{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:59:53Z","timestamp":1791291593218,"version":"4.3.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","archives-pmr.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Physical Medicine and Rehabilitation"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.apmr.2018.05.007","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T07:01:43Z","timestamp":1528354903000},"page":"2478-2484.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["A High-Intensity Multicomponent Agility Intervention Improves Parkinson Patients\u2019 Clinical and Motor Symptoms"],"prefix":"10.1016","volume":"99","author":[{"given":"J\u00f3zsef","family":"Toll\u00e1r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apmr.2018.05.007_bib1","first-page":"754186","article-title":"Posture and locomotion coupling: a target for rehabilitation interventions in persons with Parkinson\u2019s disease","volume":"2012","author":"Mille","year":"2012","journal-title":"Parkinsons Dis"},{"key":"10.1016\/j.apmr.2018.05.007_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1590\/0004-282X20160074","article-title":"Postural instability and falls are more frequent in Parkinson\u2019s disease patients with worse trunk mobility","volume":"74","author":"Artigas","year":"2016","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.apmr.2018.05.007_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/PHM.0b013e31828cd254","article-title":"The beneficial role of intensive exercise on Parkinson disease progression","volume":"92","author":"Frazzitta","year":"2013","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2018.05.007_bib4","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/mds.25658","article-title":"Effects of exercise on mobility in people with Parkinson\u2019s disease","volume":"28","author":"van der Kolk","year":"2013","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.14802\/jmd.15018","article-title":"What is wrong with balance in Parkinson\u2019s disease?","volume":"8","author":"Park","year":"2015","journal-title":"J Mov Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.parkreldis.2017.02.006","article-title":"Effectiveness of exergaming in improving functional balance, fatigue and quality of life in Parkinson\u2019s disease: a pilot randomized controlled trial","volume":"38","author":"Ribas","year":"2017","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib7","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1136\/bjsports-2016-096547","article-title":"Exercise to prevent falls in older adults: an updated systematic review and meta-analysis","volume":"51","author":"Sherrington","year":"2017","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.apmr.2018.05.007_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/NPT.0000000000000117","article-title":"Effects of exercise therapy on postural instability in Parkinson disease: a meta-analysis","volume":"40","author":"Klamroth","year":"2016","journal-title":"J Neurol Phys Ther"},{"key":"10.1016\/j.apmr.2018.05.007_bib9","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/mds.26363","article-title":"Nonpharmacological treatments for patients with Parkinson\u2019s disease","volume":"30","author":"Bloem","year":"2015","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1743-0003-11-33","article-title":"The role of exergaming in Parkinson\u2019s disease rehabilitation: a systematic review of the evidence","volume":"11","author":"Barry","year":"2014","journal-title":"J Neuroeng Rehabil"},{"key":"10.1016\/j.apmr.2018.05.007_bib11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/WNL.0b013e318225ab66","article-title":"Does vigorous exercise have a neuroprotective effect in Parkinson disease?","volume":"77","author":"Ahlskog","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.apmr.2018.05.007_bib12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2522\/ptj.20080214","article-title":"Delaying mobility disability in people with Parkinson disease using a sensorimotor agility exercise program","volume":"89","author":"King","year":"2009","journal-title":"Phys Ther"},{"issue":"Suppl 3","key":"10.1016\/j.apmr.2018.05.007_bib13","doi-asserted-by":"crossref","first-page":"S478","DOI":"10.1016\/S1353-8020(08)70053-1","article-title":"Impact of physical therapy for Parkinson\u2019s disease: a critical review of the literature","volume":"13","author":"Kwakkel","year":"2007","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1249\/MSS.0000000000001159","article-title":"Instability resistance training improves neuromuscular outcome in Parkinson\u2019s disease","volume":"49","author":"Silva-Batista","year":"2017","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.apmr.2018.05.007_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/NPT.0b013e3181990fcc","article-title":"The effects of exercise on balance in persons with Parkinson\u2019s disease: a systematic review across the disability spectrum","volume":"33","author":"Dibble","year":"2009","journal-title":"J Neurol Phys Ther"},{"key":"10.1016\/j.apmr.2018.05.007_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta20630","article-title":"Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson\u2019s disease: a large pragmatic randomised controlled trial (PD REHAB)","volume":"20","author":"Clarke","year":"2016","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.apmr.2018.05.007_bib17","first-page":"854328","article-title":"Exercise and motor training in people with Parkinson\u2019s disease: a systematic review of participant characteristics, intervention delivery, retention rates, adherence, and adverse events in clinical trials","volume":"2012","author":"Allen","year":"2012","journal-title":"Parkinsons Dis"},{"issue":"Suppl 1","key":"10.1016\/j.apmr.2018.05.007_bib18","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.parkreldis.2015.09.005","article-title":"Rehabilitation for Parkinson\u2019s disease: current outlook and future challenges","volume":"22","author":"Abbruzzese","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.pmrj.2013.05.019","article-title":"Wii Fit balance board playing improves balance and gait in Parkinson disease","volume":"5","author":"Mhatre","year":"2013","journal-title":"PM R"},{"key":"10.1016\/j.apmr.2018.05.007_bib20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3233\/NRE-141119","article-title":"The impact of high intensity physical training on motor and non-motor symptoms in patients with Parkinson\u2019s disease (PIP): a preliminary study","volume":"35","author":"Morberg","year":"2014","journal-title":"NeuroRehabilitation"},{"key":"10.1016\/j.apmr.2018.05.007_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.TGR.0000318898.87690.0d","article-title":"Intensive amplitude-specific therapeutic appraoches for Parkinson\u2019s disease: toward a neuroplasticity principled regabilitation model","volume":"24","author":"Farley","year":"2008","journal-title":"Topics Ger Rehab"},{"key":"10.1016\/j.apmr.2018.05.007_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.gaitpost.2015.09.013","article-title":"Motor intensive anti-gravity training improves performance in dynamic balance related tasks in persons with Parkinson\u2019s disease","volume":"43","author":"Malling","year":"2016","journal-title":"Gait Posture"},{"key":"10.1016\/j.apmr.2018.05.007_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/1545968314567150","article-title":"The effects of highly challenging balance training in elderly with Parkinson\u2019s disease: a randomized controlled trial","volume":"29","author":"Conradsson","year":"2015","journal-title":"Neurorehabil Neural Repair"},{"key":"10.1016\/j.apmr.2018.05.007_bib24","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jagp.2012.12.026","article-title":"Executive functions of sedentary elderly may benefit from walking: a systematic review and meta-analysis","volume":"22","author":"Scherder","year":"2014","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.apmr.2018.05.007_bib25","article-title":"Effectiveness of physical activity on patients with depression and Parkinson\u2019s disease: a systematic review","volume":"12","author":"Wu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.apmr.2018.05.007_bib26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.apmr.2018.05.007_bib27","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson\u2019s disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/mds.26960","article-title":"Minimal clinically important differences for the experiences of daily living parts of movement disorder society-sponsored unified Parkinson\u2019s disease rating scale","volume":"32","author":"Horvath","year":"2017","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000455863","article-title":"Changes in quality of life in Parkinson\u2019s disease: how large must they be to be relevant?","volume":"48","author":"Horvath","year":"2017","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.apmr.2018.05.007_bib30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.physio.2013.10.003","article-title":"Feasibility, safety and outcomes of playing Kinect Adventures! for people with Parkinson\u2019s disease: a pilot study","volume":"100","author":"Pompeu","year":"2014","journal-title":"Physiotherapy"},{"key":"10.1016\/j.apmr.2018.05.007_bib31","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand J Stat"},{"key":"10.1016\/j.apmr.2018.05.007_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1001\/jamaneurol.2013.646","article-title":"Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease","volume":"70","author":"Shulman","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.apmr.2018.05.007_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1545968314542981","article-title":"Intensive rehabilitation treatment in early Parkinson\u2019s disease: a randomized pilot study with a 2-year follow-up","volume":"29","author":"Frazzitta","year":"2015","journal-title":"Neurorehabil Neural Repair"},{"key":"10.1016\/j.apmr.2018.05.007_bib34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.apmr.2015.10.095","article-title":"Comparative effect of power training and high-speed yoga on motor function in older patients with Parkinson disease","volume":"97","author":"Ni","year":"2016","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.apmr.2018.05.007_bib35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.parkreldis.2013.05.017","article-title":"The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson\u2019s disease","volume":"19","author":"Rodriguez-Blazquez","year":"2013","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib36","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1177\/0269215514521044","article-title":"Effects of Tai Chi on balance and fall prevention in Parkinson\u2019s disease: a randomized controlled trial","volume":"28","author":"Gao","year":"2014","journal-title":"Clin Rehabil"},{"key":"10.1016\/j.apmr.2018.05.007_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1123\/japa.7.2.129","article-title":"Reliability and validity of the Fullerton Functional Fitness Test: an independent replication study","volume":"7","author":"Rikli","year":"1999","journal-title":"J Aging Phys Activ"},{"key":"10.1016\/j.apmr.2018.05.007_bib38","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1532-5415.1996.tb04068.x","article-title":"The relative importance of strength and balance in chair rise by functionally impaired older individuals","volume":"44","author":"Schenkman","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.apmr.2018.05.007_bib39","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/mds.25449","article-title":"Clinical and posturographic correlates of falling in Parkinson\u2019s disease","volume":"28","author":"Johnson","year":"2013","journal-title":"Mov Disord"},{"key":"10.1016\/j.apmr.2018.05.007_bib40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnagi.2012.00020","article-title":"Static posturography in aging and Parkinson\u2019s disease","volume":"4","author":"Ickenstein","year":"2012","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.apmr.2018.05.007_bib41","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0197-4580(89)90010-9","article-title":"Components of postural dyscontrol in the elderly: a review","volume":"10","author":"Horak","year":"1989","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.apmr.2018.05.007_bib42","doi-asserted-by":"crossref","first-page":"M72","DOI":"10.1093\/geronj\/49.2.M72","article-title":"A prospective study of postural balance and risk of falling in an ambulatory and independent elderly population","volume":"49","author":"Maki","year":"1994","journal-title":"J Gerontol"},{"key":"10.1016\/j.apmr.2018.05.007_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jocn.2017.05.012","article-title":"Evidence based effects of yoga in neurological disorders","volume":"43","author":"Mooventhan","year":"2017","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.apmr.2018.05.007_bib44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ctim.2016.09.016","article-title":"Effects of mind-body exercises on the physiological and psychosocial well-being of individuals with Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"29","author":"Kwok","year":"2016","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.apmr.2018.05.007_bib45","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40520-013-0044-7","article-title":"Executive function moderates the role of muscular fitness in determining functional mobility in older adults","volume":"25","author":"Forte","year":"2013","journal-title":"Aging Clin Exp Res"}],"container-title":["Archives of Physical Medicine and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999318303538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999318303538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T05:32:53Z","timestamp":1604381573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003999318303538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0003999318303538"],"URL":"https:\/\/doi.org\/10.1016\/j.apmr.2018.05.007","relation":{},"ISSN":["0003-9993"],"issn-type":[{"value":"0003-9993","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A High-Intensity Multicomponent Agility Intervention Improves Parkinson Patients\u2019 Clinical and Motor Symptoms","name":"articletitle","label":"Article Title"},{"value":"Archives of Physical Medicine and Rehabilitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apmr.2018.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the American Congress of Rehabilitation Medicine","name":"copyright","label":"Copyright"}]}}