{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:46:02Z","timestamp":1788176762909,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81321004"],"award-info":[{"award-number":["81321004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81361138020"],"award-info":[{"award-number":["81361138020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Mega-project for Innovative Drugs","award":["2012ZX09301002-001"],"award-info":[{"award-number":["2012ZX09301002-001"]}]},{"name":"National Mega-project for Innovative Drugs","award":["2012ZX09301002-005"],"award-info":[{"award-number":["2012ZX09301002-005"]}]},{"name":"National Mega-project for Innovative Drugs","award":["2014ZX09507009"],"award-info":[{"award-number":["2014ZX09507009"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.apsb.2014.06.004","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T10:30:46Z","timestamp":1405420246000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Genetic basis of high level aminoglycoside resistance in Acinetobacter baumannii from Beijing, China"],"prefix":"10.1016","volume":"4","author":[{"given":"Lu","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongying","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiukun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefu","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1016\/j.apsb.2014.06.004_bib1","first-page":"1","article-title":"In vitro activity of colistin plus sulbactam against extensive-drug-resistant Acinetobacter baumannii by checkerboard method","volume":"97 Suppl 3","author":"Thamlikitkul","year":"2014","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.apsb.2014.06.004_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1086\/675612","article-title":"Multidrug-resistant Acinetobacter baumannii infection, colonization, and transmission related to a long-term care facility providing subacute care","volume":"35","author":"Mortensen","year":"2014","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.apsb.2014.06.004_bib3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/CMR.00058-07","article-title":"Acinetobacter baumannii: emergence of a successful pathogen","volume":"21","author":"Peleg","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.apsb.2014.06.004_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1615\/CritRevImmunol.v30.i1.60","article-title":"The global problem of antibiotic resistance","volume":"30","author":"Gootz","year":"2010","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.apsb.2014.06.004_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/0091270011435988","article-title":"Correlation between carbapenem consumption and antimicrobial resistance rates of Acinetobacter baumannii in a university-affiliated hospital in China","volume":"53","author":"Cao","year":"2013","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.apsb.2014.06.004_bib6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1261\/rna.042572.113","article-title":"Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host","volume":"20","author":"Lioy","year":"2014","journal-title":"RNA"},{"key":"10.1016\/j.apsb.2014.06.004_bib7","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/jac\/dkp312","article-title":"Plasmid-mediated 16S rRNA methylases among extended spectrum beta-lactamase producing Salmonella enterica Senftenberg isolates from Algeria","volume":"64","author":"Naas","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.apsb.2014.06.004_bib8","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1128\/AAC.00560-07","article-title":"Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America","volume":"51","author":"Doi","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.apsb.2014.06.004_bib9","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.4161\/rna.25757","article-title":"Riboswitch control of induction of aminoglycoside resistance acetyl and adenyl-transferases","volume":"10","author":"He","year":"2013","journal-title":"RNA Biol"},{"key":"10.1016\/j.apsb.2014.06.004_bib10","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.4155\/fmc.13.80","article-title":"Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections","volume":"5","author":"Labby","year":"2013","journal-title":"Future Med Chem"},{"key":"10.1016\/j.apsb.2014.06.004_bib11","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s10096-010-1004-1","article-title":"Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides","volume":"29","author":"Zhou","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.apsb.2014.06.004_bib12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3904\/kjim.2012.27.2.128","article-title":"Current epidemiology and growing resistance of Gram-negative pathogens","volume":"27","author":"Livermore","year":"2012","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.apsb.2014.06.004_bib13","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1128\/AAC.00300-11","article-title":"Susceptibility of vertilmicin to modifications by three types of recombinant aminoglycoside-modifying enzymes","volume":"55","author":"Yuan","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.apsb.2014.06.004_bib14","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1128\/AAC.00223-09","article-title":"In vivo antibacterial activity of vertilmicin, a new aminoglycoside antibiotic","volume":"53","author":"You","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.apsb.2014.06.004_bib15","first-page":"727","article-title":"Analysis of antibiotic resistance profile and gene patterns for aminoglycoside modifying enzymes in 64 strains of Escherichia coli","volume":"25","author":"Yao","year":"2005","journal-title":"Chin J Microbiol Immunol"},{"key":"10.1016\/j.apsb.2014.06.004_bib16","first-page":"2371","article-title":"Identification on a new subtype gene of aminoglycoside modifying enzyme in multi-drug resistant Acinetobacter baumannii","volume":"18","author":"Zhu","year":"2009","journal-title":"Chin J Nosocomiol"},{"key":"10.1016\/j.apsb.2014.06.004_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/jac\/43.2.253","article-title":"The prevalence of aminoglycoside resistance and corresponding resistance genes in clinical isolates of staphylococci from 19 European hospitals","volume":"43","author":"Schmitz","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.apsb.2014.06.004_bib18","first-page":"677","article-title":"Detection of aminoglycosides resistance condition and the relative genes of Pseudomonas aeruginosa","volume":"27","author":"Tang","year":"2006","journal-title":"Inter J Lab Med"},{"key":"10.1016\/j.apsb.2014.06.004_bib19","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1128\/AAC.47.4.1423-1426.2003","article-title":"Multiplex PCR for detection of aminoglycoside resistance genes in enterococci","volume":"47","author":"Vakulenko","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.apsb.2014.06.004_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1086\/518605","article-title":"16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides","volume":"45","author":"Doi","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.apsb.2014.06.004_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.diagmicrobio.2009.02.010","article-title":"Genetic basis of resistance to aminoglycosides in Acinetobacter spp. and spread of armA in Acinetobacter baumannii sequence group 1 in Korean hospitals","volume":"64","author":"Cho","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.apsb.2014.06.004_bib22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1099\/jmm.0.048991-0","article-title":"Diverse carbapenem-resistance mechanisms in 16S rRNA methylase-producing Acinetobacter baumannii","volume":"62","author":"Yamada","year":"2013","journal-title":"J Med Microbiol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383514000562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383514000562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:33:34Z","timestamp":1761928414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383514000562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S2211383514000562"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2014.06.004","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic basis of high level aminoglycoside resistance in Acinetobacter baumannii from Beijing, China","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2014.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}