{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:22:57Z","timestamp":1789474977823,"version":"build-2803163510"},"reference-count":52,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective\nThe aim of this study was to compare the unilateral and bilateral approaches in treating osteoporotic vertebral compression fractures.\nMethods\nBased on the principles and methods of the Cochrane systematic reviews, the records of the Cochrane Library, PubMed, Web of Science, Chinese Bio-medicine database, China Journal Full-text Database, VIP database, and Wanfang database were reviewed until October 2014. The randomized controlled trials on unilateral and bilateral approaches to percutaneous vertebroplasty (PVP)\/percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures were included. The risk of bias of included trials was assessed based on the Cochrane Handbook for Systematic Reviews of Interventions Version. The RevMan Software 5.0 was used for meta-analysis.\nResults\nFifteen randomized controlled trials with a total of 850 patients were included. Risk of bias in the included studies was inevitable. There was no statistically significant difference in visual analog scale, vertebral height, kyphotic angular, and quality of life. The main operative complications were bone cement leakage and adjacent vertebral fracture, without difference between the two groups.\nConclusions\nIn view of the current evidence, there is insufficient evidence to show any difference between the unilateral and bilateral approaches in both the PVP and PKP treatment in osteoporotic vertebral compression fractures.\nLevel of Evidence\nLevel I, Therapeutic study.\nER -\n\nKeywords\n\n\n\tMinimally invasive surgery\n\tOsteoporotic vertebral compression fracture\n\tPercutaneous kyphoplasty\n\tPercutaneous vertebroplasty\n\tSystematic review<\/jats:p>","DOI":"10.1016\/j.aott.2017.05.006","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T08:01:10Z","timestamp":1498118470000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["A systematic review of unilateral versus bilateral percutaneous vertebroplasty\/percutaneous kyphoplasty for osteoporotic vertebral compression fractures"],"prefix":"10.5152","volume":"51","author":[{"given":"Shengping","family":"YANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxian","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlong","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqun","family":"L\u0130U","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"issue":"3","key":"10.1016\/j.aott.2017.05.006_bib1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tripleo.2005.04.010","article-title":"Oral implications of osteoporosis","volume":"100","author":"Dervis","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol, Oral Radiol, Endodontol"},{"issue":"10","key":"10.1016\/j.aott.2017.05.006_bib2","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00198-004-1622-5","article-title":"Health-related quality of life after osteoporotic fractures","volume":"15","author":"Hallberg","year":"2004","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.aott.2017.05.006_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00007611-200295060-00005","article-title":"Vertebroplasty and kyphoplasty","volume":"95","author":"linville","year":"2002","journal-title":"South Med J"},{"issue":"14","key":"10.1016\/j.aott.2017.05.006_bib4","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1097\/00007632-200107150-00002","article-title":"New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures","volume":"26","author":"Garfin","year":"2001","journal-title":"Spine"},{"issue":"9","key":"10.1016\/j.aott.2017.05.006_bib5","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1007\/s00586-012-2441-6","article-title":"Balloon kyphoplasty versus percutaneous vertebroplasty in treating osteoporotic vertebral compression fracture: grading the evidence through a systematic review and meta-analysis","volume":"21","author":"Ma","year":"2012","journal-title":"Eur Spine J"},{"issue":"2","key":"10.1016\/j.aott.2017.05.006_bib6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00330-004-2549-0","article-title":"Percutaneous vertebroplasty immediately relieves pain of osteoporotic vertebral compression fractures and prevents prolonged immobilization of patients","volume":"15","author":"Kobayashi","year":"2005","journal-title":"Eur Radiol"},{"issue":"5","key":"10.1016\/j.aott.2017.05.006_bib7","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s00586-011-2105-y","article-title":"Treatment of MM-associated spinal fracture with percutaneous vertebroplasty (PVP) and chemotherapy","volume":"21","author":"Yang","year":"2012","journal-title":"Eur Spine J"},{"issue":"7308","key":"10.1016\/j.aott.2017.05.006_bib8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/bmj.323.7308.334","article-title":"A\u00a0new system for grading recommendations in evidence based guidelines","volume":"323","author":"Harbour","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.aott.2017.05.006_bib9","series-title":"Assessment of Osteoporosis at the Primary Health Care Level","author":"World Health Organization","year":"2008"},{"key":"10.1016\/j.aott.2017.05.006_bib10","unstructured":"Higgins JP and Green S. 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