{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:15:23Z","timestamp":1793088923185,"version":"4.5.0"},"reference-count":192,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Appetite"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.appet.2022.105965","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T02:32:49Z","timestamp":1645065169000},"page":"105965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Creating the amylin story"],"prefix":"10.1016","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-8548","authenticated-orcid":false,"given":"Thomas A.","family":"Lutz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.appet.2022.105965_bib1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fendo.2017.00324","article-title":"Involvement of amylin and leptin in the development of projections from the area postrema to the nucleus of the solitary tract","volume":"8","author":"Abegg","year":"2017","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib2","first-page":"873","article-title":"The nature of the hyaline material in the pancreatic islands in diabetes mellitus","volume":"19","author":"Ahronheim","year":"1943","journal-title":"American Journal Of Pathology"},{"key":"10.1016\/j.appet.2022.105965_bib3","doi-asserted-by":"crossref","first-page":"E24","DOI":"10.1152\/ajpendo.00121.2014","article-title":"A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats","volume":"307","author":"Andreassen","year":"2014","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib4","doi-asserted-by":"crossref","first-page":"101282","DOI":"10.1016\/j.molmet.2021.101282","article-title":"KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats","volume":"53","author":"Andreassen","year":"2021","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib5","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1210\/jc.2006-2003","article-title":"Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: A phase 2, randomized, placebo-controlled, dose-escalation study","volume":"92","author":"Aronne","year":"2007","journal-title":"The Journal of Cinical Endocrinology and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib6","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1111\/ejn.15376","article-title":"Selective role of RAMP in the sub-chronic action of the amylin selective receptor agonist NN1213 compared to salmon calcitonin on body weight and food intake in male mice","volume":"54","author":"Arrigoni","year":"2021","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib7","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0006-291X(90)90400-H","article-title":"Regional distribution and molecular forms of rat islet amyloid polypeptide","volume":"169","author":"Asai","year":"1990","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.appet.2022.105965_bib8","first-page":"101090","article-title":"Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease","author":"Baggio","year":"2020","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0196-9781(91)90038-Q","article-title":"Syntheses, structures and anorectic effects of human and rat amylin","volume":"12","author":"Balasubramaniam","year":"1991","journal-title":"Peptides"},{"key":"10.1016\/j.appet.2022.105965_bib10","doi-asserted-by":"crossref","first-page":"R1011","DOI":"10.1152\/ajpregu.00424.2010","article-title":"Brain activation following peripheral administration of the GLP-1 receptor agonist exendin-4","volume":"301","author":"Baraboi","year":"2011","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib11","doi-asserted-by":"crossref","first-page":"12015","DOI":"10.1073\/pnas.1713074114","article-title":"GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs","volume":"114","author":"Barbash","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.appet.2022.105965_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.isci.2018.12.024","article-title":"Detection of concordance between transcriptional levels of GPCRs and receptor-activity-modifying proteins","volume":"11","author":"Barbash","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.appet.2022.105965_bib13","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0140-6736(21)00944-2","article-title":"Cagrilintide plus semaglutide for obesity management","volume":"397","author":"Becerril","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.appet.2022.105965_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2007.06.016","article-title":"Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK","volume":"1162","author":"Becskei","year":"2007","journal-title":"Brain Research"},{"key":"10.1016\/j.appet.2022.105965_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainres.2004.10.012","article-title":"Immunohistochemical mapping of calcitonin receptors in the adult rat brain","volume":"1030","author":"Becskei","year":"2004","journal-title":"Brain Research"},{"key":"10.1016\/j.appet.2022.105965_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/338211a0","article-title":"Amylin' hormone","volume":"338","author":"Betsholtz","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.appet.2022.105965_bib17","doi-asserted-by":"crossref","first-page":"170366","DOI":"10.1016\/j.peptides.2020.170366","article-title":"Amylin brain circuitry","volume":"132","author":"Boccia","year":"2020","journal-title":"Peptides"},{"key":"10.1016\/j.appet.2022.105965_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101444","article-title":"Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons","author":"Boccia","year":"2022","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib19","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1096\/fj.202001456RRR","article-title":"Noradrenaline signaling in the LPBN mediates amylin's and salmon calcitonin's hypophagic effect in male rats","volume":"34","author":"Boccia","year":"2020","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.appet.2022.105965_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cmet.2019.12.004","article-title":"GDF15 induces anorexia through nausea and emesis","volume":"31","author":"Borner","year":"2020","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib21","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1523\/JNEUROSCI.5369-03.2004","article-title":"Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice","volume":"24","author":"Bouret","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.1095004","article-title":"Trophic action of leptin on hypothalamic neurons that regulate feeding","volume":"304","author":"Bouret","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.appet.2022.105965_bib23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1399-0004.2006.00684.x","article-title":"Developmental programming of hypothalamic feeding circuits","volume":"70","author":"Bouret","year":"2006","journal-title":"Clinical Genetics"},{"key":"10.1016\/j.appet.2022.105965_bib24","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/bph.13496","article-title":"Amylin structure-function relationships and receptor pharmacology: Implications for amylin mimetic drug development","volume":"173","author":"Bower","year":"2016","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib25","first-page":"636","article-title":"Diet-induced obesity, hyperamylinemia and amylin sensitivity","volume":"54","author":"Boyle","year":"2010","journal-title":"Appetite"},{"key":"10.1016\/j.appet.2022.105965_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.physbeh.2011.04.044","article-title":"Influence of high-fat feeding, diet-induced obesity, and hyperamylinemia on the sensitivity to acute amylin","volume":"104","author":"Boyle","year":"2011","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib27","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1111\/ejn.12672","article-title":"The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: Behavioral and neuronal phenotyping","volume":"40","author":"Braegger","year":"2014","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib28","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nn.4574","article-title":"Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus","volume":"20","author":"Campos","year":"2017","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib29","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cmet.2016.04.006","article-title":"Parabrachial CGRP neurons control meal termination","volume":"23","author":"Campos","year":"2016","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib30","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1523\/JNEUROSCI.3729-14.2015","article-title":"Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion","volume":"35","author":"Carter","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature12596","article-title":"Genetic identification of a neural circuit that suppresses appetite","volume":"503","author":"Carter","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.appet.2022.105965_bib32","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0196-9781(92)90057-A","article-title":"Tests of adipsia and conditioned taste aversion following the intrahypothalamic injection of amylin","volume":"13","author":"Chance","year":"1992","journal-title":"Peptides"},{"key":"10.1016\/j.appet.2022.105965_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0006-8993(93)91505-M","article-title":"Anorexia following the systemic injection of amylin","volume":"607","author":"Chance","year":"1993","journal-title":"Brain Research"},{"key":"10.1016\/j.appet.2022.105965_bib34","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0006-8993(91)91644-G","article-title":"Anorexia following the intrahypothalamic administration of amylin","volume":"539","author":"Chance","year":"1991","journal-title":"Brain Research"},{"key":"10.1016\/j.appet.2022.105965_bib35","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2310\/JIM.0b013e3181b91911","article-title":"It takes two to tango: Combined amylin\/leptin agonism as a potential approach to obesity drug development","volume":"57","author":"Chan","year":"2009","journal-title":"Journal of Investigative Medicine"},{"key":"10.1016\/j.appet.2022.105965_bib36","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s00125-005-1732-4","article-title":"Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetes","volume":"48","author":"Chapman","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.appet.2022.105965_bib37","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cmet.2019.12.012","article-title":"Calcitonin receptor neurons in the mouse nucleus tractus solitarius control energy balance via the non-aversive suppression of feeding","volume":"31","author":"Cheng","year":"2020","journal-title":"Cell Metabolism"},{"issue":"Suppl 2","key":"10.1016\/j.appet.2022.105965_bib38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/dom.13401","article-title":"Islet prohormone processing in health and disease","volume":"20","author":"Chen","year":"2018","journal-title":"Diabetes, Obesity and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1124\/mol.56.1.235","article-title":"Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product","volume":"56","author":"Christopoulos","year":"1999","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0140-6736(87)90825-7","article-title":"Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes","volume":"2","author":"Clark","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.appet.2022.105965_bib41","doi-asserted-by":"crossref","first-page":"112992","DOI":"10.1016\/j.physbeh.2020.112992","article-title":"Viral depletion of calcitonin receptors in the area postrema: A proof-of-concept study","volume":"223","author":"Coester","year":"2020","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib42","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.2337\/db19-0849","article-title":"Amylin\/calcitonin receptor-mediated signaling in POMC neurons influences energy balance and locomotor activity in chow-fed male mice","volume":"69","author":"Coester","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuroscience.2019.11.036","article-title":"RAMP1 and RAMP3 differentially control amylin's effects on food intake, glucose and energy balance in male and female mice","volume":"447","author":"Coester","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1210\/edrv-15-2-163","article-title":"Amylin compared with calcitonin gene-related peptide: Structure, biology, and relevance to metabolic disease","volume":"15","author":"Cooper","year":"1994","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.appet.2022.105965_bib45","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","article-title":"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients","volume":"84","author":"Cooper","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.appet.2022.105965_bib46","article-title":"Efficacy and safety of AM833 for weight loss: A dose-finding trial in adults with overweight\/obesity","author":"David","year":"2020","journal-title":"Proceedings, the Obesity Week, oral presentation"},{"key":"10.1016\/j.appet.2022.105965_bib47","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1471-4159.2009.06422.x","article-title":"Central amylin expression and its induction in rat dams","volume":"111","author":"Dobolyi","year":"2009","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.appet.2022.105965_bib48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/ni.2591","article-title":"When metabolism met immunology","volume":"14","author":"Donath","year":"2013","journal-title":"Nature Immunology"},{"key":"10.1016\/j.appet.2022.105965_bib49","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.cmet.2013.05.001","article-title":"Inflammation in obesity and diabetes: Islet dysfunction and therapeutic opportunity","volume":"17","author":"Donath","year":"2013","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib50","doi-asserted-by":"crossref","first-page":"101240","DOI":"10.1016\/j.molmet.2021.101240","article-title":"A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing","volume":"53","author":"Dowsett","year":"2021","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib51","doi-asserted-by":"crossref","first-page":"R856","DOI":"10.1152\/ajpregu.00179.2018","article-title":"Rodent models of leptin receptor deficiency are less sensitive to amylin","volume":"315","author":"Duffy","year":"2018","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib52","article-title":"Area postrem (AP)-lesions block the regulation of gastric emptying by amylin","volume":"10","author":"Edwards","year":"1998","journal-title":"Neuro-Gastroenterology and Motility"},{"key":"10.1016\/j.appet.2022.105965_bib53","first-page":"49","article-title":"Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and non-diabetic individuals","volume":"38","author":"Ehrlich","year":"1961","journal-title":"American Journal Of Pathology"},{"key":"10.1016\/j.appet.2022.105965_bib54","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1113\/jphysiol.2002.018671","article-title":"Salmon calcitonin - a potent inhibitor of food intake in states of impaired leptin signalling in laboratory rodents","volume":"541","author":"Eiden","year":"2002","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib55","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(21)00845-X","article-title":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2\u00b74 mg for weight management: A randomised, controlled, phase 1b trial","volume":"397","author":"Enebo","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.appet.2022.105965_bib56","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1210\/en.2012-2172","article-title":"Amylin acts in the central nervous system to increase sympathetic nerve activity","volume":"154","author":"Fernandes-Santos","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib57","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/jme.0.003R001","article-title":"Expression of the rat amylin (IAPP\/DAP) gene","volume":"3","author":"Ferrier","year":"1989","journal-title":"Journal of Molecular Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib58","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1053\/meta.2002.32022","article-title":"The human amylin analog, pramlintide, corrects postprandial hyperglucagonemia in patients with type 1 diabetes","volume":"51","author":"Fineman","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib59","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1055\/s-2002-34790","article-title":"The human amylin analog, pramlintide, reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus","volume":"34","author":"Fineman","year":"2002","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.appet.2022.105965_bib60","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1042\/bst0300455","article-title":"Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs)","volume":"30","author":"Fischer","year":"2002","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.appet.2022.105965_bib61","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1210\/jcem-57-6-1314","article-title":"Salmon and human calcitonin-like peptides coexist in the human thyroid and brain","volume":"57","author":"Fischer","year":"1983","journal-title":"The Journal of Cinical Endocrinology and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1124\/jpet.121.000567","article-title":"AM833 is a novel agonist of calcitonin family G protein-coupled receptors: Pharmacological comparison with six selective and nonselective agonists","volume":"377","author":"Fletcher","year":"2021","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.appet.2022.105965_bib63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2012.11.051","article-title":"Electrophysiologically identified presynaptic mechanisms underlying amylinergic modulation of area postrema neuronal excitability in rat brain slices","volume":"1494","author":"Fukuda","year":"2013","journal-title":"Brain Research"},{"key":"10.1016\/j.appet.2022.105965_bib64","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab072","article-title":"Paraventricular calcitonin receptor-expressing neurons modulate energy homeostasis in male mice","volume":"162","author":"Gonzalez","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib65","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1073\/pnas.0906471106","article-title":"Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons","volume":"106","author":"Guardado-Mendoza","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.appet.2022.105965_bib66","doi-asserted-by":"crossref","first-page":"E821","DOI":"10.1152\/ajpendo.00514.2015","article-title":"KBP-088, a novel DACRA with prolonged receptor activation, is superior to davalintide in terms of efficacy on body weight","volume":"310","author":"Gydesen","year":"2016","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib67","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/bph.13723","article-title":"A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference","volume":"174","author":"Gydesen","year":"2017","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib68","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1124\/pr.115.010629","article-title":"Amylin: Pharmacology, physiology, and clinical potential","volume":"67","author":"Hay","year":"2015","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.appet.2022.105965_bib69","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1124\/mol.104.008615","article-title":"Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes","volume":"67","author":"Hay","year":"2005","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bph.14075","article-title":"Update on the pharmacology of calcitonin\/CGRP family of peptides: IUPHAR review 25","volume":"175","author":"Hay","year":"2018","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib71","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1042\/BST20150237","article-title":"Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins","volume":"44","author":"Hay","year":"2016","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.appet.2022.105965_bib72","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1111\/bcp.14921","article-title":"Safety, tolerability and pharmacokinetic characterisation of DACRA KBP-042 in healthy male subjects","volume":"87","author":"Henriksen","year":"2021","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib73","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/ilar.47.3.234","article-title":"Feline models of type 2 diabetes mellitus","volume":"47","author":"Henson","year":"2006","journal-title":"ILAR Journal"},{"key":"10.1016\/j.appet.2022.105965_bib74","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/oby.2004.76","article-title":"Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients","volume":"12","author":"Hollander","year":"2004","journal-title":"Obesity Research"},{"key":"10.1016\/j.appet.2022.105965_bib75","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1007\/BF00400803","article-title":"Chronic overproduction of islet amyloid polypeptide\/amylin in transgenic mice: Lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia","volume":"36","author":"Hoppener","year":"1993","journal-title":"Diabetologia"},{"key":"10.1016\/j.appet.2022.105965_bib76","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-2007-1003714","article-title":"Effects of glucagon-like peptide 1 (7-36) amide and glucagon on amylin release from perfused rat pancreas","volume":"23","author":"Inoue","year":"1991","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.appet.2022.105965_bib77","first-page":"416","article-title":"Spontaneous diabetes mellitus-islet amyloid complex in adult cats","volume":"125","author":"Johnson","year":"1986","journal-title":"American Journal Of Pathology"},{"key":"10.1016\/j.appet.2022.105965_bib78","first-page":"1","article-title":"Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques","volume":"130","author":"Johnson","year":"1988","journal-title":"American Journal Of Pathology"},{"key":"10.1016\/j.appet.2022.105965_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11892-015-0693-3","article-title":"GLP-1 and amylin in the treatment of obesity","volume":"16","author":"Jorsal","year":"2016","journal-title":"Current Diabetes Reports"},{"key":"10.1016\/j.appet.2022.105965_bib80","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.ajpath.2011.02.036","article-title":"beta-cell loss and beta-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition","volume":"178","author":"Jurgens","year":"2011","journal-title":"American Journal Of Pathology"},{"key":"10.1016\/j.appet.2022.105965_bib81","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/adb.12603","article-title":"Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents","volume":"24","author":"Kalafateli","year":"2019","journal-title":"Addiction Biology"},{"key":"10.1016\/j.appet.2022.105965_bib82","doi-asserted-by":"crossref","first-page":"112958","DOI":"10.1016\/j.physbeh.2020.112958","article-title":"Distributed amylin receptor signaling and its influence on motivated behavior","volume":"222","author":"Kern","year":"2020","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib83","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s001250050646","article-title":"Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM","volume":"40","author":"Kong","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.appet.2022.105965_bib84","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/cne.902190307","article-title":"Organization of the projections of a circumventricular organ: The area postrema in the rat","volume":"219","author":"van der Kooy","year":"1983","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.appet.2022.105965_bib85","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2337\/db14-0645","article-title":"Amylin-induced central IL-6 production enhances ventromedial hypothalamic leptin signaling","volume":"64","author":"Le Foll","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib86","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/j.2040-4603.2020.tb00140.x","article-title":"Systemic and central amylin, amylin receptor signaling, and their physiological and pathophysiological roles in metabolism","volume":"10","author":"Le Foll","year":"2020","journal-title":"Comprehensive Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib87","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tem.2016.11.004","article-title":"Amylin and leptin: Co-regulators of energy homeostasis and neuronal development","volume":"28","author":"Levin","year":"2017","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib88","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.molmet.2016.06.015","article-title":"The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats","volume":"5","author":"Liberini","year":"2016","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib89","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/ejn.13163","article-title":"Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons","volume":"43","author":"Liberini","year":"2016","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib90","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cmet.2015.10.012","article-title":"Hypothalamic amylin acts in concert with leptin to regulate food intake","volume":"22","author":"Li","year":"2015","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib91","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","article-title":"Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus","volume":"368","author":"Lorenzo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.appet.2022.105965_bib92","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s42255-021-00363-1","article-title":"A genetic map of the mouse dorsal vagal complex and its role in obesity","volume":"3","author":"Ludwig","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.appet.2022.105965_bib93","doi-asserted-by":"crossref","first-page":"R1475","DOI":"10.1152\/ajpregu.00703.2009","article-title":"The role of amylin in the control of energy homeostasis","volume":"298","author":"Lutz","year":"2010","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib94","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000264394","article-title":"Roles of amylin in satiation, adiposity and brain development","volume":"63","author":"Lutz","year":"2010","journal-title":"Forum of nutrition"},{"key":"10.1016\/j.appet.2022.105965_bib95","first-page":"R1777","article-title":"Anorectic effect of amylin is not transmitted by capsaicin-sensitive nerve fibers","volume":"274","author":"Lutz","year":"1998","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib96","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2337\/db17-1347","article-title":"Amylin selectively signals onto POMC neurons in the arcuate nucleus of the hypothalamus","volume":"67","author":"Lutz","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib97","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0031-9384(94)90076-0","article-title":"Reduction of food intake in rats by intraperitoneal injection of low doses of amylin","volume":"55","author":"Lutz","year":"1994","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib98","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0196-9781(94)00203-I","article-title":"Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin","volume":"16","author":"Lutz","year":"1995","journal-title":"Peptides"},{"key":"10.1016\/j.appet.2022.105965_bib99","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0196-9781(96)00199-4","article-title":"The histaminergic, but not the serotoninergic, system mediates amylin's anorectic effect","volume":"17","author":"Lutz","year":"1996","journal-title":"Peptides"},{"key":"10.1016\/j.appet.2022.105965_bib100","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0031-9384(95)02067-5","article-title":"Amylin decreases meal size in rats","volume":"58","author":"Lutz","year":"1995","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib101","doi-asserted-by":"crossref","first-page":"R791","DOI":"10.1152\/ajpregu.00004.2019","article-title":"Endogenous amylin contributes to birth of microglial cells in arcuate nucleus of hypothalamus and area postrema during fetal development","volume":"316","author":"Lutz","year":"2019","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib102","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fnins.2015.00216","article-title":"Amylin at the interface between metabolic and neurodegenerative disorders","volume":"9","author":"Lutz","year":"2015","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib103","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.ijo.0801664","article-title":"The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema\/nucleus of the solitary tract (AP\/NTS) lesioned rats","volume":"25","author":"Lutz","year":"2001","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1016\/j.appet.2022.105965_bib104","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0007-1935(05)80037-5","article-title":"A review of new developments in type 2 diabetes in human beings and cats","volume":"149","author":"Lutz","year":"1993","journal-title":"British Veterinary Journal"},{"key":"10.1016\/j.appet.2022.105965_bib105","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0195-5616(95)50051-8","article-title":"Pathogenesis of feline diabetes mellitus","volume":"25","author":"Lutz","year":"1995","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1016\/j.appet.2022.105965_bib106","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0021-9975(97)80073-4","article-title":"Detection of amyloid deposition in various regions of the feline pancreas by different staining techniques","volume":"116","author":"Lutz","year":"1997","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.appet.2022.105965_bib107","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0196-9781(97)00292-1","article-title":"Lesion of the area postrema\/nucleus of the solitary tract (AP\/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats","volume":"19","author":"Lutz","year":"1998","journal-title":"Peptides"},{"key":"10.1016\/j.appet.2022.105965_bib108","doi-asserted-by":"crossref","first-page":"R1697","DOI":"10.1152\/ajpregu.2001.280.6.R1697","article-title":"Dopamine D(2) receptors mediate amylin's acute satiety effect","volume":"280","author":"Lutz","year":"2001","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib109","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ijo.2009.238","article-title":"Davalintide (AC2307), a novel amylin-mimetic peptide: Enhanced pharmacological properties over native amylin to reduce food intake and body weight","volume":"34","author":"Mack","year":"2010","journal-title":"International Journal of Obesity"},{"key":"10.1016\/j.appet.2022.105965_bib110","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diabetes.53.1.141","article-title":"Role of beta-cell prohormone convertase (PC)1\/3 in processing of pro-islet amyloid polypeptide","volume":"53","author":"Marzban","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib111","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.2337\/db05-1672","article-title":"Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes","volume":"55","author":"Matveyenko","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib112","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ilar.47.3.225","article-title":"Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes","volume":"47","author":"Matveyenko","year":"2006","journal-title":"ILAR Journal"},{"key":"10.1016\/j.appet.2022.105965_bib113","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"McLatchie","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.appet.2022.105965_bib114","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.physbeh.2014.01.013","article-title":"Amylin activates distributed CNS nuclei to control energy balance","volume":"136","author":"Mietlicki-Baase","year":"2014","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib115","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuropharm.2017.05.024","article-title":"Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior","volume":"123","author":"Mietlicki-Baase","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib116","doi-asserted-by":"crossref","first-page":"E1116","DOI":"10.1152\/ajpendo.00087.2015","article-title":"Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake","volume":"308","author":"Mietlicki-Baase","year":"2015","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib117","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/npp.2013.66","article-title":"Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake","volume":"38","author":"Mietlicki-Baase","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib118","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.physbeh.2004.01.006","article-title":"Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats","volume":"81","author":"Mollet","year":"2004","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib119","doi-asserted-by":"crossref","first-page":"R1442","DOI":"10.1152\/ajpregu.2001.281.5.R1442","article-title":"Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin","volume":"281","author":"Mollet","year":"2001","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib120","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1210\/en.2007-1735","article-title":"Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors","volume":"149","author":"Morfis","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib121","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1021\/bi981658g","article-title":"Effects of sequential proline substitutions on amyloid formation by human amylin20-29","volume":"38","author":"Moriarty","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.appet.2022.105965_bib122","first-page":"R178","article-title":"Modulation of food intake by peripherally administered amylin","volume":"267","author":"Morley","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib123","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0014-5793(89)81260-8","article-title":"The complete islet amyloid polypeptide precursor is encoded by two exons","volume":"247","author":"Mosselman","year":"1989","journal-title":"FEBS Letters"},{"key":"10.1016\/j.appet.2022.105965_bib124","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/endo.140.6.6930","article-title":"An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3","volume":"140","author":"Muff","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib125","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1523\/JNEUROSCI.15-11-07625.1995","article-title":"Islet amyloid polypeptide (amylin) is expressed in sensory neurons","volume":"15","author":"Mulder","year":"1995","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib126","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/ijo.2016.38","article-title":"Eating in mice with gastric bypass surgery causes exaggerated activation of brainstem anorexia circuit","volume":"40","author":"Mumphrey","year":"2016","journal-title":"International Journal of Obesity"},{"key":"10.1016\/j.appet.2022.105965_bib127","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-291X(89)91732-4","article-title":"Establishment of radioimmunoassay for human islet amyloid polypeptide and its tissue content and plasma concentration","volume":"164","author":"Nakazato","year":"1989","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.appet.2022.105965_bib128","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0006-291X(90)90389-5","article-title":"Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation","volume":"169","author":"Nakazato","year":"1990","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.appet.2022.105965_bib129","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1677\/jme.0.0090157","article-title":"Extra-pancreatic expression of the rat islet amyloid polypeptide (amylin) gene","volume":"9","author":"Nicholl","year":"1992","journal-title":"Journal of Molecular Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/030098589303000401","article-title":"Islet amyloid polypeptide: A review of its biology and potential roles in the pathogenesis of diabetes mellitus","volume":"30","author":"O'Brien","year":"1993","journal-title":"Veterinary Pathology Online"},{"key":"10.1016\/j.appet.2022.105965_bib131","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/030098588502200308","article-title":"High dose intravenous glucose tolerance test and serum insulin and glucagon levels in diabetic and non-diabetic cats: Relationships to insular amyloidosis","volume":"22","author":"O'Brien","year":"1985","journal-title":"Veterinary Pathology Online"},{"key":"10.1016\/j.appet.2022.105965_bib132","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2337\/diab.40.12.1701","article-title":"Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats","volume":"40","author":"O'Brien","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib133","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.5.5.527","article-title":"The relation oe diabetes mellitus to lesions OF the pancreas. Hyaline degeneration OF the islands oe langerhans","volume":"5","author":"Opie","year":"1901","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.appet.2022.105965_bib134","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ajpath.2014.11.016","article-title":"In vivo seeding and cross-seeding of localized amyloidosis: A molecular link between type 2 diabetes and alzheimer disease","volume":"185","author":"Oskarsson","year":"2015","journal-title":"American Journal Of Pathology"},{"key":"10.1016\/j.appet.2022.105965_bib135","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.physbeh.2007.03.017","article-title":"Modulation of the satiating effect of amylin by central ghrelin, leptin and insulin","volume":"91","author":"Osto","year":"2007","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib136","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1210\/en.2017-03259","article-title":"Essential role for hypothalamic calcitonin receptor\u2012expressing neurons in the control of food intake by leptin","volume":"159","author":"Pan","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib137","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1210\/en.2017-03259","article-title":"Essential role for hypothalamic calcitonin ReceptorExpressing neurons in the control of food intake by leptin","volume":"159","author":"Pan","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib138","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00125-006-0206-7","article-title":"Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets","volume":"49","author":"Paulsson","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.appet.2022.105965_bib139","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.2337\/diabetes.54.7.2117","article-title":"Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation","volume":"54","author":"Paulsson","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib140","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.physbeh.2010.03.001","article-title":"Brainstem mechanisms of amylin-induced anorexia","volume":"100","author":"Potes","year":"2010","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib141","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2010.03.114","article-title":"Identification of central projections from amylin-activated neurons to the lateral hypothalamus","volume":"1334","author":"Potes","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.appet.2022.105965_bib142","doi-asserted-by":"crossref","first-page":"R623","DOI":"10.1152\/ajpregu.00791.2009","article-title":"Noradrenergic neurons of the area postrema mediate amylin's hypophagic action","volume":"299","author":"Potes","year":"2010","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib143","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1124\/pr.54.2.233","article-title":"International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors","volume":"54","author":"Poyner","year":"2002","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.appet.2022.105965_bib144","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1007\/s00125-009-1506-5","article-title":"Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload","volume":"52","author":"Preston","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.appet.2022.105965_bib145","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1038\/oby.2009.184","article-title":"Enhanced weight loss with pramlintide\/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy","volume":"17","author":"Ravussin","year":"2009","journal-title":"Obesity"},{"key":"10.1016\/j.appet.2022.105965_bib146","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3940(02)00482-2","article-title":"Amylin and glucose co-activate area postrema neurons of the rat","volume":"328","author":"Riediger","year":"2002","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.appet.2022.105965_bib147","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1152\/ajpregu.00333.2003","article-title":"The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis","volume":"286","author":"Riediger","year":"2004","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib148","doi-asserted-by":"crossref","first-page":"9662","DOI":"10.1073\/pnas.86.24.9662","article-title":"Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus","volume":"86","author":"Roberts","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.appet.2022.105965_bib149","volume":"Vol. 8","author":"Roesti","year":"2020"},{"key":"10.1016\/j.appet.2022.105965_bib150","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0706473105","article-title":"Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies","volume":"105","author":"Roth","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.appet.2022.105965_bib151","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0706473105","article-title":"Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies","volume":"105","author":"Roth","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.appet.2022.105965_bib152","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.brainres.2010.01.027","article-title":"Weighing in\" on synergy: Preclinical research on neurohormonal anti-obesity combinations","volume":"1350","author":"Roth","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.appet.2022.105965_bib153","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1210\/endo.142.11.8593","article-title":"Inhibition of central amylin signaling increases food intake and body adiposity in rats","volume":"142","author":"Rushing","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib154","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1210\/endo.141.2.7378","article-title":"Amylin: A novel action in the brain to reduce body weight","volume":"141","author":"Rushing","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib155","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0196-9781(02)00022-0","article-title":"Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences","volume":"23","author":"Rushing","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.appet.2022.105965_bib156","doi-asserted-by":"crossref","first-page":"17243","DOI":"10.1016\/S0021-9258(19)77825-9","article-title":"An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing","volume":"263","author":"Sanke","year":"1988","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.appet.2022.105965_bib157","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0306-4522(94)90388-3","article-title":"In vitro autoradiographic localization of amylin binding sites in rat brain","volume":"62","author":"Sexton","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.appet.2022.105965_bib158","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/cne.902340306","article-title":"The central neural connections of the area postrema of the rat","volume":"234","author":"Shapiro","year":"1985","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.appet.2022.105965_bib159","doi-asserted-by":"crossref","first-page":"R440","DOI":"10.1152\/ajpregu.00326.2015","article-title":"Leptin influences the excitability of area postrema neurons","volume":"310","author":"Smith","year":"2016","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib160","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1016\/j.celrep.2017.11.036","article-title":"Nutritive, post-ingestive signals are the primary regulators of AgRP neuron activity","volume":"21","author":"Su","year":"2017","journal-title":"Cell Reports"},{"key":"10.1016\/j.appet.2022.105965_bib161","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1096\/fj.11-191841","article-title":"Amylin is a novel neuropeptide with potential maternal functions in the rat","volume":"26","author":"Szabo","year":"2012","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.appet.2022.105965_bib162","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1163\/1568539X-00003305","article-title":"Behavioral changes in mothers and maternally sensitized female mice","volume":"152","author":"Szab\u00f3","year":"2015","journal-title":"Behaviour"},{"key":"10.1016\/j.appet.2022.105965_bib163","first-page":"R726","article-title":"Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats","volume":"272","author":"Thiele","year":"1997","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.appet.2022.105965_bib164","series-title":"Proceedings, the obesity week","article-title":"AM833 \u2013 development of a long-acting amylin analogue","author":"Thomas Kruse","year":"2020"},{"key":"10.1016\/j.appet.2022.105965_bib165","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1007\/s001250050821","article-title":"Effects of 4 weeks' administration of pramlintide, a human amylin analogue, on glycaemia control in patients with IDDM: Effects on plasma glucose profiles and serum fructosamine concentrations","volume":"40","author":"Thompson","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.appet.2022.105965_bib166","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0022-3565(24)39040-8","article-title":"Amylin receptor phenotypes derived from human calcitonin receptor\/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment","volume":"294","author":"Tilakaratne","year":"2000","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.appet.2022.105965_bib167","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1210\/en.2008-0770","article-title":"Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: Magnitude and mechanisms","volume":"149","author":"Trevaskis","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib168","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/oby.2009.187","article-title":"Interaction of leptin and amylin in the long-term maintenance of weight loss in diet-induced obese rats","volume":"18","author":"Trevaskis","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.appet.2022.105965_bib169","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tem.2010.03.006","article-title":"Insights into amylin-leptin synergy","volume":"21","author":"Trevaskis","year":"2010","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.appet.2022.105965_bib171","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/osp4.62","article-title":"Amylin\/leptin synergy is absent in extreme obesity and not restored by calorie restriction-induced weight loss in rats","volume":"2","author":"Trevaskis","year":"2016","journal-title":"Obesity Science & Practice"},{"key":"10.1016\/j.appet.2022.105965_bib172","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/en.2009-0546","article-title":"Mechanisms of amylin\/leptin synergy in rodent models","volume":"151","author":"Turek","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.appet.2022.105965_bib173","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0169-328X(01)00179-6","article-title":"Expression of receptor-activity modifying protein (RAMP) mRNAs in the mouse brain","volume":"93","author":"Ueda","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.appet.2022.105965_bib174","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.appet.2022.105965_bib175","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0006-291X(86)90708-4","article-title":"A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas","volume":"140","author":"Westermark","year":"1986","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.appet.2022.105965_bib176","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2174\/1381612013397357","article-title":"Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: A physiological approach toward improved metabolic control","volume":"7","author":"Weyer","year":"2001","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.appet.2022.105965_bib177","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.physbeh.2017.03.023","article-title":"The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc)","volume":"176","author":"Whiting","year":"2017","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.appet.2022.105965_bib178","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1100\/tsw.2006.263","article-title":"Amylin in the periphery II: An updated mini-review","volume":"6","author":"Wookey","year":"2006","journal-title":"The Scientific World Journal"},{"key":"10.1016\/j.appet.2022.105965_bib179","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/030098588101800507","article-title":"Feline insular amyloid: Association with diabetes mellitus","volume":"18","author":"Yano","year":"1981","journal-title":"Veterinary Pathology Online"},{"key":"10.1016\/j.appet.2022.105965_bib180","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/030098588101800303","article-title":"Feline insular amyloid: Incidence in adult cats with no clinicopathologic evidence of overt diabetes mellitus","volume":"18","author":"Yano","year":"1981","journal-title":"Veterinary Pathology Online"},{"key":"10.1016\/j.appet.2022.105965_bib181","doi-asserted-by":"crossref","first-page":"109204","DOI":"10.1016\/j.celrep.2021.109204","article-title":"Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care","volume":"35","author":"Yoshihara","year":"2021","journal-title":"Cell Reports"},{"key":"10.1016\/j.appet.2022.105965_bib182","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1054-3589(05)52013-1","article-title":"Effects in fat","volume":"52","author":"Young","year":"2005","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib183","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1054-3589(05)52012-X","article-title":"Effects in liver","volume":"52","author":"Young","year":"2005","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib184","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1054-3589(05)52011-8","article-title":"Effects in skeletal muscle","volume":"52","author":"Young","year":"2005","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1054-3589(05)52001-5","article-title":"Historical background","volume":"52","author":"Young","year":"2005","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib186","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1054-3589(05)52009-X","article-title":"Inhibition of insulin secretion","volume":"52","author":"Young","year":"2005","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib187","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1054-3589(05)52002-7","article-title":"Tissue expression and secretion of amylin","volume":"52","author":"Young","year":"2005","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib188","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/bcpt.13427","article-title":"Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases","volume":"127","author":"Zakariassen","year":"2020","journal-title":"Basic and Clinical Pharmacology and Toxicology"},{"key":"10.1016\/j.appet.2022.105965_bib189","doi-asserted-by":"crossref","first-page":"107987","DOI":"10.1016\/j.neuropharm.2020.107987","article-title":"Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice","volume":"167","author":"Zakariassen","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.appet.2022.105965_bib190","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuron.2020.11.010","article-title":"Area postrema cell types that mediate nausea-associated behaviors","volume":"109","author":"Zhang","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.appet.2022.105965_bib191","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2337\/db10-0692","article-title":"Neuronal receptor activity modifying protein-1 promotes energy expenditure in mice","volume":"60","author":"Zhang","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.appet.2022.105965_bib192","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1177\/0300985815591078","article-title":"Endocrine pancreas in cats with diabetes mellitus","volume":"53","author":"Zini","year":"2016","journal-title":"Veterinary Pathology Online"},{"key":"10.1016\/j.appet.2022.105965_bib193","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.physbeh.2013.02.006","article-title":"Amylin and GLP-1 target different populations of area postrema neurons that are both modulated by nutrient stimuli","volume":"112\u2013113","author":"Zuger","year":"2013","journal-title":"Physiology & Behavior"}],"container-title":["Appetite"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195666322000563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195666322000563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T02:50:42Z","timestamp":1759287042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195666322000563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":192,"alternative-id":["S0195666322000563"],"URL":"https:\/\/doi.org\/10.1016\/j.appet.2022.105965","relation":{},"ISSN":["0195-6663"],"issn-type":[{"value":"0195-6663","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Creating the amylin story","name":"articletitle","label":"Article Title"},{"value":"Appetite","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.appet.2022.105965","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105965"}}