{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:10:34Z","timestamp":1775599834567,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005031","name":"Bhabha Atomic Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.apradiso.2024.111644","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:33:54Z","timestamp":1734453234000},"page":"111644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Multi-dose formulation and clinical deployment of [90Y]Y-labeled hydroxyapatite (HA) microparticles for radiation synovectomy in India\u2013 the inherent intricacies"],"prefix":"10.1016","volume":"217","author":[{"given":"K.V.","family":"Vimalnath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rajeswari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourav","family":"Patra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.K.","family":"Kamaleshwaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-439X","authenticated-orcid":false,"given":"Sudipta","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.apradiso.2024.111644_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1759720X211055309","article-title":"Radiosynovectomy in routine care: an old tool with modern applications","volume":"13","author":"Caballero Motta","year":"2021","journal-title":"Ther. Adv. Musculoskel. Dis."},{"key":"10.1016\/j.apradiso.2024.111644_bib2","first-page":"621","article-title":"Availability of yttrium-90 from strontium-90: a nuclear medicine perspective","volume":"27","author":"Chakravarty","year":"2012","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.apradiso.2024.111644_bib3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/MNM.0b013e32832b52b9","article-title":"Yttrium-90 radiation synovectomy in knee osteoarthritis: a prospective assessment at 6 and 12 months","volume":"30","author":"Chatzopoulos","year":"2009","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.apradiso.2024.111644_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.reuma.2018.10.009","article-title":"Radioisotope synoviorthesis in the control of refractory synovitis in Castilla-La Mancha. A 10-year experience","volume":"16","author":"Corredor","year":"2020","journal-title":"Reumatol. Cl\u00edn."},{"key":"10.1016\/j.apradiso.2024.111644_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10967-014-3326-4","article-title":"Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy","volume":"302","author":"Davarpanah","year":"2014","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1016\/j.apradiso.2024.111644_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nbt.2786","article-title":"Clinical development success rates for investigational drugs","volume":"32","author":"Hay","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.apradiso.2024.111644_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00006231-200102000-00017","article-title":"Long-term results of radiation synovectomy: a clinical follow-up study","volume":"22","author":"Kampen","year":"2001","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.apradiso.2024.111644_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/rheumatology\/kel352","article-title":"Therapeutic status of radiosynoviorthesis of the knee with yttrium [90Y] colloid in rheumatoid arthritis and related indications","volume":"46","author":"Kampen","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.apradiso.2024.111644_bib9","first-page":"22","article-title":"Radiation Synovectomy: an effective alternative treatment for inflamed small joints","volume":"14","author":"Karavida","year":"2010","journal-title":"PubMed (Hippokratia)"},{"key":"10.1016\/j.apradiso.2024.111644_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1450-1147.222289","article-title":"Treatment response evaluation using Yttrium-90 in patients with rheumatoid arthritis of knee joint","volume":"17","author":"Kim","year":"2018","journal-title":"World J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2024.111644_bib11","doi-asserted-by":"crossref","first-page":"127115","DOI":"10.1016\/j.matchemphys.2022.127115","article-title":"Radiolabeled nanoporous hydroxyapatite microspheres: an advanced material for potential use in radiation synovectomy","volume":"295","author":"Patra","year":"2023","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.apradiso.2024.111644_bib12","first-page":"130","article-title":"Radiation synovectomy with 90Yttrium, 186Rhenium and 169Erbium: a systematic literature review with meta-analyses","volume":"27","author":"Van der Zant","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.apradiso.2024.111644_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nucmedbio.2015.01.006","article-title":"Radiochemistry, pre-clinical studies and first clinical investigation of 90Y-labeled hydroxyapatite (HA) particles prepared utilizing 90Y produced by (n,\u03b3) route","volume":"42","author":"Vimalnath","year":"2015","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2024.111644_bib14","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1093\/rheumatology\/keaa637","article-title":"Safety and therapeutic value of radiosynoviorthesis with yttrium-90: a Canadian single-centre experience","volume":"60","author":"Zeiadin","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.apradiso.2024.111644_bib15","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s12149-008-0167-7","article-title":"Radiosynoviorthesis (RSO): influencing factors and therapy monitoring","volume":"22","author":"Zuderman","year":"2008","journal-title":"Ann. Nucl. Med."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096980432400472X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096980432400472X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:22:03Z","timestamp":1737613323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096980432400472X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":15,"alternative-id":["S096980432400472X"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2024.111644","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-dose formulation and clinical deployment of [90Y]Y-labeled hydroxyapatite (HA) microparticles for radiation synovectomy in India\u2013 the inherent intricacies","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2024.111644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111644"}}