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EL PA\u00cdS, 17 de julio de 2007. [consultado 1\/5\/2011]. Disponible en: http:\/\/www.elpais.com\/articulo\/salud\/dentistas\/usan\/demasiados\/antibioticos\/elpepusocsal\/20070717elpepisal_1\/Tes"},{"key":"10.1016\/j.aprim.2011.06.009_bib0380","first-page":"363","article-title":"Documento de consenso sobre el tratamiento antimicrobiano de las infecciones bacterianas odontog\u00e9nicas","volume":"9","author":"Bascones","year":"2004","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.aprim.2011.06.009_bib0385","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/jac\/dkm090","article-title":"Incidence of antibiotic prescribing in dental practice in Norway and its contribution to national consumption","volume":"59","author":"Al-Haroni","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.aprim.2011.06.009_bib0390","unstructured":"Sim\u00f3 J. 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Treinta a\u00f1os de la Federaci\u00f3n de Asociaciones para la Defensa de la Sanidad P\u00fablica (1981-2011) (en prensa)."}],"container-title":["Atenci\u00f3n Primaria"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0212656711004082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0212656711004082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T18:25:05Z","timestamp":1560882305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0212656711004082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":78,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0212656711004082"],"URL":"https:\/\/doi.org\/10.1016\/j.aprim.2011.06.009","relation":{},"ISSN":["0212-6567"],"issn-type":[{"value":"0212-6567","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}