{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:59:55Z","timestamp":1780959595234,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"NIPER \u2013 Ahmedabad","award":["NIPERA160712"],"award-info":[{"award-number":["NIPERA160712"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.apsb.2014.02.002","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T07:15:13Z","timestamp":1396422913000},"page":"151-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route"],"prefix":"10.1016","volume":"4","author":[{"given":"Rudree","family":"Pathak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjeet","family":"Prasad Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Nivsarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2014.02.002_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood\u2013brain barrier: bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.apsb.2014.02.002_bib2","first-page":"46","article-title":"Bypassing the blood-brain barrier to delivery therapeutic agents to the brain and spinal cord","volume":"2","author":"Frey","year":"2002","journal-title":"Drug Deliv Technol"},{"key":"10.1016\/j.apsb.2014.02.002_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","article-title":"Delivery of insulin like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration","volume":"127","author":"Thorne","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.apsb.2014.02.002_bib4","first-page":"64","article-title":"Approaches for drug deposition in the human olfactory epithelium","volume":"5","author":"Dhanda","year":"2005","journal-title":"Drug Deliv Technol"},{"key":"10.1016\/j.apsb.2014.02.002_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1211\/0022357022539","article-title":"Is nose-to-brain transport of drugs in man a reality?","volume":"56","author":"Illum","year":"2004","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.apsb.2014.02.002_bib6","first-page":"522","article-title":"Distribution of nimodipine in brain following intranasal administration in rats","volume":"25","author":"Zhang","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2014.02.002_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1248\/cpb.38.176","article-title":"Utility of 2-hydroxypropyl-\u03b2-cyclodextrin in an intramuscular injectable preparation of nimodipine","volume":"38","author":"Yoshida","year":"1990","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.apsb.2014.02.002_bib8","first-page":"861","article-title":"Nifedipine and nimodipine solubility in the presence of diheptanoyl phosphatidylcholine","volume":"47","author":"Glertlova","year":"1992","journal-title":"Pharmazie"},{"key":"10.1016\/j.apsb.2014.02.002_bib9","first-page":"293","article-title":"The influence of age on the pharmacokinetics of nimodipine","volume":"34","author":"M\u00fcck","year":"1996","journal-title":"Int J Clin Pharmacol"},{"key":"10.1016\/j.apsb.2014.02.002_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijpharm.2004.01.039","article-title":"Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain","volume":"275","author":"Zhang","year":"2004","journal-title":"Int J Pharm"},{"key":"10.1016\/j.apsb.2014.02.002_bib11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v16.i5.20","article-title":"Microemulsions: an overview and pharmaceutical applications","volume":"16","author":"Tenjarla","year":"1999","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"10.1016\/j.apsb.2014.02.002_bib12","series-title":"Pharmaceutical dosage forms: disperse systems","author":"Lieberman","year":"1996"},{"key":"10.1016\/j.apsb.2014.02.002_bib13","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/jps.2600830336","article-title":"Reduced inter-and intra-individual variability in cyclosporine pharmacokinetics from a microemulsion formulation","volume":"83","author":"Kovarik","year":"1994","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.apsb.2014.02.002_bib14","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1208\/pt070108","article-title":"Preliminary brain targeting studies on intranasal mucoadhesive microemulsions of Sumatriptan","volume":"7","author":"Vyas","year":"2006","journal-title":"AAPS Pharm Sci Tech"},{"key":"10.1016\/j.apsb.2014.02.002_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2011.02.040","article-title":"Poly(ethelene oxide\/propelene oxide) copolymer thermoreversible gelling system for the enhancement of intranasal zidovudine to the brain","volume":"411","author":"Ved","year":"2011","journal-title":"Int J Pharm Sci"},{"key":"10.1016\/j.apsb.2014.02.002_bib16","first-page":"1","article-title":"Various evaluation parameters used for the evaluation of different mucoadhesive dosage forms: a review","volume":"2","author":"Alexander","year":"2011","journal-title":"Int J Drug Formul Res"},{"key":"10.1016\/j.apsb.2014.02.002_bib17","first-page":"56","article-title":"Design and development of carbamazepine mucoadhesive microemulsion for intranasal delivery: an ex-vivo study","volume":"3","author":"Mandal","year":"2010","journal-title":"Int J Pharma Sci Rev Res"},{"key":"10.1016\/j.apsb.2014.02.002_bib18","first-page":"130","article-title":"Bioanalytics of nimodipine \u2013 an overview of methods","volume":"49","author":"Muck","year":"1994","journal-title":"Pharmazie"},{"key":"10.1016\/j.apsb.2014.02.002_bib19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0169-409X(00)00103-4","article-title":"Microemulsion based media as novel drug delivery system","volume":"45","author":"Lawrence","year":"2000","journal-title":"Adv Drug Del Rev"},{"key":"10.1016\/j.apsb.2014.02.002_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0928-0987(00)00087-7","article-title":"Transport of drugs from the nasal cavity to the central nervous system","volume":"11","author":"Illum","year":"2000","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.apsb.2014.02.002_bib21","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S1359-6446(02)02529-1","article-title":"Nasal drug delivery: new developments and strategies","volume":"7","author":"Illum","year":"2002","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.apsb.2014.02.002_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0168-3659(02)00363-2","article-title":"Nasal drug delivery-possibilities, problems and solutions","volume":"87","author":"Illum","year":"2003","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2014.02.002_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00418-008-0410-2","article-title":"Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat","volume":"130","author":"Wolburg","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.apsb.2014.02.002_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejpb.2007.05.008","article-title":"The addition of calcium ions to starch\/Carbopol(R) mixtures enhances the nasal bioavailability of insulin","volume":"68","author":"Pringels","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.apsb.2014.02.002_bib25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ejpb.2004.10.001","article-title":"The influence of gellan gum on the transfer of fluorescein dextran across rat nasal epithelium in vivo","volume":"59","author":"Jansson","year":"2005","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.apsb.2014.02.002_bib26","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.addr.2005.07.009","article-title":"Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives","volume":"57","author":"Ugwoke","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2014.02.002_bib27","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejpb.2008.08.015","article-title":"Oral microemulsions of paclitaxel: in situ and pharmacokinetic studies","volume":"71","author":"Nornoo","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.apsb.2014.02.002_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2004.03.001","article-title":"Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo","volume":"278","author":"Cornaire","year":"2004","journal-title":"Int J Pharm"},{"key":"10.1016\/j.apsb.2014.02.002_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-3659(99)00228-X","article-title":"Lectin-mediated drug delivery: the second generation of bioadhesives","volume":"65","author":"Lehr","year":"2000","journal-title":"J Control Release"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383514000227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383514000227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:34:24Z","timestamp":1761928464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383514000227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S2211383514000227"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2014.02.002","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2014.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}