{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T04:00:31Z","timestamp":1794542431084,"version":"4.9.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23mk0121267h0001"],"award-info":[{"award-number":["23mk0121267h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24mk0121267h0002"],"award-info":[{"award-number":["24mk0121267h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24ck0106889h0002"],"award-info":[{"award-number":["24ck0106889h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K17218"],"award-info":[{"award-number":["19K17218"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.apradiso.2025.111835","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T19:09:01Z","timestamp":1744398541000},"page":"111835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Feasibility study of accelerator-based boron neutron capture therapy for thoracic tumors: treatment planning aspect"],"prefix":"10.1016","volume":"221","author":[{"given":"Mihiro","family":"Takemori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6205-4296","authenticated-orcid":false,"given":"Satoshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Nakaichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Shuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Yonemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homare","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nishitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuka","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimitsu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tairo","family":"Kashihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Igaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apradiso.2025.111835_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.apradiso.2014.04.007","article-title":"BNCT for advanced or recurrent head and neck cancer","volume":"88","author":"Aihara","year":"2014","journal-title":"Appl. Radiat. Isot."},{"issue":"23","key":"10.1016\/j.apradiso.2025.111835_bib2","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1016\/j.jacc.2019.03.500","article-title":"Cardiac radiation dose, cardiac disease, and mortality in patients with lung cancer","volume":"73","author":"Atkins","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.apradiso.2025.111835_bib3","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0360-3016(97)00891-2","article-title":"Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory","volume":"40","author":"Chadha","year":"1998","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"4","key":"10.1016\/j.apradiso.2025.111835_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/biology10040334","article-title":"Salvage boron neutron capture therapy for malignant brain tumor patients in compliance with emergency and compassionate use: evaluation of 34 cases in Taiwan","volume":"10","author":"Chen","year":"2021","journal-title":"Biology"},{"issue":"8","key":"10.1016\/j.apradiso.2025.111835_bib5","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.ejmp.2014.07.342","article-title":"Exploring boron neutron capture therapy for non-small cell lung cancer","volume":"30","author":"Farias","year":"2014","journal-title":"Phys. Med."},{"issue":"5","key":"10.1016\/j.apradiso.2025.111835_bib6","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.ijrobp.2008.11.039","article-title":"Sensitivity analysis of parameters in linear-quadratic radiobiologic modeling","volume":"73","author":"Fowler","year":"2009","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"2","key":"10.1016\/j.apradiso.2025.111835_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.radonc.2006.04.015","article-title":"Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)","volume":"88","author":"Henriksson","year":"2008","journal-title":"Radiother. Oncol."},{"issue":"6","key":"10.1016\/j.apradiso.2025.111835_bib8","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/jrr\/rraa068","article-title":"Long-term outcome of cutaneous melanoma patients treated with boron neutron capture therapy (BNCT)","volume":"61","author":"Hiratsuka","year":"2020","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.apradiso.2025.111835_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.radonc.2020.11.001","article-title":"Boron neutron capture therapy using cyclotron-based epithermal neutron source and borofalan ((10)B) for recurrent or locally advanced head and neck cancer (JHN002): an open-label phase II trial","volume":"155","author":"Hirose","year":"2021","journal-title":"Radiother. Oncol."},{"issue":"12","key":"10.1016\/j.apradiso.2025.111835_bib10","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.apradiso.2011.03.036","article-title":"Investigation of irradiation conditions for recurrent breast cancer in JRR-4","volume":"69","author":"Horiguchi","year":"2011","journal-title":"Appl. Radiat. Isot."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib11","article-title":"Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region","volume":"12","author":"Hu","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.apradiso.2025.111835_bib12","first-page":"128","article-title":"Scalp angiosarcoma treated with linear accelerator-based boron neutron capture therapy: a report of two patients","volume":"33","author":"Igaki","year":"2022","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.apradiso.2025.111835_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1272507","article-title":"Acral cutaneous malignant melanoma treated with linear accelerator-based boron neutron capture therapy system: a case report of first patient","volume":"13","author":"Igaki","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.apradiso.2025.111835_bib14","article-title":"Boron neutron capture therapy for cutaneous angiosarcoma and malignant melanoma: first in-human phase I clinical trial","author":"Kashihara","year":"2024","journal-title":"Radiother. Oncol."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib15","article-title":"Accelerator-based BNCT for patients with recurrent glioblastoma: a multicenter phase II study","volume":"3","author":"Kawabata","year":"2021","journal-title":"Neurooncol Adv"},{"issue":"4","key":"10.1016\/j.apradiso.2025.111835_bib16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.semradonc.2008.04.005","article-title":"The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery","volume":"18","author":"Kirkpatrick","year":"2008","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/j.apradiso.2025.111835_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2019.04.033","article-title":"Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: an analysis of dose response and survival","volume":"137","author":"Koivunoro","year":"2019","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.apradiso.2025.111835_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.21037\/tro.2018.10.12","article-title":"Treatment planning system and patient positioning for boron neutron capture therapy","volume":"2","author":"Kumada","year":"2018","journal-title":"Therapeutic Radiology and Oncology"},{"key":"10.1016\/j.apradiso.2025.111835_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2020.109222","article-title":"Verification for dose estimation performance of a Monte-Carlo based treatment planning system in University of Tsukuba","volume":"166","author":"Kumada","year":"2020","journal-title":"Appl. Radiat. Isot."},{"issue":"4","key":"10.1016\/j.apradiso.2025.111835_bib20","article-title":"The effects of boron neutron capture therapy on the lungs in recurrent breast cancer treatment","volume":"16","author":"Kurosaki","year":"2024","journal-title":"Cureus"},{"issue":"7\u20138 Suppl. l","key":"10.1016\/j.apradiso.2025.111835_bib21","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.apradiso.2009.03.090","article-title":"Clinical results of BNCT for malignant brain tumors in children","volume":"67","author":"Nakagawa","year":"2009","journal-title":"Appl. Radiat. Isot."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib22","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1038\/s41598-021-87627-8","article-title":"Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target","volume":"11","author":"Nakamura","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/00223131.2023.2275736","article-title":"Recent improvements of the particle and heavy ion transport code system \u2013 PHITS version 3.33","volume":"61","author":"Sato","year":"2023","journal-title":"J. Nucl. Sci. Technol."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijrobp.2019.02.047","article-title":"Biological principles of stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS): indirect cell death","volume":"110","author":"Song","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"1\u20132","key":"10.1016\/j.apradiso.2025.111835_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.icrp.2012.02.001","article-title":"ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs--threshold doses for tissue reactions in a radiation protection context","volume":"41","author":"Stewart","year":"2012","journal-title":"Ann. ICRP"},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.radonc.2009.01.010","article-title":"Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma","volume":"92","author":"Suzuki","year":"2009","journal-title":"Radiother. Oncol."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/jrr\/rrt098","article-title":"Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer","volume":"55","author":"Suzuki","year":"2014","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.apradiso.2025.111835_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2023.110898","article-title":"Initial evaluation of accelerator-based neutron source system at the Shonan Kamakura General Hospital","volume":"199","author":"Suzuki","year":"2023","journal-title":"Appl. Radiat. Isot."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111835_bib29","doi-asserted-by":"crossref","first-page":"NP.2","DOI":"10.1093\/jicru\/ndq001","volume":"10","year":"2010","journal-title":"J. ICRU"},{"issue":"2","key":"10.1016\/j.apradiso.2025.111835_bib30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0360-3016(02)04617-5","article-title":"Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results","volume":"56","author":"Wu","year":"2003","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"10.1016\/j.apradiso.2025.111835_bib31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/HP.0000000000000601","article-title":"Influence of neutron sources and 10B concentration on boron neutron capture therapy for shallow and deeper non-small cell lung cancer","volume":"112","author":"Yu","year":"2017","journal-title":"Health Phys."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325001800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325001800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:04:30Z","timestamp":1762347870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804325001800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":31,"alternative-id":["S0969804325001800"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.111835","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility study of accelerator-based boron neutron capture therapy for thoracic tumors: treatment planning aspect","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.111835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111835"}}