{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:56:46Z","timestamp":1790287006445,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Foundation for Science and Technology of the State of Pernambuco","doi-asserted-by":"publisher","award":["1410.4.05\/12"],"award-info":[{"award-number":["1410.4.05\/12"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["484726\/2012-9"],"award-info":[{"award-number":["484726\/2012-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Appetite"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.appet.2017.12.004","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T17:48:14Z","timestamp":1512755294000},"page":"114-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Pre-weaning maternal separation increases eating later in life in male and female offspring, but increases brainstem dopamine receptor 1a and 2a only in males"],"prefix":"10.1016","volume":"123","author":[{"given":"Julliet Ara\u00fajo","family":"de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde Cesiana","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhowena Jane Barbosa","family":"de Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Cavalcanti","family":"do Amaral Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Cruz","family":"Beltr\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Leit\u00e3o","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-2031","authenticated-orcid":false,"given":"Raul Manh\u00e3es","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Lopes","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.appet.2017.12.004_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.physbeh.2016.04.052","article-title":"Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse","volume":"163","author":"Amiri","year":"2016","journal-title":"Physiol Behav"},{"issue":"3","key":"10.1016\/j.appet.2017.12.004_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/00221309.2014.897215","article-title":"Effects of early maternal separation on subsequent reproductive and behavioral outcomes in male rats","volume":"141","author":"Bodensteiner","year":"2014","journal-title":"Journal of General Psychology"},{"issue":"17","key":"10.1016\/j.appet.2017.12.004_bib3","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1523\/JNEUROSCI.5322-03.2004","article-title":"Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat","volume":"24","author":"Champagne","year":"2004","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.appet.2017.12.004_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0031-9384(03)00149-5","article-title":"Variations in maternal care in the rat as a mediating influence for the effects of environment on development","volume":"79","author":"Champagne","year":"2003","journal-title":"Physiol Behav"},{"key":"10.1016\/j.appet.2017.12.004_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.brainres.2009.12.093","article-title":"The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: An autoradiography study","volume":"1321","author":"Chavez","year":"2010","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.appet.2017.12.004_bib6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.physbeh.2009.08.010","article-title":"Early trauma and adult obesity: Is psychological dysfunction the mediating mechanism?","volume":"98","author":"D'Argenio","year":"2009","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2017.12.004_bib7","article-title":"From passive overeating to \u201cfood addiction\u201d: A spectrum of compulsion and severity","volume":"2013","author":"Davis","year":"2013","journal-title":"International Scholarly Research Network Obesity"},{"issue":"2","key":"10.1016\/j.appet.2017.12.004_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbr.2004.09.018","article-title":"Maternal separation affects male rat copulatory behaviour and hypothalamic corticotropin releasing factor in concert","volume":"158","author":"Greisen","year":"2005","journal-title":"Behav Brain Res."},{"issue":"1","key":"10.1016\/j.appet.2017.12.004_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4","article-title":"Maternal deprivation of neonatal rats produces enduring changes in dopamine function","volume":"32","author":"Hall","year":"1999","journal-title":"Synapse"},{"issue":"11","key":"10.1016\/j.appet.2017.12.004_bib10","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.bbadis.2014.08.009","article-title":"Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain","volume":"1842","author":"Hill","year":"2014","journal-title":"Biochimica et Biophysica Acta"},{"issue":"2","key":"10.1016\/j.appet.2017.12.004_bib11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2826.2012.02377.x","article-title":"Developmental changes in desensitisation of c-Fos expression induced by repeated maternal separation in pre-weaned mice","volume":"25","author":"Horii-Hayashi","year":"2013","journal-title":"Journal of Neuroendocrinology"},{"issue":"2","key":"10.1016\/j.appet.2017.12.004_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-8993(88)91523-5","article-title":"Estrogen treatment increases the density of D1 dopamine receptors in the rat striatum","volume":"442","author":"Hruska","year":"1988","journal-title":"Brain Res."},{"issue":"15","key":"10.1016\/j.appet.2017.12.004_bib13","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1097\/01.wnr.0000180142.91644.65","article-title":"Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats","volume":"16","author":"Iraj Mirzaii","year":"2005","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.appet.2017.12.004_bib14","first-page":"165","article-title":"Structure and function of the brain serotonin system","volume":"72","author":"Jacobs","year":"1992","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2017.12.004_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/497101","article-title":"Increased mesohippocampal dopaminergic activity and improved depression-like behaviors in maternally separated rats following repeated fasting\/refeeding cycles","volume":"2012","author":"Jahng","year":"2012","journal-title":"Journal of Obesity"},{"issue":"1","key":"10.1016\/j.appet.2017.12.004_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1037\/a0031219","article-title":"Implications of temporal variation in maternal care for the prediction of neurobiological and behavioral outcomes in offspring","volume":"127","author":"Jensen Pena","year":"2013","journal-title":"Behavioral Neuroscience"},{"issue":"6","key":"10.1016\/j.appet.2017.12.004_bib17","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jpeds.2008.06.016","article-title":"Psychological stress and obesity","volume":"153","author":"Koch","year":"2008","journal-title":"Journal of Pediatrics"},{"issue":"7","key":"10.1016\/j.appet.2017.12.004_bib18","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/PSY.0b013e3181ae6aee","article-title":"War-related exposure and psychological distress as predictors of health and sleep: A longitudinal study of kuwaiti children","volume":"71","author":"Llabre","year":"2009","journal-title":"Psychosomatic Medicine"},{"issue":"1","key":"10.1016\/j.appet.2017.12.004_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/dev.1024","article-title":"Maternally separated rats show deficits in maternal care in adulthood","volume":"39","author":"Lovic","year":"2001","journal-title":"Developmental Psychobiology"},{"issue":"4","key":"10.1016\/j.appet.2017.12.004_bib20","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1460-9568.2004.03541.x","article-title":"Dissociation in the effects of neonatal maternal separations on maternal care and the offspring's HPA and fear responses in rats","volume":"20","author":"Macri","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.appet.2017.12.004_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijdevneu.2017.01.001","article-title":"The effects of early-life stress on dopamine system function in adolescent female rats","volume":"57","author":"Majcher-Maslanka","year":"2017","journal-title":"International Journal of Developmental Neuroscience"},{"issue":"5","key":"10.1016\/j.appet.2017.12.004_bib22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.psyneuen.2009.10.013","article-title":"Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment","volume":"35","author":"Maniam","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.appet.2017.12.004_bib23","series-title":"Dopamine receptor expression in the central nervous","author":"Mansour","year":"2000"},{"issue":"6","key":"10.1016\/j.appet.2017.12.004_bib25","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.celrep.2014.08.037","article-title":"Serotonergic versus nonserotonergic dorsal raphe projection Neurons: Differential participation in reward circuitry","volume":"8","author":"McDevitt Ross","year":"2014","journal-title":"Cell Reports"},{"issue":"4","key":"10.1016\/j.appet.2017.12.004_bib26","first-page":"231","article-title":"Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in rat brain","volume":"5","author":"Meador-Woodruff","year":"1991","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.appet.2017.12.004_bib27","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.pbb.2007.03.007","article-title":"Enhanced sensitivity to naltrexone-induced drinking suppression of fluid intake and sucrose consumption in maternally separated rats","volume":"86","author":"Michaels","year":"2007","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"2","key":"10.1016\/j.appet.2017.12.004_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0145-2134(93)90050-F","article-title":"The relationship between childhood sexual abuse and subsequent onset of bulimia nervosa","volume":"17","author":"Miller","year":"1993","journal-title":"Child Abuse & Neglect"},{"issue":"4","key":"10.1016\/j.appet.2017.12.004_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/erv.940","article-title":"Unfavourable family characteristics and their associations with childhood obesity: A cross-sectional study","volume":"17","author":"Moens","year":"2009","journal-title":"European Eating Disorders Review"},{"issue":"4","key":"10.1016\/j.appet.2017.12.004_bib29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1037\/h0077599","article-title":"Mother rats interact differently with male and female offspring","volume":"93","author":"Moore","year":"1979","journal-title":"Journal of Comparative and Physiological Psychology"},{"issue":"5","key":"10.1016\/j.appet.2017.12.004_bib30","doi-asserted-by":"crossref","first-page":"e1096","DOI":"10.1542\/peds.2012-0895","article-title":"Influence of stress in parents on child obesity and related behaviors","volume":"130","author":"Parks","year":"2012","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.appet.2017.12.004_bib31","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1242\/dmm.009043","article-title":"Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats","volume":"5","author":"Paternain","year":"2012","journal-title":"Disease Models & Mechanisms"},{"issue":"6","key":"10.1016\/j.appet.2017.12.004_bib32","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/ejn.12479","article-title":"Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring","volume":"39","author":"Pena","year":"2014","journal-title":"European Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.appet.2017.12.004_bib33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0306-4522(03)00499-8","article-title":"Long-term effects of maternal separation on ethanol intake and brain opioid and dopamine receptors in male Wistar rats","volume":"121","author":"Ploj","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.appet.2017.12.004_bib500","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0169-328X(93)90189-V","article-title":"Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats","volume":"18","author":"Plotsky","year":"1993","journal-title":"Molecular Brain Research"},{"issue":"3","key":"10.1016\/j.appet.2017.12.004_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091151","article-title":"Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway","volume":"9","author":"Purves-Tyson","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.appet.2017.12.004_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(00)00381-8","article-title":"Effects of maternal separation during early postnatal development on male sexual behavior and female reproductive function","volume":"123","author":"Rhees","year":"2001","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.appet.2017.12.004_bib36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2009.08.006","article-title":"Post-weaning isolation promotes food intake and body weight gain in rats that experienced neonatal maternal separation","volume":"1295","author":"Ryu","year":"2009","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/j.appet.2017.12.004_bib37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1017\/S204017441400018X","article-title":"Effects of maternal separation on the dietary preference and behavioral satiety sequence in rats","volume":"5","author":"da Silva","year":"2014","journal-title":"Journal of Developmental Origins of Health and Disease"},{"key":"10.1016\/j.appet.2017.12.004_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1744-9081-7-49","article-title":"Maternal separation affects dopamine transporter function in the spontaneously hypertensive rat: An in\u00a0vivo electrochemical study","volume":"7","author":"Womersley","year":"2011","journal-title":"Behavioral and Brain Functions"},{"issue":"5","key":"10.1016\/j.appet.2017.12.004_bib39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.npep.2011.07.005","article-title":"The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation","volume":"45","author":"Yoo","year":"2011","journal-title":"Neuropeptides"}],"container-title":["Appetite"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195666317313892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195666317313892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T07:44:25Z","timestamp":1565336665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195666317313892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":40,"alternative-id":["S0195666317313892"],"URL":"https:\/\/doi.org\/10.1016\/j.appet.2017.12.004","relation":{},"ISSN":["0195-6663"],"issn-type":[{"value":"0195-6663","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-weaning maternal separation increases eating later in life in male and female offspring, but increases brainstem dopamine receptor 1a and 2a only in males","name":"articletitle","label":"Article Title"},{"value":"Appetite","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.appet.2017.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}