{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:51:23Z","timestamp":1784735483758,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010221","name":"Higher Education Commision, Pakistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.apradiso.2025.112168","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T06:51:37Z","timestamp":1757400697000},"page":"112168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Head-to-head evaluation of DFO and 3,4,3-LI(1,2-HOPO) chelators through site-specific conjugation of Anti-STEAP1 antibody V6-19-D11 for 89Zr-immuno-PET imaging"],"prefix":"10.1016","volume":"226","author":[{"given":"Syed Qaiser","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Shirin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apradiso.2025.112168_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.nucmedbio.2010.12.011","article-title":"In vivo biodistribution and accumulation of 89Zr in mice","volume":"38","author":"Abou","year":"2011","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2025.112168_bib2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.apradiso.2025.112168_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/j.semnuclmed.2020.12.001","article-title":"Future imaging in dementia","volume":"51","author":"Brooks","year":"2021","journal-title":"Semin. Nucl. Med."},{"key":"10.1016\/j.apradiso.2025.112168_bib4","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.3390\/pharmaceutics14102114","article-title":"Toward optimized (89)Zr-immuno-PET: Side-by-side comparison of [(89)Zr]Zr-DFO-, [(89)Zr]Zr-3,4,3-(LI-1,2-HOPO)- and [(89)Zr]Zr-DFO\u2217-cetuximab for tumor imaging: which chelator is the most suitable?","volume":"14","author":"Damerow","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.apradiso.2025.112168_bib5","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.3390\/cancers13246349","article-title":"Side-by-side comparison of five chelators for 89Zr-labeling of biomolecules: investigation of chemical\/radiochemical properties and complex stability","volume":"13","author":"Damerow","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.apradiso.2025.112168_bib6","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1021\/jm500389b","article-title":"Alternative chelator for 89Zr radiopharmaceuticals: radiolabeling and evaluation of 3,4,3-(LI-1,2-HOPO)","volume":"57","author":"Deri","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.apradiso.2025.112168_bib7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1158\/1541-7786.MCR-11-0281","article-title":"STEAP proteins: from structure to applications in cancer therapy","volume":"10","author":"Gomes","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.apradiso.2025.112168_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/1078-0432.CCR-15-0820","article-title":"New strategies in prostate cancer: Prostate-specific membrane antigen (PSMA) ligands for diagnosis and therapy","volume":"22","author":"Haberkorn","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.apradiso.2025.112168_bib9","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.math.2007.09.008","article-title":"Premanipulative testing and the velocimeter","volume":"13","author":"Haynes","year":"2008","journal-title":"Man. Ther."},{"key":"10.1016\/j.apradiso.2025.112168_bib10","article-title":"Comparison of 89Zr-Lumi804-IAB2MA and 89Zr-DFO-IAB2MA for PSMA-targeted PET imaging of prostate cancer","volume":"126\u2013127","author":"Ho","year":"2023","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2025.112168_bib11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00259-019-04612-0","article-title":"225Ac-PSMA-617\/177Lu-PSMA-617 tandem therapy of metastatic castration-resistant prostate cancer: pilot experience","volume":"47","author":"Khreish","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.apradiso.2025.112168_bib12","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1007\/s00259-019-04623-x","article-title":"Positive FAPI-PET\/CT in a metastatic castration-resistant prostate cancer patient with PSMA-negative\/FDG-positive disease","volume":"47","author":"Khreish","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.apradiso.2025.112168_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/104248","article-title":"Pharmacokinetic and biodistribution assessment of a near infrared-labeled PSMA-specific small molecule in tumor-bearing mice","volume":"2014","author":"Kovar","year":"2014","journal-title":"Prostate Cancer"},{"key":"10.1016\/j.apradiso.2025.112168_bib14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1053\/j.semnuclmed.2020.12.005","article-title":"Advances in brain amyloid imaging","volume":"51","author":"Krishnadas","year":"2021","journal-title":"Semin. Nucl. Med."},{"key":"10.1016\/j.apradiso.2025.112168_bib15","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1021\/acs.bioconjchem.1c00188","article-title":"EpCAM-targeting aptamer radiotracer for tumor-specific PET imaging","volume":"32","author":"Li","year":"2021","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.apradiso.2025.112168_bib16","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.nucmedbio.2011.04.005","article-title":"Comparative biodistribution of imaging agents for in vivo molecular profiling of disseminated prostate cancer in mice bearing prostate cancer xenografts: focus on 111In- and 125I-labeled anti-HER2 humanized monoclonal trastuzumab and ABY-025 Affibody","volume":"38","author":"Malmberg","year":"2011","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2025.112168_bib17","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/mt.2014.83","article-title":"ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities","volume":"22","author":"Nair","year":"2014","journal-title":"Mol. Ther."},{"key":"10.1016\/j.apradiso.2025.112168_bib18","doi-asserted-by":"crossref","first-page":"17181","DOI":"10.1021\/acsomega.3c01547","article-title":"Evaluation of (89)Zr-labeled anti-PD-L1 monoclonal antibodies using DFO and novel HOPO analogues as chelating agents for immuno-PET","volume":"8","author":"Radaram","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.apradiso.2025.112168_bib19","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1158\/1078-0432.CCR-14-2021","article-title":"Molecular pathways: endothelial cell FAK\u2014A target for cancer treatment","volume":"22","author":"Roy-Luzarraga","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.apradiso.2025.112168_bib20","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1158\/1078-0432.CCR-16-1137","article-title":"Targeting androgen receptor aberrations in castration-resistant prostate cancer","volume":"22","author":"Sharp","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.apradiso.2025.112168_bib21","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.apradiso.2025.112168_bib22","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1007\/s00259-024-06870-z","article-title":"PSMA radioligand therapy rechallenging: expanding the therapeutic possibilities in metastatic castration resistant prostate cancer","volume":"51","author":"Volpe","year":"2024","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.apradiso.2025.112168_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1053\/j.semnuclmed.2019.02.008","article-title":"PSMA-targeted radiopharmaceuticals for imaging and therapy","volume":"49","author":"Wester","year":"2019","journal-title":"Semin. Nucl. Med."},{"key":"10.1016\/j.apradiso.2025.112168_bib24","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/biomedicines13040794","article-title":"The role of STEAP1 in prostate cancer: implications for diagnosis and therapeutic strategies","volume":"13","author":"Zhang","year":"2025","journal-title":"Biomedicines"}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325005135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325005135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:09:33Z","timestamp":1769731773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804325005135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":24,"alternative-id":["S0969804325005135"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.112168","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Head-to-head evaluation of DFO and 3,4,3-LI(1,2-HOPO) chelators through site-specific conjugation of Anti-STEAP1 antibody V6-19-D11 for 89Zr-immuno-PET imaging","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.112168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112168"}}