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Perioperative nurses should understand the pathways that lead to pain to better assist in managing patients\u2019 pain symptoms. Approaching pain from a patient\u2010centered stance includes acknowledging that pain is defined entirely by the subjective experience of the patient, which may not be proportional with the level of tissue damage. This article provides a brief description of the pathophysiology of pain and the components of nociceptive and neuropathic pain pathways to aid the perioperative nurse in pain management.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.aorn.2014.12.008","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T22:45:44Z","timestamp":1424472344000},"page":"338-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pathophysiology of Pain: Implications for Perioperative Nursing"],"prefix":"10.1002","volume":"101","author":[{"given":"Les","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.18.2470"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00457.2012"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9068-6"},{"volume-title":"Guide to Pain Management in Low\u2010Resource Settings","year":"2010","author":"Kopf A.","key":"e_1_2_2_5_2"},{"volume-title":"Pain: Clinical Manual","year":"1999","author":"McCaffery M.","key":"e_1_2_2_6_2"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2008.17.7.29059"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0790-y"},{"volume-title":"Pain: Current Understanding of Assessment, Management, and Treatments","year":"2001","author":"National Pharmaceutical Council and Joint Commission on Accreditation of Healthcare Organizations","key":"e_1_2_2_9_2"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42843"},{"volume-title":"Bonica's Management of Pain","year":"2010","author":"Fishman S.M.","key":"e_1_2_2_11_2"},{"issue":"23","key":"e_1_2_2_12_2","first-page":"51","article-title":"Total hip replacement: improving patients\u2019 quality of life","volume":"24","author":"Walker J.A.","year":"2010","journal-title":"Nurs Stand"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363070-00003"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2007.00171.x"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-5153.2011.00431.x"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1179\/175361409X12472218840889"},{"issue":"9","key":"e_1_2_2_17_2","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/brain\/121.9.1603","article-title":"The perception of phantom limbs. 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