{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:55:19Z","timestamp":1792792519695,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["HKBU\/RC-IRCs\/17-18\/03"],"award-info":[{"award-number":["HKBU\/RC-IRCs\/17-18\/03"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703487"],"award-info":[{"award-number":["81703487"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773926"],"award-info":[{"award-number":["81773926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005407","name":"Hong Kong Food and Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["HMRF17182541"],"award-info":[{"award-number":["HMRF17182541"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["HMRF17182551"],"award-info":[{"award-number":["HMRF17182551"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.apsb.2022.01.017","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T12:44:31Z","timestamp":1643892271000},"page":"1707-1722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy"],"prefix":"10.1016","volume":"12","author":[{"given":"Chuanbin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6479-3271","authenticated-orcid":false,"given":"Chengfu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Iyaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthil Kumar","family":"Krishnamoorthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Chunkit","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-6232","authenticated-orcid":false,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravan G.","family":"Sreenivasmurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aston Jiaxi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis Shiying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-1654","authenticated-orcid":false,"given":"Kingho","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juxian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8288-4038","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2022.01.017_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/alz.12068","article-title":"2020 Alzheimer's disease facts and figures","volume":"16","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.apsb.2022.01.017_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuron.2006.09.016","article-title":"A hundred years of Alzheimer's disease research","volume":"52","author":"Hardy","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.apsb.2022.01.017_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/ijms17040531","article-title":"Distinct dasatinib-induced mechanisms of apoptotic response and exosome release in imatinib-resistant human chronic myeloid leukemia cells","volume":"17","author":"Liu","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2022.01.017_bib4","doi-asserted-by":"crossref","first-page":"153648","DOI":"10.1016\/j.phymed.2021.153648","article-title":"Qingyangshen mitigates amyloid-\u03b2 and Tau aggregate defects involving PPAR\u03b1-TFEB activation in transgenic mice of Alzheimer's disease","volume":"91","author":"Iyaswamy","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.apsb.2022.01.017_bib5","doi-asserted-by":"crossref","first-page":"n1682","DOI":"10.1136\/bmj.n1682","article-title":"Aducanumab for Alzheimer\u2019s disease?.","volume":"374","author":"Walsh","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.apsb.2022.01.017_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrneurol.2013.223","article-title":"Alzheimer disease therapy\u2014moving from amyloid-\u03b2 to tau","volume":"9","author":"Giacobini","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.apsb.2022.01.017_bib7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.apsb.2022.01.017_bib8","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2022.01.017_bib9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrn3961","article-title":"Compromised autophagy and neurodegenerative diseases","volume":"16","author":"Menzies","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.apsb.2022.01.017_bib10","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.apsb.2022.01.017_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/C3NP70065H","article-title":"Natural product-derived pharmacological modulators of Nrf2\/ARE pathway for chronic diseases","volume":"31","author":"Kumar","year":"2014","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.apsb.2022.01.017_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fphar.2017.00343","article-title":"Potential of central, eastern and western Africa medicinal plants for cancer therapy: spotlight on resistant cells and molecular targets","volume":"8","author":"Mbaveng","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2022.01.017_bib13","first-page":"2190","article-title":"The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid \u03b2 accumulation in mice","volume":"118","author":"Pickford","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2022.01.017_bib14","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/hep.30770","article-title":"Dual roles of mammalian target of rapamycin in regulating liver injury and tumorigenesis in autophagy-defective mouse liver","volume":"70","author":"Ni","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2022.01.017_bib15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2016.04.025","article-title":"Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice","volume":"65","author":"Ni","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2022.01.017_bib16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.biopsych.2019.05.008","article-title":"Autophagy dysfunction in Alzheimer's disease: mechanistic insights and new therapeutic opportunities","volume":"87","author":"Di Meco","year":"2020","journal-title":"Biol Psychiatr"},{"key":"10.1016\/j.apsb.2022.01.017_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-016-0386-8","article-title":"Autophagy and Alzheimer's disease","volume":"37","author":"Li","year":"2017","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.apsb.2022.01.017_bib18","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/s41556-018-0235-8","article-title":"Autophagy and the cell biology of age-related disease","volume":"20","author":"Leidal","year":"2018","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.apsb.2022.01.017_bib19","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1080\/15548627.2017.1379633","article-title":"NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models","volume":"13","author":"Yang","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-019-0342-4","article-title":"Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice","volume":"14","author":"Lachance","year":"2019","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.apsb.2022.01.017_bib21","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41374-020-0433-4","article-title":"Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory","volume":"100","author":"Ouyang","year":"2020","journal-title":"Lab Invest"},{"key":"10.1016\/j.apsb.2022.01.017_bib22","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1080\/15548627.2020.1760623","article-title":"NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation","volume":"17","author":"Cai","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib23","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/archneurol.2010.258","article-title":"Beclin 1 complex in autophagy and Alzheimer disease","volume":"67","author":"Jaeger","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.apsb.2022.01.017_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.celrep.2013.08.042","article-title":"A\u03b2 secretion and plaque formation depend on autophagy","volume":"5","author":"Nilsson","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.apsb.2022.01.017_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ajpath.2014.10.011","article-title":"Autophagy-related protein 7 deficiency in amyloid \u03b2 (A\u03b2) precursor protein transgenic mice decreases A\u03b2 in the multivesicular bodies and induces A\u03b2 accumulation in the Golgi","volume":"185","author":"Nilsson","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2022.01.017_bib26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuropharm.2015.02.003","article-title":"LC3 overexpression reduces A\u03b2 neurotoxicity through increasing \u03b17nAchR expression and autophagic activity in neurons and mice","volume":"93","author":"Hung","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.apsb.2022.01.017_bib27","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.apsb.2022.01.017_bib28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.apsb.2022.01.017_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4161\/auto.19653","article-title":"MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB","volume":"8","author":"Martina","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib30","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.15252\/emmm.201303671","article-title":"Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB","volume":"6","author":"Polito","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.apsb.2022.01.017_bib31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tins.2016.02.002","article-title":"The autophagy\u2013lysosomal pathway in neurodegeneration: a TFEB perspective","volume":"39","author":"Martini-Stoica","year":"2016","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.apsb.2022.01.017_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fmed.2017.00069","article-title":"Celastrol: a spectrum of treatment\u00a0opportunities in chronic diseases","volume":"4","author":"Casc\u00e3o","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.apsb.2022.01.017_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molcel.2017.03.008","article-title":"Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy","volume":"66","author":"Hu","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2022.01.017_bib34","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2022.01.017_bib35","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cmet.2015.08.005","article-title":"Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1\u2013PGC1\u03b1 transcriptional axis","volume":"22","author":"Ma","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.apsb.2022.01.017_bib36","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/emboj.2012.32","article-title":"A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB","volume":"31","author":"Settembre","year":"2012","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2022.01.017_bib37","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1080\/15548627.2016.1179404","article-title":"A novel curcumin analog binds to and activates TFEB in\u00a0vitro and in\u00a0vivo independent of MTOR inhibition","volume":"12","author":"Song","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib38","doi-asserted-by":"crossref","first-page":"9340","DOI":"10.1523\/JNEUROSCI.22-21-09340.2002","article-title":"Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein","volume":"22","author":"Allen","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.apsb.2022.01.017_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3233\/JAD-201014","article-title":"Sexual dimorphism in the 3xTg-AD mouse model and its impact on pre-clinical research","volume":"80","author":"Dennison","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.apsb.2022.01.017_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13069","article-title":"A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models","volume":"19","author":"Song","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.apsb.2022.01.017_bib41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jfda.2019.09.004","article-title":"NeuroDefend, a novel Chinese medicine, attenuates amyloid-\u03b2 and tau pathology in experimental Alzheimer's disease models","volume":"28","author":"Iyaswamy","year":"2020","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.apsb.2022.01.017_bib42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The open field test for measuring locomotor activity and anxiety-like behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.apsb.2022.01.017_bib43","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1037\/0735-7044.113.5.867","article-title":"Contextual fear conditioning, conjunctive representations, pattern completion, and the hippocampus","volume":"113","author":"Rudy","year":"1999","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.apsb.2022.01.017_bib44","article-title":"Morris water maze test for learning and memory deficits in Alzheimer's disease model mice","volume":"53","author":"Bromley-Brits","year":"2011","journal-title":"J Vis Exp"},{"key":"10.1016\/j.apsb.2022.01.017_bib45","doi-asserted-by":"crossref","first-page":"101445","DOI":"10.1016\/j.redox.2020.101445","article-title":"A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB\/TFE3-dependent autophagy and lysosomal biogenesis independent of p38","volume":"32","author":"Yang","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.apsb.2022.01.017_bib46","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1080\/15548627.2021.1886720","article-title":"Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)","volume":"17","author":"Zheng","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib47","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1021\/acschemneuro.5b00115","article-title":"N-Propargyl caffeate amide (PACA) potentiates nerve growth factor (NGF)-induced neurite outgrowth and attenuates 6-hydroxydopamine (6-OHDA)-induced toxicity by activating the Nrf2\/HO-1 pathway","volume":"6","author":"Yang","year":"2015","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.apsb.2022.01.017_bib48","article-title":"TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2","author":"Yang","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2022.01.017_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081682","article-title":"Bimolecular fluorescence complementation; lighting-up tau\u2013tau interaction in living cells","volume":"8","author":"Tak","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2022.01.017_bib50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.mcb.2014.11.011","article-title":"TFEB and the CLEAR network","volume":"126","author":"Settembre","year":"2015","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.apsb.2022.01.017_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib52","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798804","article-title":"The complex relationship between TFEB transcription factor phosphorylation and subcellular localization","volume":"37","author":"Puertollano","year":"2018","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2022.01.017_bib53","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.apsb.2022.01.017_bib54","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin\u2013cyclosporin A and FKBP\u2013FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2022.01.017_bib55","doi-asserted-by":"crossref","first-page":"12525","DOI":"10.1074\/jbc.RA118.003471","article-title":"Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress","volume":"293","author":"Martina","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2022.01.017_bib56","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2019.1596486","article-title":"Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib57","doi-asserted-by":"crossref","first-page":"107673","DOI":"10.1016\/j.pharmthera.2020.107673","article-title":"A natural product solution to aging and aging-associated diseases","volume":"216","author":"Yang","year":"2020","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.apsb.2022.01.017_bib58","doi-asserted-by":"crossref","first-page":"584770","DOI":"10.3389\/fphar.2020.584770","article-title":"Yuan-Hu Zhi Tong Prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of Alzheimer's disease","volume":"11","author":"Iyaswamy","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2022.01.017_bib59","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3390\/ijms21041515","article-title":"A curcumin derivative activates TFEB and protects against parkinsonian neurotoxicity in\u00a0vitro","volume":"21","author":"Wang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2022.01.017_bib60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4161\/auto.26751","article-title":"HMGB1 is involved in autophagy inhibition caused by SNCA\/\u03b1-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B","volume":"10","author":"Song","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2022.01.017_bib61","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41591-019-0358-x","article-title":"IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects","volume":"25","author":"Feng","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2022.01.017_bib62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s40265-015-0529-0","article-title":"Tau biology and tau-directed therapies for Alzheimer's disease","volume":"76","author":"Bakota","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.apsb.2022.01.017_bib63","doi-asserted-by":"crossref","first-page":"56053","DOI":"10.1074\/jbc.M409267200","article-title":"Celastrols as inducers of the heat shock response and cytoprotection","volume":"279","author":"Westerheide","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2022.01.017_bib64","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00109-007-0251-9","article-title":"Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response","volume":"85","author":"Zhang","year":"2007","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.apsb.2022.01.017_bib65","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000090364","article-title":"Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis","volume":"2","author":"Kiaei","year":"2005","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.apsb.2022.01.017_bib66","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1742-2094-7-17","article-title":"Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease","volume":"7","author":"Paris","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.apsb.2022.01.017_bib67","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.redox.2014.11.006","article-title":"Mitochondrial dynamics and mitochondrial quality control","volume":"4","author":"Ni","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.apsb.2022.01.017_bib68","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tibs.2019.08.002","article-title":"Post-translational modifications of key machinery in the control of mitophagy","volume":"45","author":"Wang","year":"2020","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.apsb.2022.01.017_bib69","doi-asserted-by":"crossref","first-page":"100973","DOI":"10.1016\/j.mam.2021.100973","article-title":"Autophagy in liver diseases: a review","volume":"82","author":"Qian","year":"2021","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.apsb.2022.01.017_bib70","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1053\/j.gastro.2018.05.027","article-title":"Impaired TFEB-mediated lysosome biogenesis and autophagy promote chronic ethanol-induced liver injury and steatosis in mice","volume":"155","author":"Chao","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2022.01.017_bib71","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jcmgh.2020.01.008","article-title":"Critical role of TFEB-mediated lysosomal biogenesis in alcohol-induced pancreatitis in mice and humans","volume":"10","author":"Wang","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2022.01.017_bib72","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1080\/15548627.2018.1489170","article-title":"Insufficient autophagy: a novel autophagic flux scenario uncovered by impaired liver TFEB-mediated lysosomal biogenesis from chronic alcohol-drinking mice","volume":"14","author":"Chao","year":"2018","journal-title":"Autophagy"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522000478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522000478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:15:19Z","timestamp":1762604119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383522000478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S2211383522000478"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2022.01.017","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2022.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}