dadac\u0131","year":"2016","journal-title":"Turk J Ophthalmol"},{"key":"10.1016\/j.aopr.2025.04.001_bib6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2147\/PRBM.S314214","article-title":"Fear and anxiety associated with cataract surgery under local anesthesia in adults: a systematic review","volume":"14","author":"Obuchowska","year":"2021","journal-title":"Psychol Res Behav Manag"},{"key":"10.1016\/j.aopr.2025.04.001_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2020-000464","article-title":"Cataract surgery practice patterns worldwide: a survey","volume":"6","author":"Rossi","year":"2021","journal-title":"BMJ Open Ophthalmol"},{"key":"10.1016\/j.aopr.2025.04.001_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0974-620X.71881","article-title":"Anesthesia for cataract surgery: recent trends","volume":"3","author":"Shah","year":"2010","journal-title":"Oman J Ophthalmol"},{"key":"10.1016\/j.aopr.2025.04.001_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/112067210801800308","article-title":"Patient comfort and surgeon satisfaction during cataract surgery using topical anesthesia with or without dexmedetomidine sedation","volume":"18","author":"Erdurmus","year":"2008","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.aopr.2025.04.001_bib10","first-page":"100","article-title":"Pharmacology of anaesthetic agents I: intravenous anaesthetic agents","volume":"14","author":"Khan","year":"2014","journal-title":"Cont Educ Anaesth Crit Care Pain"},{"key":"10.1016\/j.aopr.2025.04.001_bib11","first-page":"211","article-title":"Conscious sedation during ophthalmic surgery under local anesthesia","volume":"75","author":"Woo","year":"2009","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.aopr.2025.04.001_bib12","article-title":"Comparison of the sedation quality of etomidate, propofol, and midazolam in combination with fentanyl during phacoemulsification cataract surgery: a double-blind, randomized, controlled, clinical trial","volume":"9","author":"Adinehmehr","year":"2019","journal-title":"Anesth Pain Med"},{"key":"10.1016\/j.aopr.2025.04.001_bib13","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2147\/OPTH.S415852","article-title":"Successful use of low-dose combination propofol and fentanyl in cataract surgery phacoemulsification","volume":"17","author":"Irawati","year":"2023","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.aopr.2025.04.001_bib14","first-page":"179","article-title":"Agents for sedation in ophthalmic surgery: a review of the pharmacodynamics and clinical applications","volume":"17","author":"Loots","year":"2006","journal-title":"Curr Anaesth Crit Care"},{"key":"10.1016\/j.aopr.2025.04.001_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4097\/kja.19314","article-title":"Lack of recall after sedation for cataract surgery and its effect on the validity of measuring patient satisfaction","volume":"73","author":"Chadha","year":"2020","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.aopr.2025.04.001_bib16","first-page":"1198","article-title":"Comparison of midazolam, propofol and fentanyl combinations for sedation and hemodynamic parameters in cataract extraction","volume":"28","author":"Celiker","year":"2007","journal-title":"Saudi Med J"},{"key":"10.1016\/j.aopr.2025.04.001_bib17","article-title":"Estudos cl\u00ednicos de n\u00e3o-inferioridade: fundamentos e controv\u00e9rsias","volume":"vol. 9","author":"Pinto","year":"2010"},{"key":"10.1016\/j.aopr.2025.04.001_bib18","article-title":"CONSORT 2010 statement: extension to randomised crossover trials","volume":"366","author":"Dwan","year":"2019","journal-title":"Bmj"},{"key":"10.1016\/j.aopr.2025.04.001_bib19","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2012.87802","article-title":"CONSORT group ft: reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement","volume":"308","author":"Piaggio","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.aopr.2025.04.001_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/acem.12604","article-title":"The use of subdissociative-dose ketamine for acute pain in the emergency department","volume":"22","author":"Sin","year":"2015","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.aopr.2025.04.001_bib21","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/bmj.2.5920.656","article-title":"Controlled sedation with alphaxalone-alphadolone","volume":"2","author":"Ramsay","year":"1974","journal-title":"Br Med J."},{"key":"10.1016\/j.aopr.2025.04.001_bib22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inf"},{"key":"10.1016\/j.aopr.2025.04.001_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inf"},{"key":"10.1016\/j.aopr.2025.04.001_bib24","first-page":"521","article-title":"Consensus guidelines on the use of intravenous ketamine infusions for chronic pain from the American society of regional anesthesia and pain medicine, the American academy of pain medicine, and the American society of anesthesiologists","volume":"43","author":"Cohen","year":"2018","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.aopr.2025.04.001_bib25","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/EJA.0000000000001081","article-title":"Association between intra-operative fentanyl dosing and postoperative nausea\/vomiting and pain: a prospective cohort study","volume":"36","author":"Mauermann","year":"2019","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.aopr.2025.04.001_bib26","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.4103\/jfmpc.jfmpc_2140_20","article-title":"The adverse effects of ketamine on procedural sedation and analgesia (PSA) in the emergency department","volume":"10","author":"Dilip","year":"2021","journal-title":"J Family Med Prim Care"},{"key":"10.1016\/j.aopr.2025.04.001_bib27","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.21832.1","article-title":"Management strategies for the treatment and prevention of postoperative\/postdischarge nausea and vomiting: an updated review","volume":"9","author":"Elvir-Lazo","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.aopr.2025.04.001_bib28","first-page":"1001","article-title":"Use of midazolam and ketamine as sedation for children undergoing minor operative procedures","volume":"13","author":"Cheuk","year":"2005","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.aopr.2025.04.001_bib29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1553-2712.2000.tb01064.x","article-title":"A combination of midazolam and ketamine for procedural sedation and analgesia in adult emergency department patients","volume":"7","author":"Chudnofsky","year":"2000","journal-title":"Acad Emerg Med"},{"year":"2019","series-title":"Comparison between the Effects of Propofol-Ketamine and Propofol-Fentanyl for Sedation in Cataract Surgery","author":"Heidari","key":"10.1016\/j.aopr.2025.04.001_bib30"},{"key":"10.1016\/j.aopr.2025.04.001_bib31","article-title":"Protocol for comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification (BEKEF): a double-blind crossover non-inferiority clinical trial study","volume":"16","author":"Torres","year":"2024","journal-title":"Cureus"}],"container-title":["Advances in Ophthalmology Practice and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667376225000162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667376225000162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T07:05:09Z","timestamp":1755932709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667376225000162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2667376225000162"],"URL":"https:\/\/doi.org\/10.1016\/j.aopr.2025.04.001","relation":{},"ISSN":["2667-3762"],"issn-type":[{"type":"print","value":"2667-3762"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification: A double-blind crossover non-inferiority clinical trial (BEKEF study)","name":"articletitle","label":"Article Title"},{"value":"Advances in Ophthalmology Practice and Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aopr.2025.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Zhejiang University Press.","name":"copyright","label":"Copyright"}]}}