{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:54:56Z","timestamp":1792007696301,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81073148"],"award-info":[{"award-number":["81073148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773997"],"award-info":[{"award-number":["81773997"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004029"],"award-info":[{"award-number":["82004029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004045"],"award-info":[{"award-number":["82004045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2020-JYB-ZDGG-038"],"award-info":[{"award-number":["2020-JYB-ZDGG-038"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.apsb.2021.03.018","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T06:06:13Z","timestamp":1615529173000},"page":"3527-3541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"11","author":[{"given":"Xiaojiaoyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junde","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2021.03.018_bib1","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1002\/hep.31599","article-title":"NAFLD: reporting histologic findings in clinical practice","volume":"73","author":"Brunt","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.03.018_bib2","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/hep.31533","article-title":"Tackling nonalcoholic fatty liver disease: three targeted populations","volume":"73","author":"Wegermann","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.03.018_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S2468-1253(20)30294-6","article-title":"Redefining fatty liver disease: an international patient perspective","volume":"6","author":"Shiha","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2021.03.018_bib4","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.apsb.2021.03.018_bib5","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/hep.30649","article-title":"A tale of two complications of obesity: NASH and hepatocellular carcinoma","volume":"70","author":"Dhanasekaran","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.03.018_bib6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.drudis.2018.09.020","article-title":"The future R&D landscape in non-alcoholic steatohepatitis (NASH)","volume":"24","author":"Black","year":"2019","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.apsb.2021.03.018_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrendo.2016.135","article-title":"PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD","volume":"13","author":"Gross","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.apsb.2021.03.018_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41575-020-00366-5","article-title":"Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors","volume":"18","author":"Francque","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2021.03.018_bib9","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jhep.2020.04.025","article-title":"Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages","volume":"73","author":"Lefere","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.03.018_bib10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gutjnl-2016-312431","article-title":"Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease","volume":"66","author":"Rotman","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.apsb.2021.03.018_bib11","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2016.01.038","article-title":"Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening","volume":"150","author":"Ratziu","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2021.03.018_bib12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00535-017-1415-1","article-title":"Current and future pharmacological therapies for NAFLD\/NASH","volume":"53","author":"Sumida","year":"2018","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.apsb.2021.03.018_bib13","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2021.03.018_bib14","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2021.03.018_bib15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jhep.2020.03.024","article-title":"Volixibat in adults with non-alcoholic steatohepatitis: 24-week interim analysis from a randomized, phase II study","volume":"73","author":"Newsome","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.03.018_bib16","first-page":"1","article-title":"Strengthen the research on the medicinal and edible substances to advance the development of the comprehensive healthcare industry of TCMs","volume":"17","author":"Gao","year":"2019","journal-title":"Chin J Nat Med"},{"key":"10.1016\/j.apsb.2021.03.018_bib17","first-page":"517","article-title":"A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition","volume":"17","author":"Wang","year":"2019","journal-title":"Chin J Nat Med"},{"key":"10.1016\/j.apsb.2021.03.018_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.phymed.2018.09.174","article-title":"A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins","volume":"50","author":"Li","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.apsb.2021.03.018_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12906-017-1733-0","article-title":"Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study","volume":"17","author":"Li","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.apsb.2021.03.018_bib20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A diet-induced animal model of non-alcoholic fatty\u00a0liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.03.018_bib21","doi-asserted-by":"crossref","first-page":"W212","DOI":"10.1093\/nar\/gkz446","article-title":"ChEA3: transcription factor enrichment analysis by orthogonal omics integration","volume":"47","author":"Keenan","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2021.03.018_bib22","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.30662","article-title":"Cholangiocyte-derived exosomal long noncoding RNA H19 promotes hepatic stellate cell activation and cholestatic liver fibrosis","volume":"70","author":"Liu","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.03.018_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2011.12.018","article-title":"FAT SIGNALS\u2014lipases and lipolysis in lipid metabolism and signaling","volume":"15","author":"Zechner","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.apsb.2021.03.018_bib24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature14557","article-title":"The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1","volume":"524","author":"Han","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.03.018_bib25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41586-020-2183-2","article-title":"The gluconeogenic enzyme PCK1 phosphorylates INSIG1\/2 for lipogenesis","volume":"580","author":"Xu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.03.018_bib26","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1074\/jbc.M111041200","article-title":"Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors","volume":"277","author":"Joseph","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.03.018_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molmet.2019.08.012","article-title":"Genetically-encoded sensors to detect fatty acid production and trafficking","volume":"29","author":"Mottillo","year":"2019","journal-title":"Mol Metab"},{"key":"10.1016\/j.apsb.2021.03.018_bib28","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.3390\/ijms19061738","article-title":"Functional regulation of PPARs through post-translational modifications","volume":"19","author":"Brunmeir","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2021.03.018_bib29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrgastro.2017.32","article-title":"Lipid droplets and liver disease: from basic biology to clinical implications","volume":"14","author":"Gluchowski","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2021.03.018_bib30","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","article-title":"The perilipin family of lipid droplet proteins: gatekeepers of intracellular lipolysis","volume":"1862","author":"Sztalryd","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.apsb.2021.03.018_bib31","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.bbalip.2017.07.007","article-title":"Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors","volume":"1862","author":"de la Rosa Rodriguez","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.apsb.2021.03.018_bib32","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1038\/s41467-020-17585-8","article-title":"Triacylglycerols sequester monotopic membrane proteins to lipid droplets","volume":"11","author":"Caillon","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2021.03.018_bib33","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jhep.2020.02.020","article-title":"Update on NAFLD genetics: from new variants to the clinic","volume":"72","author":"Trepo","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.03.018_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molmet.2019.01.013","article-title":"Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice","volume":"22","author":"Linden","year":"2019","journal-title":"Mol Metab"},{"key":"10.1016\/j.apsb.2021.03.018_bib35","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1073\/pnas.1901974116","article-title":"Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis","volume":"116","author":"BasuRay","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2021.03.018_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/BCJ20180680","article-title":"Ribavirin-induced down-regulation of CCAAT\/enhancer-binding protein alpha leads to suppression of lipogenesis","volume":"476","author":"Satoh","year":"2019","journal-title":"Biochem J"},{"key":"10.1016\/j.apsb.2021.03.018_bib37","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1194\/jlr.M081836","article-title":"Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice","volume":"59","author":"Linden","year":"2018","journal-title":"J Lipid Res"},{"key":"10.1016\/j.apsb.2021.03.018_bib38","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cmet.2017.07.004","article-title":"Sweet sixteenth for ChREBP: established roles and future goals","volume":"26","author":"Abdul-Wahed","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.apsb.2021.03.018_bib39","doi-asserted-by":"crossref","first-page":"19269","DOI":"10.1074\/jbc.M112.445445","article-title":"Impaired very long-chain acyl-CoA beta-oxidation in human X-linked adrenoleukodystrophy fibroblasts is a direct consequence of ABCD1 transporter dysfunction","volume":"288","author":"Wiesinger","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.03.018_bib40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nature21380","article-title":"EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice","volume":"542","author":"Arif","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.03.018_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93626","article-title":"Peroxisomal beta-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease","volume":"3","author":"Moreno-Fernandez","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.apsb.2021.03.018_bib42","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1172\/JCI63967","article-title":"Malonyl-CoA: the regulator of fatty acid synthesis and oxidation","volume":"122","author":"Foster","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2021.03.018_bib43","doi-asserted-by":"crossref","first-page":"bqz046","DOI":"10.1210\/endocr\/bqz046","article-title":"CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential","volume":"161","author":"Schlaepfer","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.apsb.2021.03.018_bib44","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPARalpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.apsb.2021.03.018_bib45","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/CIRCRESAHA.110.226860","article-title":"The PPAR-RXR transcriptional complex in the vasculature: energy in the balance","volume":"108","author":"Plutzky","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.apsb.2021.03.018_bib46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","article-title":"Regulation of energy metabolism by long-chain fatty acids","volume":"53","author":"Nakamura","year":"2014","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.apsb.2021.03.018_bib47","doi-asserted-by":"crossref","first-page":"E8499","DOI":"10.1073\/pnas.1810724115","article-title":"Macrophages release plasma membrane-derived particles rich in accessible cholesterol","volume":"115","author":"He","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2021.03.018_bib48","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1038\/s41467-018-05383-2","article-title":"Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2021.03.018_bib49","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3390\/ijms19041260","article-title":"The role of PPAR and its cross-talk with CAR and LXR in obesity and atherosclerosis","volume":"19","author":"Xu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2021.03.018_bib50","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41574-018-0037-x","article-title":"Liver X receptors in lipid signalling and membrane homeostasis","volume":"14","author":"Wang","year":"2018","journal-title":"Nat Rev Endocrinol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521000897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521000897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:52:52Z","timestamp":1761929572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383521000897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2211383521000897"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2021.03.018","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2021.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}