{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:34:03Z","timestamp":1786484043617,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["archives-pmr.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Physical Medicine and Rehabilitation"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.apmr.2026.02.488","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:19:01Z","timestamp":1773332341000},"page":"2083-2093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Blood Flow Restriction Training Improve Mental Health and Quality of Life in Multiple Sclerosis?"],"prefix":"10.1016","volume":"107","author":[{"given":"Javier","family":"Cano-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-9199","authenticated-orcid":false,"given":"Agust\u00edn","family":"Aibar-Almaz\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidel","family":"Hita-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Castellote-Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Carmen","family":"Carcel\u00e9n-Fraile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apmr.2026.02.488_bib0001","first-page":"948","article-title":"Multiple sclerosis- diagnosis, management and prognosis","volume":"40","author":"Tsang","year":"2011","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.apmr.2026.02.488_bib0002","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult Scler"},{"key":"10.1016\/j.apmr.2026.02.488_bib0003","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7224\/1537-2073.2018-036","article-title":"Changes in activity participation after multiple sclerosis diagnosis","volume":"22","author":"Goverover","year":"2020","journal-title":"Int J MS Care"},{"key":"10.1016\/j.apmr.2026.02.488_bib0004","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/healthcare12121180","article-title":"Assessment of the daily living activities of older people (2004-2023): a bibliometric and visual analysis","volume":"12","author":"Cui","year":"2024","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.apmr.2026.02.488_bib0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s40520-025-03131-3","article-title":"Patterns of social participation among older adults and their association with self-rated health: the mediating role of activities of daily living","volume":"37","author":"Zhou","year":"2025","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.apmr.2026.02.488_bib0006","doi-asserted-by":"crossref","unstructured":"Odom LB, Thomas GA, Zachariah JJ, Zagon IS, McLaughlin PJ. Exploring the relationships of physical, mental, and emotional symptoms and serum biomarkers of angiogenesis in multiple sclerosis. Mult Scler J Exp Transl Clin. 20251;11:20552173251329904.","DOI":"10.1177\/20552173251329904"},{"key":"10.1016\/j.apmr.2026.02.488_bib0007","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1352\/1944-7558-125.1.49","article-title":"Associated risk factors for depression and anxiety in adults with intellectual and developmental disabilities: five-year follow up","volume":"125","author":"Hsieh","year":"2020","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.apmr.2026.02.488_bib0008","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41398-023-02555-7","article-title":"Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis","volume":"13","author":"Margoni","year":"2023","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.apmr.2026.02.488_bib0009","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/1352458507077175","article-title":"Fatigue in multiple sclerosis: association with disease-related, behavioural and psychosocial factors","volume":"13","author":"Trojan","year":"2007","journal-title":"Mult Scler"},{"key":"10.1016\/j.apmr.2026.02.488_bib0010","article-title":"The prevalence and risk factors of anxiety in multiple sclerosis: a systematic review and meta-analysis","volume":"17","author":"Zhang","year":"2023","journal-title":"Front Neurosci"},{"key":"10.1016\/j.apmr.2026.02.488_bib0011","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/1352458514564487","article-title":"The incidence and prevalence of psychiatric disorders in multiple sclerosis: a systematic review","volume":"21","author":"Marrie","year":"2015","journal-title":"Mult Scler"},{"key":"10.1016\/j.apmr.2026.02.488_bib0012","article-title":"Experience of the burden of using multiple medicines and the associated impact on health-related quality of life","volume":"12","author":"Gurung","year":"2025","journal-title":"J Patient Exp"},{"key":"10.1016\/j.apmr.2026.02.488_bib0013","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.pjnns.2018.09.003","article-title":"Psychiatric comorbidity in multiple sclerosis","volume":"52","author":"Panda","year":"2018","journal-title":"Neurol Neurochir Pol"},{"key":"10.1016\/j.apmr.2026.02.488_bib0014","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fneur.2017.00461","article-title":"Pain in people with multiple sclerosis: associations with modifiable lifestyle factors, fatigue, depression, anxiety, and mental health quality of life","volume":"8","author":"Marck","year":"2017","journal-title":"Front Neurol"},{"key":"10.1016\/j.apmr.2026.02.488_bib0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.14336\/AD.2013.0400329","article-title":"Depression treatment non-adherence and its psychosocial predictors: differences between young and older adults?","volume":"4","author":"Stein-Shvachman","year":"2013","journal-title":"Aging Dis"},{"key":"10.1016\/j.apmr.2026.02.488_bib0016","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40263-018-0489-5","article-title":"Depression in multiple sclerosis: epidemiology, aetiology, diagnosis and treatment","volume":"32","author":"Solaro","year":"2018","journal-title":"CNS Drugs"},{"key":"10.1016\/j.apmr.2026.02.488_bib0017","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x202010428","article-title":"Depression and anxiety disorders in patients with multiple sclerosis: association with neurodegeneration and neurofilaments","volume":"54","author":"Tauil","year":"2021","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.apmr.2026.02.488_bib0018","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11910-015-0585-6","article-title":"Benefits of exercise training in multiple sclerosis","volume":"15","author":"Motl","year":"2015","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.apmr.2026.02.488_bib0019","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3390\/jcm10061320","article-title":"Association of barriers, fear of falling and fatigue with objectively measured physical activity and sedentary behavior in chronic stroke","volume":"10","author":"S\u00e1nchez-S\u00e1nchez","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.apmr.2026.02.488_bib0020","doi-asserted-by":"crossref","first-page":"937","DOI":"10.4085\/418-20","article-title":"Blood flow restriction training","volume":"56","author":"Lorenz","year":"2021","journal-title":"J Athl Train"},{"key":"10.1016\/j.apmr.2026.02.488_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/app152413003","article-title":"Exploring the effect of blood flow restriction training on lower-limb muscle activation in CrossFit athletes: a pilot crossover trial","volume":"15","author":"L\u00f3pez-Tostado","year":"2025","journal-title":"Appl Sci"},{"key":"10.1016\/j.apmr.2026.02.488_bib0022","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1016\/j.asmr.2021.09.025","article-title":"Blood flow restriction therapy and its use for rehabilitation and return to sport: physiology, application, and guidelines for implementation","volume":"4","author":"Cognetti","year":"2022","journal-title":"Arthrosc Sports Med Rehabil"},{"key":"10.1016\/j.apmr.2026.02.488_bib0023","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3233\/JPD-230259","article-title":"Effects of blood flow restriction resistance training on autonomic and endothelial function in persons with Parkinson's disease","volume":"14","author":"Bane","year":"2024","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.apmr.2026.02.488_bib0024","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3390\/healthcare10122407","article-title":"Effectiveness of blood flow restriction in neurological disorders: a systematic review","volume":"30","author":"Vinolo-Gil","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.apmr.2026.02.488_bib0025","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3390\/neurolint16060104","article-title":"Effectiveness and feasibility of blood flow restriction training for people with multiple sclerosis: a systematic review","volume":"16","author":"Bl\u00e1zquez-Fern\u00e1ndez","year":"2024","journal-title":"Neurol Int"},{"key":"10.1016\/j.apmr.2026.02.488_bib0026","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00003086-199301000-00038","article-title":"Occlusion of arterial flow in the extremities at subsystolic pressures through the use of wide tourniquet cuffs","volume":"286","author":"Graham","year":"1993","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.apmr.2026.02.488_bib0027","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3389\/fphys.2019.00533","article-title":"Blood flow restriction exercise: considerations of methodology, application, and safety","volume":"10","author":"Patterson","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.apmr.2026.02.488_bib0028","first-page":"1","article-title":"Obesity: preventing and managing the global epidemic","volume":"894","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"10.1016\/j.apmr.2026.02.488_bib0029","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-3999(01)00296-3","article-title":"The validity of the Hospital Anxiety and Depression Scale. An updated literature review","volume":"52","author":"Bjelland","year":"2002","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.apmr.2026.02.488_bib0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.msard.2017.12.007","article-title":"The validity and reliability of screening measures for depression and anxiety disorders in multiple sclerosis","volume":"20","author":"Marrie","year":"2018","journal-title":"Mult Scler Relat Disord"},{"issue":"3","key":"10.1016\/j.apmr.2026.02.488_bib0031","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02260859","article-title":"A health-related quality of life measure for multiple sclerosis","volume":"4","author":"Vickrey","year":"1995","journal-title":"Qual Life Res"},{"key":"10.1016\/j.apmr.2026.02.488_bib0032","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol Bull"},{"key":"10.1016\/j.apmr.2026.02.488_bib0033","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1191\/1352458503ms930oa","article-title":"Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis","volume":"9","author":"Janssens","year":"2003","journal-title":"Mult Scler"},{"key":"10.1016\/j.apmr.2026.02.488_bib0034","first-page":"e5","article-title":"Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis","volume":"2","author":"Michalski","year":"2010","journal-title":"Ment Illn"},{"key":"10.1016\/j.apmr.2026.02.488_bib0035","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2174\/1871527313666140612102841","article-title":"Effects of exercise on anxiety and depression disorders: review of meta-analyses and neurobiological mechanisms","volume":"13","author":"Wegner","year":"2014","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.apmr.2026.02.488_bib0036","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12993-025-00273-2","article-title":"A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters","volume":"21","author":"Jie","year":"2025","journal-title":"Behav Brain Funct"},{"key":"10.1016\/j.apmr.2026.02.488_bib0037","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1249\/MSS.0000000000003747","article-title":"The impact of blood flow restriction and resistance training on functional outcomes and fatigue in people with multiple sclerosis","volume":"57","author":"Schmidt","year":"2025","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.apmr.2026.02.488_bib0038","doi-asserted-by":"crossref","DOI":"10.1111\/sms.14561","article-title":"Safety and efficacy of blood flow restriction exercise in individuals with neurological disorders: a systematic review","volume":"34","author":"J\u00f8nsson","year":"2024","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.apmr.2026.02.488_bib0039","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1046\/j.1468-1331.2002.00450.x","article-title":"Health-related quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis patients","volume":"9","author":"Benito-Le\u00f3n","year":"2002","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.apmr.2026.02.488_bib0040","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0269215513501525","article-title":"The effects of a group-based cognitive behavioral therapy on people with multiple sclerosis: a randomized controlled trial","volume":"28","author":"Graziano","year":"2014","journal-title":"Clin Rehabil"},{"key":"10.1016\/j.apmr.2026.02.488_bib0041","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1477-7525-12-40","article-title":"Improved self-efficacy in persons with relapsing remitting multiple sclerosis after an intensive social cognitive wellness program with participation of support partners: a 6-months observational study","volume":"12","author":"Jongen","year":"2014","journal-title":"Health Qual Life Outcomes"}],"container-title":["Archives of Physical Medicine and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999326005691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003999326005691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:16:14Z","timestamp":1786482974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003999326005691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0003999326005691"],"URL":"https:\/\/doi.org\/10.1016\/j.apmr.2026.02.488","relation":{},"ISSN":["0003-9993"],"issn-type":[{"value":"0003-9993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can Blood Flow Restriction Training Improve Mental Health and Quality of Life in Multiple Sclerosis?","name":"articletitle","label":"Article Title"},{"value":"Archives of Physical Medicine and Rehabilitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apmr.2026.02.488","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American Congress of Rehabilitation Medicine. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}