{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:17:11Z","timestamp":1789078631963,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100019274","name":"National Institute of Mental Health and Neurosciences","doi-asserted-by":"publisher","award":["PI-SM"],"award-info":[{"award-number":["PI-SM"]}],"id":[{"id":"10.13039\/100019274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.apradiso.2025.112216","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:01:09Z","timestamp":1759298469000},"page":"112216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Production of [18F]NAV4694 on an FX2N synthesis module for imaging amyloid plaques"],"prefix":"10.1016","volume":"226","author":[{"given":"Pardeep","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Mangalore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman Kumar","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerti","family":"Sitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Vajjala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashwanth","family":"Gurushanthappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeksha","family":"Muralidharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanimuthu T.","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apradiso.2025.112216_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13550-025-01216-8","article-title":"Autoradiographic comparison between [11C]PiB and [18F]AZD4694 in human brain tissue","volume":"15","author":"Aliaga","year":"2025","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.apradiso.2025.112216_bib2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.apradiso.2025.112216_bib3","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2967\/jnumed.109.065284","article-title":"Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain","volume":"50","author":"Choi","year":"2009","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2025.112216_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2967\/jnumed.111.094029","article-title":"Clinical validation of 18F-AZD4694, an amyloid-\u03b2\u2013specific PET radioligand","volume":"53","author":"Csel\u00e9nyi","year":"2012","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2025.112216_bib5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jalz.2018.05.006","article-title":"The national institute on aging-alzheimer\u2019s association framework on alzheimer's disease: application to clinical trials","volume":"15","author":"Cummings","year":"2018","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.apradiso.2025.112216_bib6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1017\/S109285291600047X","article-title":"Approach to atypical Alzheimer's disease and case studies of the major subtypes","volume":"22","author":"Dickerson","year":"2017","journal-title":"CNS Spectr."},{"key":"10.1016\/j.apradiso.2025.112216_bib7","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S1474-4422(21)00066-1","article-title":"Clinical diagnosis of alzheimer's disease: recommendations of the international working group","volume":"20","author":"Dubois","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.apradiso.2025.112216_bib8","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.apradiso.2025.112216_bib9","first-page":"184","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science (1979)"},{"key":"10.1016\/j.apradiso.2025.112216_bib10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00259-013-2564-y","article-title":"[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer's disease","volume":"41","author":"Hatashita","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.apradiso.2025.112216_bib11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s11910-006-0052-5","article-title":"Amyloid imaging of alzheimer's disease using pittsburgh compound B","volume":"6","author":"Johnson","year":"2006","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.apradiso.2025.112216_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2013.01.002","article-title":"Appropriate use criteria for amyloid PET: a report of the amyloid imaging task force, the society of nuclear medicine and molecular imaging, and the alzheimer's association","volume":"9","author":"Johnson","year":"2013","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.apradiso.2025.112216_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2020.109486","article-title":"Radiosynthesis challenges of 11C and 18F-labeled radiotracers in the FX2C\/N tracerlab and their validation through PET-MR imaging","author":"Joshi","year":"2021","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.apradiso.2025.112216_bib14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.apradiso.2025.112216_bib15","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1523\/JNEUROSCI.23-06-02086.2003","article-title":"The binding of 2-(4\u2019-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component","volume":"23","author":"Klunk","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.apradiso.2025.112216_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26051282","article-title":"Clinical relevance of [(18)F]florbetaben and [(18)F]FDG PET\/CT imaging on the management of patients with dementia","volume":"26","author":"Librizzi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.apradiso.2025.112216_bib17","first-page":"890","article-title":"Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer's disease","volume":"13","author":"Okamura","year":"2010","journal-title":"Idrugs"},{"key":"10.1016\/j.apradiso.2025.112216_bib18","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1212\/01.wnl.0000261919.22630.ea","article-title":"Imaging beta-amyloid burden in aging and dementia","volume":"68","author":"Rowe","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.apradiso.2025.112216_bib19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.2967\/jnumed.112.114785","article-title":"Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for \u03b2-amyloid imaging in aging and dementia","volume":"54","author":"Rowe","year":"2013","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2025.112216_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11307-013-0666-3","article-title":"Synthesis, radiolabeling, and in vivo pharmacokinetic evaluation of the amyloid beta radioligand [11C]AZD4694 in nonhuman primates","volume":"16","author":"Schou","year":"2014","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.apradiso.2025.112216_bib21","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jalz.2018.07.220","article-title":"Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer's disease","volume":"14","author":"Shaw","year":"2018","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.apradiso.2025.112216_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2967\/jnumed.120.245209","article-title":"Determining amyloid-\u03b2 positivity using (18)F-AZD4694 PET imaging","volume":"62","author":"Therriault","year":"2020","journal-title":"J. Nucl. Med."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325005615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804325005615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:35:00Z","timestamp":1773138900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804325005615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":22,"alternative-id":["S0969804325005615"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.112216","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Production of [18F]NAV4694 on an FX2N synthesis module for imaging amyloid plaques","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2025.112216","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112216"}}