{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:14:21Z","timestamp":1778793261310,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.apradiso.2026.112623","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:05:59Z","timestamp":1775898359000},"page":"112623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Preclinical and human dosimetric aspects of [113mIn]In-BPAMD: A new agent for SPECT imaging of bone metastases"],"prefix":"10.1016","volume":"234","author":[{"given":"Samaneh","family":"Zolghadri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezou","family":"Karimian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Moghaddasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Yousefnia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.apradiso.2026.112623_bib3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2967\/jnumed.114.149658","article-title":"A parallel-cone collimator for high-energy SPECT","volume":"56","author":"Beijst","year":"2015","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.apradiso.2026.112623_bib4","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4161\/cbt.5.9.3306","article-title":"Pathophysiology of bone metastases","volume":"9","author":"Berenson","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.apradiso.2026.112623_bib5","first-page":"99","article-title":"Design and construction of a 113Sn\/113mIn generator using irradiation of natural indium in a cyclotron accelerator","volume":"45","author":"Bolorinovin","year":"2024","journal-title":"JONSAT"},{"key":"10.1016\/j.apradiso.2026.112623_bib6","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.apradiso.2026.112623_bib7","author":"Chu"},{"key":"10.1016\/j.apradiso.2026.112623_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00006231-198501000-00007","article-title":"SPECT imaging of 131I (364 keV): importance of collimation","volume":"6","author":"Clarke","year":"1985","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.apradiso.2026.112623_bib9","series-title":"The ORNL Mathematical Phantom Series","author":"Eckerman","year":"1996"},{"key":"10.1016\/j.apradiso.2026.112623_bib10","article-title":"PET\/CT imaging of osteoblastic bone metastases with 68Ga-bisphosphonates: first human study","volume":"37","author":"Fellner","year":"2010","journal-title":"EJNMMI."},{"key":"10.1016\/j.apradiso.2026.112623_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/j.semnuclmed.2004.11.005","article-title":"Positron emission tomography and bone metastases","volume":"3","author":"Fogelman","year":"2005","journal-title":"Nucl Med Semin"},{"key":"10.1016\/j.apradiso.2026.112623_bib12","first-page":"67","article-title":"Convenient formulation of 68Ga-BPAMD patient dose using lyophilized BPAMD kit and 68Ga sourced from different commercial generators for imaging of skeletal metastases","volume":"34","author":"Guleria","year":"2019","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.apradiso.2026.112623_bib15","first-page":"80","article-title":"Preliminary experience of 68Ga-BPAMD for imaging distant bone metastases in cancer patients","volume":"34","author":"Kaur","year":"2019","journal-title":"IJNM"},{"key":"10.1016\/j.apradiso.2026.112623_bib16","first-page":"94","article-title":"Development of a [177Lu]BPAMD labeling kit and an automated synthesis module for routine bone targeted endoradiotherapy","volume":"30","author":"Meckel","year":"2015","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.apradiso.2026.112623_bib17","article-title":"99Mo\/99mTc-113Sn\/113mIn dual radioisotope generator based on 6-tungstocerate (IV) column matrix","volume":"10","author":"Mostafa","year":"2009","journal-title":"JNRS"},{"key":"10.1016\/j.apradiso.2026.112623_bib18","first-page":"19","article-title":"Preclinical study of 68Ga-DOTATOC: biodistribution assessment in Syrian rats and evaluation of absorbed dose in human organs","volume":"4","author":"Naderi","year":"2016","journal-title":"Asia Ocean J Nucl Med Biol"},{"key":"10.1016\/j.apradiso.2026.112623_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0969-8051(01)00305-5","article-title":"Synthesis, characterization and biodistribution of bisphosphonates Sm-153 complexes: correlation with molecular modeling interaction studies","volume":"29","author":"Neves","year":"2002","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2026.112623_bib21","first-page":"473","article-title":"Pharmacokinetic studies and human absorbed dose estimation of 68Ga-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl)acetic acid","volume":"16","author":"Rabiei","year":"2018","journal-title":"Int J Radiat Res"},{"key":"10.1016\/j.apradiso.2026.112623_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1208\/s12248-009-9160-x","article-title":"Compartmental analysis and its manifold applications to pharmacokinetics","volume":"12","author":"Rescigno","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.apradiso.2026.112623_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115735","article-title":"Pharmacologic management of metastatic bone disease","volume":"158","author":"Schwartz","year":"2022","journal-title":"Bone"},{"key":"10.1016\/j.apradiso.2026.112623_bib27","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1259\/bjr.20160153","article-title":"Estimation of human absorbed dose for Ho-166-PAM: comparison with Ho-166-DOTMP and Ho-166-TTHMP","volume":"89","author":"Vaez-Tehrani","year":"2016","journal-title":"Brit J Radiol"},{"key":"10.1016\/j.apradiso.2026.112623_bib28","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1118\/1.4927061","article-title":"Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging","volume":"42","author":"Van Audenhaege","year":"2015","journal-title":"Med. Phys."},{"key":"10.1016\/j.apradiso.2026.112623_bib32","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s10967-014-3924-1","article-title":"Preparation and biological evaluation of 166Ho-BPAMD as a potential therapeutic bone-seeking agent","volume":"304","author":"Yousefnia","year":"2015","journal-title":"J Radioanal Nucl."},{"key":"10.1016\/j.apradiso.2026.112623_bib33","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1515\/ract-2015-2391","article-title":"Preparation and biodistribution assessment of 111In-BPAMD as a novel agent for bone SPECT imaging","volume":"103","author":"Yousefnia","year":"2015","journal-title":"Radiochim. Acta"},{"key":"10.1016\/j.apradiso.2026.112623_bib30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ejmp.2015.05.015","article-title":"Estimated human absorbed dose of a new (153)Sm bone seeking agent based on biodistribution data in mice: Comparison with (153)Sm-EDTMP","volume":"31","author":"Yousefnia","year":"2015","journal-title":"Phys. Med."},{"key":"10.1016\/j.apradiso.2026.112623_bib31","first-page":"722","article-title":"Estimated human absorbed dose of 111In-BPAMD as a new bone-seeking SPECT-imaging agent","volume":"9","author":"Yousefnia","year":"2015","journal-title":"Int. J. Biol. Eng."},{"key":"10.1016\/j.apradiso.2026.112623_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1515\/ract-2023-0236","article-title":"Development of [64Cu]Cu-BPAMD for PET imaging of bone metastases","volume":"112","author":"Zolghadri","year":"2024","journal-title":"Radiochim. Acta"},{"key":"10.1016\/j.apradiso.2026.112623_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2024.111379","article-title":"Preclinical studies and absorbed dose estimation of [89Zr] Zr-DFO-Bevacizumab for PET imaging of VEGF-expressing tumors","volume":"210","author":"Zolghadri","year":"2024","journal-title":"Appl. Radiat. Isot."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804326002071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804326002071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:00:07Z","timestamp":1778792407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804326002071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":26,"alternative-id":["S0969804326002071"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2026.112623","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical and human dosimetric aspects of [113mIn]In-BPAMD: A new agent for SPECT imaging of bone metastases","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2026.112623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"112623"}}