{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:34:18Z","timestamp":1792154058104,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51520105004"],"award-info":[{"award-number":["51520105004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51673189"],"award-info":[{"award-number":["51673189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51833010"],"award-info":[{"award-number":["51833010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973215"],"award-info":[{"award-number":["51973215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018ZX09711003-012"],"award-info":[{"award-number":["2018ZX09711003-012"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA198999"],"award-info":[{"award-number":["CA198999"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.apsb.2020.09.004","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T02:48:39Z","timestamp":1600138119000},"page":"2171-2182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy"],"prefix":"10.1016","volume":"10","author":[{"given":"Guofeng","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lushun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghui","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leaf","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4564-9917","authenticated-orcid":false,"given":"Wantong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2020.09.004_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.apsb.2020.09.004_bib2","first-page":"5","article-title":"Report of cancer incidence and mortality in China, 2014","volume":"40","author":"Chen","year":"2018","journal-title":"Chin J Oncol"},{"key":"10.1016\/j.apsb.2020.09.004_bib3","first-page":"1","article-title":"Cancer incidence and mortality in China, 2014","volume":"30","author":"Chen","year":"2018","journal-title":"Chin J Oncol"},{"key":"10.1016\/j.apsb.2020.09.004_bib4","first-page":"87","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.apsb.2020.09.004_bib5","doi-asserted-by":"crossref","first-page":"S248","DOI":"10.1053\/j.gastro.2004.09.039","article-title":"Hepatocellular carcinoma: current surgical management","volume":"127","author":"Song","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2020.09.004_bib6","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2020.09.004_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.canlet.2017.10.008","article-title":"Precision diagnosis and treatment of liver cancer in China","volume":"412","author":"Fu","year":"2018","journal-title":"Cancer lett"},{"key":"10.1016\/j.apsb.2020.09.004_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.actbio.2019.05.028","article-title":"Co-administration of combretastatin A4 nanoparticles and sorafenib for systemic therapy of hepatocellular carcinoma","volume":"92","author":"Wang","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2020.09.004_bib9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrclinonc.2014.122","article-title":"Treatment of intermediate-stage hepatocellular carcinoma","volume":"11","author":"Forner","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.apsb.2020.09.004_bib10","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2020.09.004_bib11","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1002\/cncr.30825","article-title":"A phase 2 study of the efficacy and biomarker on the combination of transarterial chemoembolization and axitinib in the treatment of inoperable hepatocellular carcinoma","volume":"123","author":"Chan","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.apsb.2020.09.004_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1470-2045(08)70285-7","article-title":"Efficacy and safety of sorafenib in patients in the Asia\u2012Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial","volume":"10","author":"Cheng","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.apsb.2020.09.004_bib13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/aps.2017.5","article-title":"New knowledge of the mechanisms of sorafenib resistance in liver cancer","volume":"38","author":"Zhu","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2020.09.004_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.biomaterials.2017.09.017","article-title":"Nanomaterials for cancer immunotherapy","volume":"148","author":"Song","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2020.09.004_bib15","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1038\/s41467-018-04605-x","article-title":"Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap","volume":"9","author":"Song","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2020.09.004_bib16","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41590-018-0044-z","article-title":"The immunology of hepatocellular carcinoma","volume":"19","author":"Ringelhan","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2020.09.004_bib17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrgastro.2015.173","article-title":"Immunological landscape and immunotherapy of hepatocellular carcinoma","volume":"12","author":"Prieto","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2020.09.004_bib18","first-page":"30011","article-title":"Camrelizumab in patients with previously treated advanced hepatocellular carcinoma: a multicentre, open-label, parallel-group, randomised, phase 2 trial","author":"Qin","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.apsb.2020.09.004_bib19","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/S0140-6736(17)31046-2","article-title":"Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1\/2 dose escalation and expansion trial","volume":"389","author":"El-Khoueiry","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2020.09.004_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1189\/JLB.0309135","article-title":"Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases","volume":"86","author":"Gao","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.apsb.2020.09.004_bib21","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.4049\/jimmunol.0711086","article-title":"Enrichment of human CD4+ V(alpha)24\/Vbeta11 invariant NKT cells in intrahepatic malignant tumors","volume":"182","author":"Bricard","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.apsb.2020.09.004_bib22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut\u2012liver axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2020.09.004_bib23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","article-title":"Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4","volume":"21","author":"Dapito","year":"2012","journal-title":"Canc Cell"},{"key":"10.1016\/j.apsb.2020.09.004_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201805007","article-title":"Trapping of lipopolysaccharide to promote immunotherapy against colorectal cancer and attenuate liver metastasis","volume":"30","author":"Song","year":"2018","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2020.09.004_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells","volume":"360","author":"Ma","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.apsb.2020.09.004_bib26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","article-title":"Understanding the holobiont: how microbial metabolites affect human health and shape the immune system","volume":"26","author":"Postler","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.apsb.2020.09.004_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/17512433.2015.1092381","article-title":"Obeticholic acid for the treatment of primary biliary cirrhosis","volume":"9","author":"Trivedi","year":"2016","journal-title":"Expet Rev Clin Pharmacol"},{"key":"10.1016\/j.apsb.2020.09.004_bib28","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/hep.29569","article-title":"A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis","volume":"67","author":"Kowdley","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2020.09.004_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/MOG.0000000000000525","article-title":"Obeticholic acid in primary biliary cholangitis: where we stand","volume":"35","author":"Manne","year":"2019","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.apsb.2020.09.004_bib30","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1371\/journal.pbio.0030113","article-title":"Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids","volume":"3","author":"Geissmann","year":"2005","journal-title":"PLoS Biol"},{"key":"10.1016\/j.apsb.2020.09.004_bib31","doi-asserted-by":"crossref","first-page":"10130","DOI":"10.1021\/acsnano.8b04947","article-title":"Dense and dynamic polyethylene glycol shells cloak nanoparticles from uptake by liver endothelial cells for long blood circulation","volume":"12","author":"Zhou","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2020.09.004_bib32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.trecan.2020.01.011","article-title":"Nanotherapeutics for immuno-oncology: a crossroad for new paradigms","volume":"6","author":"Song","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.apsb.2020.09.004_bib33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jconrel.2017.11.049","article-title":"Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: formulation development, stability issues, basic considerations and applications","volume":"270","author":"Rai","year":"2018","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2020.09.004_bib34","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.colsurfb.2019.06.006","article-title":"Nanoemulsion improves hypoglycemic efficacy of berberine by overcoming its gastrointestinal challenge","volume":"181","author":"Xu","year":"2019","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.apsb.2020.09.004_bib35","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1038\/s41598-017-12629-4","article-title":"The FXR agonist, obeticholic acid, suppresses HCC proliferation & metastasis: role of IL-6\/STAT3 signalling pathway","volume":"7","author":"Attia","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2020.09.004_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210077","article-title":"The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma","volume":"14","author":"Di Matteo","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.09.004_bib37","doi-asserted-by":"crossref","first-page":"10980","DOI":"10.1073\/pnas.1106634108","article-title":"Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform","volume":"108","author":"Hu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.09.004_bib38","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.apsb.2019.06.001","article-title":"Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma","volume":"9","author":"Zhao","year":"2019","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2020.09.004_bib39","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1055\/s-2008-1040583","article-title":"The intrahepatic biliary epithelium: an area of\u00a0growing interest in hepatology","volume":"7","author":"Tavoloni","year":"1987","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.apsb.2020.09.004_bib40","first-page":"757","article-title":"The numerical proportions of cell types in rat liver during carcinogenesis by 4-dimethylaminoazobenzene (DAB)","volume":"19","author":"Daoust","year":"1959","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2020.09.004_bib41","first-page":"1365","article-title":"Cellular distribution of injected PLGA-nanoparticles in the live","volume":"12","author":"Park","year":"2016","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.apsb.2020.09.004_bib42","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41575-018-0020-y","article-title":"Liver sinusoidal endothelial cells\u2014gatekeepers of hepatic immunity","volume":"15","author":"Shetty","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2020.09.004_bib43","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2353\/ajpath.2007.060929","article-title":"Murine models to evaluate novel and conventional therapeutic strategies for cancer","volume":"170","author":"Talmadge","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2020.09.004_bib44","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.7150\/thno.31683","article-title":"Evaluation of polymer nanoformulations in hepatoma therapy by established rodent models","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2020.09.004_bib45","first-page":"1604","article-title":"Generation of effective antitumor vaccines using photodynamic therapy","volume":"62","author":"Gollnick","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2020.09.004_bib46","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1158\/0008-5472.1018.65.3","article-title":"Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response","volume":"65","author":"Korbelik","year":"2005","journal-title":"Cancer Res"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383520307048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383520307048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:47:59Z","timestamp":1761929279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383520307048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2211383520307048"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2020.09.004","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2020.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}