{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:23:54Z","timestamp":1791260634142,"version":"4.1.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.apsb.2021.07.022","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T22:43:22Z","timestamp":1627512202000},"page":"801-820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9024-4783","authenticated-orcid":false,"given":"Mallory","family":"Little","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moumita","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4080-0013","authenticated-orcid":false,"given":"Adam","family":"Matson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabby","family":"Mascarinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruk","family":"Molla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Weigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-6157","authenticated-orcid":false,"given":"Sridhar","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-1784","authenticated-orcid":false,"given":"Julia Yue","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2021.07.022_bib1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1124\/dmd.115.065698","article-title":"Review: mechanisms of how the intestinal microbiota alters the effects of drugs and bile acids","volume":"43","author":"Klaassen","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MOG.0000000000000057","article-title":"Bile acids and the gut microbiome","volume":"30","author":"Ridlon","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.apsb.2021.07.022_bib3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting\u00a0intracellular thyroid hormone activation","volume":"439","author":"Watanabe","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.07.022_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/bs.apha.2015.04.003","article-title":"Bile acid metabolism and signaling in cholestasis, inflammation, and cancer","volume":"74","author":"Li","year":"2015","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.apsb.2021.07.022_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ajpath.2010.11.026","article-title":"Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis","volume":"178","author":"Allen","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2021.07.022_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40168-019-0689-3","article-title":"Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease","volume":"7","author":"Heinken","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.apsb.2021.07.022_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-019-1785-z","article-title":"Bile acid metabolites control TH17 and Treg cell differentiation","volume":"576","author":"Hang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.07.022_bib8","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1124\/dmd.117.077313","article-title":"RNA-Seq profiling of intestinal expression of xenobiotic processing genes in germ-free mice","volume":"45","author":"Fu","year":"2017","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib9","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1124\/dmd.117.077024","article-title":"Novel interactions between gut microbiome and host drug-processing genes modify the hepatic metabolism of the environmental chemicals polybrominated diphenyl ethers","volume":"45","author":"Li","year":"2017","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/mol.117.110155","article-title":"PXR: more than just a master xenobiotic receptor","volume":"93","author":"Oladimeji","year":"2018","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.apsb.2021.07.022_bib11","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1124\/dmd.112.045112","article-title":"Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARalpha-, and Nrf2-null mice","volume":"40","author":"Aleksunes","year":"2012","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.drudis.2014.11.011","article-title":"Targeting xenobiotic receptors PXR and CAR in human diseases","volume":"20","author":"Banerjee","year":"2015","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.apsb.2021.07.022_bib13","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1124\/dmd.118.081547","article-title":"PBDEs altered gut microbiome and bile acid homeostasis in male C57BL\/6 mice","volume":"46","author":"Li","year":"2018","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.envpol.2018.02.067","article-title":"In\u00a0vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion","volume":"237","author":"Pencikova","year":"2018","journal-title":"Environ Pollut"},{"key":"10.1016\/j.apsb.2021.07.022_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.steroids.2014.04.016","article-title":"Bile acids are nutrient signaling hormones","volume":"86","author":"Zhou","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.apsb.2021.07.022_bib16","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bbagrm.2016.04.010","article-title":"RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome","volume":"1859","author":"Cui","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.apsb.2021.07.022_bib17","article-title":"Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism","volume":"15","author":"Zhang","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.07.022_bib18","first-page":"111","article-title":"Gut microbiome and colon cancer: role of bacterial metabolites and their molecular targets in the host","volume":"13","author":"Bhutia","year":"2017","journal-title":"Curr Colorectal Cancer Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/toxsci\/kfv110","article-title":"Developmental regulation of drug-processing genes in livers of germ-free mice","volume":"147","author":"Selwyn","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.apsb.2021.07.022_bib20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/00498250802651984","article-title":"Intestinal flora induces the expression of Cyp3a in the mouse liver","volume":"39","author":"Toda","year":"2009","journal-title":"Xenobiotica"},{"key":"10.1016\/j.apsb.2021.07.022_bib21","doi-asserted-by":"crossref","first-page":"G1114","DOI":"10.1152\/ajpgi.00528.2006","article-title":"Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression","volume":"292","author":"Shah","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib22","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbagrm.2016.02.009","article-title":"PXR- and CAR-mediated herbal effect on human diseases","volume":"1859","author":"Xu","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.apsb.2021.07.022_bib23","doi-asserted-by":"crossref","first-page":"31936","DOI":"10.1038\/srep31936","article-title":"Pregnane X receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through toll-like receptor 4","volume":"6","author":"Qiu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib24","doi-asserted-by":"crossref","first-page":"101199","DOI":"10.11131\/2016\/101199","article-title":"Xenobiotic receptor-mediated regulation of intestinal barrier function and innate immunity","volume":"3","author":"Ranhotra","year":"2016","journal-title":"Nucl Recept Res"},{"key":"10.1016\/j.apsb.2021.07.022_bib25","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/pr.2018.14","article-title":"Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis","volume":"83","author":"Huang","year":"2018","journal-title":"Pediatr Res"},{"key":"10.1016\/j.apsb.2021.07.022_bib26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2014.06.014","article-title":"Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4","volume":"41","author":"Venkatesh","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2021.07.022_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fimmu.2018.00005","article-title":"Nutrients mediate intestinal bacteria-mucosal immune crosstalk","volume":"9","author":"Ma","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2021.07.022_bib28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40168-019-0637-2","article-title":"Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family","volume":"7","author":"Lagkouvardos","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.apsb.2021.07.022_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s40168-017-0312-4","article-title":"Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism","volume":"5","author":"Caparros-Martin","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.apsb.2021.07.022_bib30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/toxsci\/kfy271","article-title":"Pharmacological activation of PXR and CAR downregulates distinct bile acid-metabolizing intestinal bacteria and alters bile acid homeostasis","volume":"168","author":"Dempsey","year":"2019","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.apsb.2021.07.022_bib31","first-page":"269","article-title":"Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis","volume":"166","author":"Cheng","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.apsb.2021.07.022_bib32","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1038\/s41598-018-38452-z","article-title":"Association of PXR and CAR polymorphisms and antituberculosis drug-induced hepatotoxicity","volume":"9","author":"Wang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib33","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2021.07.022_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.61.1.1","article-title":"Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital","volume":"61","author":"Ueda","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.apsb.2021.07.022_bib35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1124\/dmd.106.012831","article-title":"The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A","volume":"35","author":"Ma","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib36","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1124\/dmd.115.066639","article-title":"Age-specific regulation of drug-processing genes in mouse liver by ligands of xenobiotic-sensing transcription factors","volume":"44","author":"Li","year":"2016","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib37","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1124\/dmd.119.086538","article-title":"Polybrominated diphenyl ethers and gut microbiome modulate metabolic syndrome-related aqueous metabolites in mice","volume":"47","author":"Scoville","year":"2019","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib38","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/toxsci\/kfm025","article-title":"The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators","volume":"97","author":"Pacyniak","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.apsb.2021.07.022_bib39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/toxsci\/kft243","article-title":"Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes","volume":"137","author":"Sueyoshi","year":"2014","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.apsb.2021.07.022_bib40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/toxsci\/kfaa090","article-title":"Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice","volume":"177","author":"Lim","year":"2020","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.apsb.2021.07.022_bib41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.apsb.2021.07.022_bib42","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.apsb.2021.07.022_bib43","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.toxrep.2021.03.010","article-title":"Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis","volume":"8","author":"Wahlang","year":"2021","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib44","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1128\/JCM.02017-05","article-title":"Nongastric Helicobacter species detected in the intestinal tract of children","volume":"44","author":"Zhang","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib45","article-title":"The Lactobacillus bile salt hydrolase repertoire reveals niche-specific adaptation","volume":"3","author":"O'Flaherty","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.apsb.2021.07.022_bib46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.apsb.2021.07.022_bib47","doi-asserted-by":"crossref","first-page":"807483","DOI":"10.1155\/2011\/807483","article-title":"Lactobacillus paracasei reduces intestinal inflammation in adoptive transfer mouse model of experimental colitis","volume":"2011","author":"Oliveira","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.apsb.2021.07.022_bib48","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/jgh.14362","article-title":"Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress","volume":"34","author":"Kim","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2021.07.022_bib49","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/s41598-018-38253-4","article-title":"Antimicrobial and inflammatory properties of South African clinical Lactobacillus isolates and vaginal probiotics","volume":"9","author":"Chetwin","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib50","doi-asserted-by":"crossref","first-page":"4607491","DOI":"10.1155\/2017\/4607491","article-title":"Probiotic Lactobacillus strains stimulate the inflammatory response and activate human macrophages","volume":"2017","author":"Rocha-Ramirez","year":"2017","journal-title":"J Immunol Res"},{"key":"10.1016\/j.apsb.2021.07.022_bib51","first-page":"1706","article-title":"Mucosal prevalence and interactions with the epithelium indicate commensalism of","volume":"7","author":"Hiippala","year":"2016","journal-title":"Sutterella spp. Front Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib52","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00261-11","article-title":"Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances","volume":"3","author":"Williams","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.apsb.2021.07.022_bib53","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3390\/nu9121329","article-title":"Meta-analysis of fecal microbiota and metabolites in experimental colitic mice during the inflammatory and healing phases","volume":"9","author":"Osaka","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.apsb.2021.07.022_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00224-15","article-title":"Genome sequence of the butyrate-producing anaerobic bacterium Anaerostipes hadrus PEL 85","volume":"3","author":"Kant","year":"2015","journal-title":"Genome Announc"},{"key":"10.1016\/j.apsb.2021.07.022_bib55","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/oby.2011.111","article-title":"Responses of gut microbiota to diet composition and weight loss in lean and obese mice","volume":"20","author":"Ravussin","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.apsb.2021.07.022_bib56","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1124\/dmd.115.067504","article-title":"Regulation of hepatic drug-metabolizing enzymes in germ-free mice by conventionalization and probiotics","volume":"44","author":"Selwyn","year":"2016","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.apsb.2021.07.022_bib57","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.3389\/fmicb.2017.02707","article-title":"Bile-salt-hydrolases from the probiotic strain Lactobacillus johnsonii La1 mediate anti-giardial activity in\u00a0vitro and in\u00a0vivo","volume":"8","author":"Allain","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib58","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1038\/ajg.2010.281","article-title":"Mucolytic bacteria with increased prevalence in IBD mucosa augment in\u00a0vitro utilization of mucin by other bacteria","volume":"105","author":"Png","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.apsb.2021.07.022_bib59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/CEG.S186235","article-title":"Fecal microbiota profiles in treatment-naive pediatric inflammatory bowel disease\u2014associations with disease phenotype, treatment, and outcome","volume":"12","author":"Olbjorn","year":"2019","journal-title":"Clin Exp Gastroenterol"},{"key":"10.1016\/j.apsb.2021.07.022_bib60","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jam.12027","article-title":"Molecular cloning, characterization and comparison of bile salt hydrolases from Lactobacillus johnsonii PF01","volume":"114","author":"Chae","year":"2013","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib61","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2672.1995.tb03140.x","article-title":"Significance of bile salt hydrolytic activities of Lactobacilli","volume":"79","author":"De Smet","year":"1995","journal-title":"J Appl Bacteriol"},{"key":"10.1016\/j.apsb.2021.07.022_bib62","doi-asserted-by":"crossref","first-page":"32516","DOI":"10.1074\/jbc.M604172200","article-title":"Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase","volume":"281","author":"Kumar","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.07.022_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007581","article-title":"Bile salt hydrolases: gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract","volume":"15","author":"Foley","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.apsb.2021.07.022_bib64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fmicb.2018.00089","article-title":"Bile salt hydrolase activities: a novel target to screen anti-giardia Lactobacilli?.","volume":"9","author":"Allain","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib65","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2337\/dbi16-0066","article-title":"Targeting the gut microbiota-FXR signaling axis for glycemic control: does a dietary supplement work magic?.","volume":"66","author":"Shyng","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.apsb.2021.07.022_bib66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell Metabol"},{"key":"10.1016\/j.apsb.2021.07.022_bib67","doi-asserted-by":"crossref","first-page":"643857","DOI":"10.3389\/fphar.2021.643857","article-title":"Xanthohumol ameliorates diet-induced liver dysfunction via farnesoid X receptor-dependent and independent signaling","volume":"12","author":"Paraiso","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2021.07.022_bib68","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.tem.2011.07.002","article-title":"Hepatic FXR: key regulator of whole-body energy metabolism","volume":"22","author":"Teodoro","year":"2011","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.apsb.2021.07.022_bib69","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/hep.23450","article-title":"Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine","volume":"51","author":"Thomas","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.07.022_bib70","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1002\/jcp.25742","article-title":"TUDCA: an agonist of the bile acid receptor GPBAR1\/TGR5 with anti-inflammatory effects in microglial cells","volume":"232","author":"Yanguas-Casas","year":"2017","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib71","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3109\/07420528.2013.805762","article-title":"Sex differences in the circadian variation of cytochrome p450 genes and corresponding nuclear receptors in mouse liver","volume":"30","author":"Lu","year":"2013","journal-title":"Chronobiol Int"},{"key":"10.1016\/j.apsb.2021.07.022_bib72","doi-asserted-by":"crossref","first-page":"15625","DOI":"10.1038\/s41598-018-33893-y","article-title":"Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice","volume":"8","author":"Lai","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib73","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiw089","article-title":"Molecular exploration of fecal microbiome in quinoa-supplemented obese mice","volume":"92","author":"Garcia-Mazcorro","year":"2016","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.apsb.2021.07.022_bib74","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.3389\/fmicb.2018.02380","article-title":"Huang-Lian-Jie-Du-Decoction ameliorates hyperglycemia and insulin resistant in association with gut microbiota modulation","volume":"9","author":"Chen","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib75","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/imcb.12000","article-title":"The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota","volume":"96","author":"Alteber","year":"2018","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.apsb.2021.07.022_bib76","doi-asserted-by":"crossref","first-page":"7415975","DOI":"10.1155\/2018\/7415975","article-title":"Time-, sex-, and dose-dependent alterations of the gut microbiota by consumption of dietary daikenchuto (TU-100)","volume":"2018","author":"Miyoshi","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.apsb.2021.07.022_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159631","article-title":"Hypocholesterolemic properties and prebiotic effects of Mexican Ganoderma lucidum in C57BL\/6 mice","volume":"11","author":"Meneses","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.07.022_bib78","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/19490976.2018.1511663","article-title":"Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice","volume":"10","author":"Ring","year":"2019","journal-title":"Gut Microb"},{"key":"10.1016\/j.apsb.2021.07.022_bib79","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3389\/fmicb.2017.01804","article-title":"Protective effect of Akkermansia muciniphila against immune-mediated liver injury in a mouse model","volume":"8","author":"Wu","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JME-16-0054","article-title":"Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice","volume":"58","author":"Zhao","year":"2017","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.apsb.2021.07.022_bib81","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib82","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1477-7819-12-164","article-title":"Secondary bile acids: an underrecognized cause of colon cancer","volume":"12","author":"Ajouz","year":"2014","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.apsb.2021.07.022_bib83","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.chom.2020.01.021","article-title":"Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation","volume":"27","author":"Sinha","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.apsb.2021.07.022_bib84","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1757-4749-6-33","article-title":"Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis","volume":"6","author":"Luerce","year":"2014","journal-title":"Gut Pathog"},{"key":"10.1016\/j.apsb.2021.07.022_bib85","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.4014\/jmb.1503.03033","article-title":"Anticancer and anti-inflammatory activity of probiotic Lactococcus lactis NK34","volume":"25","author":"Han","year":"2015","journal-title":"J Microbiol Biotechnol"},{"key":"10.1016\/j.apsb.2021.07.022_bib86","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01298-18","article-title":"Acinetobacter baumannii gastrointestinal colonization is facilitated by secretory IgA which is reductively dissociated by bacterial thioredoxin A","volume":"9","author":"Ketter","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.apsb.2021.07.022_bib87","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","article-title":"Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease","volume":"158","author":"Palm","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2021.07.022_bib88","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imm.12760","article-title":"The immune response to Prevotella bacteria in chronic inflammatory disease","volume":"151","author":"Larsen","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.apsb.2021.07.022_bib89","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2021.07.022_bib90","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.3748\/wjg.v19.i23.3562","article-title":"Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease","volume":"19","author":"Golinska","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.apsb.2021.07.022_bib91","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3389\/fmicb.2017.00357","article-title":"Comparative genomic analysis reveals ecological differentiation in the genus Carnobacterium","volume":"8","author":"Iskandar","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib92","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.ajpath.2017.04.019","article-title":"Western diet-induced dysbiosis in farnesoid X receptor knockout mice causes persistent hepatic inflammation after antibiotic treatment","volume":"187","author":"Jena","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2021.07.022_bib93","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/s41598-019-38874-3","article-title":"Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia","volume":"9","author":"Granado-Serrano","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib94","doi-asserted-by":"crossref","first-page":"4953120","DOI":"10.1155\/2016\/4953120","article-title":"Treatment with a monoclonal anti-IL-12p40 antibody induces substantial gut microbiota changes in an experimental\u00a0colitis model","volume":"2016","author":"Castro-Mejia","year":"2016","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.apsb.2021.07.022_bib95","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1099\/jmm.0.46823-0","article-title":"Acinetobacter baumannii lipopolysaccharides are potent stimulators of human monocyte activation via Toll-like receptor 4 signalling","volume":"56","author":"Erridge","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203657","article-title":"Propionate-producing bacteria in the intestine may associate\u00a0with skewed responses of IL10-producing regulatory T cells in patients\u00a0with relapsing polychondritis","volume":"13","author":"Shimizu","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.07.022_bib97","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3390\/nu4081095","article-title":"Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease","volume":"4","author":"Brown","year":"2012","journal-title":"Nutrients"},{"key":"10.1016\/j.apsb.2021.07.022_bib98","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/ijo.2017.70","article-title":"Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling","volume":"41","author":"Pallister","year":"2017","journal-title":"Int J Obes"},{"key":"10.1016\/j.apsb.2021.07.022_bib99","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.apsb.2021.07.022_bib100","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13073-016-0262-7","article-title":"Signatures of early frailty in the gut microbiota","volume":"8","author":"Jackson","year":"2016","journal-title":"Genome Med"},{"key":"10.1016\/j.apsb.2021.07.022_bib101","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.apsb.2021.07.022_bib102","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2567.2005.02107.x","article-title":"Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor","volume":"114","author":"Rahim","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.apsb.2021.07.022_bib103","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1513\/AnnalsATS.201506-377AW","article-title":"The role of type 2 inflammation in the pathogenesis of asthma exacerbations","volume":"12 Suppl 2","author":"Dunican","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.apsb.2021.07.022_bib104","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.4049\/jimmunol.179.2.1282","article-title":"Maternal transmission of resistance to development of allergic airway disease","volume":"179","author":"Matson","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.apsb.2021.07.022_bib105","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.ajpath.2018.01.009","article-title":"A newly discovered antifibrotic pathway regulated by two fatty acid receptors: GPR40 and GPR84","volume":"188","author":"Gagnon","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2021.07.022_bib106","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fmicb.2018.01085","article-title":"Acclimation and institutionalization of the mouse microbiota following transportation","volume":"9","author":"Montonye","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.apsb.2021.07.022_bib107","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1016\/j.celrep.2019.05.042","article-title":"Dynamic and asymmetric changes of the microbial communities after cohousing in laboratory mice","volume":"27","author":"Caruso","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.apsb.2021.07.022_bib108","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/ani7120088","article-title":"To group or not to group? Good practice for housing male laboratory mice","volume":"7","author":"Kappel","year":"2017","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.apsb.2021.07.022_bib109","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2014.09.053","article-title":"Human genetics shape the gut microbiome","volume":"159","author":"Goodrich","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2021.07.022_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116704","article-title":"Effects of vendor and genetic background on the composition of the fecal microbiota of inbred mice","volume":"10","author":"Ericsson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.07.022_bib111","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/ar1917","article-title":"Interleukin-6 and chronic inflammation","volume":"2 Suppl 8","author":"Gabay","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.apsb.2021.07.022_bib112","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-065X.2008.00697.x","article-title":"Interleukin-2 in the development and control of inflammatory disease","volume":"226","author":"Hoyer","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1016\/j.apsb.2021.07.022_bib113","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/mi.2008.45","article-title":"IL-12 family members in experimental colitis","volume":"1 Suppl 1","author":"Neurath","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.apsb.2021.07.022_bib114","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.3748\/wjg.v13.i42.5635","article-title":"Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse","volume":"13","author":"Baskin-Bey","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.apsb.2021.07.022_bib115","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/hep.21236","article-title":"Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins","volume":"44","author":"Baskin-Bey","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.07.022_bib116","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.tips.2012.03.003","article-title":"Pregnane X receptor as a target for treatment of inflammatory bowel disorders","volume":"33","author":"Cheng","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.apsb.2021.07.022_bib117","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jnutbio.2014.04.006","article-title":"Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway","volume":"25","author":"Dou","year":"2014","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.apsb.2021.07.022_bib118","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/toxsci\/kfs211","article-title":"Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice","volume":"129","author":"Cheng","year":"2012","journal-title":"Toxicol Sci"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521002707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521002707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:50:18Z","timestamp":1761929418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383521002707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":118,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S2211383521002707"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2021.07.022","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2021.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}