{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:50:29Z","timestamp":1789019429179,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Physical Medicine and Rehabilitation"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.apmr.2010.06.029","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T04:14:04Z","timestamp":1296533644000},"page":"399-410","source":"Crossref","is-referenced-by-count":33,"title":["Safety, Tolerance, and Efficacy of Extended-Release Niacin Monotherapy for Treating Dyslipidemia Risks in Persons With Chronic Tetraplegia: A Randomized Multicenter Controlled Trial"],"prefix":"10.1016","volume":"92","author":[{"given":"Mark S.","family":"Nash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor A.","family":"Dyson-Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaga","family":"Szlachcic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando J.","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Spungen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Bauman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apmr.2010.06.029_bib1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/sj.sc.3102161","article-title":"Coronary heart disease in individuals with spinal cord injury: assessment of risk factors","volume":"46","author":"Bauman","year":"2008","journal-title":"Spinal Cord"},{"key":"10.1016\/j.apmr.2010.06.029_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1310\/sci1204-35","article-title":"Risk assessment for coronary heart disease in a veteran population with spinal cord injury","volume":"12","author":"Bauman","year":"2007","journal-title":"Top Spinal Cord Inj Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/PHM.0b013e31802f0247","article-title":"Cardiovascular disease in spinal cord injury: an overview of prevalence, risk, evaluation, and management","volume":"86","author":"Myers","year":"2007","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib4","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.apmr.2010.06.029_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/10790268.2009.11760749","article-title":"Nutrient intake and body habitus after spinal cord injury: an analysis by sex and level of injury","volume":"32","author":"Groah","year":"2009","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1310\/sci1204-1","article-title":"Prevalence of obesity after spinal cord injury","volume":"12","author":"Gorgey","year":"2007","journal-title":"Top Spinal Cord Inj Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib7","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1152\/japplphysiol.00729.2002","article-title":"Factors influencing body composition in persons with spinal cord injury: a cross-sectional study","volume":"95","author":"Spungen","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib8","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2337\/diab.29.11.906","article-title":"Glucose intolerance due to insulin resistance in patients with spinal cord injuries","volume":"29","author":"Duckworth","year":"1980","journal-title":"Diabetes"},{"key":"10.1016\/j.apmr.2010.06.029_bib9","first-page":"107","article-title":"Glucose intolerance in spinal cord injury","volume":"64","author":"Duckworth","year":"1983","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib10","first-page":"445","article-title":"High density lipoprotein cholesterol concentrations in physically active and sedentary spinal cord injured patients","volume":"67","author":"Brenes","year":"1986","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.apmr.2007.02.031","article-title":"A guideline-driven assessment of need for cardiovascular disease risk intervention in persons with chronic paraplegia","volume":"88","author":"Nash","year":"2007","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib12","first-page":"163","article-title":"Coronary artery disease: metabolic risk factors and latent disease in individuals with paraplegia","volume":"59","author":"Bauman","year":"1992","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib13","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.metabol.2004.04.013","article-title":"Factor analysis of the metabolic syndrome in spinal cord-injured men","volume":"53","author":"Jones","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.apmr.2010.06.029_bib14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/10790268.2004.11754559","article-title":"Combined hyperlipidemia in a single subject with tetraplegia: ineffective risk reduction after atorvastatin monotherapy","volume":"27","author":"Nash","year":"2004","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib15","first-page":"569","article-title":"Body weight, serum uric acid and lipid profile one year after spinal cord injury","volume":"24","author":"Wong","year":"2001","journal-title":"Chang Gung Med J"},{"key":"10.1016\/j.apmr.2010.06.029_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/sj.sc.3100776","article-title":"Changes in lipid, lipoprotein and apolipoprotein profiles in persons with spinal cord injuries during the first 2 years post-injury","volume":"37","author":"Dallmeijer","year":"1999","journal-title":"Spinal Cord"},{"key":"10.1016\/j.apmr.2010.06.029_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1249\/00005768-199104000-00004","article-title":"Lipid and lipoprotein profiles relate to peak aerobic power in spinal cord injured men","volume":"23","author":"Bostom","year":"1991","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.apmr.2010.06.029_bib18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.apmr.2007.08.121","article-title":"Elevated C-reactive protein associated with decreased high-density lipoprotein cholesterol in men with spinal cord injury","volume":"89","author":"Liang","year":"2008","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/sc.1992.136","article-title":"Depressed serum high density lipoprotein cholesterol levels in veterans with spinal cord injury","volume":"30","author":"Bauman","year":"1992","journal-title":"Paraplegia"},{"key":"10.1016\/j.apmr.2010.06.029_bib20","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0140-6736(83)92482-0","article-title":"HDL cholesterol across a spectrum of physical activity from quadriplegia to marathon running","volume":"1","author":"LaPorte","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.apmr.2010.06.029_bib21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/sj.sc.3100917","article-title":"High density lipoprotein cholesterol in individuals with spinal cord injury: the potential role of physical activity","volume":"37","author":"Washburn","year":"1999","journal-title":"Spinal Cord"},{"key":"10.1016\/j.apmr.2010.06.029_bib22","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1056\/NEJM198711123172001","article-title":"Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia","volume":"317","author":"Frick","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11883-000-0095-z","article-title":"Nonpharmacologic and pharmacologic treatment of patients with low levels of high-density lipoprotein cholesterol","volume":"2","author":"Bowen","year":"2000","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.apmr.2010.06.029_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/01.psy.0000155663.93160.d2","article-title":"Behavioral and emotional triggers of acute coronary syndromes: a systematic review and critique","volume":"67","author":"Strike","year":"2005","journal-title":"Psychosom Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.eatbeh.2008.12.002","article-title":"The contributions of weight loss and increased physical fitness to improvements in health-related quality of life","volume":"10","author":"Ross","year":"2009","journal-title":"Eat Behav"},{"key":"10.1016\/j.apmr.2010.06.029_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/01.NPT.0000282514.94093.c6","article-title":"Exercise as a health-promoting activity following spinal cord injury","volume":"29","author":"Nash","year":"2005","journal-title":"J Neurol Phys Ther"},{"key":"10.1016\/j.apmr.2010.06.029_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/CRD.0b013e31816b43d3","article-title":"Fibrate therapy: an update","volume":"16","author":"Remick","year":"2008","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.apmr.2010.06.029_bib28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/0026-0495(85)90092-7","article-title":"Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: clues to mechanism of action of niacin","volume":"34","author":"Knopp","year":"1985","journal-title":"Metabolism"},{"key":"10.1016\/j.apmr.2010.06.029_bib29","doi-asserted-by":"crossref","first-page":"29U","DOI":"10.1016\/S0002-9149(98)00732-2","article-title":"A new extended-release niacin (Niaspan): efficacy, tolerability, and safety in hypercholesterolemic patients","volume":"82","author":"Morgan","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib30","doi-asserted-by":"crossref","first-page":"35U","DOI":"10.1016\/S0002-9149(98)00952-7","article-title":"Clinical trial experience with extended-release niacin (Niaspan): dose-escalation study","volume":"82","author":"Goldberg","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib31","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1161\/01.CIR.0000034508.55617.65","article-title":"ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness","volume":"106","author":"Taylor","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.apmr.2010.06.029_bib32","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1001\/jama.1987.03390230069027","article-title":"Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts","volume":"257","author":"Blankenhorn","year":"1987","journal-title":"JAMA"},{"key":"10.1016\/j.apmr.2010.06.029_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1310\/sci1403-32","article-title":"Guideline-driven assessment of cardiovascular disease and related risks after spinal cord injury","volume":"14","author":"Dyson-Hudson","year":"2009","journal-title":"Top Spinal Cord Inj Rehabil"},{"issue":"Suppl 1","key":"10.1016\/j.apmr.2010.06.029_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/10790268.2003.11754575","article-title":"International standards for neurological classification of spinal cord injury","volume":"26","author":"Marino","year":"2003","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.amjcard.2004.03.042","article-title":"A meta-analysis of randomized controlled studies on the effects of extended-release niacin in women","volume":"94","author":"Goldberg","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib36","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/sj.clpt.6100180","article-title":"Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1","volume":"81","author":"Lai","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.apmr.2010.06.029_bib37","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jacc.2004.07.001","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines","volume":"44","author":"Grundy","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib38","doi-asserted-by":"crossref","first-page":"11i","DOI":"10.1016\/S0002-9149(02)02631-0","article-title":"Approach to lipoprotein management in 2001 National Cholesterol Guidelines","volume":"90","author":"Grundy","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib39","doi-asserted-by":"crossref","first-page":"74U","DOI":"10.1016\/S0002-9149(98)00731-0","article-title":"Efficacy and safety of an extended-release niacin (Niaspan): a long-term study","volume":"82","author":"Capuzzi","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11883-000-0096-y","article-title":"Niacin dosing: relationship to benefits and adverse effects","volume":"2","author":"Capuzzi","year":"2000","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.apmr.2010.06.029_bib41","first-page":"165","article-title":"The effect of aspirin on niacin-induced cutaneous reactions","volume":"34","author":"Whelan","year":"1992","journal-title":"J Fam Pract"},{"key":"10.1016\/j.apmr.2010.06.029_bib42","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1525-1497.1997.07118.x","article-title":"Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions","volume":"12","author":"Jungnickel","year":"1997","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib43","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1368-5031.2004.00233.x","article-title":"Niaspan, the prolonged release preparation of nicotinic acid (niacin), the broad-spectrum lipid drug","volume":"58","author":"Carlson","year":"2004","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.apmr.2010.06.029_bib44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11883-000-0093-1","article-title":"Mechanism of action of niacin on lipoprotein metabolism","volume":"2","author":"Kamanna","year":"2000","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.apmr.2010.06.029_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1310\/sci1403-69","article-title":"EXERCISE is Medicine\u00a9: exercise prescription after SCI to manage CVD risk factors","volume":"14","author":"Cowan","year":"2009","journal-title":"Top Spinal Cord Inj Rehabil"},{"key":"10.1016\/j.apmr.2010.06.029_bib46","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/10790268.2001.11753551","article-title":"The effect of dietary intervention on lipid profiles in individuals with spinal cord injury","volume":"24","author":"Szlachcic","year":"2001","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib47","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.CIR.83.1.356","article-title":"An updated coronary risk profile","volume":"83","author":"Anderson","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.apmr.2010.06.029_bib48","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJM199108083250601","article-title":"A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction","volume":"325","author":"Stampfer","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apmr.2010.06.029_bib49","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/sj.sc.3100911","article-title":"Risk factors for atherogenesis and cardiovascular autonomic function in persons with spinal cord injury","volume":"37","author":"Bauman","year":"1999","journal-title":"Spinal Cord"},{"key":"10.1016\/j.apmr.2010.06.029_bib50","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0735-1097(86)80293-5","article-title":"Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin","volume":"8","author":"Canner","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.apmr.2010.06.029_bib51","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1194\/jlr.M200439-JLR200","article-title":"Impact of simvastatin, niacin, and\/or antioxidants on cholesterol metabolism in CAD patients with low HDL","volume":"44","author":"Matthan","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.apmr.2010.06.029_bib52","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0167-5273(01)00625-8","article-title":"Are high-density lipoprotein and triglyceride levels important in secondary prevention: impressions from the BIP and VA-HIT trials","volume":"82","author":"Rizos","year":"2002","journal-title":"Int J Cardiol"}],"container-title":["Archives of Physical Medicine and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999310003758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999310003758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T03:40:36Z","timestamp":1559965236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003999310003758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0003999310003758"],"URL":"https:\/\/doi.org\/10.1016\/j.apmr.2010.06.029","relation":{},"ISSN":["0003-9993"],"issn-type":[{"value":"0003-9993","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}