{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:40:23Z","timestamp":1790563223699,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-042"],"award-info":[{"award-number":["2021-I2M-1-042"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.apsb.2022.09.003","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T08:38:05Z","timestamp":1662971885000},"page":"1216-1230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosis in\u00a0vitro and in vivo"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-3920","authenticated-orcid":false,"given":"Jiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-4298","authenticated-orcid":false,"given":"Wenfeng","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-9334","authenticated-orcid":false,"given":"Deguan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2022.09.003_bib1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1126\/science.abc1507","article-title":"Opening the floodgates at fukushima","volume":"369","author":"Buesseler","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.apsb.2022.09.003_bib2","doi-asserted-by":"crossref","unstructured":"Ogasa N. Nuclear fallout is showing up in U.S. honey, decades after bomb tests. Science 2021. Available from: https:\/\/www.science.org\/content\/article\/nuclear-fallout-showing-us-honey-decades-after-bomb-tests.","DOI":"10.1126\/science.abj0989"},{"key":"10.1016\/j.apsb.2022.09.003_bib3","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1038\/s41467-021-22081-8","article-title":"Bomb 137Cs in modern honey reveals a regional soil control on pollutant cycling by plants","volume":"12","author":"Kaste","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2022.09.003_bib4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1126\/science.abg2365","article-title":"Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident","volume":"372","author":"Yeager","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.apsb.2022.09.003_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.abg2538","article-title":"Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident","volume":"372","author":"Morton","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.apsb.2022.09.003_bib6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1165\/rcmb.2020-0077OC","article-title":"NOX1 promotes mesothelial-mesenchymal transition through modulation of reactive oxygen species-mediated signaling","volume":"64","author":"Qin","year":"2021","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.apsb.2022.09.003_bib7","first-page":"1","article-title":"Lipoxin A4 reduces ventilator-induced lung injury in rats with large-volume mechanical ventilation","volume":"2020","author":"Wang","year":"2020","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.apsb.2022.09.003_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/toxsci\/kfu255","article-title":"Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D","volume":"144","author":"Malaviya","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.apsb.2022.09.003_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13014-022-02038-x","article-title":"The roles of CC chemokines in response to radiation","volume":"17","author":"Wang","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.apsb.2022.09.003_bib10","doi-asserted-by":"crossref","first-page":"12727","DOI":"10.1093\/nar\/gkaa1110","article-title":"Serine-70 phosphorylated BCL-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism","volume":"48","author":"Chong","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2022.09.003_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/0034-4885\/79\/11\/116601","article-title":"Radiation track, DNA damage and response: a review","volume":"79","author":"Nikjoo","year":"2016","journal-title":"Rep Prog Phys"},{"key":"10.1016\/j.apsb.2022.09.003_bib12","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1128\/jb.177.19.5495-5505.1995","article-title":"Interchromosomal recombination in the extremely radioresistant bacterium Deinococcus radiodurans","volume":"177","author":"Daly","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1016\/j.apsb.2022.09.003_bib13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.dnarep.2004.02.002","article-title":"Early studies on recombination and DNA repair in","volume":"3","author":"Holliday","year":"2004","journal-title":"Ustilago maydis. DNA Repair"},{"key":"10.1016\/j.apsb.2022.09.003_bib14","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/nrmicro1264","article-title":"Deinococcus radiodurans\u2013the consummate survivor","volume":"3","author":"Cox","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.apsb.2022.09.003_bib15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.yexcr.2018.07.003","article-title":"Tannic acid attenuated irradiation-induced apoptosis in megakaryocytes","volume":"370","author":"Xu","year":"2018","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.apsb.2022.09.003_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.canlet.2017.02.010","article-title":"Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of Caspase-2","volume":"393","author":"Badawi","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2022.09.003_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.radonc.2011.06.037","article-title":"Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma","volume":"101","author":"Reichert","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.apsb.2022.09.003_bib18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ijrobp.2020.09.005","article-title":"Simultaneous targeting of RSK and AKT efficiently inhibits YB-1-mediated repair of ionizing radiation-induced DNA double-strand breaks in breast cancer cells","volume":"109","author":"Lettau","year":"2021","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.apsb.2022.09.003_bib19","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccell.2019.01.020","article-title":"Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair","volume":"35","author":"Ma","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.apsb.2022.09.003_bib20","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1158\/0008-5472.CAN-19-0680","article-title":"Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high-grade gliomas","volume":"79","author":"Todorova","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2022.09.003_bib21","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41422-019-0263-3","article-title":"The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression","volume":"30","author":"Lei","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.apsb.2022.09.003_bib22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/acschembio.9b00939","article-title":"Radiation-induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers","volume":"15","author":"Ye","year":"2020","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.apsb.2022.09.003_bib23","first-page":"111","article-title":"Progress in clinical application of radiation protective agents","volume":"62","author":"Yu","year":"2022","journal-title":"Shandong Med J"},{"key":"10.1016\/j.apsb.2022.09.003_bib24","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ijrobp.2017.02.211","article-title":"Current Status of Targeted radioprotection and radiation injury mitigation and treatment agents: a critical review of the literature","volume":"98","author":"Kalman","year":"2017","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.apsb.2022.09.003_bib25","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1200\/JCO.2000.18.19.3339","article-title":"Phase III randomized trial of amifostine as a radioprotector in head and neck cancer","volume":"18","author":"Brizel","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.apsb.2022.09.003_bib26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/HP.0000000000000279","article-title":"Medical countermeasures for radiation exposure and related injuries: characterization of medicines, FDA-approval status and inclusion into the strategic national stockpile","volume":"108","author":"Singh","year":"2015","journal-title":"Health Phys"},{"key":"10.1016\/j.apsb.2022.09.003_bib27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41392-020-0150-x","article-title":"DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer","volume":"5","author":"Huang","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.apsb.2022.09.003_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2307\/3577098","article-title":"Single- and double-strand break formation in DNA irradiated in aqueous solution: dependence on dose and oh radical scavenger concentration","volume":"112","author":"Siddiqi","year":"1987","journal-title":"Radiat Res"},{"key":"10.1016\/j.apsb.2022.09.003_bib29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000502979","article-title":"Use of amifostine for cytoprotection during radiation therapy: a review","volume":"98","author":"King","year":"2020","journal-title":"Oncology"},{"key":"10.1016\/j.apsb.2022.09.003_bib30","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/bmj.2.1909.272","article-title":"Deep tissue traumatism from roentgen ray exposure","volume":"2","author":"Walsh","year":"1897","journal-title":"BMJ"},{"key":"10.1016\/j.apsb.2022.09.003_bib31","first-page":"43","article-title":"Modifiers of radiation effects in the eye","volume":"15","author":"Kleiman","year":"2017","journal-title":"Life Sci Space Res"},{"key":"10.1016\/j.apsb.2022.09.003_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/1874467210666171108165641","article-title":"Targeting of inflammation for radiation protection and mitigation","volume":"11","author":"Yahyapour","year":"2018","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.apsb.2022.09.003_bib33","series-title":"Herbal radiomodulators: applications in medicine, homeland defence, and space","author":"Arora","year":"2008"},{"key":"10.1016\/j.apsb.2022.09.003_bib34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41419-020-2335-1","article-title":"Suppressing STAT5 signaling affects osteosarcoma growth and stemness","volume":"11","author":"Subramaniam","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2022.09.003_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/980890","article-title":"Qualitative and quantitative analysis of Eclipta prostrata L. by LC\/MS","volume":"2015","author":"Han","year":"2015","journal-title":"Sci World J"},{"key":"10.1016\/j.apsb.2022.09.003_bib36","series-title":"Qualitative analysis and in\u00a0vivo metabolic profile study of rabbit auricularifolia based on UPLC\u2012Q-TOF-MS technology","author":"Wang","year":"2021"},{"key":"10.1016\/j.apsb.2022.09.003_bib37","series-title":"Study on the metabolic behavior of Luteolin in rats by HPLC\u2013MS\/MS","author":"Yang","year":"2016"},{"key":"10.1016\/j.apsb.2022.09.003_bib38","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1089\/ars.2010.3644","article-title":"P53, oxidative stress, and aging","volume":"15","author":"Liu","year":"2011","journal-title":"Antioxid Redox Sign"},{"key":"10.1016\/j.apsb.2022.09.003_bib39","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1016\/j.matpr.2020.12.649","article-title":"FDA recommended potent drugs against COVID-19: insight through molecular docking","volume":"45","author":"Gumber","year":"2021","journal-title":"Mater Today Proc"},{"key":"10.1016\/j.apsb.2022.09.003_bib40","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1111\/jcmm.14159","article-title":"The protective effects of XH-105 against radiation-induced intestinal injury","volume":"23","author":"Cheng","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.apsb.2022.09.003_bib41","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2013.11.008","article-title":"Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration","volume":"14","author":"Metcalfe","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.apsb.2022.09.003_bib42","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1469-7580.2008.00925.x","article-title":"Small intestinal stem cell markers","volume":"213","author":"Montgomery","year":"2008","journal-title":"J Anat"},{"key":"10.1016\/j.apsb.2022.09.003_bib43","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1053\/j.gastro.2021.01.028","article-title":"Axin2+ peribiliary glands in the periampullary region generate biliary epithelial stem cells that give rise to ampullary carcinoma","volume":"160","author":"Hayata","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2022.09.003_bib44","first-page":"1","article-title":"APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps","volume":"19","author":"Rezasoltani","year":"2020","journal-title":"Cancer Inf"},{"key":"10.1016\/j.apsb.2022.09.003_bib45","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1136\/gutjnl-2019-319514","article-title":"Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence","volume":"69","author":"Khaloian","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.apsb.2022.09.003_bib46","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.immuni.2020.07.010","article-title":"Paneth cell-derived lysozyme defines the composition of mucolytic microbiota and the inflammatory tone of the intestine","volume":"53","author":"Yu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2022.09.003_bib47","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.it.2020.10.010","article-title":"Lysozyme: a double-edged sword in the intestine","volume":"41","author":"Zigdon","year":"2020","journal-title":"Trends Immunol"},{"key":"10.1016\/j.apsb.2022.09.003_bib48","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2022.09.003_bib49","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1073\/pnas.0913089107","article-title":"Caspase 3\/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks","volume":"107","author":"Larsen","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2022.09.003_bib50","doi-asserted-by":"crossref","first-page":"11921","DOI":"10.7150\/thno.46006","article-title":"Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy","volume":"10","author":"Hu","year":"2020","journal-title":"Theranostics"}],"updated-by":[{"DOI":"10.1016\/j.apsb.2023.03.026","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000}}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522003914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522003914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:59:13Z","timestamp":1761929953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383522003914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2211383522003914"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2022.09.003","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosis in\u00a0vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2022.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}