{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:50:10Z","timestamp":1792450210110,"version":"4.5.0"},"reference-count":202,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573410"],"award-info":[{"award-number":["81573410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018ZX09711001-004-006"],"award-info":[{"award-number":["2018ZX09711001-004-006"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.apsb.2020.12.003","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T02:03:34Z","timestamp":1607479414000},"page":"1412-1433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["The Ca2+-activated chloride channel ANO1\/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?"],"prefix":"10.1016","volume":"11","author":[{"given":"Yani","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-9998","authenticated-orcid":false,"given":"KeWei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2020.12.003_bib1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00424-016-1790-0","article-title":"Cellular functions of TMEM16\/anoctamin","volume":"468","author":"Oh","year":"2016","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1146\/annurev.physiol.67.032003.154341","article-title":"Calcium-activated chloride channels","volume":"67","author":"Hartzell","year":"2005","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib3","doi-asserted-by":"crossref","first-page":"7856","DOI":"10.1002\/jcp.27865","article-title":"Recent advances in TMEM16A: structure, function, and disease","volume":"234","author":"Ji","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib4","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nature07313","article-title":"TMEM16A confers receptor-activated calcium-dependent chloride conductance","volume":"455","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2020.12.003_bib5","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1126\/science.1163518","article-title":"TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity","volume":"322","author":"Caputo","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.apsb.2020.12.003_bib6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.09.003","article-title":"Expression cloning of TMEM16A as a calcium-activated chloride channel subunit","volume":"134","author":"Schroeder","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2020.12.003_bib7","doi-asserted-by":"crossref","first-page":"11776","DOI":"10.1073\/pnas.0903304106","article-title":"ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification","volume":"106","author":"Stephan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib8","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1523\/JNEUROSCI.5546-08.2009","article-title":"TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals","volume":"29","author":"Stohr","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.apsb.2020.12.003_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuron.2012.01.033","article-title":"Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons","volume":"74","author":"Huang","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.apsb.2020.12.003_bib10","doi-asserted-by":"crossref","first-page":"13791","DOI":"10.1038\/ncomms13791","article-title":"The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons","volume":"7","author":"Ha","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2020.12.003_bib11","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.neuron.2017.08.010","article-title":"Inferior olivary TMEM16B mediates cerebellar motor learning","volume":"95","author":"Zhang","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.apsb.2020.12.003_bib12","doi-asserted-by":"crossref","first-page":"7838","DOI":"10.1074\/jbc.M109.065367","article-title":"Expression and function of epithelial anoctamins","volume":"285","author":"Schreiber","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib13","doi-asserted-by":"crossref","first-page":"C482","DOI":"10.1152\/ajpcell.00140.2011","article-title":"ANOs 3\u20137 in the anoctamin\/Tmem16 Cl\u2013 channel family are intracellular proteins","volume":"302","author":"Duran","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature09583","article-title":"Calcium-dependent phospholipid scrambling by TMEM16F","volume":"468","author":"Suzuki","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2020.12.003_bib15","doi-asserted-by":"crossref","first-page":"13305","DOI":"10.1074\/jbc.M113.457937","article-title":"Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members","volume":"288","author":"Suzuki","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1128\/MCB.00919-15","article-title":"A role of TMEM16E carrying a scrambling domain in sperm motility","volume":"36","author":"Gyobu","year":"2016","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.apsb.2020.12.003_bib17","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jcp.25823","article-title":"Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels","volume":"233","author":"Kamaleddin","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib18","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/HYPERTENSIONAHA.119.13287","article-title":"ANO4 (Anoctamin 4) is a novel marker of Zona glomerulosa that regulates stimulated aldosterone secretion","volume":"74","author":"Maniero","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.apsb.2020.12.003_bib19","doi-asserted-by":"crossref","first-page":"12758","DOI":"10.1073\/pnas.220402097","article-title":"Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium","volume":"97","author":"Marmorstein","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5607\/en.2017.26.3.113","article-title":"Distribution and function of the bestrophin-1 (Best1) channel in the brain","volume":"26","author":"Oh","year":"2017","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1152\/physrev.00022.2007","article-title":"Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies","volume":"88","author":"Hartzell","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.apsb.2020.12.003_bib22","doi-asserted-by":"crossref","first-page":"33360","DOI":"10.1074\/jbc.M109.046607","article-title":"Regulation of TMEM16A chloride channel properties by alternative splicing","volume":"284","author":"Ferrera","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib23","doi-asserted-by":"crossref","first-page":"8891","DOI":"10.1073\/pnas.1102147108","article-title":"Voltage- and calcium-dependent gating of TMEM16A\/Ano1 chloride channels are physically coupled by the first intracellular loop","volume":"108","author":"Xiao","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature13984","article-title":"X-ray structure of a calcium-activated TMEM16 lipid scramblase","volume":"516","author":"Brunner","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2020.12.003_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02772","article-title":"A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity","volume":"3","author":"Tien","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.apsb.2020.12.003_bib26","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1073\/pnas.1502291112","article-title":"Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels","volume":"112","author":"Peters","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature24652","article-title":"Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM","volume":"552","author":"Paulino","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2020.12.003_bib28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature25024","article-title":"Cryo-EM structures of the TMEM16A calcium-activated chloride channel","volume":"552","author":"Dang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2020.12.003_bib29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bpj.2019.11.015","article-title":"The molecular mechanism of ginsenoside analogs activating TMEM16A","volume":"118","author":"Guo","year":"2020","journal-title":"Biophys J"},{"key":"10.1016\/j.apsb.2020.12.003_bib30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/jcp.25621","article-title":"New insights on the regulation of Ca2+-activated chloride channel TMEM16A","volume":"232","author":"Ma","year":"2017","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib31","doi-asserted-by":"crossref","first-page":"C466","DOI":"10.1152\/ajpcell.00507.2018","article-title":"Volume-regulated Cl\u2013 current: contributions of distinct Cl\u2013 channels and localized Ca2+ signals","volume":"317","author":"Liu","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib32","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1038\/s41467-019-11784-8","article-title":"Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A","volume":"10","author":"Le","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2020.12.003_bib33","doi-asserted-by":"crossref","first-page":"19952","DOI":"10.1073\/pnas.1904012116","article-title":"A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl\u2013 channel ANO1 (TMEM16A)","volume":"116","author":"Yu","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1113\/jphysiol.2014.275107","article-title":"Activation of Ca2+ -activated Cl\u2013 channel ANO1 by localized Ca2+ signals","volume":"594","author":"Jin","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib35","doi-asserted-by":"crossref","first-page":"102050","DOI":"10.1016\/j.ceca.2019.06.004","article-title":"The multifaceted role of TMEM16A in cancer","volume":"82","author":"Crottes","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2020.12.003_bib36","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.csbj.2020.03.015","article-title":"Recent progress in structural studies on TMEM16A channel","volume":"18","author":"Shi","year":"2020","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.apsb.2020.12.003_bib37","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3390\/ijms19051432","article-title":"Calcium-activated Cl\u2013 channel: insights on the molecular identity in epithelial tissues","volume":"19","author":"Rottgen","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2020.12.003_bib38","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00424-014-1572-5","article-title":"Characterization of the effects of Cl\u2013 channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl\u2013 channels","volume":"467","author":"Liu","year":"2015","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1756-6606-1-14","article-title":"Development of selective blockers for Ca2+-activated Cl channel using Xenopus laevis oocytes with an improved drug screening strategy","volume":"1","author":"Oh","year":"2008","journal-title":"Mol Brain"},{"key":"10.1016\/j.apsb.2020.12.003_bib40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1124\/jpet.114.217315","article-title":"Downregulation of Ca2+-activated Cl\u2013 channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells","volume":"351","author":"Matsuba","year":"2014","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.apsb.2020.12.003_bib41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1164\/rccm.201207-1303OC","article-title":"The transmembrane protein 16A Ca2+-activated Cl\u2013 channel in airway smooth muscle contributes to airway hyperresponsiveness","volume":"187","author":"Zhang","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.apsb.2020.12.003_bib42","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128414","article-title":"Niclosamide repurposed for the treatment of inflammatory airway disease","volume":"4","author":"Cabrita","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.apsb.2020.12.003_bib43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00374996","article-title":"NPPB block of Ca2+-activated Cl\u2013 currents in Xenopus oocytes","volume":"420","author":"Wu","year":"1992","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib44","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1172\/JCI41084","article-title":"The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl\u2013 channels","volume":"120","author":"Liu","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2020.12.003_bib45","doi-asserted-by":"crossref","first-page":"18423","DOI":"10.1074\/jbc.M101264200","article-title":"Functional geometry of the permeation pathway of Ca2+-activated Cl-channels inferred from analysis of voltage-dependent block","volume":"276","author":"Qu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.canlet.2012.07.015","article-title":"Inhibition of Ca2+-activated Cl\u2013 channel ANO1\/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma","volume":"326","author":"Liu","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2020.12.003_bib47","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1085\/jgp.201812071","article-title":"The TMEM16A channel mediates the fast polyspermy block in Xenopus laevis","volume":"150","author":"Wozniak","year":"2018","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib48","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1073\/pnas.1214596109","article-title":"Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction","volume":"109","author":"Huang","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib49","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1124\/mol.107.043208","article-title":"Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel","volume":"73","author":"De La Fuente","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib50","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1074\/jbc.M110.175109","article-title":"TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells","volume":"286","author":"Namkung","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib51","doi-asserted-by":"crossref","first-page":"E1026","DOI":"10.1073\/pnas.1217072110","article-title":"Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling","volume":"110","author":"Britschgi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib52","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1111\/bph.13201","article-title":"New selective inhibitors of calcium-activated chloride channels-T16A(inh)-A01, CaCC(inh)-A01 and MONNA\u2014what do they inhibit?.","volume":"172","author":"Boedtkjer","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib53","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1136\/gutjnl-2013-305663","article-title":"Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice","volume":"63","author":"Ko","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.apsb.2020.12.003_bib54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12990-015-0042-1","article-title":"Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats","volume":"11","author":"Pineda-Farias","year":"2015","journal-title":"Mol Pain"},{"key":"10.1016\/j.apsb.2020.12.003_bib55","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00109-015-1337-4","article-title":"Glucose promotes secretion-dependent renal cyst growth","volume":"94","author":"Kraus","year":"2016","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.apsb.2020.12.003_bib56","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fncel.2019.00360","article-title":"TMEM16A inhibition preserves blood\u2013brain barrier Integrity after ischemic stroke","volume":"13","author":"Liu","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.apsb.2020.12.003_bib57","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41419-018-0735-2","article-title":"Inhibition of ANO1\/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-alpha signaling","volume":"9","author":"Song","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2020.12.003_bib58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaci.2019.07.049","article-title":"Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis","volume":"145","author":"Vanoni","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.apsb.2020.12.003_bib59","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/cea.12887","article-title":"Chloride ion transport and overexpression of TMEM16A in a guinea-pig asthma model","volume":"47","author":"Kondo","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.apsb.2020.12.003_bib60","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1113\/jphysiol.2012.232520","article-title":"Chronic hypoxia-induced upregulation of Ca2+-activated Cl\u2212 channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity","volume":"590","author":"Sun","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib61","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1124\/mol.113.087502","article-title":"MONNA, a potent and selective blocker for transmembrane protein with unknown function 16\/anoctamin-1","volume":"84","author":"Oh","year":"2013","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib62","doi-asserted-by":"crossref","first-page":"9722","DOI":"10.1073\/pnas.1423827112","article-title":"Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia","volume":"112","author":"Cha","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib63","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/bph.14598","article-title":"TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension","volume":"176","author":"Askew Page","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib64","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1113\/JP273795","article-title":"Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin","volume":"595","author":"Ru","year":"2017","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155771","article-title":"Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2","volume":"11","author":"Seo","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.12.003_bib66","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.3390\/ijms21072557","article-title":"Pharmacological inhibition and activation of the Ca2+ activated Cl\u2013 channel TMEM16A","volume":"21","author":"Centeio","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2020.12.003_bib67","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1021\/acs.jmedchem.7b00020","article-title":"Substituted 2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A)","volume":"60","author":"Truong","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib68","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejmech.2018.10.002","article-title":"Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors","volume":"160","author":"Seo","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib69","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phrs.2017.11.016","article-title":"Resveratrol dimer trans-epsilon-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel","volume":"129","author":"Yu","year":"2018","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib70","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fphar.2019.00051","article-title":"Drug repurposing: the anthelmintics niclosamide and nitazoxanide are potent TMEM16A antagonists that fully bronchodilate airways","volume":"10","author":"Miner","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib71","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1096\/fj.10-160648","article-title":"Inhibition of Ca2+-activated Cl\u2013 channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea","volume":"24","author":"Namkung","year":"2010","journal-title":"Faseb J"},{"key":"10.1016\/j.apsb.2020.12.003_bib72","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ejphar.2015.06.048","article-title":"Tannic acid modulates excitability of sensory neurons and nociceptive behavior and the ionic mechanism","volume":"764","author":"Zhang","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib73","doi-asserted-by":"crossref","first-page":"L625","DOI":"10.1152\/ajplung.00068.2013","article-title":"Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle","volume":"305","author":"Gallos","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038030","article-title":"Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-activated Cl\u2013 channel TMEM16A","volume":"7","author":"Yao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.12.003_bib75","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1177\/154405910708600918","article-title":"Eugenol inhibits K+ currents in trigeminal ganglion neurons","volume":"86","author":"Li","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib76","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pain.2009.03.016","article-title":"Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system","volume":"144","author":"Park","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.apsb.2020.12.003_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174935","article-title":"Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells","volume":"12","author":"Seo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.12.003_bib78","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1111\/bph.13841","article-title":"Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects","volume":"174","author":"Zhang","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib79","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4149\/gpb_2019045","article-title":"Luteolin suppresses colonic smooth muscle motility via inhibiting L-type calcium channel currents in mice","volume":"39","author":"Yang","year":"2020","journal-title":"Gen Physiol Biophys"},{"key":"10.1016\/j.apsb.2020.12.003_bib80","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3389\/fphys.2016.00549","article-title":"Role of quercetin in modulating chloride transport in the intestine","volume":"7","author":"Yu","year":"2016","journal-title":"Front Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133656","article-title":"Inhibition of ANO1\/TMEM16A chloride channel by idebenone and its cytotoxicity to cancer cell lines","volume":"10","author":"Seo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.12.003_bib82","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1681\/ASN.2018010039","article-title":"Lipid peroxidation drives renal cyst growth in\u00a0vitro through activation of TMEM16A","volume":"30","author":"Schreiber","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.apsb.2020.12.003_bib83","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3389\/fphar.2019.01181","article-title":"Plumbagin prevents secretory diarrhea by inhibiting CaCC and CFTR channel activities","volume":"10","author":"Yu","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib84","doi-asserted-by":"crossref","first-page":"104763","DOI":"10.1016\/j.phrs.2020.104763","article-title":"Inhibition of TMEM16A Ca2+-activated Cl\u2013 channels by avermectins is essential for their anticancer effects","volume":"156","author":"Zhang","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib85","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0026-895X(25)10907-3","article-title":"Niflumic and flufenamic acids are potent reversible blockers of Ca2+-activated Cl\u2013 channels in Xenopus oocytes","volume":"37","author":"White","year":"1990","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib86","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00424-017-2028-5","article-title":"Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal","volume":"469","author":"Fedigan","year":"2017","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib87","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1159\/000493036","article-title":"Effects of the calcium-activated chloride channel inhibitors T16Ainh-A01 and CaCCinh-A01 on cardiac fibroblast function","volume":"49","author":"Tian","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.apsb.2020.12.003_bib88","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/cells9030543","article-title":"Calcium- and voltage-dependent dual gating ANO1 is an intrinsic determinant of repolarization in rod bipolar cells of the mouse retina","volume":"9","author":"Paik","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2020.12.003_bib89","doi-asserted-by":"crossref","first-page":"11029","DOI":"10.1074\/jbc.M114.549188","article-title":"Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics","volume":"289","author":"Bill","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib90","doi-asserted-by":"crossref","first-page":"78619","DOI":"10.18632\/oncotarget.12524","article-title":"Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells","volume":"7","author":"Guan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.apsb.2020.12.003_bib91","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.21873\/anticanres.13489","article-title":"Biochemical inhibition of DOG1\/TMEM16A achieves antitumoral effects in human gastrointestinal stromal tumor cells in\u00a0vitro","volume":"39","author":"Frobom","year":"2019","journal-title":"Anticancer Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib92","doi-asserted-by":"crossref","first-page":"C437","DOI":"10.1152\/ajpcell.00070.2016","article-title":"Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels","volume":"311","author":"Sung","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib93","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00424-014-1598-8","article-title":"ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC)","volume":"467","author":"Sauter","year":"2015","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib94","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1476-5381.2012.02199.x","article-title":"Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh)-A01","volume":"168","author":"Davis","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib95","doi-asserted-by":"crossref","first-page":"C1102","DOI":"10.1152\/ajpcell.00126.2014","article-title":"Anoctamin-1\/TMEM16A is the major apical iodide channel of the thyrocyte","volume":"307","author":"Twyffels","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib96","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1074\/jbc.RA117.000326","article-title":"TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl\u2013 current and regulate melatonin secretion in rat pineal glands","volume":"293","author":"Yamamura","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib97","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4168\/aair.2015.7.4.367","article-title":"TMEM16A-mediated mucin secretion in IL-13-induced nasal epithelial cells from chronic rhinosinusitis patients","volume":"7","author":"Zhang","year":"2015","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib98","first-page":"32","article-title":"TMEM16A as a potential biomarker in the diagnosis and prognosis of lung cancer","volume":"22","author":"Hu","year":"2019","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.apsb.2020.12.003_bib99","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1073\/pnas.1421507112","article-title":"Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons","volume":"112","author":"Takayama","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12990-015-0061-y","article-title":"Anoctamin-1 Cl\u2013 channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01","volume":"11","author":"Deba","year":"2015","journal-title":"Mol Pain"},{"key":"10.1016\/j.apsb.2020.12.003_bib101","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1113\/JP271256","article-title":"Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B","volume":"593","author":"Cruz-Rangel","year":"2015","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib102","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00424-015-1758-5","article-title":"Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine beta-cells","volume":"468","author":"Crutzen","year":"2016","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib103","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1085\/jgp.201611626","article-title":"Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis","volume":"148","author":"Gao","year":"2016","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib104","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1002\/jcp.27529","article-title":"Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects","volume":"234","author":"Guo","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.resinv.2018.10.001","article-title":"Clarithromycin suppresses IL-13-induced goblet cell metaplasia via the TMEM16A-dependent pathway in guinea pig airway epithelial cells","volume":"57","author":"Hara","year":"2019","journal-title":"Respir Investig"},{"key":"10.1016\/j.apsb.2020.12.003_bib106","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/ALN.0000000000000769","article-title":"Antagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium","volume":"123","author":"Danielsson","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.apsb.2020.12.003_bib107","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.3390\/ijms19103204","article-title":"Prediction of novel anoctamin1 (ANO1) inhibitors using 3D-QSAR pharmacophore modeling and molecular docking","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2020.12.003_bib108","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1098\/rspb.1982.0056","article-title":"A calcium-dependent transient outward current in Xenopus laevis oocytes","volume":"215","author":"Miledi","year":"1982","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"10.1016\/j.apsb.2020.12.003_bib109","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1096\/fj.11-191627","article-title":"Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction","volume":"25","author":"Namkung","year":"2011","journal-title":"Faseb J"},{"key":"10.1016\/j.apsb.2020.12.003_bib110","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/bph.13420","article-title":"Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours","volume":"173","author":"Liu","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib111","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1113\/JP278784","article-title":"TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels","volume":"597","author":"Genovese","year":"2019","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib112","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1476-5381.2012.02193.x","article-title":"Control of TMEM16A by INO-4995 and other inositolphosphates","volume":"168","author":"Tian","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib113","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00232-017-9975-9","article-title":"Identification of resveratrol, an herbal compound, as an activator of the calcium-activated chloride channel, TMEM16A","volume":"250","author":"Chai","year":"2017","journal-title":"J Membr Biol"},{"key":"10.1016\/j.apsb.2020.12.003_bib114","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00424-017-1934-x","article-title":"Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum","volume":"469","author":"Guo","year":"2017","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib115","doi-asserted-by":"crossref","first-page":"104323","DOI":"10.1016\/j.phrs.2019.104323","article-title":"Entering the spotlight: chitosan oligosaccharides as novel activators of CaCCs\/TMEM16A","volume":"146","author":"Guo","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib116","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1164\/rccm.201908-1641OC","article-title":"TMEM16A potentiation: a novel therapeutic approach for the treatment of cystic fibrosis","volume":"201","author":"Danahay","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.apsb.2020.12.003_bib117","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1113\/JP275175","article-title":"Regulation of TMEM16A\/ANO1 and TMEM16F\/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid","volume":"596","author":"Schreiber","year":"2018","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib118","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00232-018-0052-9","article-title":"The natural compound cinnamaldehyde is a novel activator of calcium-activated chloride channel","volume":"251","author":"Huang","year":"2018","journal-title":"J Membr Biol"},{"key":"10.1016\/j.apsb.2020.12.003_bib119","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.apsb.2019.08.003","article-title":"Recent progress in drug delivery","volume":"9","author":"Li","year":"2019","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2020.12.003_bib120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13046-017-0499-z","article-title":"MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression","volume":"36","author":"Cao","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib121","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3892\/mmr.2014.1888","article-title":"Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-kappaB signaling pathway","volume":"9","author":"Liu","year":"2014","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.apsb.2020.12.003_bib122","doi-asserted-by":"crossref","first-page":"C226","DOI":"10.1152\/ajpcell.1989.256.2.C226","article-title":"Activation of an apical Cl\u2013 conductance by Ca2+ ionophores in cystic fibrosis airway epithelia","volume":"256","author":"Willumsen","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib123","doi-asserted-by":"crossref","first-page":"C213","DOI":"10.1152\/ajpcell.1994.266.1.C213","article-title":"CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse","volume":"266","author":"Gray","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib124","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00424-011-0975-9","volume":"462","author":"Kunzelmann","year":"2011","journal-title":"Anoctamins. Pflugers Arch"},{"key":"10.1016\/j.apsb.2020.12.003_bib125","doi-asserted-by":"crossref","first-page":"14875","DOI":"10.1074\/jbc.C109.000869","article-title":"Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl\u2013 secretory channel in mouse airways","volume":"284","author":"Rock","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib126","doi-asserted-by":"crossref","first-page":"28698","DOI":"10.1074\/jbc.M109.012120","article-title":"Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport","volume":"284","author":"Ousingsawat","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2020.12.003_bib127","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1096\/fj.201801333RRR","article-title":"TMEM16A is indispensable for basal mucus secretion in airways and intestine","volume":"33","author":"Benedetto","year":"2019","journal-title":"Faseb J"},{"key":"10.1016\/j.apsb.2020.12.003_bib128","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1038\/nrdp.2015.25","article-title":"Asthma","volume":"1","author":"Holgate","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.apsb.2020.12.003_bib129","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(17)33311-1","article-title":"Asthma","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2020.12.003_bib130","doi-asserted-by":"crossref","first-page":"497387","DOI":"10.1155\/2015\/497387","article-title":"Novel roles for chloride channels, exchangers, and regulators in chronic inflammatory airway diseases","volume":"2015","author":"Sala-Rabanal","year":"2015","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.apsb.2020.12.003_bib131","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1113\/jphysiol.2012.240838","article-title":"Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia","volume":"590","author":"Scudieri","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib132","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1073\/pnas.1211594110","article-title":"Dynamic modulation of ANO1\/TMEM16A HCO3\u2013 permeability by Ca2+\/calmodulin","volume":"110","author":"Jung","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib133","doi-asserted-by":"crossref","first-page":"36016","DOI":"10.1038\/srep36016","article-title":"Goblet cell hyperplasia requires high bicarbonate transport to support mucin release","volume":"6","author":"Gorrieri","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2020.12.003_bib134","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jaci.2017.05.053","article-title":"Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma","volume":"141","author":"Wang","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.apsb.2020.12.003_bib135","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(13)60222-6","article-title":"Global burden of childhood pneumonia and diarrhoea","volume":"381","author":"Walker","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2020.12.003_bib136","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00424-011-0947-0","article-title":"Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption","volume":"461","author":"Ousingsawat","year":"2011","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib137","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00424-017-1987-x","article-title":"Glucose enhances rotavirus enterotoxin-induced intestinal chloride secretion","volume":"469","author":"Yin","year":"2017","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2020.12.003_bib138","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-13-5895-1_1","article-title":"Spontaneous electrical activity and rhythmicity in gastrointestinal smooth muscles","volume":"1124","author":"Sanders","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.apsb.2020.12.003_bib139","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1113\/jphysiol.2009.176206","article-title":"A Ca2+-activated Cl\u2013 conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity","volume":"587","author":"Zhu","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib140","doi-asserted-by":"crossref","first-page":"G1370","DOI":"10.1152\/ajpgi.00074.2009","article-title":"Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract","volume":"296","author":"Gomez-Pinilla","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib141","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1113\/jphysiol.2009.176198","article-title":"Expression of anoctamin 1\/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles","volume":"587","author":"Hwang","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib142","doi-asserted-by":"crossref","first-page":"G228","DOI":"10.1152\/ajpgi.00363.2016","article-title":"Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca2+ transients and slow waves in adult mouse small intestine","volume":"312","author":"Malysz","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib143","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/bph.13431","article-title":"Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract","volume":"173","author":"Hwang","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib144","doi-asserted-by":"crossref","first-page":"C10","DOI":"10.1152\/ajpcell.00328.2017","article-title":"Dextran sulfate sodium-induced chronic colitis attenuates Ca2+-activated Cl\u2013 secretion in murine colon by downregulating TMEM16A","volume":"315","author":"Rottgen","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib145","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fphar.2016.00270","article-title":"Shikonin inhibits intestinal calcium-activated chloride channels and prevents rotaviral diarrhea","volume":"7","author":"Jiang","year":"2016","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib146","doi-asserted-by":"crossref","first-page":"15010","DOI":"10.1038\/nrdp.2015.10","article-title":"Cystic fibrosis","volume":"1","author":"Ratjen","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.apsb.2020.12.003_bib147","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1093\/hmg\/ddy188","article-title":"Recent advances in developing therapeutics for cystic fibrosis","volume":"27","author":"Strug","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.apsb.2020.12.003_bib148","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/164_2019_333","article-title":"Exploiting the diversity of ion channels: modulation of ion channels for therapeutic indications","volume":"260","author":"Liu","year":"2019","journal-title":"Handb Exp Pharmacol"},{"issue":"Suppl 1","key":"10.1016\/j.apsb.2020.12.003_bib149","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.jcf.2019.10.020","article-title":"Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis","volume":"19","author":"Quesada","year":"2020","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.apsb.2020.12.003_bib150","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1091\/mbc.e12-06-0424","article-title":"Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia","volume":"23","author":"Veit","year":"2012","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.apsb.2020.12.003_bib151","doi-asserted-by":"crossref","first-page":"12397","DOI":"10.1038\/s41598-017-10910-0","article-title":"Epithelial chloride transport by CFTR requires TMEM16A","volume":"7","author":"Benedetto","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2020.12.003_bib152","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53085","article-title":"Chloride channels regulate differentiation and barrier functions of the mammalian airway","volume":"9","author":"He","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.apsb.2020.12.003_bib153","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fphar.2019.00003","article-title":"TMEM16A in cystic fibrosis: activating or inhibiting?.","volume":"10","author":"Kunzelmann","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib154","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cellsig.2018.01.008","article-title":"Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1","volume":"44","author":"Lerias","year":"2018","journal-title":"Cell Signal"},{"key":"10.1016\/j.apsb.2020.12.003_bib155","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41467-017-00813-z","article-title":"MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology","volume":"8","author":"Sonneville","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2020.12.003_bib156","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1164\/rccm.201008-1267OC","article-title":"Denufosol tetrasodium in patients with cystic fibrosis and normal to mildly impaired lung function","volume":"183","author":"Accurso","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.apsb.2020.12.003_bib157","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jcf.2012.05.003","article-title":"Long term effects of denufosol tetrasodium in patients with cystic fibrosis","volume":"11","author":"Ratjen","year":"2012","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.apsb.2020.12.003_bib158","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jare.2020.01.006","article-title":"TMEM16A Ca2+-activated Cl\u2013 channel inhibition ameliorates acute pancreatitis via the IP3R\/Ca2+\/NFkappaB\/IL-6 signaling pathway","volume":"23","author":"Wang","year":"2020","journal-title":"J Adv Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib159","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/ki.2013.418","article-title":"Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells","volume":"85","author":"Buchholz","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.apsb.2020.12.003_bib160","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbrc.2017.04.021","article-title":"TMEM16A exacerbates renal injury by activating P38\/JNK signaling pathway to promote podocyte apoptosis in diabetic nephropathy mice","volume":"487","author":"Lian","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.apsb.2020.12.003_bib161","doi-asserted-by":"crossref","first-page":"F1777","DOI":"10.1152\/ajprenal.00638.2017","article-title":"Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria","volume":"315","author":"Schenk","year":"2018","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib162","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00109-020-01894-y","article-title":"TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells","volume":"98","author":"Cabrita","year":"2020","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.apsb.2020.12.003_bib163","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/jcp.26961","article-title":"Downregulation of microRNA-9 reduces inflammatory response and fibroblast proliferation in mice with idiopathic pulmonary fibrosis through the ANO1-mediated TGF-beta-Smad3 pathway","volume":"234","author":"Dai","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib164","first-page":"1375","article-title":"FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products","volume":"22","author":"Katoh","year":"2003","journal-title":"Int J Oncol"},{"key":"10.1016\/j.apsb.2020.12.003_bib165","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1158\/0008-5472.CAN-12-3839","article-title":"DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors","volume":"73","author":"Simon","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib166","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/sj.bjc.6605823","article-title":"ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines","volume":"103","author":"Ayoub","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.apsb.2020.12.003_bib167","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136584","article-title":"Inhibition of calcium-activated chloride channel ANO1\/TMEM16A suppresses tumor growth and invasion in human lung cancer","volume":"10","author":"Jia","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.12.003_bib168","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/ijc.31887","article-title":"Inhibition of Ca2+-activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K\/Akt signaling","volume":"144","author":"Liu","year":"2019","journal-title":"Int J Cancer"},{"key":"10.1016\/j.apsb.2020.12.003_bib169","first-page":"325","article-title":"Knockdown of TMEM16A suppressed MAPK and inhibited cell proliferation and migration in hepatocellular carcinoma","volume":"9","author":"Deng","year":"2016","journal-title":"OncoTargets Ther"},{"key":"10.1016\/j.apsb.2020.12.003_bib170","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1158\/1078-0432.CCR-12-3753","article-title":"Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization","volume":"19","author":"Shi","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib171","doi-asserted-by":"crossref","first-page":"13026","DOI":"10.1073\/pnas.1900703116","article-title":"TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis","volume":"116","author":"Crottes","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2020.12.003_bib172","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/modpathol.2012.57","article-title":"DOG1: a novel marker of salivary acinar and intercalated duct differentiation","volume":"25","author":"Chenevert","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1016\/j.apsb.2020.12.003_bib173","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1111\/cas.13715","article-title":"Transcriptional repression of human epidermal growth factor receptor 2 by ClC-3 Cl\u2013\/H+ transporter inhibition in human breast cancer cells","volume":"109","author":"Fujimoto","year":"2018","journal-title":"Cancer Sci"},{"key":"10.1016\/j.apsb.2020.12.003_bib174","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/gcc.22450","article-title":"TMEM16A\/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2\/ERBB2","volume":"56","author":"Kulkarni","year":"2017","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.apsb.2020.12.003_bib175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2019.04.027","article-title":"A mutual activation loop between the Ca2+-activated chloride channel TMEM16A and EGFR\/STAT3 signaling promotes breast cancer tumorigenesis","volume":"455","author":"Wang","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2020.12.003_bib176","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1158\/0008-5472.CAN-12-0475-T","article-title":"TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression","volume":"72","author":"Duvvuri","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib177","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1158\/1078-0432.CCR-14-0363","article-title":"To \"grow\" or \"go\": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN","volume":"20","author":"Shiwarski","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib178","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1158\/1078-0432.CCR-17-1561","article-title":"TMEM16A\/ANO1 inhibits apoptosis via downregulation of bim expression","volume":"23","author":"Godse","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2020.12.003_bib179","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/carcin\/bgz077","article-title":"Genome-wide copy number variation analysis identified ANO1 as a novel oncogene and prognostic biomarker in esophageal squamous cell cancer","volume":"40","author":"Yu","year":"2019","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.apsb.2020.12.003_bib180","doi-asserted-by":"crossref","first-page":"11585","DOI":"10.18632\/oncotarget.3412","article-title":"TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-beta signaling","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.apsb.2020.12.003_bib181","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbrc.2019.03.001","article-title":"Transcriptional activation of ANO1 promotes gastric cancer progression","volume":"512","author":"Zeng","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.apsb.2020.12.003_bib182","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s10147-020-01653-6","article-title":"Inhibition of TMEM16A suppresses growth and induces apoptosis in hepatocellular carcinoma","volume":"25","author":"Zhang","year":"2020","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.apsb.2020.12.003_bib183","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/cells9051079","article-title":"Suppression of CaMKIIbeta inhibits ANO1-mediated glioblastoma progression","volume":"9","author":"Sim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2020.12.003_bib184","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1038\/s41598-019-45941-2","article-title":"Detection of ANO1 mRNA in PBMCs is a promising method for GISTs diagnosis","volume":"9","author":"Li","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2020.12.003_bib185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115443","article-title":"Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells","volume":"9","author":"Sui","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2020.12.003_bib186","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1245\/s10434-016-5133-3","article-title":"Down-regulation of microRNA-132 is associated with poor prognosis of colorectal cancer","volume":"23","author":"Mokutani","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.apsb.2020.12.003_bib187","first-page":"2361","article-title":"MicroRNA144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer","volume":"41","author":"Jiang","year":"2019","journal-title":"Oncol Rep"},{"key":"10.1016\/j.apsb.2020.12.003_bib188","doi-asserted-by":"crossref","first-page":"C1229","DOI":"10.1152\/ajpcell.00044.2012","article-title":"Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension","volume":"303","author":"Forrest","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib189","doi-asserted-by":"crossref","first-page":"C948","DOI":"10.1152\/ajpcell.00018.2010","article-title":"Expression profile and protein translation of TMEM16A in murine smooth muscle","volume":"299","author":"Davis","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib190","doi-asserted-by":"crossref","first-page":"1800965","DOI":"10.1183\/13993003.00965-2018","article-title":"Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension","volume":"53","author":"Papp","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.apsb.2020.12.003_bib191","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1165\/rcmb.2016-0344OC","article-title":"Activation of anoctamin-1 limits pulmonary endothelial cell proliferation via p38-mitogen-activated protein kinase-dependent apoptosis","volume":"58","author":"Allawzi","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.apsb.2020.12.003_bib192","first-page":"3275","article-title":"TMEM16A regulates the cell cycle of pulmonary artery smooth muscle cells in high-flow-induced pulmonary arterial hypertension rat model","volume":"19","author":"Shang","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.apsb.2020.12.003_bib193","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2015.02.020","article-title":"Overexpression of ANO1\/TMEM16A, an arterial Ca2+-activated Cl\u2013 channel, contributes to spontaneous hypertension","volume":"82","author":"Wang","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.apsb.2020.12.003_bib194","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1172\/JCI70025","article-title":"Disruption of vascular Ca2+-activated chloride currents lowers blood pressure","volume":"124","author":"Heinze","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2020.12.003_bib195","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/HYPERTENSIONAHA.116.08874","article-title":"TMEM16A contributes to endothelial dysfunction by facilitating Nox2 NADPH oxidase-derived reactive oxygen species generation in hypertension","volume":"69","author":"Ma","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.apsb.2020.12.003_bib196","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1111\/bph.14432","article-title":"Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells","volume":"175","author":"Zeng","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2020.12.003_bib197","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1016\/j.cub.2017.01.037","article-title":"Nociception","volume":"27","author":"Tracey","year":"2017","journal-title":"Curr Biol"},{"key":"10.1016\/j.apsb.2020.12.003_bib198","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nn.3111","article-title":"The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons","volume":"15","author":"Cho","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.apsb.2020.12.003_bib199","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/14728222.2014.844792","article-title":"Protease-activated receptor 2 signalling pathways: a role in pain processing","volume":"18","author":"Bao","year":"2014","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.apsb.2020.12.003_bib200","first-page":"3744","article-title":"The association between the expression of PAR2 and TMEM16A and neuropathic pain","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.apsb.2020.12.003_bib201","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1744-8069-10-5","article-title":"Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity","volume":"10","author":"Lee","year":"2014","journal-title":"Mol Pain"},{"key":"10.1016\/j.apsb.2020.12.003_bib202","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1124\/mol.119.118844","article-title":"TMEM16A Ca2+-Activated Cl\u2013 channel regulates the proliferation and migration of brain capillary endothelial cells","volume":"98","author":"Suzuki","year":"2020","journal-title":"Mol Pharmacol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383520308352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383520308352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:48:23Z","timestamp":1761929303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383520308352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":202,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S2211383520308352"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2020.12.003","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Ca2+-activated chloride channel ANO1\/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2020.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}