{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:37:34Z","timestamp":1786984654312,"version":"build-2736575974"},"reference-count":76,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T00:00:00Z","timestamp":1483747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Thailand Excellence Center for Tissue Engineering and Stem Cells, Faculty of Medicine, Chiang Mai University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian Pacific Journal of Tropical Medicine"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.apjtm.2017.03.001","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T07:33:45Z","timestamp":1488872025000},"page":"238-252","source":"Crossref","is-referenced-by-count":20,"title":["In\u00a0vitro and in\u00a0vivo investigation of natural compounds from seed extract of Mucuna pruriens lacking l -DOPA for the treatment of erectile dysfunction"],"prefix":"10.4103","volume":"10","author":[{"given":"Natthachai","family":"Duangnin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanyaluck","family":"Phitak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peraphan","family":"Pothacharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachya","family":"Kongtawelert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.apjtm.2017.03.001_bib1","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/sj.ijir.3900905","article-title":"Prevalence of erectile dysfunction: a systematic review of population-based studies","volume":"14","author":"Prins","year":"2002","journal-title":"Int J Impot Res"},{"issue":"4","key":"10.1016\/j.apjtm.2017.03.001_bib2","first-page":"181","article-title":"National Institutes of Health. Impotence. December 7-9, 1992","volume":"5","author":"Consensus development conference statement","year":"1993","journal-title":"Int J Impot Res"},{"issue":"1","key":"10.1016\/j.apjtm.2017.03.001_bib3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1001\/jama.1993.03510010089036","article-title":"Impotence. NIH consensus development panel on impotence","volume":"270","author":"National Institutes of Health Consensus Conference","year":"1993","journal-title":"JAMA"},{"issue":"1 Pt2","key":"10.1016\/j.apjtm.2017.03.001_bib4","first-page":"445","article-title":"Anatomy, physiology, and pathophysiology of erectile dysfunction","volume":"7","author":"Gratzke","year":"2010","journal-title":"J\u00a0Sex Med"},{"issue":"4","key":"10.1016\/j.apjtm.2017.03.001_bib5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","article-title":"Physiology of penile erection and pathophysiology of erectile dysfunction","volume":"32","author":"Dean","year":"2005","journal-title":"Urol Clin North Am"},{"issue":"12B","key":"10.1016\/j.apjtm.2017.03.001_bib6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.amjcard.2005.10.007","article-title":"Sexual dysfunction and cardiovascular disease: integrative concepts and strategies","volume":"96","author":"Billups","year":"2005","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.apjtm.2017.03.001_bib7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jdiacomp.2010.03.003","article-title":"Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management","volume":"25","author":"Thorvea","year":"2011","journal-title":"J\u00a0Diabetes Complications"},{"issue":"5","key":"10.1016\/j.apjtm.2017.03.001_bib8","first-page":"S20","article-title":"Nitric oxide regulation of penile erection: biology and therapeutic implications","volume":"23","author":"Burnett","year":"2002","journal-title":"J\u00a0Androl"},{"key":"10.1016\/j.apjtm.2017.03.001_bib9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.eeus.2006.03.003","article-title":"Physiology of erectile function: an update on intracellular molecular processes","volume":"4","author":"Morelli","year":"2006","journal-title":"EAU-EBU Update Ser"},{"issue":"12B","key":"10.1016\/j.apjtm.2017.03.001_bib10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.amjcard.2005.07.004","article-title":"Erectile dysfunction: pathophysiologic mechanisms pointing to underlying cardiovascular disease","volume":"96","author":"Ganz","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.apjtm.2017.03.001_bib11","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1124\/pr.111.004515","article-title":"Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction","volume":"63","author":"Andersson","year":"2011","journal-title":"Pharmacol Rev"},{"issue":"1\u20132","key":"10.1016\/j.apjtm.2017.03.001_bib12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.5489\/cuaj.2699","article-title":"2015 CUA Practice guidelines for erectile dysfunction","volume":"9","author":"Bella","year":"2015","journal-title":"Can Urol Assoc J"},{"issue":"2","key":"10.1016\/j.apjtm.2017.03.001_bib13","first-page":"63","article-title":"Sildenafil (Viagra) and the heart","volume":"8","author":"Chamsi-Pasha","year":"2001","journal-title":"J\u00a0Fam Community Med"},{"key":"10.1016\/j.apjtm.2017.03.001_bib14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/sj.ijir.3901525","article-title":"Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?","volume":"19","author":"Doggrell","year":"2007","journal-title":"Int J Impot Res"},{"issue":"1","key":"10.1016\/j.apjtm.2017.03.001_bib15","doi-asserted-by":"publisher","first-page":"S131","DOI":"10.1016\/S2221-1691(11)60140-8","article-title":"Pharmacologically screened aphrodisiac plant - a review of current scientific literature","volume":"1","author":"Patel","year":"2011","journal-title":"Asian Pac J Trop Biomed"},{"key":"10.1016\/j.apjtm.2017.03.001_bib16","doi-asserted-by":"publisher","first-page":"868062","DOI":"10.1155\/2014\/868062","article-title":"A\u00a0review on plants used for improvement of sexual performance and virility","volume":"2014","author":"Chauhan","year":"2014","journal-title":"Biomed Res Int"},{"issue":"2","key":"10.1016\/j.apjtm.2017.03.001_bib17","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5897\/JMPR2013.5036","article-title":"Amazing bean \u2018Mucuna pruriens\u2019: a comprehensive review","volume":"8","author":"Kavitha","year":"2014","journal-title":"J\u00a0Med Plants Res"},{"key":"10.1016\/j.apjtm.2017.03.001_bib18","doi-asserted-by":"publisher","first-page":"11078","DOI":"10.1038\/srep11078","article-title":"Levodopa in Mucuna pruriens and its degradation","volume":"5","author":"Pulikkalpura","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.apjtm.2017.03.001_bib19","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.neuint.2013.03.015","article-title":"Mucuna pruriens seed extract reduces oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in paraquat-induced Parkinsonian mouse model","volume":"62","author":"Yadav","year":"2013","journal-title":"Neurochem Int"},{"issue":"7","key":"10.1016\/j.apjtm.2017.03.001_bib20","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.parkreldis.2010.04.015","article-title":"A\u00a0water extract of Mucuna pruriens provides long-term amelioration of Parkinsonism with reduced risk for dyskinesias","volume":"16","author":"Lieu","year":"2010","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.apjtm.2017.03.001_bib21","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.fitote.2008.05.008","article-title":"Hypoglycemic effect of Mucuna pruriens seed extract on normal and streptozotocin-diabetic rats","volume":"79","author":"Bhaskar","year":"2008","journal-title":"Fitoterapia"},{"issue":"8","key":"10.1016\/j.apjtm.2017.03.001_bib22","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S1995-7645(11)60161-2","article-title":"Evaluation of the anti-diabetic properties of Mucuna pruriens seed extract","volume":"4","author":"Majekodunmi","year":"2011","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.apjtm.2017.03.001_bib23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jep.2009.01.032","article-title":"Dose- and time-dependent effects of ethanolic extract of Mucuna pruriens Linn. seed on sexual behaviour of normal male rats","volume":"122","author":"Suresh","year":"2009","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.apjtm.2017.03.001_bib24","first-page":"3066","article-title":"Effect of Mucuna pruriens (Linn.) on sexual behavior and sperm parameters in streptozotocin-induced diabetic male rat","volume":"9","author":"Suresh","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.apjtm.2017.03.001_bib25","first-page":"1943","article-title":"Effect of Mucuna pruriens (Linn.) on oxidative stress-induced structural alteration of corpus cavernosum in streptozotocin-induced diabetic rat","volume":"8","author":"Suresh","year":"2011","journal-title":"J\u00a0Sex Med"},{"issue":"1","key":"10.1016\/j.apjtm.2017.03.001_bib26","doi-asserted-by":"publisher","first-page":"e54655","DOI":"10.1371\/journal.pone.0054655","article-title":"Mucuna pruriens and its major constituent l-DOPA recover spermatogenic loss by combating ROS, loss of mitochondrial membrane potential and apoptosis","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.apjtm.2017.03.001_bib27","first-page":"1","article-title":"Male sexual behaviour improving effect of lipid based extract of Mucuna pruriens in rats","volume":"1","author":"Ketkar","year":"2011","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.apjtm.2017.03.001_bib28","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/sj.npp.1300580","article-title":"Effect of a single dose of levodopa on sexual response in men and women","volume":"30","author":"Both","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.apjtm.2017.03.001_bib29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.foodchem.2004.01.084","article-title":"Variability in the physicochemical, nutritional and antinutritional attributes of six Mucuna species","volume":"89","author":"Adebowale","year":"2005","journal-title":"Food Chem"},{"key":"10.1016\/j.apjtm.2017.03.001_bib30","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1016\/j.phytochem.2004.08.045","article-title":"Alkaloidal constituents of Mucuna pruriens seeds","volume":"65","author":"Misra","year":"2004","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.apjtm.2017.03.001_bib31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4103\/0970-1591.128496","article-title":"Animal models of erectile dysfunction","volume":"31","author":"Gajbhiye","year":"2015","journal-title":"Ind J Urol"},{"key":"10.1016\/j.apjtm.2017.03.001_bib32","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.jfca.2006.01.003","article-title":"Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts","volume":"19","author":"Thaipong","year":"2006","journal-title":"J\u00a0Food Compos Anal"},{"key":"10.1016\/j.apjtm.2017.03.001_bib33","doi-asserted-by":"publisher","first-page":"12910","DOI":"10.3390\/molecules171112910","article-title":"Quantitative studies on structure-DPPH scavenging activity relationships of food phenolic acids","volume":"17","author":"Jing","year":"2012","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.apjtm.2017.03.001_bib34","first-page":"239","article-title":"Comparative GC-MS analysis and in\u00a0vitro screening of four species of Mucuna","volume":"5","author":"Karunanithi","year":"2012","journal-title":"Asian J Pharm Clin Res"},{"issue":"1","key":"10.1016\/j.apjtm.2017.03.001_bib35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1021\/pr800545q","article-title":"Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group","volume":"8","author":"Tuck","year":"2009","journal-title":"J\u00a0Proteome Res"},{"issue":"4","key":"10.1016\/j.apjtm.2017.03.001_bib36","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1163\/156853967X00091","article-title":"A\u00a0quantitative description of the behavior of rats during copulation","volume":"2","author":"Dewsbury","year":"1967","journal-title":"Behaviour"},{"issue":"2","key":"10.1016\/j.apjtm.2017.03.001_bib37","first-page":"237","article-title":"A\u00a0modification of the masson trichrome technique for routine laboratory purposes","volume":"14","author":"Goldner","year":"1938","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.apjtm.2017.03.001_bib38","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.apjtm.2017.03.001_bib39","doi-asserted-by":"publisher","first-page":"e2000","DOI":"10.7717\/peerj.2000","article-title":"Testosterone improves erectile function through inhibition of reactive oxygen species generation in castrated rats","volume":"4","author":"Li","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.apjtm.2017.03.001_bib40","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0097-6","article-title":"Quantitative real-time RT-PCR data analysis: current concepts and the novel \u2018gene expression's CT difference\u2019 formula","author":"Schefe","year":"2006","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.apjtm.2017.03.001_bib41","first-page":"801","article-title":"Lipid derivatives from Mucuna pruriens seeds","volume":"45B","author":"Misra","year":"2006","journal-title":"Ind J Chem"},{"key":"10.1016\/j.apjtm.2017.03.001_bib42","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.pharmthera.2004.11.011","article-title":"Nitric oxide and penile erectile function","volume":"106","author":"Toda","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.apjtm.2017.03.001_bib43","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.sxmr.2015.10.004","article-title":"The role of PDE5 inhibitors and the NO\/cGMP pathway in cancer","volume":"4","author":"Peak","year":"2016","journal-title":"Sex Med Rev"},{"issue":"11","key":"10.1016\/j.apjtm.2017.03.001_bib44","first-page":"3311","article-title":"Sildenafil inhibits the growth of human colorectal cancer in\u00a0vitro and in\u00a0vivo","volume":"5","author":"Mei","year":"2015","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.apjtm.2017.03.001_bib45","first-page":"95","article-title":"Diabetes and sexual dysfunction: current perspectives","volume":"7","author":"Maiorino","year":"2014","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.apjtm.2017.03.001_bib46","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejphar.2007.08.019","article-title":"Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat","volume":"576","author":"Olivier","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.apjtm.2017.03.001_bib47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.55782\/ane-2000-1322","article-title":"The role of mounts and intromissions in triggering ejaculation in rats","volume":"60","author":"Beck","year":"2000","journal-title":"Acta Neurobiol Exp"},{"issue":"12","key":"10.1016\/j.apjtm.2017.03.001_bib48","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1089\/ars.2009.2484","article-title":"Hyperglycemia and glycation in diabetic complications","volume":"11","author":"Negre-Salvayre","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"10.1016\/j.apjtm.2017.03.001_bib49","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1590\/S1677-5538.IBJU.2013.03.17","article-title":"Sinusoidal constriction and vascular hypertrophy in the diabetes-induced rabbit penis","volume":"39","author":"Pereira","year":"2013","journal-title":"Int Braz J Urol"},{"key":"10.1016\/j.apjtm.2017.03.001_bib50","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrd2466","article-title":"The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics","volume":"7","author":"Lundberg","year":"2008","journal-title":"Nat Rev Drug Dis"},{"issue":"7","key":"10.1016\/j.apjtm.2017.03.001_bib51","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"Forstermann","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.apjtm.2017.03.001_bib52","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.maturitas.2011.11.004","article-title":"Novel therapeutic targets for erectile dysfunction","volume":"71","author":"Williams","year":"2012","journal-title":"Maturitas"},{"issue":"12B","key":"10.1016\/j.apjtm.2017.03.001_bib53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.amjcard.2005.07.005","article-title":"Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: common pathways and treatments?","volume":"96","author":"Fonseca","year":"2005","journal-title":"Am J Cardiol"},{"issue":"4","key":"10.1016\/j.apjtm.2017.03.001_bib54","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2741\/s259","article-title":"Potent natural aphrodisiacs for the management of erectile dysfunction and male sexual debilities","volume":"1","author":"Pratap","year":"2012","journal-title":"Front Biosci"},{"key":"10.1016\/j.apjtm.2017.03.001_bib55","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s11934-011-0217-x","article-title":"Rise of herbal and traditional medicine in erectile dysfunction management","volume":"12","author":"Ho","year":"2011","journal-title":"Curr Urol Rep"},{"issue":"2","key":"10.1016\/j.apjtm.2017.03.001_bib56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.19026\/bjpt.5.5462","article-title":"Quercetin attenuates testicular damage and oxidative stress in streptozotocin-induced diabetic rats","volume":"5","author":"Alkhamees","year":"2014","journal-title":"Br J Pharmacol Toxicol"},{"key":"10.1016\/j.apjtm.2017.03.001_bib57","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in\u00a0vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat Rev Drug Dis"},{"key":"10.1016\/j.apjtm.2017.03.001_bib58","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jnutbio.2010.07.004","article-title":"Effects of resveratrol and other wine polyphenols on vascular function: an update","volume":"22","author":"Greselea","year":"2011","journal-title":"J\u00a0Nutr Biochem"},{"issue":"5","key":"10.1016\/j.apjtm.2017.03.001_bib59","first-page":"7599","article-title":"Effects of quercetin on intracavernous pressure and expression of nitrogen synthase isoforms in arterial erectile dysfunction rat model","volume":"8","author":"Zhang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.apjtm.2017.03.001_bib60","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.niox.2009.05.006","article-title":"Modulation of endothelial nitric oxide by plant-derived products","volume":"21","author":"Schmitt","year":"2009","journal-title":"Nitric Oxide"},{"issue":"3","key":"10.1016\/j.apjtm.2017.03.001_bib61","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1124\/jpet.104.066639","article-title":"Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells","volume":"310","author":"Li","year":"2004","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.apjtm.2017.03.001_bib62","doi-asserted-by":"publisher","first-page":"175950","DOI":"10.1155\/2015\/175950","article-title":"Phenolic extract from Moringa oleifera leaves inhibits key enzymes linked to erectile dysfunction and oxidative stress in rats' penile tissues","volume":"2015","author":"Oboh","year":"2015","journal-title":"Biochem Res Int"},{"key":"10.1016\/j.apjtm.2017.03.001_bib63","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/aja.2013.60","article-title":"Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats","volume":"15","author":"Yu","year":"2013","journal-title":"Asian J Androl"},{"issue":"1","key":"10.1016\/j.apjtm.2017.03.001_bib64","doi-asserted-by":"publisher","first-page":"e14542","DOI":"10.1371\/journal.pone.0014542","article-title":"Sildenafil reduces insulin-resistance in human endothelial cells","volume":"6","author":"Mammi","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.apjtm.2017.03.001_bib65","first-page":"643","article-title":"Pharmacological activities of protocatechuic acid","volume":"72","author":"Khan","year":"2015","journal-title":"Acta Pol Pharm Drug Res"},{"key":"10.1016\/j.apjtm.2017.03.001_bib66","first-page":"368692","article-title":"In\u00a0vitro and in\u00a0vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against plasmodial aminopeptidase","volume":"2011","author":"Kusch","year":"2011","journal-title":"J\u00a0Parasitol Res"},{"key":"10.1016\/j.apjtm.2017.03.001_bib67","first-page":"485469","article-title":"Preliminary investigation of bioactive compounds and bioautographic studies of whole plant extract of Euphorbia pulcherrima on Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Pseudomonas aeruginosa","volume":"2015","author":"Sharif","year":"2015","journal-title":"Adv Pharm"},{"issue":"9","key":"10.1016\/j.apjtm.2017.03.001_bib68","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.2174\/138920111798280965","article-title":"Identification of neuronal nitric oxide synthase (nNOS) in human penis: a potential role of reduced neuronally-derived nitric oxide in erectile dysfunction","volume":"12","author":"Dashwood","year":"2016","journal-title":"Curr Pharm Biotechnol"},{"issue":"2","key":"10.1016\/j.apjtm.2017.03.001_bib69","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.taap.2007.12.001","article-title":"Neuronal effects of 4-t-Butylcatechol: a model for catechol-containing antioxidants","volume":"228","author":"Lo","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.apjtm.2017.03.001_bib70","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0024-3205(02)02204-X","article-title":"Levodopa modulating effects of inducible nitric oxide synthase and reactive oxygen species in glioma cells","volume":"72","author":"Soliman","year":"2002","journal-title":"Life Sci"},{"issue":"5","key":"10.1016\/j.apjtm.2017.03.001_bib71","first-page":"619","article-title":"Effects of levodopa on nocturnal penile tumescence: a preliminary study","volume":"19","author":"Horita","year":"1998","journal-title":"J\u00a0Androl"},{"key":"10.1016\/j.apjtm.2017.03.001_bib72","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0091-3057(97)00484-X","article-title":"Pharmacological features of masculine sexual behavior in an animal model of depression","volume":"60","author":"Bonilla-Jaime","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"issue":"S6","key":"10.1016\/j.apjtm.2017.03.001_bib73","first-page":"S17","article-title":"Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease","volume":"24","author":"Bivalacqua","year":"2003","journal-title":"J\u00a0Androl"},{"issue":"1","key":"10.1016\/j.apjtm.2017.03.001_bib74","doi-asserted-by":"publisher","first-page":"241.e1","DOI":"10.1016\/j.urology.2011.08.026","article-title":"A\u00a0Chinese herbal formula, Shuganyiyang capsule, improves erectile function in male rats by modulating Nos-CGMP mediators","volume":"79","author":"Wang","year":"2012","journal-title":"Urology"},{"issue":"Suppl 1","key":"10.1016\/j.apjtm.2017.03.001_bib75","first-page":"S37","article-title":"The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications","volume":"49","author":"Haluzik","year":"2000","journal-title":"Physiol Res"},{"key":"10.1016\/j.apjtm.2017.03.001_bib76","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1095\/biolreprod66.1.185","article-title":"Changes in mating behavior, erectile function, and nitric oxide levels in penile corpora cavernosa in streptozotocin-diabetic rats","volume":"66","author":"Escrig","year":"2002","journal-title":"Biol Reprod"}],"container-title":["Asian Pacific Journal of Tropical Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S199576451730024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S199576451730024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T17:18:58Z","timestamp":1719076738000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S199576451730024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S199576451730024X"],"URL":"https:\/\/doi.org\/10.1016\/j.apjtm.2017.03.001","relation":{},"ISSN":["1995-7645"],"issn-type":[{"value":"1995-7645","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}