{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:34:14Z","timestamp":1786984454815,"version":"build-2736575974"},"reference-count":35,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"5","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T00:00:00Z","timestamp":1554508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AOTT"],"abstract":"<jats:p>Objective: The aim of this study was to assess the effectiveness of microfracture and cell free hyaluronic acid (HA) based scaffold combination in the treatment of talus osteochondral defects (OCD).\n\nMethods: This study retrospectively evaluated the clinical results of the 20 patients (14 males and 6 females, mean age at the time of surgery: 32.9 years (range: 16e52 years)) who were treated with MFx and cell-free HA-based scaffold combination for talus OCD smaller than 1.5 cm2 and deeper than 7 mm. Results were evaluated with AOFAS and VAS scores. Also, patients' satisfaction was questioned.\n\nResults: Patients were evaluated after an average follow-up of 20.3 months. Intraoperative measurements showed that mean depth of the lesions were 10.4 \u00b1 1.9 mm after debridement. The mean preoperative AOFAS score was 57.45 \u00b1 9.37, which increased to 92.45 \u00b1 8.4 postoperatively (p &lt; 0.05). VAS score was improved from 7.05 \u00b1 2.45 to 1.65 \u00b1 2.20 postoperatively (p &lt; 0.05).\n\nConclusion: MFx and cell-free HA-based scaffold combination appear to be a safe and efficient technique that provide good clinical outcomes for lesions deeper than 7 mm.\n\n\nLevel of evidence: Level IV, Therapeutic Study.<\/jats:p>","DOI":"10.1016\/j.aott.2019.04.002","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T11:02:26Z","timestamp":1558436546000},"page":"372-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["One step treatment of talus osteochondral lesions with microfracture and cell free hyaluronic acid based scaffold combination"],"prefix":"10.5152","volume":"53","author":[{"given":"Necip Selcuk","family":"Yontar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lercan","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Ogut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"issue":"3","key":"10.1016\/j.aott.2019.04.002_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5435\/00124635-200505000-00002","article-title":"Osteochondral lesions of the talus","volume":"13","author":"Schachter","year":"2005","journal-title":"J\u00a0Am Acad Orthop Surg"},{"issue":"10","key":"10.1016\/j.aott.2019.04.002_bib2","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.arthro.2006.05.016","article-title":"Osteochondral lesions of the talus: randomized controlled trial comparing chondroplasty, microfracture, and osteochondral autograft transplantation","volume":"22","author":"Gobbi","year":"2006","journal-title":"Arthroscopy"},{"key":"10.1016\/j.aott.2019.04.002_bib3","series-title":"Arthroscopy. Basic to Advanced","first-page":"1003","article-title":"Scaffolding as treatment for osteochondral defects in the ankle","author":"Gobbi","year":"2016"},{"key":"10.1016\/j.aott.2019.04.002_bib4","series-title":"Mann's Surgery of the Foot and Ankle","first-page":"1725","article-title":"Arthroscopy of the foot and ankle","author":"Ferkel","year":"2014"},{"key":"10.1016\/j.aott.2019.04.002_bib5","series-title":"Ankle Arthroscopy: Techniques Developed by Amsterdam Foot and Ankle School","first-page":"149","author":"van Dijk","year":"2014"},{"issue":"1","key":"10.1016\/j.aott.2019.04.002_bib6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/1947603516644298","article-title":"Operative treatment for osteochondral lesions of the talus: biologics and scaffold-based therapy","volume":"8","author":"Yasui","year":"2017","journal-title":"Cartilage"},{"issue":"8","key":"10.1016\/j.aott.2019.04.002_bib7","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1177\/0363546515584755","article-title":"Comparison of arthroscopic microfracture for osteochondral lesions of the talus with and without subchondral cyst","volume":"43","author":"Lee","year":"2015","journal-title":"Am J Sports Med"},{"issue":"9","key":"10.1016\/j.aott.2019.04.002_bib8","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1177\/0363546512455316","article-title":"Comparison of early versus delayed weightbearing outcomes after microfracture for small to midsized osteochondral lesions of the talus","volume":"40","author":"Lee","year":"2012","journal-title":"Am J Sports Med"},{"issue":"3","key":"10.1016\/j.aott.2019.04.002_bib9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/107110070402500311","article-title":"Operative treatment of osteochondral lesions of the talar dome: current concepts review","volume":"25","author":"Giannini","year":"2004","journal-title":"Foot Ankle Int"},{"issue":"7","key":"10.1016\/j.aott.2019.04.002_bib10","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1302\/0301-620X.85B7.13959","article-title":"Arthroscopic treatment of osteochondral lesions of the talus","volume":"85","author":"Robinson","year":"2003","journal-title":"J\u00a0Bone Joint Surg Br"},{"issue":"2","key":"10.1016\/j.aott.2019.04.002_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00167-009-0942-6","article-title":"Treatment of osteochondral lesions of the talus: a systematic review","volume":"18","author":"Zengerink","year":"2010","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"8","key":"10.1016\/j.aott.2019.04.002_bib12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.rco.2008.09.003","article-title":"Treatment of osteochondral defects of the talus","volume":"94","author":"Van Bergen","year":"2008","journal-title":"Rev Chir Orthop Reparatrice Appar Mot"},{"issue":"9","key":"10.1016\/j.aott.2019.04.002_bib13","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00264-013-2076-1","article-title":"Treatment principles for osteochondral lesions in foot and ankle","volume":"37","author":"Badekas","year":"2013","journal-title":"Int Orthop"},{"issue":"11","key":"10.1016\/j.aott.2019.04.002_bib14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2106\/JBJS.L.00773","article-title":"Operative treatment of osteochondral lesions of the talus","volume":"95","author":"Murawski","year":"2013","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"10","key":"10.1016\/j.aott.2019.04.002_bib15","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1177\/0363546509335765","article-title":"Osteochondral lesion of the talus: is there a\u00a0critical defect size for poor outcome?","volume":"37","author":"Choi","year":"2009","journal-title":"Am J Sports Med"},{"issue":"1","key":"10.1016\/j.aott.2019.04.002_bib16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.arthro.2007.07.022","article-title":"Microfracture for osteochondral lesions of the ankle: outcome analysis and outcome predictors of 105 cases","volume":"24","author":"Chuckpaiwong","year":"2008","journal-title":"Arthroscopy"},{"issue":"3","key":"10.1016\/j.aott.2019.04.002_bib17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/1071100716677746","article-title":"Current concepts: review update","volume":"38","author":"Kraeutler","year":"2017","journal-title":"Foot Ankle Int"},{"issue":"7","key":"10.1016\/j.aott.2019.04.002_bib18","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1007\/s00167-017-4616-5","article-title":"No superior treatment for primary osteochondral defects of the talus","volume":"26","author":"Dahmen","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"5","key":"10.1016\/j.aott.2019.04.002_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.rbo.2015.10.010","article-title":"Diagnosis and treatment of osteochondral lesions of the ankle: current concepts","volume":"51","author":"Prado","year":"2016","journal-title":"Rev Bras Ortop"},{"key":"10.1016\/j.aott.2019.04.002_bib20","series-title":"Arthroscopy. Basic to Advanced","first-page":"985","article-title":"Osteochondral defects of the ankle","author":"Vuurberg","year":"2016"},{"issue":"6","key":"10.1016\/j.aott.2019.04.002_bib21","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1007\/s00167-013-2364-8","article-title":"Critical three-dimensional factors affecting outcome in osteochondral lesion of the talus","volume":"21","author":"Angthong","year":"2013","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"3","key":"10.1016\/j.aott.2019.04.002_bib22","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/0363546512472979","article-title":"Arthroscopic bone marrow stimulation techniques for osteochondral lesions of the talus: prognostic factors for small lesions","volume":"41","author":"Yoshimura","year":"2013","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.aott.2019.04.002_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/9201492","article-title":"Cartilage defect treatments: with or without cells? Mesenchymal stem cells or chondrocytes? Traditional or matrix-assisted? A systematic review and meta-analyses","volume":"2016","author":"Deng","year":"2016","journal-title":"Stem Cells Int"},{"issue":"9","key":"10.1016\/j.aott.2019.04.002_bib24","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1177\/0363546508316773","article-title":"Arthroscopic treatment of chronic osteochondral lesions of the talus: long-term results","volume":"36","author":"Ferkel","year":"2008","journal-title":"Am J Sports Med"},{"issue":"6","key":"10.1016\/j.aott.2019.04.002_bib25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.tice.2004.07.003","article-title":"Hyaluronic acid and autologous synovial fluid induce chondrogenic differentiation of equine mesenchymal stem cells: a preliminary study","volume":"36","author":"Hegewald","year":"2004","journal-title":"Tissue Cell"},{"issue":"2","key":"10.1016\/j.aott.2019.04.002_bib26","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1016\/j.ejrad.2010.08.008","article-title":"Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle","volume":"80","author":"Battaglia","year":"2011","journal-title":"Eur J Radiol"},{"issue":"11","key":"10.1016\/j.aott.2019.04.002_bib27","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.injury.2010.09.028","article-title":"Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: from open field autologous chondrocyte to bone-marrow-derived cells transplantation","volume":"41","author":"Giannini","year":"2010","journal-title":"Injury"},{"issue":"3","key":"10.1016\/j.aott.2019.04.002_bib28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/0363546512467622","article-title":"One-step repair in talar osteochondral lesions: 4-year clinical results and t2-mapping capability in outcome prediction","volume":"41","author":"Giannini","year":"2013","journal-title":"Am J Sports Med"},{"issue":"6","key":"10.1016\/j.aott.2019.04.002_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/term.397","article-title":"Evaluation of methods for the construction of collagenous scaffolds with a radial pore structure for tissue engineering","volume":"5","author":"Brouwer","year":"2011","journal-title":"J\u00a0Tissue Eng Regen Med"},{"issue":"10","key":"10.1016\/j.aott.2019.04.002_bib30","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00167-011-1777-5","article-title":"Cell-free collagen type I matrix for repair of cartilage defects-clinical and magnetic resonance imaging results","volume":"20","author":"Efe","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"4","key":"10.1016\/j.aott.2019.04.002_bib31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.arthro.2014.11.017","article-title":"Scaffold-based cartilage treatments: with or without cells? A systematic review of preclinical and clinical evidence","volume":"31","author":"Kon","year":"2015","journal-title":"Arthroscopy"},{"issue":"4","key":"10.1016\/j.aott.2019.04.002_bib32","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.7717\/peerj.2243","article-title":"Improved cartilage regeneration by implantation of acellular biomaterials after bone marrow stimulation: a systematic review and meta-analysis of animal studies","volume":"8","author":"Pot","year":"2016","journal-title":"PeerJ"},{"issue":"15\u201316","key":"10.1016\/j.aott.2019.04.002_bib33","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1089\/ten.tea.2013.0356","article-title":"Bioinspired scaffolds for osteochondral regeneration","volume":"20","author":"Lopa","year":"2014","journal-title":"Tissue Eng A"},{"issue":"12","key":"10.1016\/j.aott.2019.04.002_bib34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1177\/107110070602701218","article-title":"Radiographic changes and clinical results of osteochondral defects of the talus with and without subchondral cysts","volume":"27","author":"Han","year":"2006","journal-title":"Foot Ankle Int"},{"issue":"5","key":"10.1016\/j.aott.2019.04.002_bib35","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s00167-011-1411-6","article-title":"Role of arthroscopic microfracture for cystic type osteochondral lesions of the talus with radiographic enhanced MRI support","volume":"19","author":"Jung","year":"2011","journal-title":"Knee Surg Sports Traumatol Arthrosc"}],"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1017995X18304917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1017995X18304917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/3493\/3439","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:46:24Z","timestamp":1763466384000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/3493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,1,5]]}},"URL":"https:\/\/doi.org\/10.1016\/j.aott.2019.04.002","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"One step treatment of talus osteochondral lesions with microfracture and cell free hyaluronic acid based scaffold combination","name":"articletitle","label":"Article Title"},{"value":"Acta Orthopaedica et Traumatologica Turcica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aott.2019.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Turkish Association of Orthopaedics and Traumatology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}