{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:05:40Z","timestamp":1771063540857,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.apradiso.2004.10.004","type":"journal-article","created":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T15:22:01Z","timestamp":1103037721000},"page":"541-549","source":"Crossref","is-referenced-by-count":26,"title":["188Re-labeled bisphosphonates as potential bifunctional agents for therapy in patients with bone metastases"],"prefix":"10.1016","volume":"62","author":[{"given":"Amal","family":"El-Mabhouh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Mercer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.apradiso.2004.10.004_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0969-8043(00)00296-7","article-title":"Labelling of Re-ABP with 188Re for bone pain palliation, Appl","volume":"54","author":"Arteaga de Murphy","year":"2001","journal-title":"Radiat. Isot."},{"key":"10.1016\/j.apradiso.2004.10.004_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0969-8051(03)00002-7","article-title":"High-yield synthesis of the terminal 188Re triple bond N multiple bond from generator-produced [188ReO4](-)","volume":"30","author":"Boschi","year":"2003","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib3","first-page":"682","article-title":"Considerations in the selection of radiopharmaceuticals for palliation of bone pain from metastatic osseous lesions","volume":"41","author":"Bouchet","year":"2000","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000137977","article-title":"Effect of biological time on the determination of the LD50 of 5-fluorouracil in mice","volume":"28","author":"Burns","year":"1984","journal-title":"Pharmacology"},{"key":"10.1016\/j.apradiso.2004.10.004_bib5","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0969-8051(01)00244-X","article-title":"Efficacy of Re-188-labelled sulphur colloid on prolongation of survival time in melanoma-bearing animals","volume":"7","author":"Chen","year":"2001","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic bone disease","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.apradiso.2004.10.004_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0883-2897(86)90027-9","article-title":"The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear medicine","volume":"13","author":"Deutsch","year":"1986","journal-title":"Int. J. Radiat. Appl. Instrum. B."},{"key":"10.1016\/j.apradiso.2004.10.004_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0969-8043(99)00283-3","article-title":"Radiolabeling of dextran with rhenium-188","volume":"53","author":"Du","year":"2000","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.apradiso.2004.10.004_bib9","doi-asserted-by":"crossref","unstructured":"El Mabhouh, A., Angelov, C.A., McEwan, A.J.B., Jia, G., Mercer, J.R., 2004. Preclinical investigations of drug and radionuclide conjugates of bisphosphonates for the treatment of metastatic bone cancer. Cancer Biother. Radiopharm. 19(5).","DOI":"10.1089\/1084978042484830"},{"key":"10.1016\/j.apradiso.2004.10.004_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/er.19.1.80","article-title":"Bisphosphonates","volume":"19","author":"Fleisch","year":"1998","journal-title":"Endocrine Rev"},{"key":"10.1016\/j.apradiso.2004.10.004_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0969-8043(97)00284-4","article-title":"Synthesis of a 188Re-HEDP complex using carrier-free 188Re, and a study of its stability","volume":"49","author":"Hashimoto","year":"1998","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.apradiso.2004.10.004_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/3-540-59469-8_9","article-title":"Rhenium complexes labeled with 186,188Re for nuclear medicine","volume":"176","author":"Hashimoto","year":"1996","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.apradiso.2004.10.004_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/sonc.2002.34066","article-title":"Novel approaches to the management of bone metastases in patients with breast cancer","volume":"29","author":"Hortobagyi","year":"2002","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib14","first-page":"105","article-title":"Targeted delivery of antineoplastic agent to bone","volume":"37","author":"Hosain","year":"1996","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib15","first-page":"26","article-title":"The preparation of W-188\/Re-188 generator for therapeutic and diagnostic applications","volume":"23","author":"Hsieh","year":"1996","journal-title":"Nucl. Sci. J. (Taiwan)"},{"key":"10.1016\/j.apradiso.2004.10.004_bib16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0969-8051(99)00075-X","article-title":"Comparison of various rhenium-188-labeled diphosphonates for the treatment of bone metastases","volume":"26","author":"Hsieh","year":"1999","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib17","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1080\/00397919608003560","article-title":"Synthesis of aminobisphosphonates","volume":"26","author":"Kantoci","year":"1996","journal-title":"Synth. Comm."},{"key":"10.1016\/j.apradiso.2004.10.004_bib18","first-page":"1783","article-title":"Availability of rhenium-188 from the alumina-based tungsten-188\/rhenium-188 generator for preparation of rhenium-188-labeled radiopharmaceuticals for cancer treatment","volume":"17","author":"Knapp Jr","year":"1997","journal-title":"Anticancer Res"},{"key":"10.1016\/j.apradiso.2004.10.004_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0021-9673(02)01798-3","article-title":"Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid","volume":"990","author":"Koudelkova","year":"2003","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.apradiso.2004.10.004_bib20","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/00003072-200111000-00006","article-title":"Rhenium-188 HEDP to treat painful bone metastases","volume":"26","author":"Li","year":"2001","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.bjc.6601158","article-title":"Therapeutic efficiency of rhenium-188-HEDP in human prostate cancer skeletal metastases","volume":"89","author":"Liepe","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.apradiso.2004.10.004_bib22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s002590050091","article-title":"Rhenium-188 hydroxyethylidene diphosphonate","volume":"24","author":"Lin","year":"1997","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0969-8051(99)00007-4","article-title":"Effect of reaction conditions on preparations of rhenium-188 hydroxyethylidene diphosphonate complexes","volume":"26","author":"Lin","year":"1999","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0969-8051(00)00205-5","article-title":"Synthesis of a new bisphosphonic acid ligand (SEDP) and preparation of a (188)Re-(Sn)SEDP bone seeking radiotracer","volume":"28","author":"Lisic","year":"2001","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1148\/radiology.176.1.1693784","article-title":"Re-186(Sn) HEDP for treatment of painful osseous metastases","volume":"176","author":"Maxon","year":"1990","journal-title":"Radiology"},{"key":"10.1016\/j.apradiso.2004.10.004_bib26","first-page":"659","article-title":"Rhenium-188(Sn)HEDP for treatment of osseous metastases","volume":"39","author":"Maxon","year":"1998","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s002590050017","article-title":"Dose escalation study with rhenium-188 hydroxyethylidene diphosphonate in prostate cancer patients with osseous metastases","volume":"27","author":"Palmedo","year":"2000","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib28","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1200\/JCO.2003.12.060","article-title":"Repeated bone-targeted therapy for hormone-refractory prostate carcinoma","volume":"21","author":"Palmedo","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib29","first-page":"117","article-title":"Biological investigation with radioactive calcium and strontium","volume":"2","author":"Pecher","year":"1942","journal-title":"Preliminary report on the use of radioactive strontium in the treatment of metastatic bone cancer. Univ. Calif. Publ. Pharmacol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11926-003-0085-6","article-title":"Bisphosphonate mechanism of action","volume":"5","author":"Reszka","year":"2003","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.apradiso.2004.10.004_bib31","doi-asserted-by":"crossref","unstructured":"Roque, M., Martinez, M.J., Alonso, P., Catala, E., Garcia, J.L., Ferrandiz, M., 2003. Radioisotopes for metastatic bone pain. Cochrane Database Syst. Rev. (4); CD003347.","DOI":"10.1002\/14651858.CD003223"},{"key":"10.1016\/j.apradiso.2004.10.004_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta8040","article-title":"A systematic review of the role of bisphosphonates in metastatic disease","volume":"8","author":"Ross","year":"2004","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.apradiso.2004.10.004_bib33","first-page":"895","article-title":"Therapy of metastatic bone pain","volume":"42","author":"Serafini","year":"2001","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0969-8051(97)00180-7","article-title":"In vivo tissue uptake and retention of Sn-117m(4+)DTPA in a human subject with metastatic bone pain and in normal mice","volume":"25","author":"Swailem","year":"1998","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/BF00817272","article-title":"Rhenium-188 sulphur colloid as a radiation synovectomy agent","volume":"22","author":"Wang","year":"1995","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01736984","article-title":"Biodistribution of rhenium-188 lipiodol infused via the hepatic artery of rats with hepatic tumours","volume":"23","author":"Wang","year":"1996","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2004.10.004_bib37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00389236","article-title":"Synthesis, antitumor activity, distribution and toxicity of 4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma","volume":"111","author":"Wingen","year":"1986","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.apradiso.2004.10.004_bib38","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1089\/108497803770418265","article-title":"Rhenium-188-HEDP therapy for the palliation of pain due to osseous metastases in lung cancer patients","volume":"18","author":"Zhang","year":"2003","journal-title":"Cancer Biother. Radiopharm."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804304005494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804304005494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T18:27:19Z","timestamp":1586024839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804304005494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0969804304005494"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2004.10.004","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}