{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:04:47Z","timestamp":1790442287283,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Appetite"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.appet.2019.02.012","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T17:07:11Z","timestamp":1551287231000},"page":"62-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Use of cyproheptadine to stimulate appetite and body weight gain: A systematic review"],"prefix":"10.1016","volume":"137","author":[{"given":"Megan E.","family":"Harrison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Spettigue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanna","family":"Isserlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib1","first-page":"40","article-title":"Appetite-stimulating and weight-gain properties of cyproheptadine (Periactin) in geriatric subjects","volume":"13","author":"Andronic","year":"1971","journal-title":"Current Therapeutic Research"},{"key":"10.1016\/j.appet.2019.02.012_bib2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1192\/bjp.117.541.681","article-title":"Cyproheptadine hydrochloride (periactin) and anorexia nervosa: A case report","volume":"117","author":"Benady","year":"1970","journal-title":"The British Journal of Psychiatry"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib3","first-page":"270","article-title":"Appetite stimulating properties of cyproheptadine","volume":"108","author":"Bergen","year":"1964","journal-title":"American Journal of Diseases of Children"},{"issue":"S3","key":"10.1016\/j.appet.2019.02.012_bib55","first-page":"S60","article-title":"Successful treatment in a child with feeding problems and growth failure","volume":"92","author":"Benjasuwantep","year":"2009","journal-title":"Journal of the Medical Association of Thailand"},{"key":"10.1016\/j.appet.2019.02.012_bib51","first-page":"81","article-title":"Evaluation of the efficacy and tolerability of an association of cyproheptadine, carnitine and pantethine in the treatment of anorexia in children","author":"Berni Canini","year":"1988","journal-title":"Double Blind Clinical Trial vs. Cyproheptadine"},{"issue":"4","key":"10.1016\/j.appet.2019.02.012_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00006565-199508000-00012","article-title":"Cyproheptadine-induced central anticholinergic syndrome in a child: A case report","volume":"11","author":"Blaustein","year":"1995","journal-title":"Pediatric Emergency Care"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13643-016-0215-7","article-title":"Comparing the coverage, recall, and precision of searches for 120 systematic reviews in embase, MEDLINE, and Google scholar: A prospective study","volume":"5","author":"Bramer","year":"2016","journal-title":"Systematic Reviews"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib6","first-page":"187","article-title":"Effect of appetite stimulation on the rate of weight recovery in children with protein-calorie malnutrition (Spanish)","volume":"52","author":"Burrows","year":"1981","journal-title":"Revista Chilena de Pediatria"},{"issue":"4","key":"10.1016\/j.appet.2019.02.012_bib7","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0031-9384(97)00246-1","article-title":"Cyproheptadine produced modest increases in total caloric intake by humans","volume":"62","author":"Comer","year":"1997","journal-title":"Physiology & Behavior"},{"issue":"11","key":"10.1016\/j.appet.2019.02.012_bib8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/MPH.0b013e3181864a5e","article-title":"The effect of cyproheptadine hydrochloride (Periactin) and megestrol acetate (Megace) on weight in children with cancer\/treatment-related cachexia","volume":"30","author":"Couluris","year":"2008","journal-title":"Journal of Pediatric Hematology"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/104454604773840508","article-title":"A chart review of cyproheptadine for stimulant-induced weight loss","volume":"14","author":"Daviss","year":"2004","journal-title":"Journal of Child and Adolescent Psychopharmacology"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/cpt196673340","article-title":"The effect of cyproheptadine on carbohydrate metabolism","volume":"7","author":"Drash","year":"1966","journal-title":"Clinical Pharmacology & Therapeutics"},{"issue":"2","key":"10.1016\/j.appet.2019.02.012_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2223\/JPED.2174","article-title":"A randomized, double-blind, placebo-controlled trial of cyproheptadine for appetite stimulation in cystic fibrosis","volume":"88","author":"Epifanio","year":"2012","journal-title":"Jornal de Pediatria"},{"issue":"2","key":"10.1016\/j.appet.2019.02.012_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4274\/jcp.18189","article-title":"Use of cyproheptadine as an appetite stimulant in children with cancer","volume":"12","author":"Erdem","year":"2014","journal-title":"G\u00fcncel Pediatri"},{"issue":"19","key":"10.1016\/j.appet.2019.02.012_bib13","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/0024-3205(90)90338-R","article-title":"Reduction of negative alliesthesia for sweet gustatory stimuli by cyproheptadine, a serotonin antagonist","volume":"46","author":"Fantino","year":"1990","journal-title":"Life Sciences"},{"issue":"18","key":"10.1016\/j.appet.2019.02.012_bib14","first-page":"826","article-title":"Ciproheptadina Droga Antihistaminica y Antiserotonimica con Accion Sobre el Peso Coroporal Communicacion Previa","volume":"54","author":"Francini","year":"1967","journal-title":"La Prensa Medica Argentina"},{"issue":"4","key":"10.1016\/j.appet.2019.02.012_bib15","first-page":"279","article-title":"Effects of cyproheptadine clorhydrate, a serotonin receptor antagonist, on endocrine parameters in weight-loss related amenorrhea","volume":"15","author":"Genazzani","year":"2001","journal-title":"Gynecological Endocrinology"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1192\/bjp.134.1.67","article-title":"Cyproheptadine in anorexia nervosa","volume":"134","author":"Goldberg","year":"1979","journal-title":"The British Journal of Psychiatry"},{"issue":"1279","key":"10.1016\/j.appet.2019.02.012_bib17","first-page":"1976","article-title":"Cyproheptadine for anorexia nervosa","author":"Halmi","year":"1982","journal-title":"The Lancet"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib18","first-page":"103","article-title":"Cyproheptadine, an antidepressant and weight-inducing drug for anorexia nervosa","volume":"19","author":"Halmi","year":"1983","journal-title":"Psychopharmacology Bulletin"},{"issue":"4","key":"10.1016\/j.appet.2019.02.012_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archpsyc.1986.01800020087011","article-title":"Anorexia nervosa","volume":"43","author":"Halmi","year":"1986","journal-title":"Archives of General Psychiatry"},{"issue":"2","key":"10.1016\/j.appet.2019.02.012_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap) \u2013 a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2010","journal-title":"Journal of Biomedical Information"},{"issue":"2","key":"10.1016\/j.appet.2019.02.012_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ppul.20043","article-title":"Cyproheptadine is an effective appetite stimulant in cystic fibrosis","volume":"38","author":"Homnick","year":"2004","journal-title":"Pediatric Pulmonology"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ppul.20265","article-title":"Long-term trial of cyproheptadine as an appetite stimulant in cystic fibrosis","volume":"40","author":"Homnick","year":"2005","journal-title":"Pediatric Pulmonology"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib23","first-page":"115","article-title":"Effect of Peritol in stimulating appetitie and promoting weight gain","volume":"25","author":"Irsy","year":"1977","journal-title":"Therapia Hungarica"},{"key":"10.1016\/j.appet.2019.02.012_bib52","series-title":"Stimulation de L\u2019App\u00e9tit Chez L\u2019Enfant","first-page":"567","volume":"5","author":"Juillard","year":"1985"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0022-3476(87)80310-4","article-title":"Enhancement of linear growth and weight gain by cyproheptadine in children with hypopituitarism receiving growth hormone therapy","volume":"110","author":"Kaplowitz","year":"1987","journal-title":"The Journal of Pediatrics"},{"key":"10.1016\/j.appet.2019.02.012_bib25","first-page":"325","article-title":"A controlled trial of cyproheptadine in cancer patients with anorexia and\/or cachexia. A Mayo Clinic\/North Central Cancer Treatment Group trial [abstract]","volume":"9","author":"Kardinal","year":"1990","journal-title":"Proceedings of the American Society of Clinical Oncology"},{"issue":"10","key":"10.1016\/j.appet.2019.02.012_bib26","first-page":"229","article-title":"Appetite and weight gain in children: A double-blind trial using cyproheptadine and methandrostenolone","volume":"15","author":"Kibel","year":"1969","journal-title":"The Central Americn Journal of Medicine"},{"issue":"11","key":"10.1016\/j.appet.2019.02.012_bib27","first-page":"90","article-title":"Effect of cyproheptadine","volume":"180","author":"Lavenstein","year":"1962","journal-title":"Journal of the American Medical Association"},{"issue":"2","key":"10.1016\/j.appet.2019.02.012_bib28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/MPG.0000000000001708","article-title":"Effect of cyproheptadine on weight and growth velocity in children with silver-russell syndrome","volume":"66","author":"Lemoine","year":"2018","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/000992289503400310","article-title":"Reversal of anorexia in a child with partial ornithine transcarbamylase deficiency by cyproheptadine therapy","volume":"34","author":"Lerman-Sagie","year":"1995","journal-title":"Clinical Pediatrics"},{"issue":"5","key":"10.1016\/j.appet.2019.02.012_bib30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1515\/JPEM.2009.22.5.425","article-title":"Short-term cyproheptadine therapy in underweight children: Effects on growth and serum insulin-like growth factor-I","volume":"22","author":"Mahachoklertwattana","year":"2009","journal-title":"Journal of Pediatric Endocrinology & Metabolism"},{"issue":"248","key":"10.1016\/j.appet.2019.02.012_bib31","first-page":"797","article-title":"Effect of cyproheptadine on anorexia and loss of weight in adults","volume":"208","author":"Mainguet","year":"1972","journal-title":"Practitioner"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.5811\/cpcem.2017.2.33313","article-title":"When too much is enough: Pediatric cyproheptadine overdose with confirmatory level","volume":"1","author":"McGovern","year":"2017","journal-title":"Clinical Practice and Cases in Emergency Medicine"},{"issue":"4","key":"10.1016\/j.appet.2019.02.012_bib33","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.appet.2019.02.012_bib34","first-page":"1429","article-title":"Cyproheptadine in severe anorexia","volume":"31","author":"Muranjan","year":"1994","journal-title":"Indian Pediatrics"},{"issue":"6","key":"10.1016\/j.appet.2019.02.012_bib35","first-page":"753","article-title":"Beneficial effect of cyproheptadine on body mass Index in undernourished children: A randomized controlled trial","volume":"24","author":"Najib","year":"2014","journal-title":"Iranian Journal of Pediatrics"},{"key":"10.1016\/j.appet.2019.02.012_bib36","first-page":"1","article-title":"The effect of cyproheptadine on body weight plasma glucose and insulin","volume":"22","author":"Najjar","year":"1969","journal-title":"The Lebanese Medical Journal"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.21037\/tp.2016.12.01","article-title":"A pilot validation study of crowdsourcing systematic reviews\u202f: Update of a searchable database of pediatric clinical trials of high- dose vitamin D","volume":"6","author":"Nama","year":"2017","journal-title":"Translational Pediatrics"},{"issue":"13","key":"10.1016\/j.appet.2019.02.012_bib38","first-page":"1","article-title":"Cyproheptadine on appetite and weight gain effect of in adults","volume":"209","author":"Noble","year":"1969","journal-title":"Journal of the American Medical Association"},{"issue":"5","key":"10.1016\/j.appet.2019.02.012_bib39","first-page":"673","article-title":"Cyproheptadine: Weight-Gain and appetitie stimulation in essential anorexic adults","volume":"18","author":"Pawlowski","year":"1975","journal-title":"Current Therapeutic Research"},{"key":"10.1016\/j.appet.2019.02.012_bib40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5694\/j.1326-5377.1971.tb50268.x","article-title":"Effect of cyproheptadine and a multivitamin preparation on appetite stimulation, weight gain, and linear growth","author":"Penfold","year":"1971","journal-title":"Medical Journal of Australia"},{"issue":"4","key":"10.1016\/j.appet.2019.02.012_bib41","first-page":"270","article-title":"Appetite stimulation and weight gain with cyproheptadine (periactin) in tuberculosis patients (Double-Blind clinical study)","volume":"29","author":"Rahman","year":"1975","journal-title":"Medical Journal of Malaysia"},{"issue":"6","key":"10.1016\/j.appet.2019.02.012_bib42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0736-4679(85)90004-6","article-title":"Central anticholinergic syndrome in a child: A case report","volume":"3","author":"Richmond","year":"1985","journal-title":"Journal of Emergency Medicine"},{"key":"10.1016\/j.appet.2019.02.012_bib53","first-page":"213","article-title":"Ingestive behavior and composition of weight change During Cyproheptadine Administration","volume":"3","author":"Saleh","year":"1979","journal-title":"International Journal of Obesity"},{"issue":"5","key":"10.1016\/j.appet.2019.02.012_bib54","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/MPG.0000000000000467","article-title":"Use of cyproheptadine in young children with feeding difficulties and poor growth in a pediatric feeding program","volume":"59","author":"Sant'anna","year":"2014","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib43","first-page":"12","article-title":"Appetite stimulation and weight gain with cyproheptadine","volume":"16","author":"Sanzgiri","year":"1969","journal-title":"Journal of Postgraduate Medicine"},{"issue":"11","key":"10.1016\/j.appet.2019.02.012_bib44","first-page":"716","article-title":"Weight gain with cyproheptadine hydrochloride ('Periactin\u2019). A double blind trial in underweight medical students","volume":"24","author":"Sardesai","year":"1970","journal-title":"Indian Journal of Medical Sciences"},{"key":"10.1016\/j.appet.2019.02.012_bib45","first-page":"374","article-title":"The weight gain effect of periactin in anorexic patients","author":"Silbert","year":"1971","journal-title":"S. A. Medical Journal"},{"key":"10.1016\/j.appet.2019.02.012_bib46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF00421472","article-title":"The effect of cyproheptadine on hunger, calorie intake, and body weight in man","volume":"40","author":"Silverstone","year":"1975","journal-title":"Psychopharmacologia"},{"issue":"3","key":"10.1016\/j.appet.2019.02.012_bib47","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0026-0495(70)90052-1","article-title":"Studies of mechanism of cyproheptadine induced weight gain in human subjects","volume":"19","author":"Stiel","year":"1970","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.appet.2019.02.012_bib48","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/095646249200300409","article-title":"Megestrol acetate vs cyproheptadine in the treatment of weight loss associated with HIV infection","volume":"3","author":"Summerbell","year":"1992","journal-title":"International Journal of STD & AIDS"},{"issue":"1","key":"10.1016\/j.appet.2019.02.012_bib49","first-page":"18","article-title":"Peritol (cyproheptadine) in clinical practice","volume":"20","author":"Tiszai","year":"1972","journal-title":"Therapia Hungarica"},{"key":"10.1016\/j.appet.2019.02.012_bib50","series-title":"The effect of cyproheptadine in anorexia nervosa: A double-blind trial","author":"Vigersky","year":"1977"}],"container-title":["Appetite"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195666318315083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195666318315083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T05:39:31Z","timestamp":1574141971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195666318315083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":55,"alternative-id":["S0195666318315083"],"URL":"https:\/\/doi.org\/10.1016\/j.appet.2019.02.012","relation":{},"ISSN":["0195-6663"],"issn-type":[{"value":"0195-6663","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of cyproheptadine to stimulate appetite and body weight gain: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Appetite","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.appet.2019.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}