{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:31:07Z","timestamp":1792801867374,"version":"4.5.0"},"reference-count":38,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Sel\u00e7uk University units of scientific research projects"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective\nThe aim of this animal study was to investigate the short and long-term local histomorphologic effects and the utility of intra-articular application of ibuprofen.\nMethods\nForty-six Wistar Albino rats were used in the study. The rats were randomized into 5 groups of 8 and a sham group of 6. The 40 rats in the study groups were anaesthetised with 60 mg\/kg of ketamine, then 0.25 ml ibuprofen (25 mg) was injected to the right knee joint of each rat (ibuprofen group) and 0.25 ml 0.9% saline to the left knee joint as the control group. To the 6 rats in the sham group, only puncture was applied to both knee joints. The rats in each of the 5 study groups were sacrificed on days 1, 2, 7, 14 and 21 respectively. The histomorphologic changes were graded on a 6-point scale regarding inflammation of the synovia, cartilage tissue, and subchondral bone. Inflammation scores were compared using the Mann Whitney U-test and comparisons of the sacrifice day and drug used were evaluated with the Kruskal Wallis test. The p values below 0.05 were considered as significant.\nResults\nStatistically significant difference was found between the ibuprofen injected knees (10\/40) and the saline injected (0\/40) and sham knees (0\/12) in respect of hematoma positivity (p = 0.002). Significantly higher inflammation scores were found in ibuprofen injected knees on the 1st, 2nd, 7th and 14th days compared to controls and sham (p &lt; 0.05). Inflammation scores were similar in ibuprofen injected knees with and without hematoma (p &gt; 0.05). Inflammation of the ibuprofen injected group was most severe on day one and the severity of inflammation reduced gradually throughout the 3 weeks.\nConclusion\nOur results show that intra-articular injection of ibuprofen can cause intra-articular hematoma. It also leads to transient inflammation of the synovia that is more severe in the early period, which gradually recovers.\n\nER -<\/jats:p>","DOI":"10.1016\/j.aott.2019.03.013","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T11:51:32Z","timestamp":1554983492000},"page":"292-296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effects of intra-articular injection of ibuprofen on knee joint cartilage and synovium in rats"],"prefix":"10.5152","volume":"53","author":[{"given":"Emine","family":"\u00c7epni K\u00dcTAHYA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"OC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyhan","family":"UGURLUOGLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipek","family":"DUMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguzhan","family":"ARUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"10.1016\/j.aott.2019.03.013_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11916-016-0592-6","article-title":"Overview of total knee arthroplasty and modern pain control strategies","volume":"20","author":"Lavie","year":"2016","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.aott.2019.03.013_bib2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2106\/00004623-200605000-00005","article-title":"Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial","volume":"88","author":"Busch","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.aott.2019.03.013_bib3","first-page":"86","article-title":"The effect of intraarticular local anaesthesia on postoperative pain in arthroscopic knee surgery","volume":"1","author":"Altay","year":"2010","journal-title":"J\u00a0Clin Exp Invest"},{"key":"10.1016\/j.aott.2019.03.013_bib4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00167-005-0655-4","article-title":"The postoperative analgesic effects of intra-articular levobupivacaine in elective day-case arthroscopy of the knee: a prospective, randomized, double-blind clinical study","volume":"14","author":"Jacobson","year":"2006","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.aott.2019.03.013_bib5","first-page":"254","article-title":"Effects of intraarticular morphine on analgesic requirements after anterior cruciate ligament repair","volume":"18","author":"Joshi","year":"1993","journal-title":"Reg Anesth"},{"key":"10.1016\/j.aott.2019.03.013_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.aott.2017.02.014","article-title":"The effects of intra-articular levobupivacain versus levobupivacain plus magnesium sulfate on postoperative analgesia in patients undergoing arthroscopic meniscectomy: a prospective randomized controlled study","volume":"51","author":"K\u0131z\u0131lc\u0131k","year":"2017","journal-title":"Acta Orthop Traumatol Turc"},{"key":"10.1016\/j.aott.2019.03.013_bib7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1399-6576.1996.tb05554.x","article-title":"Intra-articular tenoxicam relieves post-arthroscopy pain","volume":"40","author":"Elhakim","year":"1996","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.aott.2019.03.013_bib8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00167-002-0306-y","article-title":"Comparison of efficacy of intraarticular application of tenoxicam, bupivacaine and tenoxicam: bupivacaine combination in arthroscopic knee surgery","volume":"10","author":"Talu","year":"2002","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.aott.2019.03.013_bib9","first-page":"17","article-title":"Comparison of analgesic activity of Intraarticular lornoxicam, bupivacaine and saline after knee arthroscopy","volume":"20","author":"Eren","year":"2008","journal-title":"Agri"},{"key":"10.1016\/j.aott.2019.03.013_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00913847.2016.1168272","article-title":"Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine","volume":"44","author":"Richards","year":"2016","journal-title":"Phys Sports Med"},{"key":"10.1016\/j.aott.2019.03.013_bib11","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1046\/j.1365-2044.1998.00582.x","article-title":"Low-dose Intraarticular ketorolac for pain relief following arthroscopy of the knee joint","volume":"53","author":"Convery","year":"1998","journal-title":"Anaesthesia"},{"key":"10.1016\/j.aott.2019.03.013_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4097\/kjae.2015.68.1.3","article-title":"Intravenous non-opioid analgesia for peri- and postoperative pain management: a scientific review of intravenous acetaminophen and ibuprofen","volume":"68","author":"Koh","year":"2015","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.aott.2019.03.013_bib13","doi-asserted-by":"crossref","first-page":"e573","DOI":"10.3928\/01477447-20150701-54","article-title":"Efficacy of intra-articular local anesthetics in total knee arthroplasty","volume":"38","author":"Fang","year":"2015","journal-title":"Orthopedics"},{"key":"10.1016\/j.aott.2019.03.013_bib14","first-page":"1","article-title":"Single dose intraarticular morphine for pain control after knee arthroscopy","volume":"5","author":"Zou","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.aott.2019.03.013_bib15","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1139\/y04-066","article-title":"The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint","volume":"82","author":"Dogan","year":"2004","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.aott.2019.03.013_bib16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/bja\/80.6.837","article-title":"Intra-articular injection of ketorolac in the rat knee joint: effect on articular cartilage and synovium","volume":"80","author":"Irwin","year":"1998","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.aott.2019.03.013_bib17","first-page":"362","article-title":"Effect of intraarticular injection of lornoxicam on the articular cartilage & synovium in rat","volume":"127","author":"Saricaoglu","year":"2008","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.aott.2019.03.013_bib18","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.3390\/ijms11104106","article-title":"Efficacy of intraarticular injection of celecoxib in a rabbit model of osteoarthritis","volume":"11","author":"Jiang","year":"2010","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.aott.2019.03.013_bib19","first-page":"312","article-title":"Intraarticular injection of tenoxicam in rats: assessment of the local effects on the articular cartilage and synovium","volume":"32","author":"Ozyuvaci","year":"2004","journal-title":"J\u00a0Int Med Res"},{"key":"10.1016\/j.aott.2019.03.013_bib20","series-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1016\/j.aott.2019.03.013_bib21","first-page":"225","article-title":"Postoperative pain following knee arthroscopy: the effects of intra-articular ketorolac and\/or morphine","volume":"24","author":"Gupta","year":"1999","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.aott.2019.03.013_bib22","first-page":"1154","article-title":"Postoperative analgesia for outpatient arthroscopic knee surgery with Intraarticular bupivacaine and ketorolac","volume":"80","author":"Reuben","year":"1995","journal-title":"Anesth Analg"},{"key":"10.1016\/j.aott.2019.03.013_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11552-007-9042-6","article-title":"The effect of local corticosteroid or ketorolac exposure on histologic and biomechanical properties of rabbit tendon and cartilage","volume":"2","author":"Shapiro","year":"2007","journal-title":"Hand (NY)"},{"key":"10.1016\/j.aott.2019.03.013_bib24","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/jor.22674","article-title":"Intra-articular tibiofemoral injection of a nonsteroidal anti-inflammatory drug has no detrimental effects on joint mechanics in a rat model","volume":"32","author":"Riggin","year":"2014","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.aott.2019.03.013_bib25","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2460\/ajvr.2001.62.1629","article-title":"Effects of intra-articular injections of bufexamac suspension in healthy horses","volume":"62","author":"Suominen","year":"2001","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.aott.2019.03.013_bib26","first-page":"S18","article-title":"Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam","volume":"66","author":"Pruss","year":"1990","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.aott.2019.03.013_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4103\/ijp.IJP_245_16","article-title":"Comparison of clinical effectiveness and safety of newer nonsteroidal anti-inflammatory drugs in patients of osteoarthritis of knee joint: a randomized, prospective, open-label parallel-group study","volume":"49","author":"Garg","year":"2017","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.aott.2019.03.013_bib28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.22203\/eCM.v013a06","article-title":"Oxygen, nitric oxide and articular cartilage","volume":"13","author":"Fermor","year":"2007","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.aott.2019.03.013_bib29","first-page":"1061","article-title":"Adverse drug reactions and drug-drug interactions with over-the-counter NSAIDs","volume":"11","author":"Moore","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.aott.2019.03.013_bib30","first-page":"67","article-title":"Intravenous ibuprofen: the first injectable product for the treatment of pain and fever","volume":"3","author":"Bookstaver","year":"2010","journal-title":"J\u00a0Pain Res"},{"key":"10.1016\/j.aott.2019.03.013_bib31","first-page":"1288","article-title":"Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat","volume":"288","author":"Jett","year":"1999","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.aott.2019.03.013_bib32","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1007\/s001010070032","article-title":"Specific cyclooxygenase-2 inhibitors. Basis and options of a pharmacotherapeutic concept","volume":"49","author":"Hinz","year":"2000","journal-title":"Anaesthesist"},{"key":"10.1016\/j.aott.2019.03.013_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2125.1991.tb05500.x","article-title":"Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclooxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen","volume":"31","author":"Evans","year":"1991","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.aott.2019.03.013_bib34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1177\/009127000004001005","article-title":"Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers","volume":"40","author":"Van Hecken","year":"2000","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.aott.2019.03.013_bib35","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/jps.21346","article-title":"Intraarticular depot formulation principles: role in the management of postoperative pain and arthritic disorders","volume":"97","author":"Larsen","year":"2008","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.aott.2019.03.013_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2165\/00003088-198917030-00002","article-title":"Recent findings on the pharmacokinetics of non-steroidal anti-inflamatory drugs in synovial fluid","volume":"17","author":"Netter","year":"1989","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.aott.2019.03.013_bib37","first-page":"438","article-title":"Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats","volume":"49","author":"Orak","year":"2015","journal-title":"Acta Orthop Traumatol Turc"},{"key":"10.1016\/j.aott.2019.03.013_bib38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/AAP.0b013e3181bfbd9f","article-title":"Ketorolac but not morphine exerts inflamatory and metabolic effects in synovial membrane after knee arthroscopy: a double-blind randomized prospective study using the microdialysis technique","volume":"34","author":"Stalman","year":"2009","journal-title":"Reg Anesth Pain Med"}],"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1017995X18303894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1017995X18303894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/3476\/3422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:30:34Z","timestamp":1763465434000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/3476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,1,4]]}},"URL":"https:\/\/doi.org\/10.1016\/j.aott.2019.03.013","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of intra-articular injection of ibuprofen on knee joint cartilage and synovium in rats","name":"articletitle","label":"Article Title"},{"value":"Acta Orthopaedica et Traumatologica Turcica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aott.2019.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Turkish Association of Orthopaedics and Traumatology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}