{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:52:01Z","timestamp":1790009521631,"version":"4.0.1"},"reference-count":22,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nIntroduction\nThe aim of this systematic review was to analyze the results of published treatment options in Brucella infection following total joint arthroplasty (TJA).\nMethods\nWe performed a systematic review of the literature regarding outcomes of Brucella infection after TJA (hip and knee). We searched multiple databases for articles in the area published from 1950 to 2016.\nResults\nA total of 18 patients (12 male and 6 female; mean age 59 years) from 14 published studies were identified. The minimum follow-up time was 6 months (range, 6\u2013120 months). Seven patients were treated with debridement or antibrucella treatment only. Eleven patients (61%) underwent removal of the prosthesis and were treated with one or two-stage exchange arthroplasty. The mean duration of antibiotic therapy was 5.8 months. There was no relapse of infection.\nConclusions\nIn the absence of loosening of the components of the prosthesis, an attempt to treat Brucella infection medically might be a reasonable choice. One or two-stage exchange arthroplasty could provide successful results without relapse of infection when combined with appropriate antibiotherapy.\nLevel of evidence\nLevel III, therapeutic study.\nER -\n\nKeywords\n\n\n\tBrucella\n\tPeriprosthetic infection\n\tArthroplasty\n\tTreatment<\/jats:p>","DOI":"10.1016\/j.aott.2017.11.003","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T11:48:36Z","timestamp":1512647316000},"page":"148-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Brucella infection following total joint arthroplasty: A systematic review of the literature"],"prefix":"10.5152","volume":"52","author":[{"given":"Seung-ju","family":"K\u0130M","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-soo","family":"PARK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-woo","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong","family":"Hun K\u0130M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"issue":"9","key":"10.1016\/j.aott.2017.11.003_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0025-7753(02)73409-X","article-title":"Brucellosis in the 21st Century","volume":"119","author":"Ariza","year":"2002","journal-title":"Med Clin (Barc)"},{"issue":"2","key":"10.1016\/j.aott.2017.11.003_bib2","first-page":"E42","article-title":"Failure of total hip arthroplasty secondary to infection caused by Brucella abortus and the risk of transmission to operative staff","volume":"44","author":"Carothers","year":"2015","journal-title":"Am J Orthop (Belle Mead NJ)"},{"issue":"2","key":"10.1016\/j.aott.2017.11.003_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3928\/0147-7447-19830201-09","article-title":"Secondary infection of a total hip replacement with Brucella abortus","volume":"6","author":"Jones","year":"1983","journal-title":"Orthopedics"},{"issue":"7","key":"10.1016\/j.aott.2017.11.003_bib4","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1007\/s00167-010-1048-x","article-title":"Brucella melitensis infection in total knee arthroplasty: a case report","volume":"18","author":"Erdogan","year":"2010","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"267","key":"10.1016\/j.aott.2017.11.003_bib5","first-page":"179","article-title":"Brucellosis complicating bilateral total knee arthroplasty","author":"Agarwal","year":"1991","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"10.1016\/j.aott.2017.11.003_bib6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1054\/arth.2002.30284","article-title":"Brucellosis as a cause of septic loosening of total hip arthroplasty","volume":"17","author":"Ortega-Andreu","year":"2002","journal-title":"J\u00a0Arthroplasty"},{"issue":"1","key":"10.1016\/j.aott.2017.11.003_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/230949900601400122","article-title":"Total hip arthroplasty infected by Brucella: a report of two cases","volume":"14","author":"Ruiz-Iban","year":"2006","journal-title":"J\u00a0Orthop Surg (Hong Kong)"},{"issue":"11","key":"10.1016\/j.aott.2017.11.003_bib8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/BF01700416","article-title":"Brucellar prosthetic arthritis in a total knee replacement","volume":"16","author":"Orti","year":"1997","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"10.1016\/j.aott.2017.11.003_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2106\/00004623-200601000-00025","article-title":"Foreign-body osteoarticular infection by Brucella melitensis: a report of three cases","volume":"88","author":"Cairo","year":"2006","journal-title":"J\u00a0Bone Jt Surg Am"},{"issue":"1","key":"10.1016\/j.aott.2017.11.003_bib10","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.aott.2017.11.003_bib11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2106\/00004623-198264010-00021","article-title":"Brucella osteomyelitis of the distal part of the femur. 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