{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:07:58Z","timestamp":1762348078564,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010749","name":"Brazilian Nuclear Energy Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.apradiso.2025.111918","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T19:11:12Z","timestamp":1747163472000},"page":"111918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["In vitro analysis of the suitability of different biodosimetric techniques for the study of human biomonitoring with low concentrations of Radon-222"],"prefix":"10.1016","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7224-0302","authenticated-orcid":false,"given":"La\u00eds Melo da Silva","family":"Trigo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Celina Tavares de","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessa Castro da Silva","family":"Drewke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewson Rocha","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suy Ferreira","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Cordeiro de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Ferreira de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Esposito","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Mendon\u00e7a Albuquerque","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Farias de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.apradiso.2025.111918_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4103\/jcrt.jcrt_2058_22","article-title":"Biodosimetric analysis of head and neck cancer patients undergoing radiotherapy by dicentric chromosome aberration assay","volume":"20","author":"Agarwal","year":"2024","journal-title":"J. Cancer Res. Therapeut."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111918_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/09553000802635054","article-title":"Health effects of radon: a review of the literature","volume":"85","author":"Al-Zoughool","year":"2009","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.apradiso.2025.111918_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mrgentox.2019.04.007","article-title":"Technical recommendations to perform the alkaline standard and enzyme-modified comet assay in human biomonitoring studies","volume":"843","author":"Azqueta","year":"2019","journal-title":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"},{"key":"10.1016\/j.apradiso.2025.111918_bib4","series-title":"Comprehensive Medicinal Chemistry III","first-page":"195","article-title":"Genetic toxicology","author":"Beedanagari","year":"2017"},{"issue":"5","key":"10.1016\/j.apradiso.2025.111918_bib5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1667\/RR14294.1","article-title":"Adaption of the cytokinesis-block micronucleus cytome assay for improved triage biodosimetry","volume":"185","author":"Beinke","year":"2016","journal-title":"Radiat. Res."},{"issue":"9","key":"10.1016\/j.apradiso.2025.111918_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/life10090161","article-title":"Modelling dose effects from space irradiations: combination of high-LET and low-LET radiations with a modified microdosimetric kinetic model","volume":"10","author":"Bertolet","year":"2020","journal-title":"Life"},{"key":"10.1016\/j.apradiso.2025.111918_bib7","article-title":"Calibration of the comet assay using ionising radiation","volume":"873","author":"Brunborg","year":"2023","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"issue":"3","key":"10.1016\/j.apradiso.2025.111918_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/gem051","article-title":"The comet assay: topical issues","volume":"23","author":"Collins","year":"2008","journal-title":"Mutagenesis"},{"issue":"1","key":"10.1016\/j.apradiso.2025.111918_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/rpd\/nch012","article-title":"Chromosome aberrations induced in human lymphocytes by heavy charged particles in track segment mode","volume":"108","author":"Di Giorgio","year":"2004","journal-title":"Radiat. Protect. Dosim."},{"issue":"4","key":"10.1016\/j.apradiso.2025.111918_bib10","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.34119\/bjhrv2n4-152","article-title":"Rad\u00f4nio-222 em \u00e1guas de po\u00e7os em \u00e1reas do fosforito uran\u00edfero da regi\u00e3o metropolitana do Recife","volume":"2","author":"Do Amaral","year":"2019","journal-title":"Braz. J. Health Rev."},{"issue":"6","key":"10.1016\/j.apradiso.2025.111918_bib11","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s12594-018-0926-6","article-title":"Measurement of radon concentration in drinking water in Bhiwani district of Haryana","volume":"91","author":"Duggal","year":"2018","journal-title":"J. Geol. Soc. India"},{"issue":"8","key":"10.1016\/j.apradiso.2025.111918_bib12","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1080\/09553002.2022.2110314","article-title":"Chromosome aberrations, micronucleus frequency, and catalase concentration in a population chronically exposed to high levels of radon","volume":"99","author":"Dwi Ramadhani","year":"2023","journal-title":"Int. J. Radiat. Biol."},{"issue":"5","key":"10.1016\/j.apradiso.2025.111918_bib13","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/nprot.2007.77","article-title":"Cytokinesis-block micronucleus cytome assay","volume":"2","author":"Fenech","year":"2007","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.apradiso.2025.111918_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3857\/roj.2021.00339","article-title":"Cytogenetic biological dosimetry assays: recent developments and updates","volume":"39","author":"Gnanasekaran","year":"2021","journal-title":"Radiat. Oncol. J."},{"issue":"2","key":"10.1016\/j.apradiso.2025.111918_bib15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/09553002.2021.1844338","article-title":"Improved harvest and fixation methodology for isolated human peripheral blood mononuclear cells in cytokinesis-block micronucleus assay","volume":"97","author":"Goh","year":"2020","journal-title":"Int. J. Radiat. Biol."},{"issue":"3","key":"10.1016\/j.apradiso.2025.111918_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/rpd\/ncn060","article-title":"A simple method to irradiate blood cells in vitro with radon gas","volume":"130","author":"Hamza","year":"2008","journal-title":"Radiat. Protect. Dosim."},{"issue":"1\u20132","key":"10.1016\/j.apradiso.2025.111918_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2008.10.010","article-title":"Cytogenetic damage in human blood lymphocytes exposed in vitro to radon","volume":"661","author":"Hamza","year":"2009","journal-title":"Mutat. Res. Fund Mol. Mech. Mutagen"},{"article-title":"Manual da OMS sobre rad\u00f4nio em ambientes internos: uma perspectiva de sa\u00fade p\u00fablica","year":"2016","series-title":"Editado por Hajo Zeeb e Ferid Shannoun","key":"10.1016\/j.apradiso.2025.111918_bib18"},{"key":"10.1016\/j.apradiso.2025.111918_bib19","first-page":"247","article-title":"Cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies","year":"2011","journal-title":"Man. Ser."},{"issue":"3","key":"10.1016\/j.apradiso.2025.111918_bib20","article-title":"Radiological protection against radon exposure. ICRP publication 126","volume":"43","year":"2014","journal-title":"Ann. ICRP"},{"issue":"3\u20134","key":"10.1016\/j.apradiso.2025.111918_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000534433","article-title":"Assessment of micronuclei frequency in the peripheral blood of adult and pediatric patients receiving fractionated total body irradiation","volume":"163","author":"Kanagaraj","year":"2023","journal-title":"Cytogenet. Genome Res."},{"issue":"4","key":"10.1016\/j.apradiso.2025.111918_bib22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1088\/0952-4746\/22\/4\/304","article-title":"Doses to organs and tissues from radon and its decay products","volume":"22","author":"Kendall","year":"2002","journal-title":"J. Radiol. Prot."},{"key":"10.1016\/j.apradiso.2025.111918_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00411-018-0771-4","article-title":"Production and distribution of chromosome aberrations in human lymphocytes by particle beams with different LET","volume":"58","author":"Kowalska","year":"2019","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.apradiso.2025.111918_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tox.2013.01.011","article-title":"Biomonitoring a human population inhabiting nearby a deactivated uranium mine","volume":"305","author":"Louren\u00e7o","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.apradiso.2025.111918_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00411-023-01027-2","article-title":"Transfer of elements from soil to earthworms and ground beetles in boreal forest","volume":"62","author":"Majlesi","year":"2023","journal-title":"Radiat. Environ. Biophys."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111918_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mrgentox.2013.06.018","article-title":"Synergistic effect of radon in blood cells of smokers \u2013 an in vitro study","volume":"757","author":"Meenakshi","year":"2013","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"issue":"9","key":"10.1016\/j.apradiso.2025.111918_bib28","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1080\/09553002.2019.1625494","article-title":"Correlation between cytogenetic biomarkers obtained from DC and CBMN assays caused by low dose radon exposure in smokers","volume":"95","author":"Meenakshi","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.apradiso.2025.111918_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrgentox.2016.12.004","article-title":"Nucleoplasmic bridges as a biomarker of DNA damage exposed to radon","volume":"814","author":"Meenakshi","year":"2017","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.apradiso.2025.111918_bib30","doi-asserted-by":"crossref","DOI":"10.1590\/1678-4685-gmb-2018-0370","article-title":"Calibration curves by 60^{60}60Co with low dose rate are different in terms of dose estimation: a comparative study","volume":"43","author":"Mendes","year":"2020","journal-title":"Genet. Mol. Biol."},{"issue":"14","key":"10.1016\/j.apradiso.2025.111918_bib31","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.3390\/app11146471","article-title":"Natural radioactivity, radiological hazard and petrographical studies on Aswan granites used as building materials in Egypt","volume":"11","author":"Moghazy","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.apradiso.2025.111918_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvrad.2021.106791","article-title":"Use of Biomphalaria glabrata as a bioindicator of groundwater quality under the influence of NORM","volume":"242","author":"Morais","year":"2022","journal-title":"J. Environ. Radioact."},{"issue":"1","key":"10.1016\/j.apradiso.2025.111918_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radmp.2020.01.001","article-title":"Opinion on reconsideration of lung cancer risk from domestic radon exposure","volume":"1","author":"Nilsson","year":"2020","journal-title":"Radiat. Med. Protect."},{"volume":"vol. 4","year":"2016","key":"10.1016\/j.apradiso.2025.111918_bib34"},{"key":"10.1016\/j.apradiso.2025.111918_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182010757","article-title":"Chromosome aberrations in lymphocytes of patients undergoing radon spa therapy: an explorative mFISH study","volume":"18","author":"Paz","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"3","key":"10.1016\/j.apradiso.2025.111918_bib36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.25061\/2527-2675\/ReBraM\/2023.v26i3.1945","article-title":"Rad\u00f4nio-222 indoor e associa\u00e7\u00e3o com risco de c\u00e2ncer de pulm\u00e3o na Regi\u00e3o Metropolitana de Recife, Brasil","volume":"26","author":"Ramos","year":"2023","journal-title":"Revista Brasileira Multidisciplinar"},{"issue":"4","key":"10.1016\/j.apradiso.2025.111918_bib47","first-page":"745","article-title":"Application of the micronucleus assay performed by different scorers in case of large-scale radiation accidents","volume":"60","author":"Rawoj\u0107","year":"2015","journal-title":"Nukleonika"},{"key":"10.1016\/j.apradiso.2025.111918_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140031","article-title":"Integration of ecosystem science into radioecology: a consensus perspective","volume":"740","author":"Rhodes","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.apradiso.2025.111918_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00411-019-00817-x","article-title":"Dose limits for occupational exposure to ionising radiation and genotoxic carcinogens: a German perspective","volume":"59","author":"R\u00fchm","year":"2020","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.apradiso.2025.111918_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/ojgen.2014.41001","article-title":"The cytokinesis-block micronucleus assay on peripheral blood lymphocytes as a prospective biological test-system to estimate the influence of radon on the human organism: Recent progress and future prospects","volume":"4","author":"Sinitsky","year":"2014","journal-title":"Open J. Genetics"},{"issue":"1","key":"10.1016\/j.apradiso.2025.111918_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00411-023-01053-0","article-title":"Long-term retention and distribution of highly enriched uranium in an occupationally exposed female","volume":"63","author":"Tolmachev","year":"2024","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.apradiso.2025.111918_bib41","article-title":"Residential exposure to radon and levels of histone \u03b3H2AX and DNA damage in peripheral blood lymphocytes of residents of Kowary city regions (Poland)","volume":"247","author":"Walczak","year":"2020","journal-title":"Chemosphere"},{"year":"2009","series-title":"WHO Handbook on Indoor Radon: A Public Health Perspective","key":"10.1016\/j.apradiso.2025.111918_bib42"},{"year":"2010","series-title":"WHO Guidelines for Indoor Air Quality: Selected Pollutants","key":"10.1016\/j.apradiso.2025.111918_bib43"},{"key":"10.1016\/j.apradiso.2025.111918_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106257","article-title":"Towards a systematic use of effect biomarkers in population and occupational biomonitoring","volume":"146","author":"Zare Jeddi","year":"2021","journal-title":"Environ. Int."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325002635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325002635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:05:44Z","timestamp":1762347944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804325002635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":44,"alternative-id":["S0969804325002635"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.111918","relation":{},"ISSN":["0969-8043"],"issn-type":[{"type":"print","value":"0969-8043"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro analysis of the suitability of different biodosimetric techniques for the study of human biomonitoring with low concentrations of Radon-222","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.111918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111918"}}