{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:11:47Z","timestamp":1790485907156,"version":"4.1.0"},"reference-count":192,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773754"],"award-info":[{"award-number":["81773754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930102"],"award-info":[{"award-number":["81930102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.apsb.2021.11.001","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T18:37:31Z","timestamp":1636137451000},"page":"1761-1780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"title":["The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-1929","authenticated-orcid":false,"given":"Tiecheng","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaojun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2021.11.001_bib1","doi-asserted-by":"crossref","first-page":"L652","DOI":"10.1152\/ajplung.00113.2014","article-title":"Role of MMP2 and MMP9 in TRPV4-induced lung injury","volume":"307","author":"Villalta","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.apsb.2021.11.001_bib2","doi-asserted-by":"crossref","first-page":"113603","DOI":"10.1016\/j.bcp.2019.08.005","article-title":"The regulatory roles of calcium channels in tumors","volume":"169","author":"Zhong","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib3","doi-asserted-by":"crossref","first-page":"a003962","DOI":"10.1101\/cshperspect.a003962","article-title":"The role of transient receptor potential cationchannels in Ca2+ signaling","volume":"2","author":"Gees","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.11.001_bib5","doi-asserted-by":"crossref","first-page":"102106","DOI":"10.1016\/j.ceca.2019.102106","article-title":"Structural biology of thermoTRPV channels","volume":"84","author":"Yuan","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib6","doi-asserted-by":"crossref","first-page":"104545","DOI":"10.1016\/j.neuint.2019.104545","article-title":"Neuropsychiatric implications of transient receptor potential vanilloid (TRPV) channels in the reward system","volume":"131","author":"Singh","year":"2019","journal-title":"Neurochem Int"},{"key":"10.1016\/j.apsb.2021.11.001_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-3-642-54215-2_9","article-title":"TRPV1","volume":"222","author":"Bevan","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-3-642-54215-2_12","article-title":"The TRPV4 channel","volume":"222","author":"Garcia-Elias","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/35077544","article-title":"The TRP ion channel family","volume":"2","author":"Clapham","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.apsb.2021.11.001_bib10","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.3390\/cells9091983","article-title":"Transient receptor potential canonical (TRPC) channels: then and now","volume":"9","author":"Chen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2021.11.001_bib11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0092-8674(02)00719-5","article-title":"TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization","volume":"109","author":"Launay","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2021.11.001_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.11.001_bib13","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/35079092","article-title":"LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability","volume":"411","author":"Nadler","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.11.001_bib14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.tips.2004.10.004","article-title":"The TRPM ion channel subfamily: molecular, biophysical and functional features","volume":"25","author":"Fleig","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib15","doi-asserted-by":"crossref","first-page":"582975","DOI":"10.3389\/fcell.2020.582975","article-title":"TRP channels regulation of Rho GTPases in brain context and diseases","volume":"8","author":"Lavanderos","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib16","doi-asserted-by":"crossref","first-page":"38168","DOI":"10.1074\/jbc.M111.288993","article-title":"Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy","volume":"286","author":"Cvetkov","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"TRP channels","volume":"76","author":"Venkatachalam","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.apsb.2021.11.001_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature14383","article-title":"Structural biology: pain-sensing TRPA1 channel resolved","volume":"520","author":"Clapham","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.11.001_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-94-007-0265-3_16","article-title":"TRPP channels and polycystins","volume":"704","author":"Hofherr","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib20","article-title":"Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia","volume":"5","author":"Lee","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.11.001_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00210-005-1034-x","article-title":"Function and pharmacology of TRPM cation channels","volume":"371","author":"Harteneck","year":"2005","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib22","doi-asserted-by":"crossref","first-page":"F1245","DOI":"10.1152\/ajprenal.90522.2008","article-title":"TRPMLs: in sickness and in health","volume":"296","author":"Puertollano","year":"2009","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.apsb.2021.11.001_bib23","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ccell.2018.05.001","article-title":"Cancer cells co-opt the neuronal redox-sensing channel TRPA1 to promote oxidative-stress tolerance","volume":"33","author":"Takahashi","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.apsb.2021.11.001_bib24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10637-017-0438-z","article-title":"First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors","volume":"35","author":"Fu","year":"2017","journal-title":"Invest N Drugs"},{"key":"10.1016\/j.apsb.2021.11.001_bib25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bcp.2012.11.019","article-title":"Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells","volume":"85","author":"Schaefer","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/cells9020388","article-title":"The role of TRPC1 in modulating cancer progression","volume":"9","author":"Elzamzamy","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2021.11.001_bib27","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/glia.20994","article-title":"Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas","volume":"58","author":"Bomben","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.apsb.2021.11.001_bib28","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/onc.2008.475","article-title":"Transient receptor potential channel C3 contributes to the progression of human ovarian cancer","volume":"28","author":"Yang","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2021.11.001_bib29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3390\/cancers11040558","article-title":"TRPC3 regulates the proliferation and apoptosis resistance of triple negative breast cancer cells through the TRPC3\/RASA4\/MAPK pathway","volume":"11","author":"Wang","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.apsb.2021.11.001_bib30","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1113\/JP274659","article-title":"Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells","volume":"595","author":"Wei","year":"2017","journal-title":"J Physiol"},{"key":"10.1016\/j.apsb.2021.11.001_bib31","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1042\/CS20171069","article-title":"Overexpression of TrpC5 promotes tumor metastasis via the HIF-1alpha-Twist signaling pathway in colon cancer","volume":"131","author":"Chen","year":"2017","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.apsb.2021.11.001_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/aps.2015.109","article-title":"Transient receptor potential channel C5 in cancer chemoresistance","volume":"37","author":"He","year":"2016","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2021.11.001_bib33","doi-asserted-by":"crossref","first-page":"621614","DOI":"10.3389\/fonc.2021.621614","article-title":"TRP channels interactome as a novel therapeutic target in breast cancer","volume":"11","author":"Saldias","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.apsb.2021.11.001_bib34","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/jnci\/djq217","article-title":"Essential role of TRPC6 channels in G2\/M phase transition and development of human glioma","volume":"102","author":"Ding","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.apsb.2021.11.001_bib35","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1158\/0008-5472.CAN-09-2654","article-title":"Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness","volume":"70","author":"Chigurupati","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceca.2019.03.002","article-title":"TRPM2 in cancer","volume":"80","author":"Miller","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib37","doi-asserted-by":"crossref","first-page":"36284","DOI":"10.1074\/jbc.M114.620922","article-title":"A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1\/2alpha","volume":"289","author":"Chen","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib38","doi-asserted-by":"crossref","first-page":"8026702","DOI":"10.1155\/2016\/8026702","article-title":"Targeting TRPM2 channels impairs radiation-induced cell cycle arrest and fosters cell death of T cell leukemia cells in a Bcl-2-dependent manner","volume":"2016","author":"Klumpp","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.apsb.2021.11.001_bib39","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/sj.bjp.0707675","article-title":"Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)","volume":"153","author":"Togashi","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib40","doi-asserted-by":"crossref","first-page":"166665","DOI":"10.1016\/j.jmb.2020.09.024","article-title":"Small molecular inhibitors block TRPM4 currents in prostate cancer cells, with limited impact on cancer hallmark functions","volume":"433","author":"Borgstrom","year":"2021","journal-title":"J Mol Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib41","doi-asserted-by":"crossref","first-page":"102053","DOI":"10.1016\/j.ceca.2019.06.007","article-title":"TRP channels in gastric cancer: new hopes and clinical perspectives","volume":"82","author":"Sterea","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5142\/jgr.2013.37.201","article-title":"Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells","volume":"37","author":"Kim","year":"2013","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib43","doi-asserted-by":"crossref","first-page":"39328","DOI":"10.1074\/jbc.M111.264341","article-title":"Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels","volume":"286","author":"Zierler","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib44","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1471-2407-10-212","article-title":"Estrogen regulation of TRPM8 expression in breast cancer cells","volume":"10","author":"Chodon","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib45","doi-asserted-by":"crossref","first-page":"173312","DOI":"10.1016\/j.ejphar.2020.173312","article-title":"TRPM8 channels: a review of distribution and clinical role","volume":"882","author":"Liu","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib46","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1158\/0008-5472.CAN-04-2146","article-title":"Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib47","first-page":"1431","article-title":"Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines","volume":"40","author":"Okamoto","year":"2012","journal-title":"Int J Oncol"},{"key":"10.1016\/j.apsb.2021.11.001_bib48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ceca.2006.07.002","article-title":"Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators","volume":"41","author":"Beck","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib49","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846685","article-title":"HRAS-driven cancer cells are vulnerable to TRPML1 inhibition","volume":"20","author":"Jung","year":"2019","journal-title":"EMBO Rep"},{"key":"10.1016\/j.apsb.2021.11.001_bib50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3390\/cancers11040525","article-title":"Transient receptor potential mucolipin-1 channels in glioblastoma: role in patient's survival","volume":"11","author":"Morelli","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.apsb.2021.11.001_bib51","doi-asserted-by":"crossref","first-page":"8188","DOI":"10.3390\/ijms22158188","article-title":"Transient receptor potential channels in the epithelial-to-mesenchymal transition","volume":"22","author":"Van den Eynde","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ceca.2014.04.006","article-title":"Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression","volume":"56","author":"Wu","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib53","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1158\/0008-5472.CAN-08-3263","article-title":"Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis","volume":"69","author":"Bode","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib54","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1471-4159.2007.04582.x","article-title":"Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation","volume":"102","author":"Amantini","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.apsb.2021.11.001_bib55","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/nm.2827","article-title":"Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1","volume":"18","author":"Stock","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2021.11.001_bib56","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41374-019-0333-7","article-title":"The TRPV2 cation channels: from urothelial cancer invasiveness to glioblastoma multiforme interactome signature","volume":"100","author":"Santoni","year":"2020","journal-title":"Lab Invest"},{"key":"10.1016\/j.apsb.2021.11.001_bib57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.bjc.6603236","article-title":"A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme","volume":"95","author":"Guzman","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib58","doi-asserted-by":"crossref","first-page":"581455","DOI":"10.3389\/fphar.2020.581455","article-title":"TRP channels and small GTPases interplay in the main hallmarks of metastatic cancer","volume":"11","author":"Chinigo","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib59","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1158\/0008-5472.CAN-17-0360","article-title":"Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel","volume":"77","author":"Xie","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib60","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1038\/s41388-019-0709-6","article-title":"VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism","volume":"38","author":"Tang","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2021.11.001_bib61","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/13543776.2021.1903432","article-title":"TRPV4 antagonists: a patent review (2015\u20132020)","volume":"31","author":"Lawhorn","year":"2021","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.apsb.2021.11.001_bib62","doi-asserted-by":"crossref","first-page":"374","DOI":"10.7150\/jca.31640","article-title":"TRPV6 as A target for cancer therapy","volume":"11","author":"Stewart","year":"2020","journal-title":"J Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058866","article-title":"In\u00a0vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin","volume":"8","author":"Bowen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.11.001_bib64","doi-asserted-by":"crossref","first-page":"R1004","DOI":"10.1016\/j.cub.2020.06.101","article-title":"Physiology: new insights into central oxygen sensing","volume":"30","author":"SheikhBahaei","year":"2020","journal-title":"Curr Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib65","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.biopha.2018.12.077","article-title":"Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line","volume":"111","author":"Deveci","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2021.11.001_bib66","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1016\/j.cub.2020.06.047","article-title":"O2-dependent protein internalization underlies astrocytic sensing of acute hypoxia by restricting multimodal TRPA1 channel responses","volume":"30","author":"Uchiyama","year":"2020","journal-title":"Curr Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib67","doi-asserted-by":"crossref","first-page":"24449","DOI":"10.1074\/jbc.M116.747147","article-title":"Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics","volume":"291","author":"Bao","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib68","first-page":"3317","article-title":"Crucial role of TRPC6 in maintaining the stability of HIF-1alpha in glioma cells under hypoxia","volume":"128","author":"Li","year":"2015","journal-title":"J Cell Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib69","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nchembio.640","article-title":"TRPA1 underlies a sensing mechanism for O2","volume":"7","author":"Takahashi","year":"2011","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib70","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13046-017-0570-9","article-title":"Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids","volume":"36","author":"Riffle","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib71","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ygyno.2019.04.628","article-title":"High expression of TRPV-1 is associated with poor prognosis in cervical cancer","volume":"154","author":"Chay","year":"2019","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.apsb.2021.11.001_bib72","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ceb.2011.05.006","article-title":"Cross-talk between calcium and protein kinase A in the regulation of cell migration","volume":"23","author":"Howe","year":"2011","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib73","doi-asserted-by":"crossref","first-page":"16321","DOI":"10.18632\/oncotarget.3872","article-title":"Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.apsb.2021.11.001_bib74","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1158\/0008-5472.CAN-11-3863","article-title":"TRPM7 is required for breast tumor cell metastasis","volume":"72","author":"Middelbeek","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib75","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.emboj.7600931","article-title":"TRPM7, a novel regulator of actomyosin contractility and cell adhesion","volume":"25","author":"Clark","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2021.11.001_bib76","doi-asserted-by":"crossref","first-page":"28254","DOI":"10.1074\/jbc.M604272200","article-title":"Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores","volume":"281","author":"Lopez","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/onc.2015.83","article-title":"Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy","volume":"35","author":"Adapala","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2021.11.001_bib78","doi-asserted-by":"crossref","first-page":"27903","DOI":"10.1038\/srep27903","article-title":"TRPV4 regulates breast cancer cell extravasation, stiffness and actin cortex","volume":"6","author":"Lee","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.11.001_bib79","first-page":"33","article-title":"TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, non-selective cation currents in a cervical cancer cell cine, HeLa cells","volume":"62","author":"Gomi","year":"2014","journal-title":"Shinshu Med J"},{"key":"10.1016\/j.apsb.2021.11.001_bib80","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/onc.2011.231","article-title":"TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling","volume":"31","author":"Fiorio Pla","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2021.11.001_bib81","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3390\/cancers11070956","article-title":"Transient receptor potential channel expression signatures in tumor-derived endothelial cells: functional roles in prostate cancer angiogenesis","volume":"11","author":"Bernardini","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.apsb.2021.11.001_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042541","article-title":"Store-operated Ca2+ entry is remodelled and controls in\u00a0vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients","volume":"7","author":"Lodola","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.11.001_bib83","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1083\/jcb.201506024","article-title":"TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1","volume":"216","author":"Genova","year":"2017","journal-title":"J Cell Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib84","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2020.05.181","article-title":"TRPC1 exacerbate metastasis in gastric cancer via ciRS-7\/miR-135a-5p\/TRPC1 axis","volume":"529","author":"Zhang","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.apsb.2021.11.001_bib85","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/ijms19010217","article-title":"Endothelial Ca2+ signaling and the resistance to anticancer treatments: partners in crime","volume":"19","author":"Moccia","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib86","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.3390\/ijms19092467","article-title":"Functional expression of TRP ion channels in endometrial stromal cells of endometriosis patients","volume":"19","author":"Persoons","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib87","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1158\/1541-7786.MCR-07-0271","article-title":"Arachidonic acid-induced Ca2+ entry is involved in early steps of tumor angiogenesis","volume":"6","author":"Fiorio Pla","year":"2008","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib88","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.canlet.2018.07.042","article-title":"Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis","volume":"442","author":"Cappelli","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2021.11.001_bib89","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-immunol-032414-112212","article-title":"Ion channels in innate and adaptive immunity","volume":"33","author":"Feske","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.apsb.2021.11.001_bib90","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/bph.13392","article-title":"What is the evidence for the role of TRP channels in inflammatory and immune cells?.","volume":"173","author":"Parenti","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib91","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12974-015-0239-2","article-title":"Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons","volume":"12","author":"Santoni","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.apsb.2021.11.001_bib92","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/his.13204","article-title":"TRPM4 expression is associated with activated B cell subtype and poor survival in diffuse large B cell lymphoma","volume":"71","author":"Loo","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.apsb.2021.11.001_bib93","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/mi.2016.60","article-title":"TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection","volume":"10","author":"Beceiro","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.apsb.2021.11.001_bib94","first-page":"4561","article-title":"TRPM7 regulates proliferation and polarisation of macrophages","volume":"127","author":"Schilling","year":"2014","journal-title":"J Cell Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib95","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.taap.2013.08.009","article-title":"TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways","volume":"272","author":"Fang","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib96","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2013.10.030","article-title":"Blockage of TRPM7 channel induces hepatic stellate cell death through endoplasmic reticulum stress-mediated apoptosis","volume":"94","author":"Zhu","year":"2014","journal-title":"Life Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib97","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/mi.2016.16","article-title":"Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production","volume":"9","author":"Khalil","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.apsb.2021.11.001_bib98","doi-asserted-by":"crossref","first-page":"E6486","DOI":"10.1073\/pnas.1518966112","article-title":"TRPC6 channel translocation into phagosomal membrane augments phagosomal function","volume":"112","author":"Riazanski","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2021.11.001_bib99","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1128\/MCB.00256-15","article-title":"Transient receptor potential channel 1 deficiency impairs host defense and proinflammatory responses to bacterial infection by regulating protein kinase C\u03b1 signaling","volume":"35","author":"Zhou","year":"2015","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib100","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10555-016-9634-0","article-title":"Calcium role in human carcinogenesis: a comprehensive analysis and critical review of literature","volume":"35","author":"Kadio","year":"2016","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.apsb.2021.11.001_bib101","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.jid.2018.02.040","article-title":"TRPA1 acts in a protective manner in imiquimod-induced psoriasiform dermatitis in mice","volume":"138","author":"Kemeny","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.apsb.2021.11.001_bib102","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"Ogata","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib103","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.cellbio.18.011402.160624","article-title":"Transcriptional and translational control in the mammalian unfolded protein response","volume":"18","author":"Harding","year":"2002","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib104","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1053\/j.gastro.2011.02.052","article-title":"Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity","volume":"140","author":"Kim","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2021.11.001_bib105","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1172\/JCI38857","article-title":"Calcium\/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways","volume":"119","author":"Timmins","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2021.11.001_bib106","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1161\/CIRCRESAHA.109.213314","article-title":"The constitutive function of native TRPC3 channels modulates vascular cell adhesion molecule-1 expression in coronary endothelial cells through nuclear factor kappaB signaling","volume":"106","author":"Smedlund","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib107","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ceca.2011.08.008","article-title":"Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes","volume":"50","author":"Chen","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib108","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1124\/jpet.107.119412","article-title":"Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells","volume":"321","author":"Thomas","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.apsb.2021.11.001_bib109","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","article-title":"ER stress and the unfolded protein response","volume":"569","author":"Schroder","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib110","doi-asserted-by":"crossref","first-page":"L111","DOI":"10.1152\/ajplung.00231.2011","article-title":"Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in\u00a0vitro and lung injury","volume":"302","author":"Thomas","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.apsb.2021.11.001_bib111","doi-asserted-by":"crossref","first-page":"32591","DOI":"10.1074\/jbc.M109.019687","article-title":"The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channels","volume":"284","author":"Gallego-Sandin","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib112","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.biopha.2018.03.014","article-title":"Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway","volume":"101","author":"Fang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2021.11.001_bib113","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1002\/hep.22263","article-title":"Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation","volume":"47","author":"El Boustany","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2021.11.001_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190307","article-title":"Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes","volume":"13","author":"Olivan-Viguera","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.11.001_bib115","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1248\/bpb.b18-00370","article-title":"Taurine inhibits TRPV-dependent activity to overcome oxidative stress in Caenorhabditis elegans","volume":"41","author":"Moriuchi","year":"2018","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.apsb.2021.11.001_bib116","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00232-006-0017-2","article-title":"Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells","volume":"211","author":"El Hiani","year":"2006","journal-title":"J Membr Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib117","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ceca.2003.10.011","article-title":"The role of the calcium-sensing receptor in cancer","volume":"35","author":"Rodland","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib118","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.canlet.2019.04.012","article-title":"TRPM4 channel and cancer","volume":"454","author":"Gao","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2021.11.001_bib119","article-title":"TRPV4 channel inhibits TGF-beta1-induced proliferation of hepatic stellate cells","volume":"9","author":"Song","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2021.11.001_bib120","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1053\/j.gastro.2018.02.015","article-title":"P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts","volume":"154","author":"Dou","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2021.11.001_bib121","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00424-018-2130-3","article-title":"TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation","volume":"470","author":"Ohashi","year":"2018","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2021.11.001_bib122","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nature07577","article-title":"Calcium flickers steer cell migration","volume":"457","author":"Wei","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.11.001_bib123","doi-asserted-by":"crossref","first-page":"11260","DOI":"10.1074\/jbc.M512885200","article-title":"TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain","volume":"281","author":"Su","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib124","doi-asserted-by":"crossref","first-page":"8825","DOI":"10.2147\/OTT.S257056","article-title":"TRPM8 inhibition regulates the proliferation, migration and ROS metabolism of bladder cancer cells","volume":"13","author":"Wang","year":"2020","journal-title":"OncoTargets Ther"},{"key":"10.1016\/j.apsb.2021.11.001_bib125","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/excr.1997.3876","article-title":"Scavenger receptors mediate adhesion of activated B lymphocytes","volume":"239","author":"Yokota","year":"1998","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib126","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s13277-013-1167-3","article-title":"The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer","volume":"35","author":"Du","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib127","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrc.2017.118","article-title":"EMT in cancer","volume":"18","author":"Brabletz","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib128","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1535-6108(03)00304-0","article-title":"Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of \u03b2-catenin, and enhanced tumor cell invasion","volume":"4","author":"Lu","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.apsb.2021.11.001_bib129","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1038\/oncsis.2017.39","article-title":"TRPV4 plays a role in breast cancer cell migration via Ca2+-dependent activation of AKT and downregulation of E-cadherin cell cortex protein","volume":"6","author":"Lee","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.apsb.2021.11.001_bib130","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.juro.2011.04.107","article-title":"The mechanoreceptor TRPV4 is localized in adherence junctions of the human bladder urothelium: a morphological study","volume":"186","author":"Janssen","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.apsb.2021.11.001_bib131","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"Thiery JP. Emt: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2021.11.001_bib132","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41467-017-00983-w","article-title":"TRPA1\u2013FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p","volume":"8","author":"Berrout","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2021.11.001_bib133","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ceca.2010.03.003","article-title":"TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca2+ influx","volume":"47","author":"Chen","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib134","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neo.2017.01.004","article-title":"The transient receptor potential melastatin 7 channel regulates pancreatic cancer cell invasion through the Hsp90alpha\/uPA\/MMP2 pathway","volume":"19","author":"Rybarczyk","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.apsb.2021.11.001_bib135","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1038\/s41598-019-40330-1","article-title":"TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway","volume":"9","author":"Almasi","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.11.001_bib136","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13046-019-1061-y","article-title":"TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K\/AKT oncogenic signaling","volume":"38","author":"Liu","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib137","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00424-008-0515-4","article-title":"TRPC1 channels regulate directionality of migrating cells","volume":"457","author":"Fabian","year":"2008","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.apsb.2021.11.001_bib138","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/jcp.22518","article-title":"Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas","volume":"226","author":"Bomben","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2021.11.001_bib139","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-642-54215-2_2","article-title":"Trpc1","volume":"222","author":"Nesin","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib140","doi-asserted-by":"crossref","first-page":"E978","DOI":"10.1210\/jc.2011-3156","article-title":"A high prevalence of dual thyroid ectopy in congenital hypothyroidism: evidence for insufficient signaling gradients during embryonic thyroid migration or for the polyclonal nature of the thyroid gland?","volume":"97","author":"Wildi-Runge","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.apsb.2021.11.001_bib141","doi-asserted-by":"crossref","first-page":"769","DOI":"10.18632\/oncotarget.13647","article-title":"Ion channels in control of pancreatic stellate cell migration","volume":"8","author":"Storck","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.apsb.2021.11.001_bib142","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12576-016-0480-1","article-title":"Transient receptor potential cation 3 channel regulates melanoma proliferation and migration","volume":"67","author":"Oda","year":"2017","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib143","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1038\/oncsis.2013.40","article-title":"The histone variant MacroH2A regulates Ca2+ influx through TRPC3 and TRPC6 channels","volume":"2","author":"Kim","year":"2013","journal-title":"Oncogenesis"},{"key":"10.1016\/j.apsb.2021.11.001_bib144","doi-asserted-by":"crossref","first-page":"16116","DOI":"10.1074\/jbc.M115.643668","article-title":"Transient receptor potential canonical 1 (TRPC1) channels as regulators of sphingolipid and VEGF receptor expression: implications for thyroid cancer cell migration and proliferation","volume":"290","author":"Asghar","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib145","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib146","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2021.11.001_bib147","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2021.11.001_bib148","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1002\/eji.201545655","article-title":"NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5","volume":"45","author":"Baker","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.apsb.2021.11.001_bib149","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib150","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2021.11.001_bib151","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/imr.12285","article-title":"NLRP3 at the interface of metabolism and inflammation","volume":"265","author":"Haneklaus","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.apsb.2021.11.001_bib152","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4049\/jimmunol.190.Supp.116.12","article-title":"TRPM2 links oxidative stress to the NLRP3 inflammasome activation (P1268)","volume":"190","author":"Zhong","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.apsb.2021.11.001_bib153","doi-asserted-by":"crossref","first-page":"2975648","DOI":"10.1155\/2017\/2975648","article-title":"Transient receptor potential melastatin 2 negatively regulates LPS-ATP-induced caspase-1-dependent pyroptosis of bone marrow-derived macrophage by modulating ROS production","volume":"2017","author":"Wang","year":"2017","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.apsb.2021.11.001_bib154","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.apsb.2021.11.001_bib155","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/cvr\/cvr135","article-title":"Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death","volume":"91","author":"Becerra","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib156","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ceca.2017.05.007","article-title":"The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis","volume":"70","author":"Maher","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.apsb.2021.11.001_bib157","doi-asserted-by":"crossref","first-page":"35124","DOI":"10.18632\/oncotarget.16703","article-title":"Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP","volume":"8","author":"Sander","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.apsb.2021.11.001_bib158","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.canlet.2011.12.007","article-title":"Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma","volume":"318","author":"Yee","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2021.11.001_bib159","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.pan.2018.08.011","article-title":"Silencing of TRPM8 inhibits aggressive tumor phenotypes and enhances gemcitabine sensitivity in pancreatic cancer","volume":"18","author":"Liu","year":"2018","journal-title":"Pancreatology"},{"key":"10.1016\/j.apsb.2021.11.001_bib160","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/10799893.2017.1369121","article-title":"Synergic prooxidant, apoptotic and TRPV1 channel activator effects of alpha-lipoic acid and cisplatin in MCF-7 breast cancer cells","volume":"37","author":"Nur","year":"2017","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib161","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1074\/jbc.M114.590364","article-title":"Inhibition of transient receptor potential channel 5 reverses 5-fluorouracil resistance in human colorectal cancer cells","volume":"290","author":"Wang","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2021.11.001_bib162","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1186\/s12889-018-5920-9","article-title":"Promoting prompt help-seeking for symptoms\u2014assessing the impact of a gynaecological cancer leaflet on presentations to primary care: a record-based randomised control trial","volume":"18","author":"Campbell","year":"2018","journal-title":"BMC Publ Health"},{"key":"10.1016\/j.apsb.2021.11.001_bib163","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/ijc.29573","article-title":"Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner","volume":"137","author":"Nabissi","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib164","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s12640-019-0009-5","article-title":"Selenium enhances the apoptotic efficacy of docetaxel through activation of TRPM2 channel in DBTRG glioblastoma cells","volume":"35","author":"Ertilav","year":"2019","journal-title":"Neurotox Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib165","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/carcin\/bgs328","article-title":"Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents","volume":"34","author":"Nabissi","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.apsb.2021.11.001_bib166","doi-asserted-by":"crossref","first-page":"16282","DOI":"10.1073\/pnas.1202989109","article-title":"Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells","volume":"109","author":"Ma","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2021.11.001_bib167","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1038\/s41598-017-03230-w","article-title":"TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKK\u03b2\/AMPK\u03b1\/mTOR pathway","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2021.11.001_bib168","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/carcin\/bgq019","article-title":"TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner","volume":"31","author":"Nabissi","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.apsb.2021.11.001_bib169","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3389\/fphar.2019.01198","article-title":"2-APB and CBD-mediated targeting of charged cytotoxic compounds into tumor cells suggests the involvement of TRPV2 channels","volume":"10","author":"Neumann-Raizel","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib170","doi-asserted-by":"crossref","first-page":"90","DOI":"10.7150\/ijbs.7738","article-title":"Knockdown of TRPM8 suppresses cancer malignancy and enhances epirubicin-induced apoptosis in human osteosarcoma cells","volume":"10","author":"Wang","year":"2013","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib171","doi-asserted-by":"crossref","first-page":"E1067","DOI":"10.1002\/ijc.27588","article-title":"The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation","volume":"131","author":"Morelli","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib172","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/ijc.32648","article-title":"Dacarbazine alone or associated with melanoma-bearing cancer pain model induces painful hypersensitivity by TRPA1 activation in mice","volume":"146","author":"Brusco","year":"2020","journal-title":"Int J Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib173","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1124\/mol.114.092759","article-title":"A methylation-based regulatory network for microRNA 320a in chemoresistant breast cancer","volume":"86","author":"He","year":"2014","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.apsb.2021.11.001_bib174","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1158\/1535-7163.MCT-07-0478","article-title":"The role of TRPV6 in breast carcinogenesis","volume":"7","author":"Bolanz","year":"2008","journal-title":"Mol Cancer Therapeut"},{"key":"10.1016\/j.apsb.2021.11.001_bib175","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1158\/0008-5472.CAN-09-2205","article-title":"Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance","volume":"70","author":"Monet","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2021.11.001_bib176","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1158\/1535-7163.MCT-11-0965","article-title":"Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer","volume":"11","author":"Peters","year":"2012","journal-title":"Mol Cancer Therapeut"},{"key":"10.1016\/j.apsb.2021.11.001_bib177","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/cancers10090331","article-title":"TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure","volume":"10","author":"Jardin","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.apsb.2021.11.001_bib178","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/cancers11020145","article-title":"Calcium signaling in brain cancers: roles and therapeutic targeting","volume":"11","author":"Maklad","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.apsb.2021.11.001_bib179","first-page":"1548","article-title":"Silencing TRPC1 expression inhibits invasion of CNE2 nasopharyngeal tumor cells","volume":"27","author":"He","year":"2012","journal-title":"Oncol Rep"},{"key":"10.1016\/j.apsb.2021.11.001_bib180","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.pain.2011.02.051","article-title":"Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation","volume":"152","author":"Nassini","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.apsb.2021.11.001_bib181","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1038\/ncomms6736","article-title":"Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1","volume":"5","author":"Fusi","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2021.11.001_bib182","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11095-010-0249-9","article-title":"Chemical inhibitors of the calcium entry channel TRPV6","volume":"28","author":"Landowski","year":"2011","journal-title":"Pharm Res (N Y)"},{"key":"10.1016\/j.apsb.2021.11.001_bib183","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.7150\/ijbs.59918","article-title":"The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review","volume":"17","author":"Li","year":"2021","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.apsb.2021.11.001_bib184","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.7150\/jca.20639","article-title":"Inhibition of transient receptor potential vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model","volume":"9","author":"Xue","year":"2018","journal-title":"J Cancer"},{"key":"10.1016\/j.apsb.2021.11.001_bib185","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1876386301306010095","article-title":"Resiniferatoxin for pain treatment: an interventional approach to personalized pain medicine","volume":"6","author":"Iadarola","year":"2013","journal-title":"Open Pain J"},{"key":"10.1016\/j.apsb.2021.11.001_bib186","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/j.pain.0000000000000115","article-title":"Intrathecal resiniferatoxin in a dog model: efficacy in bone cancer pain","volume":"156","author":"Brown","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.apsb.2021.11.001_bib187","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1021\/ml500479v","article-title":"Discovery of a selective TRPM8 antagonist with clinical efficacy in cold-related pain","volume":"6","author":"Andrews","year":"2015","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.apsb.2021.11.001_bib188","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/jpet.114.216010","article-title":"Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans","volume":"351","author":"Winchester","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.apsb.2021.11.001_bib189","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/19336950.2020.1740506","article-title":"Mutations in calmodulin-binding domains of TRPV4\/6 channels confer invasive properties to colon adenocarcinoma cells","volume":"14","author":"Arbabian","year":"2020","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.apsb.2021.11.001_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2020.07.1583","article-title":"TRPV 1 regulates the proliferation and cisplatin sensitivity of esophageal cancer","volume":"108","author":"OuYang","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.apsb.2021.11.001_bib191","doi-asserted-by":"crossref","first-page":"739494","DOI":"10.1155\/2014\/739494","article-title":"Store-operated Ca2+ entry does not control proliferation in primary cultures of human metastatic renal cellular carcinoma","volume":"2014","author":"Dragoni","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.apsb.2021.11.001_bib192","doi-asserted-by":"crossref","first-page":"41783","DOI":"10.18632\/oncotarget.6157","article-title":"Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells","volume":"6","author":"Holzmann","year":"2015","journal-title":"Oncotarget"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521004329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383521004329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T16:42:14Z","timestamp":1749832934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383521004329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":192,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S2211383521004329"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2021.11.001","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2021.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}