{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:12:06Z","timestamp":1784542326622,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901878"],"award-info":[{"award-number":["81901878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M662553"],"award-info":[{"award-number":["2019M662553"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020T130611"],"award-info":[{"award-number":["2020T130611"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009101","name":"Education Department of Henan Province","doi-asserted-by":"publisher","award":["20HASTIT049"],"award-info":[{"award-number":["20HASTIT049"]}],"id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.apsb.2022.10.021","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:13:20Z","timestamp":1666934000000},"page":"775-786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy"],"prefix":"10.1016","volume":"13","author":[{"given":"Qianhua","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbiao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-8842","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2022.10.021_bib1","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.1002\/anie.201916142","article-title":"Specific \u201cunlocking\u201d of a nanozyme-based butterfly effect to break the evolutionary fitness of thaotic tumors","volume":"59","author":"Zhen","year":"2020","journal-title":"Angew Chem, Int Ed"},{"key":"10.1016\/j.apsb.2022.10.021_bib2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41568-020-0273-y","article-title":"Metabolism of immune cells in cancer","volume":"20","author":"Leone","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2022.10.021_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fimmu.2017.00248","article-title":"Metabolic hallmarks of tumor and immune cells in the tumor microenvironment","volume":"8","author":"Renner","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2022.10.021_bib4","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/s41467-019-10015-4","article-title":"Competition for nutrients and its role in controlling immune responses","volume":"10","author":"Kedia-Mehta","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2022.10.021_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41571-019-0203-7","article-title":"Navigating metabolic pathways to enhance antitumour immunity and immunotherapy","volume":"16","author":"Li","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.apsb.2022.10.021_bib6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fonc.2018.00284","article-title":"Metabolic switch in the tumor microenvironment determines immune responses to anti-cancer therapy","volume":"8","author":"Wegiel","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.apsb.2022.10.021_bib7","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.cclet.2020.02.007","article-title":"Recent progress in tumor photodynamic immunotherapy","volume":"31","author":"Shen","year":"2020","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.apsb.2022.10.021_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201905751","article-title":"Dual-locking nanoparticles disrupt the PD-1\/PD-L1 pathway for efficient cancer immunotherapy","volume":"31","author":"Zhang","year":"2019","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2022.10.021_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202002138","article-title":"A biomimetic nanogenerator of reactive nitrogen species based on battlefield transfer strategy for enhanced immunotherapy","volume":"16","author":"Feng","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.apsb.2022.10.021_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ccell.2020.09.004","article-title":"Immunometabolic interplay in the tumor microenvironment","volume":"39","author":"Kaymak","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.apsb.2022.10.021_bib11","doi-asserted-by":"crossref","first-page":"11055","DOI":"10.1021\/acsnano.9b10037","article-title":"Metabolic modulation of the tumor microenvironment leads to multiple checkpoint inhibition and immune cell infiltration","volume":"14","author":"Kolb","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2022.10.021_bib12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccell.2016.08.005","article-title":"Lactate dehydrogenase B controls lysosome activity and autophagy in cancer","volume":"30","author":"Brisson","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.apsb.2022.10.021_bib13","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cell.2020.08.049","article-title":"Lactate elicits ER-mitochondrial Mg2+ dynamics to integrate cellular metabolism","volume":"183","author":"Daw","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2022.10.021_bib14","doi-asserted-by":"crossref","first-page":"32278","DOI":"10.1021\/acsami.0c05783","article-title":"Dual-modal therapeutic role of the lactate oxidase-embedded hierarchical porous zeolitic imidazolate framework as a nanocatalyst for effective tumor suppression","volume":"12","author":"Zhou","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.apsb.2022.10.021_bib15","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.apsb.2021.12.001","article-title":"Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors","volume":"12","author":"Zhou","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2022.10.021_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904639","article-title":"Intra\/extracellular lactic acid exhaustion for synergistic metabolic therapy and immunotherapy of tumors","volume":"31","author":"Gao","year":"2019","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2022.10.021_bib17","doi-asserted-by":"crossref","first-page":"22054","DOI":"10.1002\/anie.202001469","article-title":"Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation","volume":"59","author":"Tang","year":"2020","journal-title":"Angew Chem, Int Ed"},{"key":"10.1016\/j.apsb.2022.10.021_bib18","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.1021\/acs.chemmater.8b03348","article-title":"Ultrasmall nanozymes isolated within porous carbonaceous frameworks for synergistic cancer therapy: enhanced oxidative damage and reduced energy supply","volume":"30","author":"Cao","year":"2018","journal-title":"Chem Mater"},{"key":"10.1016\/j.apsb.2022.10.021_bib19","doi-asserted-by":"crossref","first-page":"7904","DOI":"10.1021\/jacs.8b03613","article-title":"Cerium metal-organic framework for photocatalysisl","volume":"140","author":"Wu","year":"2018","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2022.10.021_bib20","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cclet.2019.11.036","article-title":"Metal-organic framework-based nanomaterials for biomedical applications","volume":"31","author":"Zhang","year":"2020","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.apsb.2022.10.021_bib21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/cplu.201900325","article-title":"A cerium-containing metal-organic framework: synthesis and heterogeneous catalytic activity toward fenton-like reactions","volume":"84","author":"Dang","year":"2019","journal-title":"Chempluschem"},{"key":"10.1016\/j.apsb.2022.10.021_bib22","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1021\/acs.accounts.0c00268","article-title":"Metal-organic framework derived nanozymes in biomedicine","volume":"53","author":"Wang","year":"2020","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.apsb.2022.10.021_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100896","article-title":"Vesicular antibodies for immunotherapy: the blooming intersection of nanotechnology and biotechnology","volume":"34","author":"Ren","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.apsb.2022.10.021_bib24","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1038\/s41467-020-18745-6","article-title":"Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death","volume":"11","author":"Deng","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2022.10.021_bib25","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.3390\/cells9092102","article-title":"Nano-enhanced cancer immunotherapy: immunology encounters nanotechnology","volume":"9","author":"Bockamp","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2022.10.021_bib26","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.apsb.2022.10.021_bib27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fonc.2020.00428","article-title":"Metabolic reprogramming in triple-negative breast cancer","volume":"10","author":"Sun","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.apsb.2022.10.021_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.immuni.2015.02.017","article-title":"A Broken krebs cycle in macrophages","volume":"42","author":"O'Neill","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2022.10.021_bib29","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/1535-7163.MCT-13-0870","article-title":"Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer","volume":"13","author":"Gross","year":"2014","journal-title":"Mol Cancer Therapeut"},{"key":"10.1016\/j.apsb.2022.10.021_bib30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/09553002.2018.1558299","article-title":"Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice","volume":"95","author":"Boysen","year":"2019","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.apsb.2022.10.021_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4331\/wjbc.v6.i4.281","article-title":"Targeting amino acid metabolism in cancer growth and antitumor immune response","volume":"6","author":"Ananieva","year":"2015","journal-title":"World J Biol Chem"},{"key":"10.1016\/j.apsb.2022.10.021_bib32","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.aav2588","article-title":"Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion","volume":"366","author":"Leone","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.apsb.2022.10.021_bib33","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.cclet.2021.09.036","article-title":"A multisite-binding fluorescent probe for simultaneous monitoring of mitochondrial homocysteine, cysteine and glutathione in live cells and zebrafish","volume":"33","author":"Jiang","year":"2022","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.apsb.2022.10.021_bib34","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.cclet.2021.03.036","article-title":"Nanozymes for regulation of reactive oxygen species and disease therapy","volume":"32","author":"Dai","year":"2021","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.apsb.2022.10.021_bib35","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1021\/acs.bioconjchem.9b00618","article-title":"Repolarization of M2 to M1 macrophages triggered by lactate oxidase released from methylcellulose hydrogel","volume":"30","author":"Liao","year":"2019","journal-title":"Bioconjugate Chem"},{"key":"10.1016\/j.apsb.2022.10.021_bib36","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/acs.analchem.9b05593","article-title":"Nanoceria-templated metal organic frameworks with oxidase-mimicking activity boosted by hexavalent chromium","volume":"92","author":"Wang","year":"2020","journal-title":"Anal Chem"},{"key":"10.1016\/j.apsb.2022.10.021_bib37","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1021\/es8001508","article-title":"Fenton-like reaction catalyzed by the rare earth inner transition metal cerium","volume":"42","author":"Heckert","year":"2008","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.apsb.2022.10.021_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/EXP.20210005","article-title":"Nanozyme for tumor\u00a0therapy: surface modification matters","volume":"1","author":"Tang","year":"2021","journal-title":"Explorations"},{"key":"10.1016\/j.apsb.2022.10.021_bib39","article-title":"Exploration of nanozymes in viral diagnosis and therapy","volume":"1","author":"Lee","year":"2022","journal-title":"Explorations"},{"key":"10.1016\/j.apsb.2022.10.021_bib40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From krebs to clinic: glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2022.10.021_bib41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fonc.2020.00231","article-title":"Lactate beyond a waste metabolite: metabolic affairs and signaling in malignancy","volume":"10","author":"Baltazar","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.apsb.2022.10.021_bib42","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1021\/acs.nanolett.9b05210","article-title":"Endoplasmic reticulum targeting to amplify immunogenic cell death for cancer immunotherapy","volume":"20","author":"Deng","year":"2020","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2022.10.021_bib43","doi-asserted-by":"crossref","first-page":"13526","DOI":"10.1002\/anie.202004180","article-title":"Self-boosting catalytic nanoreactors integrated with triggerable crosslinking membrane networks for initiation of immunogenic cell death by pyroptosis","volume":"59","author":"Li","year":"2020","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.apsb.2022.10.021_bib44","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.apsb.2020.07.013","article-title":"The progress and perspective of nanoparticle-enabled tumor metastasis treatment","volume":"10","author":"Zhang","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2022.10.021_bib45","article-title":"Strategies for enhancing cancer chemodynamic therapy performance","volume":"2","author":"Jana","year":"2022","journal-title":"Explorations"},{"key":"10.1016\/j.apsb.2022.10.021_bib46","article-title":"Recent advances in overcoming barriers to cell-based delivery systems for cancer immunotherapy","volume":"2","author":"Ding Yy, Wang Yx, Hu Qy","year":"2022","journal-title":"Explorations"},{"key":"10.1016\/j.apsb.2022.10.021_bib47","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1016\/j.apsb.2022.02.024","article-title":"Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K\/mTOR and CDK inhibitors to enhance antitumor immunity","volume":"12","author":"Yang Qc, Ma Xb, Xiao Y, Zhang T, Yang Ll, Yang Sc","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2022.10.021_bib48","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1016\/j.apsb.2022.03.002","article-title":"Generation of \u03b1 Gal-enhanced bifunctional tumor vaccine","volume":"12","author":"He","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2022.10.021_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201703674","article-title":"Theranostic prodrug vesicles for reactive oxygen species-triggered ultrafast drug release and local-regional therapy of metastatic triple-negative breast cancer","volume":"27","author":"Zhou","year":"2017","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2022.10.021_bib50","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1111\/cas.13827","article-title":"Reinforce the antitumor activity of CD8+ T cells via glutamine restriction","volume":"109","author":"Nabe","year":"2018","journal-title":"Cancer Sci"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522004464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522004464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:56:58Z","timestamp":1761929818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383522004464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2211383522004464"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2022.10.021","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2022.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}