{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:50:24Z","timestamp":1787932224387,"version":"build-2784847793"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Physical Medicine and Rehabilitation"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.apmr.2011.08.045","type":"journal-article","created":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T16:59:00Z","timestamp":1325609940000},"page":"396-403","source":"Crossref","is-referenced-by-count":67,"title":["Radial Nerve Mobilization Decreases Pain Sensitivity and Improves Motor Performance in Patients With Thumb Carpometacarpal Osteoarthritis: A Randomized Controlled Trial"],"prefix":"10.1016","volume":"93","author":[{"given":"Jorge H.","family":"Villafa\u00f1e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo B.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josue","family":"Fernandez-Carnero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apmr.2011.08.045_bib1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0363-5023(10)80054-1","article-title":"Osteoarthritis of the trapeziometacarpal joint: the pathophysiology of articular cartilage degeneration","volume":"16","author":"Pellegrini","year":"1991","journal-title":"J Hand Surg Am"},{"key":"10.1016\/j.apmr.2011.08.045_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0266-7681(88)90171-4","article-title":"Tendon interposition arthroplasty of the first carpo-metacarpal joint","volume":"13","author":"Weilby","year":"1988","journal-title":"J Hand Surg Br"},{"key":"10.1016\/j.apmr.2011.08.045_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jht.2008.09.002","article-title":"Exercise and hand osteoarthritis symptomatology: a controlled crossover trial","volume":"22","author":"Rogers","year":"2009","journal-title":"J Hand Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s10067-003-0792-4","article-title":"The effect of hand osteoarthritis on grip and pinch strength and hand function in postmenopausal women","volume":"22","author":"Bagis","year":"2003","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.apmr.2011.08.045_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0004-9514(05)70005-2","article-title":"No difference between two splint and exercise regimens for people with osteoarthritis of the thumb: a randomised controlled trial","volume":"51","author":"Wajon","year":"2005","journal-title":"Aust J Physiother"},{"key":"10.1016\/j.apmr.2011.08.045_bib6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/01.bor.0000172800.49120.97","article-title":"The sources of pain in knee osteoarthritis","volume":"17","author":"Felson","year":"2005","journal-title":"Curr Opin Rheumatol"},{"issue":"4 Suppl 2","key":"10.1016\/j.apmr.2011.08.045_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0049-0172(89)90015-2","article-title":"Para-articular connective tissue in osteoarthritis","volume":"18","author":"Akeson","year":"1989","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.apmr.2011.08.045_bib8","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Smith","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.apmr.2011.08.045_bib9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/0470867639.ch17","article-title":"Lessons from fibromyalgia: abnormal pain sensitivity in knee osteoarthritis","volume":"260","author":"Bradley","year":"2004","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.apmr.2011.08.045_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pain.2010.04.003","article-title":"Sensitization in patients with painful knee osteoarthritis","volume":"149","author":"Arendt-Nielsen","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.apmr.2011.08.045_bib11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejpain.2006.02.013","article-title":"Short-term efficacy of pharmacotherapeutic interventions in osteoarthritic knee pain: a meta-analysis of randomised placebo-controlled trials","volume":"11","author":"Bjordal","year":"2007","journal-title":"Eur J Pain"},{"key":"10.1016\/j.apmr.2011.08.045_bib12","first-page":"441","article-title":"Pain and hyperalgesia in osteoarthritis of the hands","volume":"27","author":"Farrell","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.apmr.2011.08.045_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1054\/jpai.2000.8279","article-title":"Increased movement pain in osteoarthritis of the hands is associated with a beta-mediated cutaneous mechanical sensitivity","volume":"1","author":"Farrell","year":"2000","journal-title":"J Pain"},{"key":"10.1016\/j.apmr.2011.08.045_bib14","series-title":"Mobilisation of the nervous system","author":"Butler","year":"1991"},{"key":"10.1016\/j.apmr.2011.08.045_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1179\/106698108790818602","article-title":"Neural mobilization: a systematic review of randomized controlled trials with an analysis of therapeutic efficacy","volume":"16","author":"Shacklock","year":"2008","journal-title":"J Man Manip Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0894-1130(98)80035-5","article-title":"Nerve and tendon gliding exercises and the conservative management of carpal tunnel syndrome","volume":"11","author":"Rozmaryn","year":"1998","journal-title":"J Hand Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.math.2005.07.002","article-title":"Slump stretching in the management of non-radicular low back pain: a pilot clinical trial","volume":"11","author":"Cleland","year":"2006","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.math.2006.12.008","article-title":"Do \u2018sliders\u2019 slide and \u2018tensioners\u2019 tension?","volume":"13","author":"Coppieters","year":"2008","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.pain.2005.08.018","article-title":"Pressure and stretch mechanosensitivity of peripheral nerve fibres following local inflammation of the nerve trunk","volume":"117","author":"Dilley","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.apmr.2011.08.045_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0026-2862(86)90050-6","article-title":"Reduced nerve blood flow in edematous neuropathies: a biomechanical mechanism","volume":"32","author":"Myers","year":"1986","journal-title":"Microvasc Res"},{"key":"10.1016\/j.apmr.2011.08.045_bib21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2519\/jospt.2009.3117","article-title":"A randomized sham-controlled trial of a neurodynamic technique in the treatment of carpal tunnel syndrome","volume":"39","author":"Bialosky","year":"2009","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2519\/jospt.2009.2954","article-title":"Effects of upper extremity neural mobilization on thermal pain sensitivity: a sham-controlled study in asymptomatic participants","volume":"39","author":"Beneciuk","year":"2009","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib23","series-title":"Clinical neurodynamics: a new system of neuromusculoskeletal treatment","author":"Shacklock","year":"2005"},{"key":"10.1016\/j.apmr.2011.08.045_bib24","first-page":"1309","article-title":"Practice tips","volume":"53","author":"Jaggi","year":"2007","journal-title":"Can Fam Physician"},{"key":"10.1016\/j.apmr.2011.08.045_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1590\/S0100-879X2005000300011","article-title":"Validation of the Beck Depression Inventory for a Portuguese-speaking Chinese community in Brazil","volume":"38","author":"Wang","year":"2005","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.apmr.2011.08.045_bib26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1590\/S1516-44462005000400003","article-title":"Depression, anxiety and quality of life scores in seniors after an endurance exercise program","volume":"27","author":"Antunes","year":"2005","journal-title":"Rev Bras Psiquiatr"},{"key":"10.1016\/j.apmr.2011.08.045_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ptj\/78.2.160","article-title":"Reliability of clinical pressure-pain algometric measurements obtained on consecutive days","volume":"78","author":"Nussbaum","year":"1998","journal-title":"Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0004-9514(07)70032-6","article-title":"Pressure algometry","volume":"53","author":"Ylinen","year":"2007","journal-title":"Aust J Physiother"},{"key":"10.1016\/j.apmr.2011.08.045_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2519\/jospt.2007.2542","article-title":"Immediate effects on pressure pain threshold following a single cervical spine manipulation in healthy subjects","volume":"37","author":"Fernandez-de-las-Penas","year":"2007","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib30","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/art.24120","article-title":"Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis","volume":"59","author":"Imamura","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.apmr.2011.08.045_bib31","first-page":"69","article-title":"Grip and pinch strength: normative data for adults","volume":"66","author":"Mathiowetz","year":"1985","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2011.08.045_bib32","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/rheumatology\/38.6.521","article-title":"Predicting 'normal' grip strength for rheumatoid arthritis patients","volume":"38","author":"Fraser","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.apmr.2011.08.045_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/230949900601400113","article-title":"Basal thumb metacarpal osteotomy for trapeziometacarpal osteoarthritis","volume":"14","author":"Gwynne-Jones","year":"2006","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"10.1016\/j.apmr.2011.08.045_bib34","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/ptj\/83.9.806","article-title":"Measurement error in grip and pinch force measurements in patients with hand injuries","volume":"83","author":"Schreuders","year":"2003","journal-title":"Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3944\/AOTT.2009.243","article-title":"[The value of intermittent ultrasound treatment in subacromial impingement syndrome] [Turkish]","volume":"43","author":"Celik","year":"2009","journal-title":"Acta Orthop Traumatol Turc"},{"key":"10.1016\/j.apmr.2011.08.045_bib36","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s00586-008-0679-9","article-title":"Independent evaluation of a clinical prediction rule for spinal manipulative therapy: a randomised controlled trial","volume":"17","author":"Hancock","year":"2008","journal-title":"Eur Spine J"},{"key":"10.1016\/j.apmr.2011.08.045_bib37","doi-asserted-by":"crossref","first-page":"c2756","DOI":"10.1136\/bmj.c2756","article-title":"Efficacy of standardised manual therapy and home exercise programme for chronic rotator cuff disease: randomised placebo controlled trial","volume":"340","author":"Bennell","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.apmr.2011.08.045_bib38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jmpt.2011.08.005","article-title":"Hypoalgesic and motor effects of Kaltenborn mobilization on elderly patients with secondary thumb carpometacarpal osteoarthritis","volume":"34","author":"Villafa\u00f1e","year":"2011","journal-title":"J Manipulative Physiol Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmpt.2008.12.002","article-title":"Submitting manuscripts to biomedical journals: common errors and helpful solutions","volume":"32","author":"Johnson","year":"2009","journal-title":"J Manipulative Physiol Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2519\/jospt.2002.32.8.391","article-title":"Characteristics of patients with lower extremity symptoms treated with slump stretching: a case series","volume":"32","author":"George","year":"2002","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2519\/jospt.2003.33.7.369","article-title":"The immediate effects of a cervical lateral glide treatment technique in patients with neurogenic cervicobrachial pain","volume":"33","author":"Coppieters","year":"2003","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib42","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jmpt.2004.10.006","article-title":"Incorporating nerve-gliding techniques in the conservative treatment of cubital tunnel syndrome","volume":"27","author":"Coppieters","year":"2004","journal-title":"J Manipulative Physiol Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib43","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jmpt.2008.10.005","article-title":"Immediate hypoalgesic and motor effects after a single cervical spine manipulation in subjects with lateral epicondylalgia","volume":"31","author":"Fernandez-Carnero","year":"2008","journal-title":"J Manipulative Physiol Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib44","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1471-2474-7-68","article-title":"Immediate effects of spinal manipulation on thermal pain sensitivity: an experimental study","volume":"7","author":"George","year":"2006","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.apmr.2011.08.045_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3959(96)03221-6","article-title":"The initial effects of a cervical spine manipulative physiotherapy treatment on the pain and dysfunction of lateral epicondylalgia","volume":"68","author":"Vicenzino","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.apmr.2011.08.045_bib46","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jmpt.2008.04.006","article-title":"Changes in pressure pain thresholds over C5-C6 zygapophyseal joint after a cervicothoracic junction manipulation in healthy subjects","volume":"31","author":"Fernandez-de-Las-Penas","year":"2008","journal-title":"J Manipulative Physiol Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1054\/math.2000.0378","article-title":"Cervical mobilisation: concurrent effects on pain, sympathetic nervous system activity and motor activity","volume":"6","author":"Sterling","year":"2001","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib48","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2519\/jospt.2009.3002","article-title":"Mechanosensitivity of the lower extremity nervous system during straight-leg raise neurodynamic testing in healthy individuals","volume":"39","author":"Boyd","year":"2009","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib49","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1054\/math.1997.0294","article-title":"Upper trapezius muscle activity during the brachial plexus tension test in asymptomatic subjects","volume":"2","author":"Balster","year":"1997","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib50","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1054\/math.2001.0406","article-title":"Pain and muscular responses to a neural tissue provocation test in the upper limb","volume":"6","author":"van der Heide","year":"2001","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1067\/mmt.2003.16","article-title":"Aberrant protective force generation during neural provocation testing and the effect of treatment in patients with neurogenic cervicobrachial pain","volume":"26","author":"Coppieters","year":"2003","journal-title":"J Manipulative Physiol Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib52","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1356-689X(98)80004-0","article-title":"Adverse mechanical tension in the nervous system?","volume":"3","author":"Hall","year":"1998","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1054\/math.2001.0408","article-title":"The initial effects of an elbow mobilization with movement technique on grip strength in subjects with lateral epicondylalgia","volume":"6","author":"Abbott","year":"2001","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib54","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ptsp.2005.10.002","article-title":"Management of peripheral neuropathic pain: integrating neurobiology, neurodynamics, and clinical evidence","volume":"7","author":"Nee","year":"2006","journal-title":"Phys Ther Sport"},{"key":"10.1016\/j.apmr.2011.08.045_bib55","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.math.2007.12.007","article-title":"Paradigm shift in manual therapy?","volume":"13","author":"Schmid","year":"2008","journal-title":"Man Ther"},{"key":"10.1016\/j.apmr.2011.08.045_bib56","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cuor.2007.02.006","article-title":"Osteoarthritis of the thumb trapeziometacarpal joint","volume":"21","author":"Batra","year":"2007","journal-title":"Curr Orthop"},{"key":"10.1016\/j.apmr.2011.08.045_bib57","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2010.03.025","article-title":"Heterogeneous sensory processing in persistent postherniotomy pain","volume":"150","author":"Aasvang","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.apmr.2011.08.045_bib58","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/AJP.0b013e3181643403","article-title":"Validity of cross-friction algometry procedure in referred muscle pain syndromes: preliminary results of a new referred pain provocation technique with the aid of a Fischer pressure algometer in patients with nonspecific low back pain","volume":"24","author":"Farasyn","year":"2008","journal-title":"Clin J Pain"}],"container-title":["Archives of Physical Medicine and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999311008306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999311008306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T23:55:35Z","timestamp":1593474935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003999311008306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0003999311008306"],"URL":"https:\/\/doi.org\/10.1016\/j.apmr.2011.08.045","relation":{},"ISSN":["0003-9993"],"issn-type":[{"value":"0003-9993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}