{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:41:00Z","timestamp":1762522860200,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.apradiso.2023.111040","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T17:11:56Z","timestamp":1695921116000},"page":"111040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Fully automated production of [11C]PiB for clinical use on Trasis-AllinOne synthesizer module"],"prefix":"10.1016","volume":"202","author":[{"given":"Paul Josef","family":"Myburgh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael David","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buddhika Liyana","family":"Pathirannahel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Rose","family":"Grace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran Kumar","family":"Solingapuram Sai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2018","series-title":"Quality Control in the Production of Radiopharmaceuticals","author":"Ballinger","key":"10.1016\/j.apradiso.2023.111040_bib1"},{"issue":"14","key":"10.1016\/j.apradiso.2023.111040_bib2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jlcr.3569","article-title":"Highly efficient solid phase supported radiosynthesis of [(11) C]PiB using tC18 cartridge as a \"3-in-1\" production entity","volume":"60","author":"Boudjemeline","year":"2017","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"1","key":"10.1016\/j.apradiso.2023.111040_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41181-019-0065-4","article-title":"Fully-automated radiosynthesis of the amyloid tracer [(11)C] PiB via direct [(11)C]CO(2) fixation-reduction","volume":"4","author":"Buccino","year":"2019","journal-title":"EJNMMI Radiopharm. Chem."},{"issue":"4","key":"10.1016\/j.apradiso.2023.111040_bib4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.apradiso.2008.08.018","article-title":"A simple, versatile, low-cost and remotely operated apparatus for [11C]acetate, [11C]choline, [11C]methionine and [11C]PIB synthesis","volume":"67","author":"Cheung","year":"2009","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.apradiso.2023.111040_bib5","series-title":"2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG)","article-title":"Synthesis optimization of pittsburgh compound B by the captive solvent method","author":"Clemente","year":"2012"},{"key":"10.1016\/j.apradiso.2023.111040_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-394816-8.00002-7","article-title":"Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta","volume":"64","author":"Cohen","year":"2012","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.apradiso.2023.111040_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.apradiso.2015.07.003","article-title":"Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), beta-amyloid PET imaging tracer for Alzheimer's disease diagnosis","volume":"105","author":"Coliva","year":"2015","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.apradiso.2023.111040_bib8","first-page":"26","article-title":"A simple one-pot apparatus for the production of carbon-11 labeled methyl iodide","author":"Dannals","year":"1985","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2023.111040_bib9","series-title":"Positron Emission Tomography","first-page":"7","article-title":"Development of positron emission tomography (PET): a historical perspective","author":"Das","year":"2015"},{"issue":"11","key":"10.1016\/j.apradiso.2023.111040_bib10","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/MNM.0b013e32834b45a3","article-title":"Fully automated and reproducible radiosynthesis of high specific activity [(1)(1)C]raclopride and [(1)(1)C]Pittsburgh compound-B using the combination of two commercial synthesizers","volume":"32","author":"Gomez-Vallejo","year":"2011","journal-title":"Nucl. Med. Commun."},{"issue":"6","key":"10.1016\/j.apradiso.2023.111040_bib11","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s12149-014-0830-0","article-title":"Evaluation of the bubble point test of a 0.22-mum membrane filter used for the sterilizing filtration of PET radiopharmaceuticals","volume":"28","author":"Hayashi","year":"2014","journal-title":"Ann. Nucl. Med."},{"key":"10.1016\/j.apradiso.2023.111040_bib12","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1259\/bjr\/97295129","article-title":"Positron emission tomography imaging in dementia","volume":"80","author":"Herholz","year":"2007","journal-title":"Br. J. Radiol."},{"issue":"1","key":"10.1016\/j.apradiso.2023.111040_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"issue":"5","key":"10.1016\/j.apradiso.2023.111040_bib14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1212\/WNL.0000000000002923","article-title":"A\/T\/N: an unbiased descriptive classification scheme for Alzheimer disease biomarkers","volume":"87","author":"Jack","year":"2016","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.apradiso.2023.111040_bib15","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/0883-2889(92)90012-4","article-title":"A simple synthesis of [11C]methyl triflate","volume":"43","author":"Jewett","year":"1992","journal-title":"Int. J. Radiat. Appl. Instrum. Appl. Radiat. Isot."},{"issue":"3","key":"10.1016\/j.apradiso.2023.111040_bib16","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1212\/WNL.0000000000004827","article-title":"Brain amyloid load and its associations with cognition and vascular risk factors in FINGER Study","volume":"90","author":"Kemppainen","year":"2018","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.apradiso.2023.111040_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"issue":"29","key":"10.1016\/j.apradiso.2023.111040_bib18","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1002\/ejoc.201500924","article-title":"Direct [11C]methylation of amines from [11C]CO2for the synthesis of PET radiotracers","volume":"2015","author":"Liger","year":"2015","journal-title":"Eur. J. Org Chem."},{"issue":"4","key":"10.1016\/j.apradiso.2023.111040_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/alz.12429","article-title":"Associations among vascular risk factors, neuroimaging biomarkers, and cognition: preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"18","author":"Lockhart","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.apradiso.2023.111040_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.nucmedbio.2011.10.016","article-title":"Synthesis of oncological [11C]radiopharmaceuticals for clinical PET","volume":"39","author":"Lodi","year":"2012","journal-title":"Nucl. Med. Biol."},{"issue":"13","key":"10.1016\/j.apradiso.2023.111040_bib21","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1021\/jm030026b","article-title":"Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents","volume":"46","author":"Mathis","year":"2003","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.apradiso.2023.111040_bib22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.apradiso.2023.111040_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.apradiso.2023.111040_bib24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0969-8051(03)00049-0","article-title":"11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease","volume":"30","author":"Ono","year":"2003","journal-title":"Nucl. Med. Biol."},{"issue":"9","key":"10.1016\/j.apradiso.2023.111040_bib25","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.apradiso.2011.04.010","article-title":"Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB)","volume":"69","author":"Philippe","year":"2011","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.apradiso.2023.111040_bib26","article-title":"Automated synthesis of 1-[11C] acetate on a commercially available TRASIS AIO synthesizer","author":"Sai","year":"2017","journal-title":"Soc. Nuclear Med."},{"key":"10.1016\/j.apradiso.2023.111040_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.apradiso.2017.07.066","article-title":"Automated synthesis of 1-[11C] acetoacetate on a TRASIS AIO module","volume":"129","author":"Sai","year":"2017","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.apradiso.2023.111040_bib28","article-title":"Automated radiosynthesis of (S)-[11C] LY2795050 for imaging \u03ba-opioid receptors in nonhuman primate brain","author":"Sai","year":"2016","journal-title":"Soc. Nuclear Med."},{"issue":"14","key":"10.1016\/j.apradiso.2023.111040_bib29","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/jlcr.1937","article-title":"Highlighting the versatility of the Tracerlab synthesis modules. Part 2: fully automated production of [11C]-labeled radiopharmaceuticals using a Tracerlab FXC-Pro","volume":"54","author":"Shao","year":"2011","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"4","key":"10.1016\/j.apradiso.2023.111040_bib30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.apradiso.2004.09.003","article-title":"Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET","volume":"62","author":"Solbach","year":"2005","journal-title":"Appl. Radiat. Isot."},{"issue":"12","key":"10.1016\/j.apradiso.2023.111040_bib31","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A\u03b2-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.apradiso.2023.111040_bib32","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1212\/01.WNL.0000129697.01779.0A","article-title":"The importance of neuritic plaques and tangles to the development and evolution of AD","volume":"62","author":"Tiraboschi","year":"2004","journal-title":"Neurology"},{"year":"2022","series-title":"Application manual- AllinOne - 11C - PiB - specific application manual","author":"Trasis","key":"10.1016\/j.apradiso.2023.111040_bib33"},{"volume":"vol. 21","first-page":"2023","year":"2003","key":"10.1016\/j.apradiso.2023.111040_bib34"},{"key":"10.1016\/j.apradiso.2023.111040_bib35","article-title":"United States Pharmacopia (USP) chapter <823>Positron Emission Tomography Drugs for compounding, investigational and research uses","volume":"35","year":"2011","journal-title":"USP"},{"issue":"10","key":"10.1016\/j.apradiso.2023.111040_bib36","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1097\/MNM.0b013e328304e0e1","article-title":"Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer","volume":"29","author":"Verdurand","year":"2008","journal-title":"Nucl. Med. Commun."},{"issue":"10","key":"10.1016\/j.apradiso.2023.111040_bib37","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/jlcr.854","article-title":"A rapid one-step radiosynthesis of the\u03b2-amyloid imaging radiotracerN-methyl-[11C]2-(4\u2032-methylaminophenyl)-6-hydroxybenzothiazole([11C]-6-OH-BTA-1)","volume":"47","author":"Wilson","year":"2004","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"6","key":"10.1016\/j.apradiso.2023.111040_bib38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0969-8051(00)00132-3","article-title":"Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method","volume":"27","author":"Wilson","year":"2000","journal-title":"Nucl. Med. Biol."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804323003937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804323003937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T04:23:42Z","timestamp":1760847822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804323003937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":38,"alternative-id":["S0969804323003937"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2023.111040","relation":{},"ISSN":["0969-8043"],"issn-type":[{"type":"print","value":"0969-8043"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fully automated production of [11C]PiB for clinical use on Trasis-AllinOne synthesizer module","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2023.111040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111040"}}