{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:15:09Z","timestamp":1781658909648,"version":"3.54.5"},"reference-count":43,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective\nThe aim of this study was to assess the effect of topical tranexamic acid on blood loss and transfusion rates in acetabular fracture surgery.\nMethods\nThe medical records of 61 patients who underwent open reduction and internal fixation for acetabular fracture between 2012 and 2015 were retrospectively reviewed. The patients were divided into two groups: Group I consisted of 31 patients (19 men and 12 women, mean age: 52 \u00b1 19 years) who received intraoperatively a topical tranexamic acid solution of 3 g and Group 2 consisted of 30 control patients (17 men and 13 women, mean age: 48 \u00b1 24 years) who received only 0.9% saline solution. The groups were compared based on their intraoperative blood loss, Postoperative drain output at 24 and 48 h, and postoperative hemoglobin levels, and transfusion rates.\nResults\nThe mean intraoperative blood loss was 410 \u00b1 100 ml in Group 1, compared to 570 ml \u00b1 160 ml of the control group (p &lt; 0.05). The postoperative drain output after 24 h was 210 \u00b1 70 ml in Group 1 compared to 330 \u00b1 90 ml of the control group (p &lt; 0.05). The drain output at 48 h was (50 \u00b1 20 ml) in group 1 compared to 90 \u00b1 40 ml of the control group (p &lt; 0.05). The transfusion rate was significantly low group 1 (42%) than the control group (97%). Hemoglobin drop was again significantly less in tranexamic acid group (2.1 \u00b1 1.1) than the control group (3.2 \u00b1 1.3). The nadir postoperative hemoglobin was higher in the Group 1 (10.4 \u00b1 1.5) than the control group (9.2 \u00b1 1.3).\nConclusion\nTopical administration of tranexamic acid reduces intraoperative and postoperative blood loss in acetabular fracture surgery, decreasing transfusion rates.\nLevel of Evidence\nLevel III, Therapeutic Study.\nER -<\/jats:p>","DOI":"10.1016\/j.aott.2019.03.006","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T09:10:44Z","timestamp":1553159444000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study"],"prefix":"10.5152","volume":"53","author":[{"given":"Sandeep","family":"KASHYAP","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"MAHAJAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukand","family":"LAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"10.1016\/j.aott.2019.03.006_bib1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/0310057X0303100507","article-title":"Use of intravenous tranexamic acid to reduce allogeneic blood transfusion in total hip and knee arthroplasty: a meta-analysis","volume":"31","author":"Ho","year":"2003","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.aott.2019.03.006_bib2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/00015458.2007.11680081","article-title":"Reduction of blood loss with tranexamic acid in primary total hip replacement surgery","volume":"107","author":"Claeys","year":"2007","journal-title":"Acta Chir Belg"},{"key":"10.1016\/j.aott.2019.03.006_bib3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/00016470510030751","article-title":"Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients","volume":"76","author":"Johansson","year":"2005","journal-title":"Acta Orthop"},{"key":"10.1016\/j.aott.2019.03.006_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1749-8090-4-25","article-title":"Can local application of tranexamic acid reduce post-coronary bypass surgery blood loss? 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