{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:55:43Z","timestamp":1789052143435,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.apsb.2021.07.007","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T11:39:01Z","timestamp":1626521941000},"page":"308-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models"],"prefix":"10.1016","volume":"12","author":[{"given":"Tuo","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily","family":"Belov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-1110","authenticated-orcid":false,"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6308-0859","authenticated-orcid":false,"given":"Andre","family":"Jeyarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve H.","family":"Rwema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-9683","authenticated-orcid":false,"given":"Wenyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4716-2122","authenticated-orcid":false,"given":"Mikhail","family":"Papisov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Josephson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond T.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2021.07.007_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2021.07.007_bib2","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis\u2014from bench to bedside","volume":"38","author":"Friedman","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.07.007_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/1536012119871455","article-title":"PET\/SPECT molecular probes for the diagnosis and staging of nonalcoholic fatty liver disease","volume":"18","author":"Shao","year":"2019","journal-title":"Mol Imag"},{"key":"10.1016\/j.apsb.2021.07.007_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jhep.2020.02.018","article-title":"[18F]-Alfatide PET imaging of integrin \u03b1v\u03b23 for the non-invasive quantification of liver fibrosis","volume":"73","author":"Shao","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.07.007_bib5","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jhep.2013.03.032","article-title":"Cannabinoid signaling and liver therapeutics","volume":"59","author":"Mallat","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.07.007_bib6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nm1421","article-title":"CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis","volume":"12","author":"Teixeira-Clerc","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2021.07.007_bib7","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1053\/j.gastro.2004.12.050","article-title":"Antifibrogenic role of the cannabinoid receptor CB2 in the liver","volume":"128","author":"Julien","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2021.07.007_bib8","doi-asserted-by":"crossref","first-page":"993","DOI":"10.2353\/ajpath.2008.070720","article-title":"Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis","volume":"173","author":"DeLeve","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2021.07.007_bib9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/labinvest.2011.191","article-title":"Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl4-induced advanced cirrhosis","volume":"92","author":"Giannone","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.apsb.2021.07.007_bib10","doi-asserted-by":"crossref","first-page":"10431","DOI":"10.1074\/jbc.M509706200","article-title":"Fatty acid amide hydrolase determines anandamide-induced cell death in the liver","volume":"281","author":"Siegmund","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.07.007_bib11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/gutjnl-2018-316137","article-title":"Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver","volume":"68","author":"Habib","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.apsb.2021.07.007_bib12","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1053\/j.gastro.2012.12.028","article-title":"Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice","volume":"144","author":"Cao","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2021.07.007_bib13","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/hep.30929","article-title":"Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis","volume":"71","author":"Tardelli","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.07.007_bib14","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1194\/jlr.M093369","article-title":"Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption","volume":"60","author":"Tardelli","year":"2019","journal-title":"J Lipid Res"},{"key":"10.1016\/j.apsb.2021.07.007_bib15","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1021\/acs.jmedchem.8b01778","article-title":"Design, synthesis, and evaluation of reversible and irreversible monoacylglycerol lipase positron emission tomography (PET) tracers using a \"tail switching\" strategy on a piperazinyl azetidine skeleton","volume":"62","author":"Chen","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2021.07.007_bib16","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jhep.2018.05.021","article-title":"Intestinal HIF-1alpha deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction","volume":"69","author":"Shao","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.07.007_bib17","doi-asserted-by":"crossref","first-page":"G357","DOI":"10.1152\/ajpgi.00456.2007","article-title":"Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis","volume":"294","author":"Siegmund","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.apsb.2021.07.007_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2017.02.033","article-title":"Monoglyceride lipase as a drug target: at the crossroads of arachidonic acid metabolism and endocannabinoid signaling","volume":"175","author":"Grabner","year":"2017","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.apsb.2021.07.007_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/gutjnl-2018-317520","article-title":"Inhibition of monoacylglycerol lipase for the treatment of liver disease: tempting but still playing with fire","volume":"68","author":"Hellerbrand","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.apsb.2021.07.007_bib20","first-page":"374","article-title":"Chronic thioacetamide poisoning as a model for experimental liver cirrhosis","volume":"82","author":"Grasedyck","year":"1976","journal-title":"Verh Dtsch Ges Inn Med"},{"key":"10.1016\/j.apsb.2021.07.007_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0168-8278(88)80461-6","article-title":"Cell population kinetics of Kupffer cells during the onset of fibrosis in rat liver by chronic carbon tetrachloride administration","volume":"6","author":"Geerts","year":"1988","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2021.07.007_bib22","first-page":"313","article-title":"An increase of choleresis in secondary biliary cirrhosis in rats is caused by bile duct secretion","volume":"14","author":"Taillandier","year":"1990","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.apsb.2021.07.007_bib23","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1073\/pnas.152334899","article-title":"Brain monoglyceride lipase participating in endocannabinoid inactivation","volume":"99","author":"Dinh","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2021.07.007_bib24","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.apsb.2021.07.007_bib25","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.chembiol.2012.03.009","article-title":"Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates","volume":"19","author":"Chang","year":"2012","journal-title":"Chem Biol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521002562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521002562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:51:23Z","timestamp":1761929483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383521002562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2211383521002562"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2021.07.007","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2021.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}