{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:06:00Z","timestamp":1788357960381,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T00:00:00Z","timestamp":1400803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cientifico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Rio Grande do Sul","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.apsb.2014.05.001","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T13:13:12Z","timestamp":1402492392000},"page":"358-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats"],"prefix":"10.1016","volume":"4","author":[{"given":"Aline Augusti","family":"Boligon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Borba","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiele Faccim","family":"de Brum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Pansera","family":"Waczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Vargas","family":"Klimaczewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana Silva","family":"de \u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareth Linde","family":"Athayde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"de Freitas Bauermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2014.05.001_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: bench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2014.05.001_bib2","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/j.fct.2010.07.007","article-title":"Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn)","volume":"48","author":"Shaker","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2014.05.001_bib3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2165\/00002512-200724080-00005","article-title":"Direct medical costs of serious gastrointestinal ulcers among users of NSAIDs","volume":"24","author":"Vonkeman","year":"2007","journal-title":"Drugs Aging"},{"key":"10.1016\/j.apsb.2014.05.001_bib4","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1016\/j.fct.2008.06.007","article-title":"Diphenyl diselenide reverses gastric lesions in rats: involvement of oxidative stress","volume":"46","author":"Ineu","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2014.05.001_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jep.2013.04.007","article-title":"Protective effect of ethyl acetate fraction of Acacia ferruginea DC. against ethanol-induced gastric ulcer in rats","volume":"148","author":"Sowndhararajan","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.apsb.2014.05.001_bib6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/BF02088232","article-title":"Gastric injury induced by ethanol and ischemia-reperfusion in the rat","volume":"41","author":"Smith","year":"1996","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.apsb.2014.05.001_bib7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cbi.2007.06.040","article-title":"Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats","volume":"170","author":"Cadirci","year":"2007","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.apsb.2014.05.001_bib8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/0960327110377646","article-title":"Effect of Vernonia cognata on oxidative damage induced by ethanol in rats","volume":"30","author":"Mota","year":"2011","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.apsb.2014.05.001_bib9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.etap.2012.04.009","article-title":"Protective effect of l-citrulline against ethanol-induced gastric ulcer in rats","volume":"34","author":"Liu","year":"2012","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.apsb.2014.05.001_bib10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.fct.2008.10.026","article-title":"Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats","volume":"47","author":"Choi","year":"2009","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2014.05.001_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0300-483X(02)00514-0","article-title":"The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions","volume":"183","author":"Kaharaman","year":"2003","journal-title":"Toxicol"},{"key":"10.1016\/j.apsb.2014.05.001_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.fct.2012.12.038","article-title":"Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats","volume":"55","author":"Amaral","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2014.05.001_bib13","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/bmj.323.7319.980","article-title":"ABC of the upper gastrointestinal tract: pathophysiology of duodenal and gastric ulcer and gastric cancer","volume":"323","author":"Calam","year":"2001","journal-title":"Br Med J"},{"key":"10.1016\/j.apsb.2014.05.001_bib14","first-page":"693","article-title":"Involvement of reactive oxygen species in gastric ulceration: protection by melatonin","volume":"40","author":"Bandyopadhyay","year":"2002","journal-title":"Ind J Exp Biol"},{"key":"10.1016\/j.apsb.2014.05.001_bib15","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3390\/molecules14030979","article-title":"Flavonoids with gastroprotective activity","volume":"14","author":"Mota","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.apsb.2014.05.001_bib16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jep.2007.02.024","article-title":"Antiulcerogenic activity of Zizyphus lotus (L.) extracts","volume":"112","author":"Wahida","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.apsb.2014.05.001_bib17","first-page":"188","article-title":"Rutin, a natural flavonoid, protects against gastric mucosal damage in experimental animals","volume":"4","author":"Hussain","year":"2009","journal-title":"Asian J Tradit Med"},{"key":"10.1016\/j.apsb.2014.05.001_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jep.2010.11.049","article-title":"Antiulcerogenic activity of Lantana camara leaves on gastric and duodenal ulcers in experimental rats","volume":"134","author":"Sathish","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.apsb.2014.05.001_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3923\/rjmp.2012.47.55","article-title":"Antioxidant and anti-ulcerogenic activity of wild Punica granatum ethanolic seed extracts","volume":"6","author":"Gill","year":"2012","journal-title":"Res J Med Plant"},{"key":"10.1016\/j.apsb.2014.05.001_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-0028-1100145","article-title":"Erstuntersuchungen na Coronilha-Scutia buxifolia Reissek","volume":"12","author":"Wasicky","year":"1964","journal-title":"Planta M\u00e9d"},{"key":"10.1016\/j.apsb.2014.05.001_bib21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jep.2012.03.045","article-title":"Endothelium-dependent and independent vasorelaxation induced by an n-butanolic fraction of bark of Scutia buxifolia Reiss (Rhamanaceae)","volume":"141","author":"Da Silva","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.apsb.2014.05.001_bib22","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.phytochem.2011.02.019","article-title":"Cyclopeptide alkaloids from Scutia buxifolia Reiss","volume":"72","author":"Maldaner","year":"2011","journal-title":"Phytochem"},{"key":"10.1016\/j.apsb.2014.05.001_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1590\/S0102-695X2011005000182","article-title":"Antimycobacterial activity of the fractions and compounds from Scutia buxifolia","volume":"22","author":"Boligon","year":"2012","journal-title":"Rev Bras Farmacognosia"},{"key":"10.1016\/j.apsb.2014.05.001_bib24","first-page":"450","article-title":"Phytoconstituents isolated from dichloromethane fraction of Scutia buxifolia Reissek stem bark","volume":"29","author":"Boligon","year":"2010","journal-title":"Latin Am J Pharm"},{"key":"10.1016\/j.apsb.2014.05.001_bib25","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.1016\/j.biortech.2009.03.091","article-title":"Antioxidant activities of flavonol derivatives from the leaves and stem bark of Scutia buxifolia Reiss","volume":"100","author":"Boligon","year":"2009","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.apsb.2014.05.001_bib26","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1016\/j.phytochem.2005.08.016","article-title":"Cyclopeptide alkaloids from Scutia buxifolia Reiss and their antimicrobial activity","volume":"66","author":"Morel","year":"2005","journal-title":"Phytochem"},{"key":"10.1016\/j.apsb.2014.05.001_bib27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/14786419.2010.535151","article-title":"Antimicrobial and cytotoxic activities of leaves, twigs and stem bark of Scutia buxifolia Reissek","volume":"26","author":"Boligon","year":"2012","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.apsb.2014.05.001_bib28","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s11738-013-1259-0","article-title":"Antimicrobial and antiviral activity-guided fractionation from Scutia buxifolia Reissek extracts","volume":"35","author":"Boligon","year":"2013","journal-title":"Acta Physiol Plantarum"},{"key":"10.1016\/j.apsb.2014.05.001_bib29","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.3390\/molecules18077570","article-title":"Hepatotoxicity evaluation of aqueous extract from Scutia buxifolia","volume":"18","author":"de Freitas","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.apsb.2014.05.001_bib30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin\u2013Ciocalteu reagent","volume":"299","author":"Singleton","year":"1999","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.apsb.2014.05.001_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00218839.1998.11100961","article-title":"Analysis of pr\u00f3polis: some parameters and procedures for chemical quality control","volume":"37","author":"Woisky","year":"1998","journal-title":"J Apic Res"},{"key":"10.1016\/j.apsb.2014.05.001_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/anbo.1995.1097","article-title":"Determination of lignin and tannin contents of cowpea seeds coats","volume":"76","author":"Morrison","year":"1995","journal-title":"Ann Bot"},{"key":"10.1016\/j.apsb.2014.05.001_bib33","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/jaoac\/86.6.1124","article-title":"Spectrophotometric method for estimation of alkaloids precipitable with Dragendorff\u05f3s reagent in plant materials","volume":"86","author":"Sreevidja","year":"2003","journal-title":"J AOAC Int"},{"key":"10.1016\/j.apsb.2014.05.001_bib34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.foodchem.2011.09.026","article-title":"Antioxidant and hepatoprotective activity of ethanolic extract of leaves of Solidago microglossa containing polyphenolic compounds","volume":"131","author":"Sabir","year":"2012","journal-title":"Food Chem"},{"key":"10.1016\/j.apsb.2014.05.001_bib35","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.fct.2013.05.022","article-title":"Antioxidant effect of zinc chloride against ethanol-induced gastrointestinal lesions in rats","volume":"58","author":"Ineu","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2014.05.001_bib36","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1023\/A:1018854107623","article-title":"Relationship between changes of active oxygen metabolism and blood flow and formation, progression, and recovery of lesions in gastric mucosa of rats with a single treatment of compound 48\/80, a mast cell degranulator","volume":"42","author":"Ohta","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.apsb.2014.05.001_bib37","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1089\/jmf.2008.0005","article-title":"Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats","volume":"12","author":"Yam","year":"2009","journal-title":"J Med Food"},{"key":"10.1016\/j.apsb.2014.05.001_bib38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0016-5085(79)90002-7","article-title":"Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury","volume":"77","author":"Robert","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2014.05.001_bib39","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1001\/jama.1977.03280260060025","article-title":"Theory and practice of histological techniques","volume":"238","author":"Vollmer","year":"1977","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.apsb.2014.05.001_bib40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.apsb.2014.05.001_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.apsb.2014.05.001_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.apsb.2014.05.001_bib43","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj1340707","article-title":"The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen","volume":"134","author":"Boveris","year":"1973","journal-title":"Biochem J"},{"key":"10.1016\/j.apsb.2014.05.001_bib44","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2014.05.001_bib45","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jpba.2005.07.006","article-title":"Analytical methods for assay of ellagic acid and its solubility studies","volume":"40","author":"Bala","year":"2006","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.apsb.2014.05.001_bib46","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jep.2008.09.015","article-title":"Evaluation of antiulcer activity of the main phenolic acids found in Brazilian Green Pr\u00f3polis","volume":"120","author":"Barros","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.apsb.2014.05.001_bib47","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.phymed.2010.05.001","article-title":"Antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis root extract in rats","volume":"17","author":"Alimi","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.apsb.2014.05.001_bib48","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jep.2006.08.021","article-title":"Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil","volume":"109","author":"Dordevic","year":"2007","journal-title":"J Ethnopharmacol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383514000422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383514000422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:34:47Z","timestamp":1761928487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383514000422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S2211383514000422"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2014.05.001","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2014.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}