{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:07:54Z","timestamp":1784182074748,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.apradiso.2026.112771","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:35:30Z","timestamp":1782257730000},"page":"112771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development and biodistribution of 131I-radiolabeled silver-doped indium oxide nanoparticles as a novel nanoplatform for tumor targeting in tumor bearing mice"],"prefix":"10.1016","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7546-7332","authenticated-orcid":false,"given":"Mohamed H.","family":"Aboumanei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa S.","family":"El Refaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.I.","family":"Khater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.apradiso.2026.112771_bib1","first-page":"221","article-title":"Improved targeting and tumor retention of a newly synthesized antineoplaston A10 derivative by intratumoral administration: molecular docking, technetium 99m radiolabeling, and in vivo biodistribution studies","volume":"33","author":"Aboumanei","year":"2018"},{"key":"10.1016\/j.apradiso.2026.112771_bib3","volume":"vol. 180","author":"Aboumanei","year":"2022"},{"issue":"2","key":"10.1016\/j.apradiso.2026.112771_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12247-022-09638-w","article-title":"Development of tamoxifen in situ gel nanoemulsion for ocular delivery in photoreceptor degeneration disorder: in vitro characterization, 131I-Radiolabeling, and in vivo biodistribution studies","volume":"18","author":"Aboumanei","year":"2023","journal-title":"J. Pharm. Innov."},{"issue":"3","key":"10.1016\/j.apradiso.2026.112771_bib4","first-page":"6055","article-title":"Photodeposition mediated synthesis of silver-doped indium oxide nanoparticles for improved photocatalytic and anticancer performance","volume":"30","author":"Alaizeri","year":"2023"},{"key":"10.1016\/j.apradiso.2026.112771_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.148295","article-title":"The sub-nanometer In2O clusters on Ag nanoparticles with highly selective electrochemical CO2 reduction to formate","volume":"481","author":"Bhalothia","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"9","key":"10.1016\/j.apradiso.2026.112771_bib6","first-page":"941","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015"},{"issue":"3","key":"10.1016\/j.apradiso.2026.112771_bib7","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"10.1016\/j.apradiso.2026.112771_bib8","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/nano10091812","article-title":"Characterization of commercial metal oxide nanomaterials: crystalline phase, particle size and specific surface area","volume":"10","author":"Bushell","year":"2020","journal-title":"Nanomaterials"},{"issue":"3","key":"10.1016\/j.apradiso.2026.112771_bib9","first-page":"214","article-title":"Controlling the biodistribution and clearance of nanomedicines","volume":"2","author":"Cabral","year":"2024"},{"issue":"12","key":"10.1016\/j.apradiso.2026.112771_bib10","first-page":"1095","article-title":"Molecular imaging and disease theranostics with renal-clearable optical agents","volume":"6","author":"Cheng","year":"2021"},{"key":"10.1016\/j.apradiso.2026.112771_bib11","series-title":"Iodine-125 Radiolabeling of Silver Nanoparticles for in Vivo SPECT Imaging","first-page":"653","author":"Chrastina","year":"2010"},{"issue":"3","key":"10.1016\/j.apradiso.2026.112771_bib12","first-page":"514","article-title":"Therapeutic advancements in metal and metal oxide nanoparticle-based radiosensitization for head and neck cancer therapy","volume":"14","author":"Dubey","year":"2022"},{"issue":"10","key":"10.1016\/j.apradiso.2026.112771_bib14","first-page":"773","article-title":"125I\u2013Amoxicillin preparation as a guide tracer for inflammation detection","volume":"109","author":"El Refaye","year":"2021"},{"issue":"9","key":"10.1016\/j.apradiso.2026.112771_bib13","first-page":"315","article-title":"Radioiodination and bioevaluation of nitrofurantoin for urinary tract imaging","volume":"55","author":"El\u2010Azony","year":"2012"},{"issue":"1\u20132","key":"10.1016\/j.apradiso.2026.112771_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijpharm.2017.06.044","article-title":"Comparative study on radiolabeling and biodistribution of core-shell silver\/polymeric nanoparticles-based theranostics for tumor targeting","volume":"529","author":"Farrag","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112771_bib16","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/s41598-018-19628-z","article-title":"Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings","volume":"8","author":"Feng","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.apradiso.2026.112771_bib17","first-page":"2256","article-title":"A recent review on","volume":"15","author":"Giri","year":"2023","journal-title":"cancer nanomedicine."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112771_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43586-023-00211-4","article-title":"Nanomaterial-based contrast agents","volume":"3","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.apradiso.2026.112771_bib19","first-page":"37","volume":"vol 115","author":"Ibrahim","year":"2016"},{"issue":"6","key":"10.1016\/j.apradiso.2026.112771_bib20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/pssb.201350161","article-title":"Review on TEM analysis of growth twins in nanocrystalline palladium thin films: toward better understanding of twin\u2010related mechanisms in high stacking fault energy metals","volume":"251","author":"Idrissi","year":"2014","journal-title":"Phys. Status Solidi"},{"issue":"38","key":"10.1016\/j.apradiso.2026.112771_bib21","first-page":"39297","article-title":"Recent advances in metal oxide and phosphate nanomaterials radiolabeling with medicinal nuclides","volume":"9","author":"Jansk\u00e1","year":"2024"},{"issue":"3","key":"10.1016\/j.apradiso.2026.112771_bib22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.22146\/ijc.56309","article-title":"Influence of calcination temperature on size, morphology and optical properties of ZnO\/C composite synthesized by a colloidal method","volume":"21","author":"Lhimr","year":"2021","journal-title":"Indones. J. Chem."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112771_bib23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/1556-276X-8-381","article-title":"Characterization of magnetic nanoparticle by dynamic light scattering","volume":"8","author":"Lim","year":"2013","journal-title":"Nanoscale Res. Lett."},{"issue":"28","key":"10.1016\/j.apradiso.2026.112771_bib24","article-title":"Smart nanosystems for overcoming multiple biological barriers in cancer nanomedicines transport: design principles, progress, and challenges","volume":"19","author":"Lin","year":"2023"},{"issue":"11","key":"10.1016\/j.apradiso.2026.112771_bib25","first-page":"16974","article-title":"Nanoparticles for cancer diagnosis, radionuclide therapy and theranostics","volume":"15","author":"Llop","year":"2021"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112771_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.addr.2012.10.002","article-title":"The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo","volume":"65","author":"Maeda","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.apradiso.2026.112771_bib27","first-page":"381","article-title":"A simple synthesis and magnetic behavior of nanocrystalline Zn0. 9Co0","volume":"305","author":"Maensiri","year":"2006","journal-title":"1O powders by using Zn and Co acetates and polyvinyl pyrrolidone as precursors"},{"key":"10.1016\/j.apradiso.2026.112771_bib29","volume":"vol. 166","author":"Mahmoud","year":"2020"},{"key":"10.1016\/j.apradiso.2026.112771_bib30","volume":"vol. 1","author":"Manke","year":"2013"},{"key":"10.1016\/j.apradiso.2026.112771_bib31","volume":"vol. 189","author":"Motaleb","year":"2022"},{"issue":"4","key":"10.1016\/j.apradiso.2026.112771_bib32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/jfb13040274","article-title":"Metal oxide nanoparticles: review of synthesis, characterization and biological effects","volume":"13","author":"Negrescu","year":"2022","journal-title":"J. Funct. Biomater."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112771_bib33","first-page":"425","article-title":"Synthesis, characterization, and magnetic properties of monodisperse CeO2 nanospheres prepared by PVP-assisted hydrothermal method","volume":"7","author":"Phokha","year":"2012"},{"key":"10.1016\/j.apradiso.2026.112771_bib34","first-page":"12","volume":"vol. 2","author":"Pouget","year":"2015"},{"key":"10.1016\/j.apradiso.2026.112771_bib35","first-page":"22","volume":"vol. 4","author":"Radulski","year":"2023"},{"issue":"12","key":"10.1016\/j.apradiso.2026.112771_bib36","first-page":"1010","article-title":"Photocatalytic, antibacterial and anticancer activity of silver-doped zinc oxide nanoparticles","volume":"24","author":"Rajendran","year":"2020"},{"issue":"6","key":"10.1016\/j.apradiso.2026.112771_bib37","first-page":"828","article-title":"Radiosynthesis, in vitro and in vivo Evaluation of 99mTc-Silodosin as a Tumor marker in Mice","volume":"63","author":"Refaye","year":"2021"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112771_bib38","first-page":"10","article-title":"Kupffer cells are central in the removal of nanoparticles from the organism","volume":"4","author":"Sadauskas","year":"2007"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112771_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2016.108","article-title":"Cancer nanomedicine: progress, challenges and opportunities","volume":"17","author":"Shi","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"17","key":"10.1016\/j.apradiso.2026.112771_bib40","first-page":"7921","article-title":"The EPR effect and beyond: strategies to improve tumor targeting and cancer nanomedicine treatment efficacy","volume":"10","author":"Shi","year":"2020"},{"issue":"5","key":"10.1016\/j.apradiso.2026.112771_bib41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41563-019-0566-2","article-title":"The entry of nanoparticles into solid tumours","volume":"19","author":"Sindhwani","year":"2020","journal-title":"Nat. Mater."},{"issue":"3","key":"10.1016\/j.apradiso.2026.112771_bib42","first-page":"752","article-title":"Synthesis and characterization of indium oxide nanoparticles using indium nitrate and polyvinylpyrrolidone (PVP) as precursors","volume":"42","author":"Sonsupap","year":"2015"},{"issue":"3","key":"10.1016\/j.apradiso.2026.112771_bib43","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.apradiso.2026.112771_bib44","first-page":"250","article-title":"Evaluating three injection sites for Sedation\/Anesthesia using ketamine-xylazine in C57BL\/6 Mice (Mus musculus): intraperitoneal, subcutaneous interscapular, and subcutaneous GV20 acupuncture sites","volume":"64","author":"Teng","year":"2025"},{"issue":"12","key":"10.1016\/j.apradiso.2026.112771_bib45","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1039\/D3NA00165B","article-title":"Platinum nanoparticles labelled with iodine-125 for combined \u201cchemo-Auger electron\u201d therapy of hepatocellular carcinoma","volume":"5","author":"Wawrowicz","year":"2023","journal-title":"Nanoscale Adv."},{"issue":"5","key":"10.1016\/j.apradiso.2026.112771_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"issue":"7","key":"10.1016\/j.apradiso.2026.112771_bib47","first-page":"6655","article-title":"Clearance pathways and tumor targeting of imaging nanoparticles","volume":"9","author":"Yu","year":"2015"},{"issue":"4","key":"10.1016\/j.apradiso.2026.112771_bib48","first-page":"179","article-title":"Magnetic nanoscalpel for the effective treatment of ascites tumors","volume":"14","author":"Zamay","year":"2023"},{"key":"10.1016\/j.apradiso.2026.112771_bib49","first-page":"332","volume":"vol. 240","author":"Zhang","year":"2016"}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804326003556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804326003556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:29:14Z","timestamp":1784179754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804326003556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":48,"alternative-id":["S0969804326003556"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2026.112771","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and biodistribution of 131I-radiolabeled silver-doped indium oxide nanoparticles as a novel nanoplatform for tumor targeting in tumor bearing mice","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2026.112771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"112771"}}