{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:51:56Z","timestamp":1788519116564,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800798"],"award-info":[{"award-number":["81800798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pacific Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.apjo.2025.100137","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T22:50:53Z","timestamp":1736895053000},"page":"100137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of substitutive growth hormone therapy on myopia control among Chinese children"],"prefix":"10.1016","volume":"14","author":[{"given":"Yi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingdong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apjo.2025.100137_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2017.09.004","article-title":"The epidemics of myopia: aetiology and prevention","volume":"62","author":"Morgan","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.apjo.2025.100137_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/iovs.62.5.5","article-title":"IMI pathologic myopia","volume":"62","author":"Ohno-Matsui","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.62.5.6","article-title":"IMI prevention of myopia and its progression","volume":"62","author":"Jonas","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.apjo.2025.100137_bib5","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1167\/iovs.05-0077","article-title":"Effect of stature and other anthropometric parameters on eye size and refraction in a population-based study of Australian children","volume":"46","author":"Ojaimi","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib6","first-page":"1408","article-title":"Height and its relationship to refraction and biometry parameters in Singapore Chinese children","volume":"43","author":"Saw","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib7","doi-asserted-by":"crossref","first-page":"7949","DOI":"10.1167\/iovs.11-7684","article-title":"Longitudinal changes of axial length and height are associated and concomitant in children","volume":"52","author":"Wang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib8","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1167\/iovs.12-10402","article-title":"The relationship between growth spurts and myopia in Singapore children","volume":"53","author":"Yip","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib9","article-title":"Correlation between increase of axial length and height growth in Chinese school-age children","volume":"9","author":"Tao","year":"2021","journal-title":"Front Public Health"},{"key":"10.1016\/j.apjo.2025.100137_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1076\/ceyr.28.1.11.23491","article-title":"Refractive evaluation in children with growth defect","volume":"28","author":"Parentin","year":"2004","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.apjo.2025.100137_bib11","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1755-3768.2009.01519.x","article-title":"Central corneal thickness in children with growth hormone deficiency","volume":"88","author":"Parentin","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.apjo.2025.100137_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000085732","article-title":"Congenital growth hormone deficiency and eye refraction: a longitudinal study","volume":"219","author":"Parentin","year":"2005","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.apjo.2025.100137_bib13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1067\/S0022-3476(03)00246-4","article-title":"Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee","volume":"143","author":"Wilson","year":"2003","journal-title":"J Pedia"},{"key":"10.1016\/j.apjo.2025.100137_bib14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1210\/clinem\/dgab746","article-title":"Approach to the patient: safety of growth hormone replacement in children and adolescents","volume":"107","author":"Bamba","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.apjo.2025.100137_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100923","article-title":"Efficacy in myopia control","volume":"83","author":"Brennan","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.apjo.2025.100137_bib16","article-title":"Interventions for myopia control in children: a living systematic review and network meta-analysis","volume":"2","author":"Lawrenson","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.apjo.2025.100137_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ghir.2016.03.004","article-title":"Growth hormone and ocular dysfunction: endocrine, paracrine or autocrine etiologies?","volume":"29","author":"Harvey","year":"2016","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.apjo.2025.100137_bib18","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8436","article-title":"Association of IGF1 single-nucleotide polymorphisms with myopia in Chinese children","volume":"8","author":"Cheng","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.apjo.2025.100137_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271809","article-title":"The G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia: updated systematic review and meta-analysis","volume":"17","author":"Meng","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.apjo.2025.100137_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1167\/iovs.08-1708","article-title":"Opposite effects of glucagon and insulin on compensation for spectacle lenses in chicks","volume":"50","author":"Zhu","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib21","first-page":"1436","article-title":"Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus","volume":"17","author":"Penha","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.apjo.2025.100137_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/opo.12696","article-title":"DNA methylation and mRNA expression of IGF-1 and MMP-2 after form-deprivation myopia in guinea pigs","volume":"40","author":"Ding","year":"2020","journal-title":"Ophthalmic Physiol Opt"},{"key":"10.1016\/j.apjo.2025.100137_bib23","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/jama.2022.24162","article-title":"Effect of low-concentration atropine eyedrops vs placebo on myopia incidence in children: the LAMP2 randomized clinical trial","volume":"329","author":"Yam","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.apjo.2025.100137_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ophtha.2018.05.029","article-title":"Low-concentration Atropine for Myopia Progression (LAMP) Study: a randomized, double-blinded, placebo-controlled trial of 0.05%, 0.025%, and 0.01% atropine eye drops in myopia control","volume":"126","author":"Yam","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.apjo.2025.100137_bib25","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1167\/iovs.12-10565","article-title":"Retardation of myopia in Orthokeratology (ROMIO) study: a 2-year randomized clinical trial","volume":"53","author":"Cho","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.apjo.2025.100137_bib26","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ophtha.2023.01.007","article-title":"The efficacy of defocus incorporated multiple segments lenses in slowing myopia progression: results from diverse clinical circumstances","volume":"130","author":"Liu","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.apjo.2025.100137_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12093210","article-title":"Myopia control efficacy and long-term safety of a novel orthokeratology lens (MESOK Study)-A randomized controlled clinical trial combining clinical and tear proteomics data","volume":"12","author":"Choi","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.apjo.2025.100137_bib28","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jamaophthalmol.2020.3820","article-title":"Safety and efficacy of low-dose atropine eyedrops for the treatment of myopia progression in Chinese children: a randomized clinical trial","volume":"138","author":"Wei","year":"2020","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.apjo.2025.100137_bib29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ophtha.2021.11.023","article-title":"Effect of repeated low-level red-light therapy for myopia control in children: a multicenter randomized controlled trial","volume":"129","author":"Jiang","year":"2022","journal-title":"Ophthalmology"}],"container-title":["Asia-Pacific Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162098925000040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162098925000040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T13:32:29Z","timestamp":1740663149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162098925000040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2162098925000040"],"URL":"https:\/\/doi.org\/10.1016\/j.apjo.2025.100137","relation":{},"ISSN":["2162-0989"],"issn-type":[{"value":"2162-0989","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of substitutive growth hormone therapy on myopia control among Chinese children","name":"articletitle","label":"Article Title"},{"value":"Asia-Pacific Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apjo.2025.100137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of Asia-Pacific Academy of Ophthalmology and Academy of Asia-Pacific Professors of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100137"}}