{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:14:05Z","timestamp":1792854845544,"version":"4.5.0"},"reference-count":183,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2019XZZX004-17"],"award-info":[{"award-number":["2019XZZX004-17"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630098"],"award-info":[{"award-number":["81630098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773703"],"award-info":[{"award-number":["81773703"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81822044"],"award-info":[{"award-number":["81822044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.apsb.2020.10.018","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T07:59:24Z","timestamp":1604044764000},"page":"1708-1720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"title":["Natural compounds modulate the autophagy with potential implication of stroke"],"prefix":"10.1016","volume":"11","author":[{"given":"Anil","family":"Ahsan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1271-0283","authenticated-orcid":false,"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-9272","authenticated-orcid":false,"given":"Shijia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-550X","authenticated-orcid":false,"given":"Zhanxun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-7403","authenticated-orcid":false,"given":"Xiangnan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2020.10.018_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12264-009-0104-3","article-title":"The mechanisms of brain ischemic insult and potential protective interventions","volume":"25","author":"Guo","year":"2009","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.apsb.2020.10.018_bib2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.neuropharm.2008.01.005","article-title":"Mechanisms of ischemic brain damage","volume":"55","author":"Doyle","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.apsb.2020.10.018_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.116.308413","article-title":"Global burden of stroke","volume":"120","author":"Feigin","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib4","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(08)60694-7","volume":"371","author":"Donnan","year":"2008","journal-title":"Stroke. Lancet"},{"key":"10.1016\/j.apsb.2020.10.018_bib5","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1161\/01.STR.0000025518.34157.51","article-title":"Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions","volume":"33","author":"Gladstone","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.apsb.2020.10.018_bib6","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1212\/01.WNL.0000151850.39648.51","article-title":"California Acute Stroke Pilot Registry (CASPR) Investigators. Prioritizing interventions to improve rates of thrombolysis for ischemic stroke","volume":"64","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.apsb.2020.10.018_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles","volume":"16","author":"Galluzzi","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2020.10.018_bib8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrn.2016.51","article-title":"Autophagy in acute brain injury","volume":"17","author":"Galluzzi","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.apsb.2020.10.018_bib9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4161\/auto.6.4.11737","article-title":"Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning","volume":"6","author":"Sheng","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4161\/auto.8.1.18274","article-title":"Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia","volume":"8","author":"Wang","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib11","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.4161\/auto.25132","article-title":"Cerebral ischemia\u2013reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance","volume":"9","author":"Zhang","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib12","doi-asserted-by":"crossref","first-page":"762","DOI":"10.4161\/auto.6412","article-title":"Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways","volume":"4","author":"Wen","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib13","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2353\/ajpath.2006.051066","article-title":"Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy","volume":"169","author":"Adhami","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2020.10.018_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4161\/auto.8.1.18217","article-title":"Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction","volume":"8","author":"Xing","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(12)70725-9","article-title":"Neuronal autophagy in cerebral ischemia\u2014a potential target for neuroprotective strategies?.","volume":"64","author":"Gabryel","year":"2012","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.apsb.2020.10.018_bib16","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.4161\/auto.32136","article-title":"Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: involvement of PARK2-dependent mitophagy","volume":"10","author":"Zhang","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nm.3097","article-title":"Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy","volume":"19","author":"Papadakis","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22236","article-title":"Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway","volume":"69","author":"Wang","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.apsb.2020.10.018_bib19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/15548627.2016.1274596","article-title":"PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window","volume":"13","author":"Shen","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","article-title":"Autophagy in ischemic stroke","volume":"163\u2013164","author":"Wang","year":"2018","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.apsb.2020.10.018_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI73938","article-title":"Development of autophagy inducers in clinical medicine","volume":"125","author":"Levine","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2020.10.018_bib22","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.apsb.2020.01.001","article-title":"Natural products, PGC-1\u03b1, and Duchenne muscular dystrophy","volume":"10","author":"Suntar","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2020.10.018_bib23","first-page":"1487","article-title":"New concepts in nutraceuticals as alternative for pharmaceuticals","volume":"5","author":"Nasri","year":"2014","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib24","first-page":"1","article-title":"The history and ups and downs of herbal medicines usage","volume":"3","author":"Sewell","year":"2014","journal-title":"J HerbMed Pharmacol"},{"key":"10.1016\/j.apsb.2020.10.018_bib25","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s11064-012-0786-1","article-title":"Catechin hydrate ameliorates redox imbalance and limits inflammatory response in focal cerebral ischemia","volume":"37","author":"Ashafaq","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at ER\u2013mitochondria contact sites","volume":"495","author":"Hamasaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2020.10.018_bib29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04135","article-title":"Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER\u2013Golgi intermediate compartment","volume":"3","author":"Ge","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.apsb.2020.10.018_bib30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2011.06.023","article-title":"Autophagosome precursor maturation requires homotypic fusion","volume":"146","author":"Moreau","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib31","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/ncomms2927","article-title":"Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice","volume":"4","author":"Pozueta","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2020.10.018_bib32","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1091\/mbc.e10-05-0457","article-title":"Membrane delivery to the yeast autophagosome from the Golgi\u2013endosomal system","volume":"21","author":"Ohashi","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib33","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.15252\/embj.201490315","article-title":"Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis","volume":"34","author":"Shpilka","year":"2015","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2020.10.018_bib34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2011.06.022","article-title":"SNARE proteins are required for macroautophagy","volume":"146","author":"Nair","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib35","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1091\/mbc.e08-12-1249","article-title":"ULK\u2212Atg 13\u2212FIP200 complexes mediate mTOR signaling to the autophagy machinery","volume":"20","author":"Jung","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib36","doi-asserted-by":"crossref","first-page":"12297","DOI":"10.1074\/jbc.M900573200","article-title":"ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy","volume":"284","author":"Ganley","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.10.018_bib37","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1091\/mbc.e08-12-1248","article-title":"Nutrient-dependent mTORC1 association with the ULK1\u2013Atg 13\u2013FIP200 complex required for autophagy","volume":"20","author":"Hosokawa","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib38","doi-asserted-by":"crossref","first-page":"649","DOI":"10.4161\/auto.5.5.8249","article-title":"A novel, human Atg 13 binding protein, Atg 101, interacts with ULK1 and is essential for macroautophagy","volume":"5","author":"Mercer","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib39","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.apsb.2019.10.003","article-title":"Targeting autophagy-related protein kinases for potential therapeutic purpose","volume":"10","author":"Xiang","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2020.10.018_bib40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tcb.2010.03.002","article-title":"The Beclin 1-VPS34 complex\u2014at the crossroads of autophagy and beyond","volume":"20","author":"Funderburk","year":"2010","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","article-title":"Mammalian autophagy: core molecular machinery and signaling regulation","volume":"22","author":"Yang","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35056522","article-title":"Molecular dissection of autophagy: two ubiquitin-like systems","volume":"2","author":"Ohsumi","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/embor.2008.163","article-title":"The Atg 8 and Atg 12 ubiquitin-like conjugation systems in macroautophagy. \u2018Protein modifications: beyond the usual suspects\u2019 review series","volume":"9","author":"Geng","year":"2008","journal-title":"EMBO Rep"},{"key":"10.1016\/j.apsb.2020.10.018_bib44","doi-asserted-by":"crossref","first-page":"37298","DOI":"10.1074\/jbc.C700195200","article-title":"The Atg 12\u2013Atg 5 conjugate has a novel E3-like activity for protein lipidation in autophagy","volume":"282","author":"Hanada","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.10.018_bib45","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1091\/mbc.e07-12-1257","article-title":"The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy","volume":"19","author":"Fujita","year":"2008","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib46","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1242\/jcs.01370","article-title":"Role for Rab 7 in maturation of late autophagic vacuoles","volume":"117","author":"Jager","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.apsb.2020.10.018_bib47","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/35022595","article-title":"Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice","volume":"406","author":"Tanaka","year":"2000","journal-title":"Nature"},{"issue":"Suppl 2","key":"10.1016\/j.apsb.2020.10.018_bib48","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/sj.cdd.4401751","article-title":"Autophagy and signaling: their role in cell survival and cell death","volume":"12","author":"Codogno","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.apsb.2020.10.018_bib49","doi-asserted-by":"crossref","first-page":"pe24","DOI":"10.1126\/scisignal.267pe24","article-title":"The pharmacology of mTOR inhibition","volume":"2","author":"Guertin","year":"2009","journal-title":"Sci Signal"},{"key":"10.1016\/j.apsb.2020.10.018_bib50","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","article-title":"TOR, a central controller of cell growth","volume":"103","author":"Schmelzle","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(06)00122-9","article-title":"Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B\u03b1","volume":"7","author":"Alessi","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib52","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1126\/science.277.5325.567","article-title":"Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B","volume":"277","author":"Stokoe","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.apsb.2020.10.018_bib53","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2005.02.053","article-title":"Rheb binds and regulates the mTOR kinase","volume":"15","author":"Long","year":"2005","journal-title":"Curr Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molcel.2006.12.009","article-title":"Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2","volume":"25","author":"Hoyer-Hansen","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib55","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ncb1537","article-title":"The energy sensing LKB1\u2013AMPK pathway regulates p27(kip 1) phosphorylation mediating the decision to enter autophagy or apoptosis","volume":"9","author":"Liang","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib56","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.molcel.2008.06.001","article-title":"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy","volume":"30","author":"Wei","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib57","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ncb1740","article-title":"Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking","volume":"10","author":"Liang","year":"2008","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib58","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/cr.2007.78","article-title":"Physiological functions of Atg 6\/Beclin 1: a unique autophagy-related protein","volume":"17","author":"Cao","year":"2007","journal-title":"Cell Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.apsb.2020.10.018_bib60","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.apsb.2020.10.018_bib61","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.apsb.2020.10.018_bib62","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tibs.2006.11.001","article-title":"Cell death by necrosis: towards a molecular definition","volume":"32","author":"Golstein","year":"2007","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.apsb.2020.10.018_bib63","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1083\/jcb.201408075","article-title":"Ypt1\/Rab 1 regulates Hrr25\/CK1delta kinase activity in ER\u2013Golgi traffic and macroautophagy","volume":"210","author":"Wang","year":"2015","journal-title":"J Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib64","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/sj.cdd.4402200","article-title":"Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium","volume":"14","author":"Hoyer-Hansen","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.apsb.2020.10.018_bib65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2016.08.008","article-title":"ER stress and impaired autophagy flux in neuronal degeneration and brain injury","volume":"34","author":"Yin","year":"2017","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.apsb.2020.10.018_bib66","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2020.10.018_bib67","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ceb.2004.09.012","article-title":"Misfolded proteins, endoplasmic reticulum stress and neurodegeneration","volume":"16","author":"Rao","year":"2004","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib68","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2006.01.010","article-title":"Hypoxia-induced energy stress regulates mRNA translation and cell growth","volume":"21","author":"Liu","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2020.10.018_bib69","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nri2359","article-title":"The endoplasmic reticulum stress response in immunity and autoimmunity","volume":"8","author":"Todd","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2020.10.018_bib70","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tem.2012.06.003","article-title":"New insights into ER stress-induced insulin resistance","volume":"23","author":"Flamment","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.apsb.2020.10.018_bib71","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/cbin.10299","article-title":"AMP-activated protein kinase is involved in induction of protective autophagy in astrocytes exposed to oxygen-glucose deprivation","volume":"38","author":"Gabryel","year":"2014","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.apsb.2020.10.018_bib72","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1111\/bph.12655","article-title":"Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy","volume":"171","author":"Jiang","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.10.018_bib73","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4161\/auto.29203","article-title":"ARRB1\/beta-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia","volume":"10","author":"Wang","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib74","doi-asserted-by":"crossref","first-page":"20491","DOI":"10.1073\/pnas.1206530109","article-title":"Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death","volume":"109","author":"Cheung","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.10.018_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087371","article-title":"Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells","volume":"9","author":"Mahalingaiah","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.10.018_bib76","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"Liu","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib77","first-page":"397","article-title":"When autophagy meets cancer through p62\/SQSTM1","volume":"2","author":"Puissant","year":"2012","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib78","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12943-017-0661-4","article-title":"C10ORF10\/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy","volume":"16","author":"Salcher","year":"2017","journal-title":"Mol Cancer"},{"key":"10.1016\/j.apsb.2020.10.018_bib79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2017.05.026","article-title":"Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK\u2013eIF2alpha\u2013ATF4 pathway","volume":"110","author":"Kim","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib80","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/cns.12005","article-title":"A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury","volume":"18","author":"Wei","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.apsb.2020.10.018_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib82","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/NEN.0b013e31821352bd","article-title":"Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy","volume":"70","author":"Wang","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.apsb.2020.10.018_bib83","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/s41401-020-0361-2","article-title":"Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury","volume":"41","author":"Wu","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2020.10.018_bib84","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","article-title":"Protective role of autophagy in neonatal hypoxia\u2013ischemia induced brain injury","volume":"32","author":"Carloni","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.apsb.2020.10.018_bib85","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nbd.2007.08.005","article-title":"Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death","volume":"29","author":"Rami","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.apsb.2020.10.018_bib86","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.2353\/ajpath.2009.090463","article-title":"Enhancement of autophagic flux after neonatal cerebral hypoxia\u2013ischemia and its region-specific relationship to apoptotic mechanisms","volume":"175","author":"Ginet","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2020.10.018_bib87","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1080\/15548627.2017.1357792","article-title":"BNIP3L\/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2","volume":"13","author":"Yuan","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib88","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1083\/jcb.201804101","article-title":"Somatic autophagy of axonal mitochondria in ischemic neurons","volume":"218","author":"Zheng","year":"2019","journal-title":"J Cell Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib89","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/00207454.2015.1059836","article-title":"Endoplasmic reticulum stress in brain ischemia","volume":"126","author":"Su","year":"2016","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.apsb.2020.10.018_bib90","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.jmb.2019.10.013","article-title":"Selective autophagy receptors in neuronal health and disease","volume":"432","author":"Conway","year":"2020","journal-title":"J Mol Biol"},{"key":"10.1016\/j.apsb.2020.10.018_bib91","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1161\/STROKEAHA.117.017287","article-title":"Role of autophagy in endothelial damage and blood\u2013brain barrier disruption in ischemic stroke","volume":"49","author":"Kim","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.apsb.2020.10.018_bib92","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.expneurol.2014.03.002","article-title":"Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia-ischemia: role of protein synthesis and autophagic pathways","volume":"255","author":"Carloni","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.apsb.2020.10.018_bib93","doi-asserted-by":"crossref","first-page":"110591","DOI":"10.1016\/j.fct.2019.110591","article-title":"Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A","volume":"131","author":"Wang","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2020.10.018_bib94","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/ijms21010202","article-title":"Neuroprotective effects of pomegranate juice against Parkinson's disease and presence of ellagitannins-derived metabolite-urolithin A-in the brain","volume":"21","author":"Kujawska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2020.10.018_bib95","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","article-title":"Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents","volume":"22","author":"Ryu","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib96","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/cns.13136","article-title":"Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in\u00a0vitro and in\u00a0vivo","volume":"25","author":"Ahsan","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.apsb.2020.10.018_bib97","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/jphp.12205","article-title":"Protective effect of tomatine against hydrogen peroxide-induced neurotoxicity in neuroblastoma (SH-SY5Y) cells","volume":"66","author":"Huang","year":"2014","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.apsb.2020.10.018_bib98","doi-asserted-by":"crossref","first-page":"46208","DOI":"10.1038\/srep46208","article-title":"Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1\/Nrf 2 pathway","volume":"7","author":"Fang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2020.10.018_bib99","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.2174\/0929867324666170801095850","article-title":"Sarcopenia, aging and prospective interventional strategies","volume":"25","author":"Waltz","year":"2018","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.apsb.2020.10.018_bib100","doi-asserted-by":"crossref","first-page":"173280","DOI":"10.1016\/j.ejphar.2020.173280","article-title":"Tomatidine protects against ischemic neuronal injury by improving lysosomal function","volume":"882","author":"Ahsan","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.apsb.2020.10.018_bib101","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1111\/bph.14706","article-title":"Spermidine-enhanced autophagic flux improves cardiac dysfunction following myocardial infarction by targeting the AMPK\/mTOR signalling pathway","volume":"176","author":"Yan","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.10.018_bib102","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jchemneu.2017.11.006","article-title":"Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: association with neuroprotection of pyramidal cells","volume":"88","author":"Kaplan","year":"2018","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.apsb.2020.10.018_bib104","doi-asserted-by":"crossref","first-page":"e2738","DOI":"10.1038\/cddis.2017.161","article-title":"Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage","volume":"8","author":"Yang","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2020.10.018_bib105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4062\/biomolther.2012.20.1.068","article-title":"Anthocyanin extracts from black soybean (Glycine max L.) protect human glial cells against oxygen\u2013glucose deprivation by promoting autophagy","volume":"20","author":"Kim","year":"2012","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.apsb.2020.10.018_bib106","doi-asserted-by":"crossref","first-page":"105651","DOI":"10.1016\/j.intimp.2019.05.036","article-title":"Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson's disease mouse model","volume":"75","author":"Yang","year":"2019","journal-title":"Int Immunopharm"},{"key":"10.1016\/j.apsb.2020.10.018_bib107","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/aps.2017.208","article-title":"Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPAR\u03b3\/NF-\u03baB\/NLRP3 inflammasome axis","volume":"39","author":"Song","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2020.10.018_bib108","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/molecules24091838","article-title":"The Role of Astragaloside IV against cerebral ischemia\/reperfusion injury: suppression of apoptosis via promotion of P62-LC3-autophagy","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.apsb.2020.10.018_bib109","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jnr.20692","article-title":"Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia","volume":"82","author":"Lim","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib110","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.3892\/mmr.2015.3322","article-title":"Curcumin inhibits autophagy and apoptosis in hypoxia\/reoxygenation-induced myocytes","volume":"11","author":"Huang","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.apsb.2020.10.018_bib111","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainresbull.2015.11.019","article-title":"Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: the possible role of Sirt1 signaling","volume":"121","author":"Miao","year":"2016","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.apsb.2020.10.018_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2018.05.010","article-title":"Curcumin attenuates cerebral ischemia injury in Sprague\u2013Dawley rats and PC12 cells by suppressing overactivated autophagy","volume":"184","author":"Zhang","year":"2018","journal-title":"J Photochem Photobiol B"},{"key":"10.1016\/j.apsb.2020.10.018_bib113","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s13105-014-0342-3","article-title":"Neuroprotective effect of schizandrin A on oxygen and glucose deprivation\/reperfusion-induced cell injury in primary culture of rat cortical neurons","volume":"70","author":"Wang","year":"2014","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.apsb.2020.10.018_bib114","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/jnr.23400","article-title":"A combination of four active compounds alleviates cerebral ischemia\u2013reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK\/mTOR and JNK pathways","volume":"92","author":"Guo","year":"2014","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib115","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.3390\/molecules24193624","article-title":"Schizandrin protects against OGD\/R-induced neuronal injury by suppressing autophagy: involvement of the AMPK\/mTOR Pathway","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.apsb.2020.10.018_bib116","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12035-015-9561-z","article-title":"l-Ascorbate protects against methamphetamine-induced neurotoxicity of cortical cells via inhibiting oxidative stress, autophagy, and apoptosis","volume":"54","author":"Huang","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.apsb.2020.10.018_bib117","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.brainres.2013.08.039","article-title":"Ascorbic acid ameliorates seizures and brain damage in rats through inhibiting autophagy","volume":"1535","author":"Dong","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib118","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbrc.2018.01.091","article-title":"Ginkgolic acid induces interplay between apoptosis and autophagy regulated by ROS generation in colon cancer","volume":"498","author":"Liu","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.apsb.2020.10.018_bib119","first-page":"6400","article-title":"Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway","volume":"15","author":"Qi","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.apsb.2020.10.018_bib120","doi-asserted-by":"crossref","first-page":"103416","DOI":"10.1016\/j.mcn.2019.103416","article-title":"Ginkgolic acid promotes autophagy-dependent clearance of intracellular \u03b1-synuclein aggregates","volume":"101","author":"Vijayakumaran","year":"2019","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.apsb.2020.10.018_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177330","article-title":"Action of tyrosinase on alpha and beta-arbutin: a kinetic study","volume":"12","author":"Garcia-Jimenez","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.10.018_bib122","doi-asserted-by":"crossref","first-page":"16808","DOI":"10.1074\/jbc.M709014200","article-title":"The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease","volume":"283","author":"Tessari","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.10.018_bib123","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12017-019-08562-6","article-title":"\u03b1-Arbutin protects against Parkinson's disease-associated mitochondrial dysfunction in\u00a0vitro and in\u00a0vivo","volume":"22","author":"Ding","year":"2020","journal-title":"NeuroMolecular Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib124","first-page":"2042","article-title":"Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K\/AKT\/mTOR pathway","volume":"11","author":"Qu","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib125","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12640-015-9579-z","article-title":"Glycyrrhizic acid attenuates neuroinflammation and oxidative stress in rotenone model of Parkinson's disease","volume":"29","author":"Ojha","year":"2016","journal-title":"Neurotox Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib126","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1007\/s11064-018-2609-5","article-title":"Glycyrrhizic acid alleviates 6-hydroxydopamine and corticosterone-induced neurotoxicity in SH-SY5Y cells through modulating autophagy","volume":"43","author":"Yang","year":"2018","journal-title":"Neurochem Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib127","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuroscience.2007.07.037","article-title":"Analysis of the action of euxanthone, a plant-derived compound that stimulates neurite outgrowth","volume":"148","author":"Naidu","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.apsb.2020.10.018_bib128","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopha.2018.04.090","article-title":"Autophagy is a pro-survival mechanism in ovarian cancer against the apoptotic effects of euxanthone","volume":"103","author":"Zhu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2020.10.018_bib129","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12031-018-1175-2","article-title":"Euxanthone Attenuates A\u03b21\u201342-induced oxidative stress and apoptosis by triggering autophagy","volume":"66","author":"Yuan","year":"2018","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.apsb.2020.10.018_bib130","doi-asserted-by":"crossref","first-page":"112319","DOI":"10.1016\/j.bbr.2019.112319","article-title":"Cornel iridoid glycoside improves cognitive impairment induced by chronic cerebral hypoperfusion via activating PI3K\/Akt\/GSK-3\u03b2\/CREB pathway in rats","volume":"379","author":"Wang","year":"2020","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib131","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s11064-018-2501-3","article-title":"Protective effects of cornel iridoid glycoside in rats after traumatic brain injury","volume":"43","author":"Ma","year":"2018","journal-title":"Neurochem Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib132","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s11418-019-01318-3","article-title":"Cornel iridoid glycoside induces autophagy to protect against tau oligomer neurotoxicity induced by the activation of glycogen synthase kinase-3 beta","volume":"73","author":"Yang","year":"2019","journal-title":"J Nat Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib133","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2017.02.027","article-title":"Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1\/AMPK signaling pathway","volume":"348","author":"Zhao","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.apsb.2020.10.018_bib134","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3390\/nu9090927","article-title":"Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer's disease","volume":"9","author":"Kou","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.apsb.2020.10.018_bib135","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/hmg\/ddq460","article-title":"ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease","volume":"20","author":"Maher","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.apsb.2020.10.018_bib136","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuint.2017.05.013","article-title":"Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation","volume":"117","author":"Vidoni","year":"2018","journal-title":"Neurochem Int"},{"key":"10.1016\/j.apsb.2020.10.018_bib137","first-page":"4823","article-title":"Genistein and Myd88 activate autophagy in high glucose-induced renal podocytes in\u00a0vitro","volume":"24","author":"Wang","year":"2018","journal-title":"Med Sci Mon Int Med J Exp Clin Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib138","doi-asserted-by":"crossref","first-page":"17054","DOI":"10.1074\/jbc.M114.555300","article-title":"The phytoestrogen genistein modulates lysosomal metabolism and transcription factor EB (TFEB) activation","volume":"289","author":"Moskot","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.10.018_bib139","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuropharm.2019.01.030","article-title":"Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer's disease","volume":"148","author":"Pierzynowska","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.apsb.2020.10.018_bib140","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4103\/1673-5374.235250","article-title":"Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant \u03b1-synuclein","volume":"13","author":"Wu","year":"2018","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib141","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12017-018-8482-1","article-title":"Correction of Huntington's disease phenotype by genistein-induced autophagy in the cellular model","volume":"20","author":"Pierzynowska","year":"2018","journal-title":"NeuroMolecular Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib142","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1002\/jcp.26583","article-title":"Autophagy induction by trehalose: molecular mechanisms and therapeutic impacts","volume":"233","author":"Hosseinpour-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2020.10.018_bib143","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s11064-012-0823-0","article-title":"Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant \u03b1-synuclein","volume":"37","author":"Lan","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib144","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090202","article-title":"Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition","volume":"9","author":"Fernandez-Estevez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.10.018_bib145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/15548627.2018.1535292","article-title":"Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration","volume":"15","author":"Rusmini","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2020.10.018_bib146","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12035-014-8700-2","article-title":"Cytotoxic effect of p-coumaric acid on neuroblastoma, N2a cell via generation of reactive oxygen species leading to dysfunction of mitochondria inducing apoptosis and autophagy","volume":"51","author":"Shailasree","year":"2015","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.apsb.2020.10.018_bib147","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.biopha.2018.03.089","article-title":"p-Coumaric acid mediated protection of H9c2 cells from doxorubicin-induced cardiotoxicity: involvement of augmented Nrf 2 and autophagy","volume":"102","author":"Sunitha","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2020.10.018_bib148","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.3390\/ijms20122942","article-title":"p-Coumaric acid has protective effects against mutant copper-zinc superoxide dismutase 1 via the activation of autophagy in N2a cells","volume":"20","author":"Ueda","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2020.10.018_bib149","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/abbs\/gmy114","article-title":"Organosulfur compounds induce cytoprotective autophagy against apoptosis by inhibiting mTOR phosphorylation activity in macrophages","volume":"50","author":"Wu","year":"2018","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.apsb.2020.10.018_bib150","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.brainres.2010.12.014","article-title":"Neuroprotective effects of diallyl trisulfide in SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis","volume":"1374","author":"Guo","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib151","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1007\/s11064-018-2651-3","article-title":"Diallyl trisulfide protects motor neurons from the neurotoxic protein TDP-43 via activating lysosomal degradation and the antioxidant response","volume":"43","author":"Liu","year":"2018","journal-title":"Neurochem Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib152","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1021\/jf050384i","article-title":"Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds","volume":"53","author":"Cerda","year":"2005","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.apsb.2020.10.018_bib153","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbagen.2017.10.006","article-title":"An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages","volume":"1862","author":"Boakye","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.apsb.2020.10.018_bib154","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.3402\/fnr.v55i0.5572","article-title":"Polyamines in foods: development of a food database","volume":"55","author":"Atiya Ali","year":"2011","journal-title":"Food Nutr Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13195-019-0484-1","article-title":"Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial","volume":"11","author":"Wirth","year":"2019","journal-title":"Alzheimer's Res Ther"},{"key":"10.1016\/j.apsb.2020.10.018_bib156","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cortex.2018.09.014","article-title":"The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial","volume":"109","author":"Wirth","year":"2018","journal-title":"Cortex"},{"key":"10.1016\/j.apsb.2020.10.018_bib157","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/nn.3512","article-title":"Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner","volume":"16","author":"Gupta","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.apsb.2020.10.018_bib158","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/bph.13627","article-title":"Effects of anthocyanins on the prevention and treatment of cancer","volume":"174","author":"Lin","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.10.018_bib159","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.freeradbiomed.2004.08.002","article-title":"Flavonoids and the brain: interactions at the blood\u2013brain barrier and their physiological effects on the central nervous system","volume":"37","author":"Youdim","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib160","doi-asserted-by":"crossref","first-page":"450592","DOI":"10.1155\/2014\/450592","article-title":"In silico insight into potent of anthocyanin regulation of FKBP52 to prevent Alzheimer's disease","volume":"2014","author":"Hung","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib161","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0254-6272(13)60189-2","article-title":"Pharmacological effects of astragaloside IV: a literature review","volume":"33","author":"Ren","year":"2013","journal-title":"J Tradit Chin Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib162","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fnmol.2018.00310","article-title":"p62-Keap1-NRF2-ARE pathway: a contentious player for selective targeting of autophagy, oxidative stress and mitochondrial dysfunction in prion diseases","volume":"11","author":"Shah","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.apsb.2020.10.018_bib163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2006-960004","article-title":"Pharmacology of Curcuma longa","volume":"57","author":"Ammon","year":"1991","journal-title":"Planta Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib164","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.bmcl.2005.04.001","article-title":"Antioxidant and antiproliferative activity of curcumin semicarbazone","volume":"15","author":"Dutta","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.apsb.2020.10.018_bib165","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.brainres.2008.06.117","article-title":"Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats","volume":"1229","author":"Zhao","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib166","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.biopha.2017.10.145","article-title":"An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis","volume":"97","author":"Sowndhararajan","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2020.10.018_bib167","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/jn\/137.10.2171","article-title":"New developments and novel therapeutic perspectives for vitamin C","volume":"137","author":"Li","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.apsb.2020.10.018_bib168","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-2236(99)01543-X","article-title":"Ascorbate regulation and its neuroprotective role in the brain","volume":"23","author":"Rice","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.apsb.2020.10.018_bib169","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nm0502-445","article-title":"New view at C","volume":"8","author":"Hediger","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2020.05.015","article-title":"Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis","volume":"155","author":"Chang","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib171","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1734-1140(10)70334-0","article-title":"Influence of vitamin C on markers of oxidative stress in the earliest period of ischemic stroke","volume":"62","author":"Lagowska-Lenard","year":"2010","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.apsb.2020.10.018_bib172","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/nu12051351","article-title":"l-Ascorbic acid inhibits breast cancer growth by inducing IRE\/JNK\/CHOP-related endoplasmic reticulum stress-mediated p62\/SQSTM1 accumulation in the nucleus","volume":"12","author":"Choi","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.apsb.2020.10.018_bib173","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0367-326X(03)00040-6","article-title":"A simple HPLC\u2013UV method for the assay of ginkgolic acids in Ginkgo biloba extracts","volume":"74","author":"Fuzzati","year":"2003","journal-title":"Fitoterapia"},{"key":"10.1016\/j.apsb.2020.10.018_bib174","first-page":"129","article-title":"Natural resources containing arbutin. Determination of arbutin in the leaves of Bergenia crassifolia (L.) Fritsch. acclimated in Romania","volume":"37","author":"Carmen","year":"2009","journal-title":"Not Bot Hort Agrobot Cluj"},{"key":"10.1016\/j.apsb.2020.10.018_bib175","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s11274-013-1302-8","article-title":"Screening of high alpha-arbutin producing strains and production of alpha-arbutin by fermentation","volume":"29","author":"Liu","year":"2013","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.apsb.2020.10.018_bib176","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.7150\/thno.25674","article-title":"AMPK: potential therapeutic target for ischemic stroke","volume":"8","author":"Jiang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2020.10.018_bib177","first-page":"1174","article-title":"Advance in research for pharmacokinetics and drug interactions of licorice","volume":"15","author":"Chen","year":"2010","journal-title":"Chin J Clin Pharmacol"},{"key":"10.1016\/j.apsb.2020.10.018_bib178","first-page":"3","article-title":"Experience analysis of using cornus officinalis","volume":"26","author":"Song","year":"2006","journal-title":"Jilin J Tradit Chin Med"},{"key":"10.1016\/j.apsb.2020.10.018_bib179","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2010.05865.x","article-title":"Neuroprotective properties of resveratrol and derivatives","volume":"1215","author":"Richard","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.apsb.2020.10.018_bib180","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/ane.12511","article-title":"Resveratrol improves delayed r-tPA treatment outcome by reducing MMPs","volume":"134","author":"Chen","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.apsb.2020.10.018_bib181","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/ja01857a013","article-title":"Genistin (an isoflavone glucoside) and its aglucone, genistein, from soybeans","volume":"63","author":"Walter","year":"1941","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2020.10.018_bib182","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/10286020310001625102","article-title":"Stilbene derivatives from Gnetum cleistostachyum","volume":"7","author":"Yao","year":"2005","journal-title":"J Asian Nat Prod Res"},{"key":"10.1016\/j.apsb.2020.10.018_bib183","series-title":"Garlic and other alliums: the lore and the sciences","first-page":"1","author":"Block","year":"2010"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221138352030770X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221138352030770X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:49:39Z","timestamp":1761929379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221138352030770X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":183,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S221138352030770X"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2020.10.018","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural compounds modulate the autophagy with potential implication of stroke","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2020.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}