{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:10:08Z","timestamp":1790500208529,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T00:00:00Z","timestamp":1449964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian Pacific Journal of Tropical Medicine"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.apjtm.2015.12.002","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T10:00:26Z","timestamp":1450519226000},"page":"1-7","source":"Crossref","is-referenced-by-count":232,"title":["Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection"],"prefix":"10.4103","volume":"9","author":[{"given":"K.H.","family":"Chiow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Phoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Putti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny K.H.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent T.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.apjtm.2015.12.002_bib1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1126\/science.1087139","article-title":"Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China","volume":"302","author":"Guan","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.apjtm.2015.12.002_bib2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1118391","article-title":"Bats are natural reservoirs of SARS-like coronaviruses","volume":"310","author":"Li","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.apjtm.2015.12.002_bib3","doi-asserted-by":"crossref","first-page":"14040","DOI":"10.1073\/pnas.0506735102","article-title":"Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats","volume":"102","author":"Lau","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apjtm.2015.12.002_bib4","doi-asserted-by":"crossref","first-page":"578","DOI":"10.4269\/ajtmh.1998.58.578","article-title":"Monitoring of dengue viruses in field-caught Aedes aegypti and Aedes albopictus mosquitoes by a type-specific polymerase chain reaction and cycle sequencing","volume":"58","author":"Chow","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.apjtm.2015.12.002_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.3277268","article-title":"Pathogenesis of dengue. Challenge to molecular biology","volume":"239","author":"Halstead","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.apjtm.2015.12.002_bib6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4269\/ajtmh.1998.58.96","article-title":"Molecular evolution of dengue type 2 virus in Thailand","volume":"58","author":"Rico-Hesse","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.apjtm.2015.12.002_bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.apjtm.2015.12.002_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-2006-958063","article-title":"Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV","volume":"61","author":"Hayashi","year":"1995","journal-title":"Planta Med"},{"key":"10.1016\/j.apjtm.2015.12.002_bib9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1248\/cpb.57.1227","article-title":"The constituents and their bioactivities of Houttuynia cordata","volume":"57","author":"Chou","year":"2009","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.apjtm.2015.12.002_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.antiviral.2011.09.005","article-title":"Houttuynia cordata blocks HSV infection through inhibition of NF-\u03baB activation","volume":"92","author":"Chen","year":"2011","journal-title":"Antiviral Res"},{"key":"10.1016\/j.apjtm.2015.12.002_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/0973-7847.125525","article-title":"A\u00a0current update on the phytopharmacological aspects of Houttuynia cordata Thunb","volume":"8","author":"Kumar","year":"2014","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.apjtm.2015.12.002_bib12","doi-asserted-by":"crossref","first-page":"e0115475","DOI":"10.1371\/journal.pone.0115475","article-title":"Houttuynia cordata targets the beginning stage of herpes simplex virus infection","volume":"10","author":"Hung","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.apjtm.2015.12.002_bib13","first-page":"78","article-title":"Houttuynia cordata extracts and constituents inhibit the infectivity of dengue virus type 2 in\u00a0vitro","volume":"14","author":"Xie","year":"2013","journal-title":"Int J Integr Biol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib14","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1248\/cpb.53.1604","article-title":"Establishment of HPLC-DAD-MS fingerprint of fresh Houttuynia cordata","volume":"53","author":"Meng","year":"2005","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.apjtm.2015.12.002_bib15","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0006-2952(83)90262-9","article-title":"Flavonoids, a class of natural products of high pharmacological potency","volume":"32","author":"Havsteen","year":"1983","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<89::AID-PTR569>3.0.CO;2-C","article-title":"Antiviral effect of flavonoids on the dengue virus","volume":"14","author":"Sanchez","year":"2000","journal-title":"Phytother Res"},{"key":"10.1016\/j.apjtm.2015.12.002_bib17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.antiviral.2005.06.010","article-title":"Antiviral effect of catechins in green tea on influenza virus","volume":"68","author":"Song","year":"2005","journal-title":"Antiviral Res"},{"key":"10.1016\/j.apjtm.2015.12.002_bib18","first-page":"97","article-title":"A\u00a0seroprevalence survey of dengue virus infection in healthy Singapore university undergraduates by enzyme immunoassay and plaque reduction neutralization test","volume":"29","author":"Chow","year":"2005","journal-title":"Dengue Bull"},{"key":"10.1016\/j.apjtm.2015.12.002_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/vim.2006.19.33","article-title":"Differential dengue cross-reactive and neutralizing antibody responses in BALB\/c and Swiss albino mice induced by immunization with flaviviral vaccines and by infection with homotypic dengue-2 virus strains","volume":"19","author":"Lim","year":"2006","journal-title":"Viral Immunol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0378-1119(92)90509-N","article-title":"Mapping of a region of dengue virus type-2 glycoprotein required for binding by a neutralizing monoclonal antibody","volume":"116","author":"Trirawatanapong","year":"1992","journal-title":"Gene"},{"key":"10.1016\/j.apjtm.2015.12.002_bib21","first-page":"522","article-title":"Structural basis for antiviral activity of flavonoids-naturally occurring compounds","volume":"32","author":"Wleklik","year":"1988","journal-title":"Acta Virol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib22","first-page":"303","article-title":"High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms","volume":"7","author":"Dubber","year":"2004","journal-title":"J\u00a0Pharm Pharm Sci"},{"key":"10.1016\/j.apjtm.2015.12.002_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jmv.1890150110","article-title":"Antiviral effect of flavonoids on human viruses","volume":"15","author":"Kaul","year":"1985","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib24","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1099\/0022-1317-69-7-1749","article-title":"Antiviral activity of flavones and potentiation by ascorbate","volume":"69","author":"Vrijsen","year":"1988","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib25","first-page":"283","article-title":"Present status and prospects of flavonoids as anti-viral agents","volume":"280","author":"Vlietinck","year":"1988","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.apjtm.2015.12.002_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.antiviral.2008.10.002","article-title":"Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus","volume":"81","author":"Choi","year":"2009","journal-title":"Antiviral Res"},{"key":"10.1016\/j.apjtm.2015.12.002_bib27","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1111\/j.1742-4658.2005.04888.x","article-title":"Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)","volume":"272","author":"Wu","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.apjtm.2015.12.002_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejps.2009.03.002","article-title":"Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication","volume":"37","author":"Choi","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.apjtm.2015.12.002_bib29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.bmc.2014.12.015","article-title":"Flavonoids as noncompetitive inhibitors of dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies","volume":"23","author":"de Sousa","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.apjtm.2015.12.002_bib30","first-page":"395","article-title":"Combined antiviral effects of flavonoids and 5-ethyl-2\u2032-deoxyuridine on the multiplication of herpesviruses","volume":"28","author":"Mucsi","year":"1984","journal-title":"Acta Virol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jep.2004.09.016","article-title":"Inhibition of fowlpox virus by an aqueous acetone extract from galls of Guiera senegalensis J. F. Gmel (Combretaceae)","volume":"96","author":"Lamien","year":"2005","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib32","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1248\/cpb.56.1400","article-title":"Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors","volume":"56","author":"Yang","year":"2008","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.apjtm.2015.12.002_bib33","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10529-011-0845-8","article-title":"Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris","volume":"34","author":"Nguyen","year":"2012","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.apjtm.2015.12.002_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virusres.2013.12.004","article-title":"Atlas of coronavirus replicase structure","volume":"194","author":"Neuman","year":"2014","journal-title":"Virus Res"},{"key":"10.1016\/j.apjtm.2015.12.002_bib35","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1021\/jf3008376","article-title":"Chemical composition and hepatoprotective effects of polyphenol-rich extract from Houttuynia cordata tea","volume":"60","author":"Tian","year":"2012","journal-title":"J\u00a0Agric Food Chem"},{"key":"10.1016\/j.apjtm.2015.12.002_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jep.2008.03.018","article-title":"Immunomodulatory and anti-SARS activities of Houttuynia cordata","volume":"118","author":"Lau","year":"2008","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/03079457.2011.605107","article-title":"In\u00a0vitro and in\u00a0vivo effects of Houttuynia cordata on infectious bronchitis virus","volume":"40","author":"Yin","year":"2011","journal-title":"Avian Pathol"},{"key":"10.1016\/j.apjtm.2015.12.002_bib38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1745-4514.2010.00514.x","article-title":"The inhibitory actions of Houttuynia cordata aqueous extract on dengue virus and dengue-infected cell","volume":"36","author":"Leardkamolkarn","year":"2012","journal-title":"J\u00a0Food Biochem"},{"key":"10.1016\/j.apjtm.2015.12.002_bib39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2015.02.030","article-title":"Development of animal models against emerging coronaviruses: from SARS to MERS coronavirus","volume":"479\u2013480C","author":"Sutton","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.apjtm.2015.12.002_bib40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4236\/cm.2013.43015","article-title":"Houttuynia cordata Thunb: a review of phytochemistry and pharmacology and quality control","volume":"4","author":"Fu","year":"2013","journal-title":"Chin Med"}],"container-title":["Asian Pacific Journal of Tropical Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1995764515002230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1995764515002230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T14:26:34Z","timestamp":1514903194000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995764515002230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1995764515002230"],"URL":"https:\/\/doi.org\/10.1016\/j.apjtm.2015.12.002","relation":{},"ISSN":["1995-7645"],"issn-type":[{"value":"1995-7645","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}