{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:08:14Z","timestamp":1788782894447,"version":"build-2803163510"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Applied Radiation and Isotopes"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.apradiso.2026.112806","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:42:30Z","timestamp":1783698150000},"page":"112806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Radiolabeling, characterization, and bioevaluation of 99mTc-Itaconic acid for detection of inflammation in mice"],"prefix":"10.1016","volume":"237","author":[{"given":"M.H.","family":"Sanad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-3254","authenticated-orcid":false,"given":"Safaa B.","family":"Challan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sh.F.","family":"Abo Zahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Massoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apradiso.2026.112806_bib1","first-page":"1","article-title":"Radiation synthesis of poly(N-vinyl pyrrolidone\/chitosan\/itaconic acid\/ZnO) nanocomposite hydrogel for antimicrobial activity and controlled release of amoxicillin","volume":"30","author":"Abou El Fadl","year":"2022","journal-title":"Polym. Polym. Compos."},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib2","first-page":"33","article-title":"Technetium-99m-salbutamol: a single photon emission imaging agent for \u03b22-adrenoceptor and regional cerebral blood flow","volume":"42","author":"Amin","year":"2009","journal-title":"Arab. J. Nucl. Sci. Appl."},{"key":"10.1016\/j.apradiso.2026.112806_bib3","first-page":"15","article-title":"99mTc-Labeled Ceftazidime and biological evaluation in experimental animals for detection of bacterial infection","volume":"4","author":"Bekheet","year":"2014","journal-title":"Am. J. Biochem."},{"key":"10.1016\/j.apradiso.2026.112806_bib4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1134\/S1066362216010136","article-title":"Optimized chromatographic separation and biological evaluation of 99mTc-clarithromycin for infective inflammation diagnosis","volume":"58","author":"Borai","year":"2016","journal-title":"Radiochemistry"},{"issue":"R1","key":"10.1016\/j.apradiso.2026.112806_bib5","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1093\/hmg\/ddae177","article-title":"Dual faces of itaconate and its derivatives: exploring diverse biological functions in immunity and infectious diseases","volume":"34","author":"Cecilie","year":"2025","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.apradiso.2026.112806_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioorg.2025.109050","article-title":"Characterization and bioevaluation of radioiodinated oseltamivir phosphate for inflammation imaging as a new perspective","volume":"165","author":"Challan","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.apradiso.2026.112806_bib7","first-page":"635","article-title":"Preparation, molecular modeling and in-vivo evaluation of 99mTc-Oseltamivir as a tumor diagnostic agent","volume":"20","author":"Challan","year":"2022","journal-title":"Int. J. Radiat. Res."},{"issue":"5","key":"10.1016\/j.apradiso.2026.112806_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1515\/ract-2019-3162","article-title":"Synthesis of radioiodinated carnosine for hepatotoxicity imaging induced by carbon tetrachloride and its biological assessment in rats","volume":"108","author":"Challan","year":"2020","journal-title":"Radiochim. Acta"},{"key":"10.1016\/j.apradiso.2026.112806_bib9","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s10967-017-5561-y","article-title":"Radiolabeling of graphene oxide by Technetium-99m for infection imaging in rats","volume":"314","author":"Challan","year":"2017","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1016\/j.apradiso.2026.112806_bib10","series-title":"Intracellular Pathogens: Methods and Protocols","first-page":"205","article-title":"Recent advancements in radiopharmaceuticals for infection imaging","author":"Dadachova","year":"2024"},{"key":"10.1016\/j.apradiso.2026.112806_bib11","series-title":"Handbook of Nuclear Chemistry","first-page":"2121","author":"Eisenhut","year":"2011"},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4274\/tjps.galenos.2022.01346","article-title":"Radiolabeling, quality control, and cell binding studies of new 99mTc-labeled bisphosphonates: 99mTc-ibandronate sodium","volume":"20","author":"Ekinci","year":"2023","journal-title":"Turk. J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.apradiso.2026.112806_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/157340561003141003155112","article-title":"Targeting molecular imaging approach for detection of infection and inflammation by diagnostic nuclear medicine techniques","volume":"10","author":"Fazli","year":"2014","journal-title":"Curr. Med. Imag."},{"issue":"14","key":"10.1016\/j.apradiso.2026.112806_bib14","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jlcr.3097","article-title":"Comparative biodistribution studies of technetium-99m radiolabeled amphiphilic nanoparticles using three different reducing agents during the labeling procedure","volume":"56","author":"Geskovski","year":"2013","journal-title":"J. Label. Compd. Radiopharm."},{"key":"10.1016\/j.apradiso.2026.112806_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymer.2025.128365","article-title":"Itaconic acid: from monomer properties to radical homo-polymerization in water","volume":"327","author":"Giunta","year":"2025","journal-title":"Polymer"},{"issue":"55","key":"10.1016\/j.apradiso.2026.112806_bib16","first-page":"1","article-title":"Preparation, molecular docking, and biological evaluation of radioiodinated cefaclor for inflammation detection","volume":"27","author":"Hussien","year":"2026","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.apradiso.2026.112806_bib17","series-title":"Technetium-99m Radiopharmaceuticals: Manufacture of Kits","year":"2008"},{"issue":"8","key":"10.1016\/j.apradiso.2026.112806_bib18","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1080\/09553002.2020.1761568","article-title":"Brain-targeting by optimized 99mTc-olanzapine: in vivo and in silico studies","volume":"96","author":"Ibrahim","year":"2020","journal-title":"Int. J. Radiat. Biol."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10967-014-3233-8","article-title":"Formulation and preclinical evaluation of 99mTc-gemcitabine as a novel radiopharmaceutical for solid tumor imaging","volume":"302","author":"Ibrahim","year":"2014","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1016\/j.apradiso.2026.112806_bib20","series-title":"Susceptibility Test Methods: Dilution and Disk Diffusion Methods","first-page":"1253","author":"Jorgensen","year":"2015"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s41181-024-00279-7","article-title":"Recently developed radiopharmaceuticals for bacterial infection imaging","volume":"9","author":"Kahts","year":"2024","journal-title":"EJNMMI Radiopharm. Chem."},{"issue":"23","key":"10.1016\/j.apradiso.2026.112806_bib22","doi-asserted-by":"crossref","first-page":"8376","DOI":"10.3390\/ma15238376","article-title":"Silver itaconate as a single-source precursor of nanocomposites for the analysis of chloride ions","volume":"15","author":"Kolesnikova","year":"2022","journal-title":"Materials"},{"key":"10.1016\/j.apradiso.2026.112806_bib23","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/tomography7040070","article-title":"Physicochemical and biological study of 99mTc and 68Ga radiolabelled ciprofloxacin and evaluation of [99mTc]Tc-CIP as potential diagnostic radiopharmaceutical for diabetic foot syndrome imaging","volume":"7","author":"Ko\u017ami\u0144ski","year":"2021","journal-title":"Tomography"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10967-020-07195-5","article-title":"Synthesis and radiolabeling of vitamin C-stabilized selenium nanoparticles as a promising approach in diagnosis of solid tumors","volume":"325","author":"Korany","year":"2020","journal-title":"J. Radioanal. Nucl. Chem."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib25","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib26","first-page":"405","article-title":"Reduction of pertechnetate by stannous ions: a pH-dependent study","volume":"55","author":"Li","year":"2016","journal-title":"Inorg. Chem."},{"issue":"6","key":"10.1016\/j.apradiso.2026.112806_bib27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3892\/ijmm.2026.5815","article-title":"Role of itaconate in intestinal disease","volume":"57","author":"Li","year":"2026","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.apradiso.2026.112806_bib28","series-title":"Transpathology","first-page":"155","article-title":"Imaging of inflammation and infection","author":"Liu","year":"2024"},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1039\/C5AY02264A","article-title":"Quantification of copolymer composition (methyl acrylate and itaconic acid) in polyacrylonitrile carbon-fiber precursors by FTIR-spectroscopy","volume":"8","author":"Loginova","year":"2016","journal-title":"Anal. Methods"},{"issue":"6","key":"10.1016\/j.apradiso.2026.112806_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/app.54921","article-title":"Preparation of carboxy sulfonic acid-containing copolymer scale inhibitors and their scale inhibition effect on CaCO3","volume":"141","author":"Ma","year":"2024","journal-title":"J. Appl. Polym. Sci."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib31","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1021\/acsomega.3c08031","article-title":"Itaconic acid-based organic-polymer monolithic column for hydrophilic capillary electrochromatography and its application in pharmaceutical analysis","volume":"9","author":"Mao","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.apradiso.2026.112806_bib32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1134\/S1066362218030141","article-title":"Comparative biological evaluation of 99mTc-Timonacic acid prepared using different reducing agents as a complex for hepatobiliary imaging","volume":"60","author":"Marzook","year":"2018","journal-title":"Radiochemistry"},{"issue":"6","key":"10.1016\/j.apradiso.2026.112806_bib33","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/10601325.2021.1873070","article-title":"Characterization of polyvinylpyrrolidone (PVP) with technetium-99m and its accumulation in mice","volume":"58","author":"Massoud","year":"2021","journal-title":"J. Macromol. Sci. Part A"},{"issue":"7699","key":"10.1016\/j.apradiso.2026.112806_bib34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10967-006-6754-y","article-title":"Preparation of 99mTc-cefoperazone complex, a novel agent for detecting sites of infection","volume":"272","author":"Motaleb","year":"2007","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1016\/j.apradiso.2026.112806_bib36","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1134\/S1066362214050154","article-title":"99mTc-Labeled Teicoplanin and its biological evaluation in experimental animals for detection of bacterial infection","volume":"56","author":"Motaleb","year":"2014","journal-title":"Radiochemistry"},{"issue":"4","key":"10.1016\/j.apradiso.2026.112806_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/jlcr.3380","article-title":"Preparation and biological evaluation of 99mTc\u2013ropinirole as a novel radiopharmaceutical for brain imaging","volume":"59","author":"Motaleb","year":"2016","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib38","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s12010-018-2915-z","article-title":"Susceptibility of 99mTc-ciprofloxacin for common infection-causing bacterial strains isolated from clinical samples: an in vitro and in vivo study","volume":"188","author":"Naqvi","year":"2019","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib39","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1038\/s41598-019-42315-6","article-title":"Itaconic acid inhibits growth of a pathogenic marine Vibrio strain: a metabolomics approach","volume":"9","author":"Nguyen","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib40","first-page":"280","article-title":"Itaconic acid-based coordination polymer: mechanochemical synthesis, characterization, and vapochromic study","volume":"8","author":"Olawale","year":"2020","journal-title":"Niger Res. J. Chem. Sci."},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148548","article-title":"The role of itaconate in host defense and inflammation","volume":"132","author":"Peace","year":"2022","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.apradiso.2026.112806_bib42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0969-8051(96)00082-0","article-title":"Direct 99mTc-labeling of antibodies by sodium dithionite reduction, and role of ascorbate as a stabilizer in cysteine challenge","volume":"23","author":"Qi","year":"1996","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2026.112806_bib43","series-title":"The Radiopharmaceutical Chemistry of technetium-99m","first-page":"311","author":"Rathmann","year":"2019"},{"key":"10.1016\/j.apradiso.2026.112806_bib44","first-page":"2088","article-title":"Synthesis and comparison of 99mTc-enrofloxacin and 99mTc-ciprofloxacin","volume":"45","author":"Rien","year":"2004","journal-title":"J. Nucl. Med."},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.revmedmi.0000244134.43170.83","article-title":"Pathogenesis of staphylococcal device-related infections: from basic science to new diagnostic, therapeutic and prophylactic approaches","volume":"17","author":"Rohde","year":"2006","journal-title":"Rev. Res. Med. Microbiol."},{"issue":"7","key":"10.1016\/j.apradiso.2026.112806_bib46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1524\/ract.2005.93.7.415","article-title":"Synthesis and biodistribution of 99mTc-vancomycin in a model of bacterial infection","volume":"93","author":"Roohi","year":"2005","journal-title":"Radiochim. Acta"},{"key":"10.1016\/j.apradiso.2026.112806_bib47","first-page":"2456","article-title":"99mTc-Labeled Erythrocin and biological evaluation in mice for detection of bacterial infection","volume":"5","author":"Safaa","year":"2018","journal-title":"Asian J. Phys. Chem. Sci."},{"key":"10.1016\/j.apradiso.2026.112806_bib48","series-title":"Fundamentals of Nuclear Pharmacy","author":"Saha","year":"2004"},{"issue":"6","key":"10.1016\/j.apradiso.2026.112806_bib49","first-page":"410","article-title":"Radioiodination of Silodosin with 131I as a selective drug for prostate imaging in mice","volume":"40","author":"Sanad","year":"2025","journal-title":"Cancer Biother. Radiopharm."},{"issue":"3","key":"10.1016\/j.apradiso.2026.112806_bib50","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1515\/ract-2024-0303","article-title":"Design of a novel complex 99mTc-Nilutamide as a tracer for prostate cancer disorder detection in mice","volume":"113","author":"Sanad","year":"2025","journal-title":"Radiochim. Acta"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1134\/S1066362223010150","article-title":"Assessment of radiolabeled L-Carnitine for hepatotoxicity imaging in rats","volume":"65","author":"Sanad","year":"2023","journal-title":"Radiochemistry"},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib52","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1515\/ract-2020-0046","article-title":"Radioiodination and biological evaluation of cimetidine as a new highly selective radiotracer for peptic ulcer disorder detection","volume":"109","author":"Sanad","year":"2021","journal-title":"Radiochim. Acta"},{"issue":"3","key":"10.1016\/j.apradiso.2026.112806_bib53","first-page":"37","article-title":"Facile one-pot strategy for brain imaging using radiolabeled [99mTc]-tricarbonyl histamine complex in mice","volume":"68","author":"Sanad","year":"2025","journal-title":"Egypt. J. Chem."},{"issue":"3","key":"10.1016\/j.apradiso.2026.112806_bib54","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1134\/S1066362223030141","article-title":"Radiocomplexation, biological evaluation, and characterization of [99mTc]-5-[(3-Carboxy-4-hydroxyphenyl) diazenyl]-2-hydroxybenzoic Acid as a novel agent for imaging of ulcerative colitis in mice","volume":"65","author":"Sanad","year":"2023","journal-title":"Radiochemistry"},{"issue":"4","key":"10.1016\/j.apradiso.2026.112806_bib55","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/ract-2017-2830","article-title":"Radioiodination of olmesartan medoxomil and biological evaluation of the product as a tracer for cardiac imaging","volume":"106","author":"Sanad","year":"2018","journal-title":"Radiochim. Acta"},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40543-014-0032-3","article-title":"Performance characteristics of biodistribution of 99mTc-cefprozil for in vivo infection imaging","volume":"5","author":"Sanad","year":"2014","journal-title":"J. Anal. Sci. Technol."},{"issue":"8","key":"10.1016\/j.apradiso.2026.112806_bib57","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/jlcr.3841","article-title":"A novel 99mTc\u2010diester complex as tumor targeting agent: synthesis, radiolabeling, and biological distribution study","volume":"63","author":"Shams El\u2010Din","year":"2020","journal-title":"J. Label. Compd. Radiopharm."},{"key":"10.1016\/j.apradiso.2026.112806_bib58","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12941-024-00667-6","article-title":"Combination antimicrobial therapy: in vitro synergistic effect of anti-staphylococcal drug oxacillin with antimicrobial peptide nisin against Staphylococcus epidermidis clinical isolates and Staphylococcus aureus biofilms","volume":"23","author":"Sharafi","year":"2024","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"issue":"23","key":"10.1016\/j.apradiso.2026.112806_bib59","first-page":"1","article-title":"Biochemistry of microbial itaconic acid production","volume":"4","author":"Steiger","year":"2013","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.apradiso.2026.112806_bib60","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-8051(02)00348-7","article-title":"99mTc-alafosfalin: an antibiotic peptide infection imaging agent","volume":"30","author":"Tsopelas","year":"2003","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.apradiso.2026.112806_bib61","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1007\/s10570-020-02983-4","article-title":"Sodium itaconate grafted nanocellulose for facile elimination of lead ions from water","volume":"27","author":"Vadakkekara","year":"2020","journal-title":"Cellulose"},{"issue":"6","key":"10.1016\/j.apradiso.2026.112806_bib62","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-0037-1620660","article-title":"99mTc-labelled compounds prepared with sodium dithionite as reducing agent","volume":"20","author":"Vil\u010dek","year":"1981","journal-title":"Nuklearmedizin"},{"issue":"19","key":"10.1016\/j.apradiso.2026.112806_bib63","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.3390\/ijms20194777","article-title":"Itaconic acid: a natural metabolite with broad-spectrum antibacterial activity","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib64","first-page":"34","article-title":"Biological evaluation of 99mTc-Kanamycin for infection imaging","volume":"2","author":"Widyasari","year":"2017","journal-title":"Indones. J. Phys. Nucl. Appl."},{"issue":"5","key":"10.1016\/j.apradiso.2026.112806_bib65","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/metabo11050270","article-title":"Validation, and initial application of sensitive LC-MS\/MS assay for quantification of the naturally occurring isomers itaconate, mesaconate, and citraconate","volume":"11","author":"Winterhoff","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.apradiso.2026.112806_bib66","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s11658-023-00503-3","article-title":"Metabolite itaconate in host immunoregulation and defense","volume":"28","author":"Yang","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.apradiso.2026.112806_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97352-x","article-title":"Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS","volume":"11","author":"Zhu","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Applied Radiation and Isotopes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804326003908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969804326003908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:18:22Z","timestamp":1788779902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969804326003908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":67,"alternative-id":["S0969804326003908"],"URL":"https:\/\/doi.org\/10.1016\/j.apradiso.2026.112806","relation":{},"ISSN":["0969-8043"],"issn-type":[{"value":"0969-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiolabeling, characterization, and bioevaluation of 99mTc-Itaconic acid for detection of inflammation in mice","name":"articletitle","label":"Article Title"},{"value":"Applied Radiation and Isotopes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apradiso.2026.112806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112806"}}