{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:01:10Z","timestamp":1788631270451,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Nursing Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.apnr.2023.151745","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T02:16:21Z","timestamp":1698459381000},"page":"151745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Ketogenic therapies in Parkinson's disease, Alzheimer's disease, and mild cognitive impairment: An integrative review"],"prefix":"10.1016","volume":"74","author":[{"given":"Susan","family":"Price","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Ruppar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apnr.2023.151745_bb0005","author":"Alzheimer'\u2019s Association"},{"issue":"1","key":"10.1016\/j.apnr.2023.151745_bb0010","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1474-4422(17)30408-8","article-title":"Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders","volume":"17","author":"Augustin","year":"2018","journal-title":"The Lancet. Neurology"},{"issue":"4","key":"10.1016\/j.apnr.2023.151745_bb0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/1028415X.2019.1627769","article-title":"Ketogenic diet: Overview, types, and possible anti-seizure mechanisms","volume":"24","author":"Barzegar","year":"2021","journal-title":"Nutritional Neuroscience"},{"issue":"3","key":"10.1016\/j.apnr.2023.151745_bb0020","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3233\/JAD-180995","article-title":"Preliminary report on the feasibility and efficacy of the modified Atkins diet for treatment of mild cognitive impairment and early Alzheimer\u2019s disease","volume":"68","author":"Brandt","year":"2019","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"1","key":"10.1016\/j.apnr.2023.151745_bb0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40035-017-0096-2","article-title":"Disease modification and neuroprotection in neurodegenerative disorders","volume":"6","author":"Cummings","year":"2017","journal-title":"Translational Neurodegeneration"},{"issue":"8","key":"10.1016\/j.apnr.2023.151745_bb0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2174\/1567205015666180119092427","article-title":"Estimating Alzheimer\u2019s disease progression rates from normal cognition through mild cognitive impairment and stages of dementia","volume":"15","author":"Davis","year":"2018","journal-title":"Current Alzheimer Research"},{"issue":"3","key":"10.1016\/j.apnr.2023.151745_bb0035","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/alz.12206","article-title":"A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT","volume":"17","author":"Fortier","year":"2021","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"1","key":"10.1016\/j.apnr.2023.151745_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1743-7075-6-31","article-title":"Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer\u2019s disease: A randomized, double-blind, placebo-controlled, multicenter trial","volume":"6","author":"Henderson","year":"2009","journal-title":"Nutrition & Metabolism"},{"issue":"6","key":"10.1016\/j.apnr.2023.151745_bb0045","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s13760-020-01486-0","article-title":"Effect of ketogenic diet versus regular diet on voice quality of patients with Parkinson\u2019s disease","volume":"121","author":"Koyuncu","year":"2021","journal-title":"Acta Neurologica Belgica"},{"issue":"2","key":"10.1016\/j.apnr.2023.151745_bb0050","doi-asserted-by":"crossref","first-page":"425.e19","DOI":"10.1016\/j.neurobiolaging.2010.10.006","article-title":"Dietary ketosis enhances memory in mild cognitive impairment","volume":"33","author":"Krikorian","year":"2012","journal-title":"Neurobiology of Aging"},{"issue":"5","key":"10.1016\/j.apnr.2023.151745_bb0055","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.nut.2009.05.021","article-title":"Dietary glycemic index is inversely associated with the risk of Parkinson\u2019s disease: A case\u2013control study in Japan","volume":"26","author":"Murakami","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.apnr.2023.151745_bb0060","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2019.09.015","article-title":"Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer\u2019s disease: A pilot study","volume":"86","author":"Neth","year":"2020","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.apnr.2023.151745_bb0065","article-title":"Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer's disease: A prospective, open-label pilot study","volume":"29","author":"Ohnuma","year":"2016","journal-title":"Clinical Interventions in Aging"},{"key":"10.1016\/j.apnr.2023.151745_bb0070","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neulet.2018.10.048","article-title":"Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer\u2019s disease","volume":"690","author":"Ota","year":"2019","journal-title":"Neuroscience Letters"},{"issue":"1","key":"10.1016\/j.apnr.2023.151745_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13195-021-00783-x","article-title":"Randomized crossover trial of a modified ketogenic diet in Alzheimer\u2019s disease","volume":"13","author":"Phillips","year":"2021","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"8","key":"10.1016\/j.apnr.2023.151745_bb0080","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/mds.27390","article-title":"Low-fat versus ketogenic diet in Parkinson\u2019s disease: A pilot randomized controlled trial","volume":"33","author":"Phillips","year":"2018","journal-title":"Movement Disorders"},{"key":"10.1016\/j.apnr.2023.151745_bb0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbacli.2015.01.001","article-title":"Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial","volume":"3","author":"Rebello","year":"2015","journal-title":"BBA Clinical"},{"issue":"3","key":"10.1016\/j.apnr.2023.151745_bb0090","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0197-4580(03)00087-3","article-title":"Effects of \u03b2-hydroxybutyrate on cognition in memory-impaired adults","volume":"25","author":"Reger","year":"2004","journal-title":"Neurobiology of Aging"},{"issue":"2","key":"10.1016\/j.apnr.2023.151745_bb0095","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3233\/JAD-180184","article-title":"Improvement of main cognitive functions in patients with Alzheimer\u2019s disease after treatment with coconut oil enriched Mediterranean diet: A pilot study","volume":"65","author":"de la Rubia Ort\u00ed","year":"2018","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"1","key":"10.1016\/j.apnr.2023.151745_bb0100","first-page":"28","article-title":"Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer\u2019s disease","volume":"4","author":"Taylor","year":"2018","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"4","key":"10.1016\/j.apnr.2023.151745_bb0105","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1212\/01.WNL.0000152046.11390.45","article-title":"Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study","volume":"64","author":"Vanitallie","year":"2005","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.apnr.2023.151745_bb0110","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2648.2005.03621.x","article-title":"The integrative review: Updated methodology","volume":"52","author":"Whittemore","year":"2005","journal-title":"Journal of Advanced Nursing"}],"container-title":["Applied Nursing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0897189723000794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0897189723000794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:53:39Z","timestamp":1760262819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0897189723000794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":22,"alternative-id":["S0897189723000794"],"URL":"https:\/\/doi.org\/10.1016\/j.apnr.2023.151745","relation":{},"ISSN":["0897-1897"],"issn-type":[{"value":"0897-1897","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketogenic therapies in Parkinson's disease, Alzheimer's disease, and mild cognitive impairment: An integrative review","name":"articletitle","label":"Article Title"},{"value":"Applied Nursing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apnr.2023.151745","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151745"}}