{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:17:23Z","timestamp":1790014643497,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","archives-pmr.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Physical Medicine and Rehabilitation"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.apmr.2015.01.010","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T13:10:42Z","timestamp":1421932242000},"page":"1103-1109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Single-Fiber Electromyography Analysis of Botulinum Toxin Diffusion in Patients With Fatigue and Pseudobotulism"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-5734","authenticated-orcid":false,"given":"Alexis","family":"Ruet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Christine","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Denys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Lofaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Genet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Schnitzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apmr.2015.01.010_bib1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1185\/030079904125003962","article-title":"Safety of botulinum toxin type A: a systematic review and meta-analysis","volume":"20","author":"Naumann","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.apmr.2015.01.010_bib2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.disamonth.2009.01.001","article-title":"Complications of botulinum neurotoxin","volume":"55","author":"Lu","year":"2009","journal-title":"Dis Mon"},{"key":"10.1016\/j.apmr.2015.01.010_bib3","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/mds.25582","article-title":"Diffusion, spread, and migration of botulinum toxin","volume":"28","author":"Ramirez-Castaneda","year":"2013","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"10.1016\/j.apmr.2015.01.010_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0039-6257(97)81995-9","article-title":"Botulinum-A toxin in the treatment of craniocervical muscle spasms: short- and long-term, local and systemic effects","volume":"41","author":"Dutton","year":"1996","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.apmr.2015.01.010_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1468-1331.2006.01652.x","article-title":"Safety and efficacy of botulinum toxin type A following long-term use","volume":"13","author":"Naumann","year":"2006","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.apmr.2015.01.010_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jaad.2005.06.011","article-title":"Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases","volume":"53","author":"Cot\u00e9","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.apmr.2015.01.010_bib7","unstructured":"Food and Drug Administration. Highlights of prescribing information. Available at: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2013\/103000s5251lbl.pdf. Accessed February, 13, 2015."},{"key":"10.1016\/j.apmr.2015.01.010_bib8","unstructured":"Food and Drug Administration. Highlights of prescribing information. Available at: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/125274s0000s0001lbl.pdf. Accessed February, 13, 2015."},{"key":"10.1016\/j.apmr.2015.01.010_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14260","article-title":"BoTULS: a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A","volume":"14","author":"Shaw","year":"2010","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.apmr.2015.01.010_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2011.04.019","article-title":"Flu-like symptoms following botulinum toxin therapy","volume":"58","author":"Baizabal-Carvallo","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.apmr.2015.01.010_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/jnnp.62.2.198","article-title":"Generalised botulism-like syndrome after intramuscular injections of botulinum toxin type A: a report of two cases","volume":"62","author":"Bakheit","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.apmr.2015.01.010_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/jnnp.67.1.90","article-title":"Generalised muscular weakness after botulinum toxin injections for dystonia: a report of three cases","volume":"67","author":"Bhatia","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.apmr.2015.01.010_bib13","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1046\/j.1365-2133.2002.49101.x","article-title":"Botulism-like syndrome after botulinum toxin type A injections for focal hyperhidrosis","volume":"147","author":"Tugnoli","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.apmr.2015.01.010_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/mds.870080106","article-title":"Time course of distant effects of local injections of botulinum toxin","volume":"8","author":"Garner","year":"1993","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2015.01.010_bib15","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/jnnp.55.9.844","article-title":"Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system","volume":"55","author":"Girlanda","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.apmr.2015.01.010_bib16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mus.880140711","article-title":"Distant effects of locally injected botulinum toxin: a double-blind study of single fiber EMG changes","volume":"14","author":"Lange","year":"1991","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.apmr.2015.01.010_bib17","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/mus.880100610","article-title":"Distant effects of local injection of botulinum toxin","volume":"10","author":"Lange","year":"1987","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.apmr.2015.01.010_bib18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/WNF.0b013e31815cba8a","article-title":"Undesirable distant effects following botulinum toxin type A injection","volume":"31","author":"Roche","year":"2008","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.apmr.2015.01.010_bib19","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/nau.21103","article-title":"Pilot study evaluating the safety of intradetrusor injections of botulinum toxin type A: investigation of generalized spread using single-fiber EMG","volume":"1537","author":"Schnitzler","year":"2011","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.apmr.2015.01.010_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pmrj.2010.12.021","article-title":"Electrophysiological dysfunction in the peripheral nervous system following spinal cord injury","volume":"3","author":"Riley","year":"2011","journal-title":"PM R"},{"key":"10.1016\/j.apmr.2015.01.010_bib21","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/jnnp.49.6.677","article-title":"Axonal stimulation for end-plate jitter studies","volume":"49","author":"Trontelj","year":"1986","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.apmr.2015.01.010_bib22","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/jnnp.51.6.814","article-title":"The jitter in stimulated orbicularis oculi muscle: technique and normal values","volume":"51","author":"Trontelj","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.apmr.2015.01.010_bib23","unstructured":"Report of CIOMS (Working Group III & V). Guidelines for preparing core clinical-safety information on drugs. 2nd ed.\u00a01998."},{"key":"10.1016\/j.apmr.2015.01.010_bib24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1212\/WNL.36.4.545","article-title":"Botulinum toxin for blepharospasm: single-fiber EMG studies","volume":"36","author":"Sanders","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/j.apmr.2015.01.010_bib25","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1212\/WNL.38.11.1780","article-title":"Neuromuscular effects distant from the site of botulinum neurotoxin injection","volume":"38","author":"Olney","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.apmr.2015.01.010_bib26","first-page":"444","article-title":"[Iatrogenic botulism: a complication to be taken into account in the treatment of child spasticity]","volume":"37","author":"Beseler-Soto","year":"2003","journal-title":"Rev Neurol"},{"key":"10.1016\/j.apmr.2015.01.010_bib27","first-page":"163","article-title":"Botulism-like syndrome after injections of botulinum toxin","volume":"42","author":"Cobb","year":"2000","journal-title":"Vet Hum Toxicol"},{"key":"10.1016\/j.apmr.2015.01.010_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.pmrj.2010.02.006","article-title":"Safety considerations in the use of botulinum toxins in children with cerebral palsy","volume":"2","author":"Apkon","year":"2010","journal-title":"PM R"},{"key":"10.1016\/j.apmr.2015.01.010_bib29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/WNF.0b013e3181f5329e","article-title":"Systemic weakness after therapeutic injections of botulinum toxin a: a case series and review of the literature","volume":"33","author":"Crowner","year":"2010","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.apmr.2015.01.010_bib30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/sj.sc.3101318","article-title":"Muscular weakness as side effect of botulinum toxin injection for neurogenic detrusor overactivity","volume":"40","author":"Wyndaele","year":"2002","journal-title":"Spinal Cord"},{"key":"10.1016\/j.apmr.2015.01.010_bib31","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/mds.20903","article-title":"Iatrogenic botulism in an amateur weight-lifter","volume":"21","author":"Duffey","year":"2006","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2015.01.010_bib32","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0140-6736(93)91580-F","article-title":"Gallbladder dysfunction induced by botulinum A toxin","volume":"342","author":"Schnider","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.apmr.2015.01.010_bib33","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/mds.870120637","article-title":"Idiosyncratic adverse reactions to intramuscular botulinum toxin type A injection","volume":"12","author":"LeWitt","year":"1997","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2015.01.010_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/mus.880170207","article-title":"Single fiber EMG and repetitive stimulation of the same muscle in myasthenia gravis","volume":"17","author":"Gilchrist","year":"1994","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.apmr.2015.01.010_bib35","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/mds.870100508","article-title":"Botulinum toxin: influence on respiratory heart rate variation","volume":"10","author":"Claus","year":"1995","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2015.01.010_bib36","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00415-008-0753-6","article-title":"Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A","volume":"255","author":"Tiple","year":"2008","journal-title":"J Neurol"},{"key":"10.1016\/j.apmr.2015.01.010_bib37","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1111\/j.1572-0241.2000.03331.x","article-title":"Fatal heart block following treatment with botulinum toxin for achalasia","volume":"95","author":"Malnick","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.apmr.2015.01.010_bib38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF02230420","article-title":"Single fiber EMG and cardiovascular reflexes in botulism: a follow-up study","volume":"7","author":"Vita","year":"1986","journal-title":"Ital J Neurol Sci"},{"key":"10.1016\/j.apmr.2015.01.010_bib39","first-page":"5","article-title":"Botulinum toxin type A: therapeutic use [French]","volume":"33","author":"Daubas Bouiri","year":"2012","journal-title":"Doss du CNHIM"},{"key":"10.1016\/j.apmr.2015.01.010_bib40","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1592\/phco.29.7.784","article-title":"Efficacy of botulinum toxin type A for the prophylaxis of episodic migraine headaches: a meta-analysis of randomized, double-blind, placebo-controlled trials","volume":"29","author":"Shuhendler","year":"2009","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.apmr.2015.01.010_bib41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/mus.23492","article-title":"Contralateral weakness following botulinum toxin for poststroke spasticity","volume":"46","author":"Thomas","year":"2012","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.apmr.2015.01.010_bib42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00500611","article-title":"125I-labeled neurotoxin from Clostridium botulinum A: preparation, binding to synaptosomes and ascent to the spinal cord","volume":"281","author":"Habermann","year":"1974","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.apmr.2015.01.010_bib43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00500893","article-title":"The action of botulinum A neurotoxin on the inhibition by antidromic stimulation of the lumbar monosynaptic reflex","volume":"298","author":"Wiegand","year":"1977","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.apmr.2015.01.010_bib44","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1523\/JNEUROSCI.0375-08.2008","article-title":"Long-distance retrograde effects of botulinum neurotoxin A","volume":"28","author":"Antonucci","year":"2008","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"10.1016\/j.apmr.2015.01.010_bib45","doi-asserted-by":"crossref","first-page":"15650","DOI":"10.1523\/JNEUROSCI.2618-11.2011","article-title":"Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT\/A)","volume":"31","author":"Restani","year":"2011","journal-title":"J Neurosci Off J Soc Neurosci"}],"container-title":["Archives of Physical Medicine and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999315000404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999315000404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:30:50Z","timestamp":1537921850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003999315000404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0003999315000404"],"URL":"https:\/\/doi.org\/10.1016\/j.apmr.2015.01.010","relation":{},"ISSN":["0003-9993"],"issn-type":[{"value":"0003-9993","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-Fiber Electromyography Analysis of Botulinum Toxin Diffusion in Patients With Fatigue and Pseudobotulism","name":"articletitle","label":"Article Title"},{"value":"Archives of Physical Medicine and Rehabilitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apmr.2015.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}