{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:13:33Z","timestamp":1793711613969,"version":"4.6.1"},"reference-count":209,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0110600"],"award-info":[{"award-number":["2019YFA0110600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.apsb.2022.11.021","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T10:38:57Z","timestamp":1669372737000},"page":"4127-4148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Advancing drug delivery to articular cartilage: From single to multiple strategies"],"prefix":"10.1016","volume":"13","author":[{"given":"Tianyuan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangpeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-2227","authenticated-orcid":false,"given":"Quanyi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2022.11.021_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.arthro.2018.08.028","article-title":"Cartilage restoration surgery: incidence rates, complications, and trends as reported by the American Board of Orthopaedic Surgery Part II Candidates","volume":"35","author":"Frank","year":"2019","journal-title":"Arthroscopy"},{"key":"10.1016\/j.apsb.2022.11.021_bib2","first-page":"Cd005328","article-title":"Intra-articular corticosteroid for knee osteoarthritis","volume":"10","author":"J\u00fcni","year":"2015","journal-title":"Cochrane Db Syst Rev"},{"key":"10.1016\/j.apsb.2022.11.021_bib3","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.joca.2016.01.983","article-title":"The OA trial bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids","volume":"24","author":"van Middelkoop","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.apsb.2022.11.021_bib4","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/jama.2017.5283","article-title":"Effect of intra-articular triamcinolone vs. saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial","volume":"317","author":"McAlindon","year":"2017","journal-title":"JAMA-J Am Med Assoc"},{"key":"10.1016\/j.apsb.2022.11.021_bib5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.semarthrit.2013.11.012","article-title":"A systematic review of recommendations and guidelines for the management of osteoarthritis: the chronic osteoarthritis management initiative of the U.S. bone and joint initiative","volume":"43","author":"Nelson","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.apsb.2022.11.021_bib6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nrrheum.2014.61","article-title":"OA guidelines: improving care or merely codifying practice?","volume":"10","author":"Block","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tips.2021.12.004","article-title":"Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs","volume":"43","author":"Gao","year":"2022","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib8","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1016\/j.biomaterials.2011.05.033","article-title":"Enhanced MSC chondrogenesis following delivery of TGF-\u03b23 from alginate microspheres within hyaluronic acid hydrogels in\u00a0vitro and in\u00a0vivo","volume":"32","author":"Bian","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/ten.teb.2012.0727","article-title":"Controlled release strategies for bone, cartilage, and osteochondral engineering\u2014part II: challenges on the evolution from single to multiple bioactive factor delivery","volume":"19","author":"Santo","year":"2013","journal-title":"Tissue Eng Part B-Re"},{"key":"10.1016\/j.apsb.2022.11.021_bib10","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1016\/j.biomaterials.2010.04.053","article-title":"Toward delivery of multiple growth factors in tissue engineering","volume":"31","author":"Chen","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.addr.2014.06.006","article-title":"Strategies for controlled delivery of biologics for cartilage repair","volume":"84","author":"Lam","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2022.11.021_bib12","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1016\/j.jbiomech.2007.02.005","article-title":"A comparison of the influence of global functional loads vs. local contact anatomy on articular cartilage thickness at the knee","volume":"40","author":"Koo","year":"2007","journal-title":"J Biomech"},{"key":"10.1016\/j.apsb.2022.11.021_bib13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.rcl.2009.04.003","article-title":"Measures of molecular composition and structure in osteoarthritis","volume":"47","author":"Burstein","year":"2009","journal-title":"Radiol Clin N Am"},{"key":"10.1016\/j.apsb.2022.11.021_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.matbio.2014.08.010","article-title":"How best to preserve and reveal the structural intricacies of cartilaginous tissue","volume":"39","author":"Hunziker","year":"2014","journal-title":"Matrix Biol"},{"key":"10.1016\/j.apsb.2022.11.021_bib15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ncprheum0216","article-title":"Technology insight: adult stem cells in cartilage regeneration and tissue engineering","volume":"2","author":"Chen","year":"2006","journal-title":"Nat Clin Pract Rheum"},{"key":"10.1016\/j.apsb.2022.11.021_bib16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1941738109350438","article-title":"The basic science of articular cartilage: structure, composition, and function","volume":"1","author":"Sophia Fox","year":"2009","journal-title":"Sports Health"},{"key":"10.1016\/j.apsb.2022.11.021_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1357-2725(02)00301-1","article-title":"The chondrocyte","volume":"35","author":"Archer","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.apsb.2022.11.021_bib18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2022.11.021_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/ar3046","article-title":"New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options","volume":"12","author":"Lotz","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib20","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.apsb.2022.11.021_bib21","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2022.11.021_bib22","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1016\/S0021-9258(19)67640-4","article-title":"Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage","volume":"266","author":"Wu","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2022.11.021_bib23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1172\/JCI108676","article-title":"Collagen synthesis in normal and osteoarthritic human cartilage","volume":"59","author":"Lippiello","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2022.11.021_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/art.1780270109","article-title":"Biochemical and metabolic abnormalities in normal and osteoarthritic human articular cartilage","volume":"27","author":"Ryu","year":"1984","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.apsb.2022.11.021_bib25","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/art.1780270405","article-title":"In\u00a0vivo and in\u00a0vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis","volume":"27","author":"Sandy","year":"1984","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.apsb.2022.11.021_bib26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF02899701","article-title":"Activation of collagen type II expression in osteoarthritic and rheumatoid cartilage","volume":"62","author":"Aigner","year":"1992","journal-title":"Virchows Arch B"},{"key":"10.1016\/j.apsb.2022.11.021_bib27","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/ar2592","article-title":"Cartilage homeostasis in health and rheumatic diseases","volume":"11","author":"Goldring","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips: II. correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.apsb.2022.11.021_bib29","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2022.11.021_bib30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.7150\/ijms.4276","article-title":"Analysis of the mineral composition of the human calcified cartilage zone","volume":"9","author":"Zhang","year":"2012","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib31","first-page":"193","article-title":"Bioactive factors for tissue regeneration: state of the art","volume":"2","author":"Ohba","year":"2012","journal-title":"Muscles Ligaments Tendons J"},{"key":"10.1016\/j.apsb.2022.11.021_bib32","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1007\/s11999-011-1857-3","article-title":"The role of growth factors in cartilage repair","volume":"469","author":"Fortier","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib33","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.2174\/1381612821666150115150712","article-title":"Bioactive hydrogel scaffolds\u2014advances in cartilage regeneration through controlled drug delivery","volume":"21","author":"Censi","year":"2015","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.apsb.2022.11.021_bib34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.apsb.2022.11.021_bib35","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/S0140-6736(17)31744-0","article-title":"Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis","volume":"390","author":"da Costa","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2022.11.021_bib36","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.joca.2013.06.026","article-title":"The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial","volume":"21","author":"Gallelli","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.apsb.2022.11.021_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.apsb.2022.11.021_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41584-018-0123-4","article-title":"Intra-articular treatment options for knee osteoarthritis","volume":"15","author":"Jones","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib39","first-page":"34","article-title":"The influence of sample size and gender composition on the meta-analysis conclusion of platelet-rich plasma treatment for osteoarthritis","volume":"22","author":"Zhao","year":"2020","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.apsb.2022.11.021_bib40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.addr.2006.01.018","article-title":"Intraarticular drug delivery in osteoarthritis","volume":"58","author":"Gerwin","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2022.11.021_bib41","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/jps.21346","article-title":"Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders","volume":"97","author":"Larsen","year":"2008","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib42","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41584-020-00518-6","article-title":"Emerging pharmaceutical therapies for osteoarthritis","volume":"16","author":"Latourte","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib43","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention","volume":"29","author":"Anderson","year":"2011","journal-title":"J Orthop Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib44","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1089\/ten.teb.2014.0014","article-title":"Anti-inflammatory strategies in cartilage repair","volume":"20","author":"Zhang","year":"2014","journal-title":"Tissue Eng Part B-Re"},{"key":"10.1016\/j.apsb.2022.11.021_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.addr.2014.08.010","article-title":"Tissue engineering strategies to study cartilage development, degeneration and regeneration","volume":"84","author":"Bhattacharjee","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2022.11.021_bib46","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.joca.2015.08.015","article-title":"Inflammation in joint injury and post-traumatic osteoarthritis","volume":"23","author":"Lieberthal","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.apsb.2022.11.021_bib47","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3389\/fbioe.2020.00860","article-title":"Infrapatellar fat pad\/synovium complex in early-stage knee osteoarthritis: potential new target and source of therapeutic mesenchymal stem\/stromal cells","volume":"8","author":"Greif","year":"2020","journal-title":"Front Bioeng Biotech"},{"key":"10.1016\/j.apsb.2022.11.021_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6390182","article-title":"Contribution of infrapatellar fat pad and synovial membrane to knee osteoarthritis pain","volume":"2019","author":"Belluzzi","year":"2019","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.apsb.2022.11.021_bib49","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41551-021-00698-w","article-title":"The evolution of commercial drug delivery technologies","volume":"5","author":"Vargason","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.apsb.2022.11.021_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2015.08.012","article-title":"Drug delivery to chondrocytes","volume":"24","author":"Evans","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.apsb.2022.11.021_bib51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrrheum.2016.210","article-title":"Cartilage-targeting drug delivery: can electrostatic interactions help?","volume":"13","author":"Bajpayee","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib52","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jsb.2003.08.006","article-title":"Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy","volume":"143","author":"Ng","year":"2003","journal-title":"J Struct Biol"},{"key":"10.1016\/j.apsb.2022.11.021_bib53","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmat2116","article-title":"Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage","volume":"7","author":"Rothenfluh","year":"2008","journal-title":"Nat Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib54","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/acs.molpharmaceut.7b00484","article-title":"Nanoparticle properties for delivery to cartilage: the implications of disease state, synovial fluid, and off-target uptake","volume":"16","author":"Brown","year":"2019","journal-title":"Mol Pharm"},{"key":"10.1016\/j.apsb.2022.11.021_bib55","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.biomaterials.2013.09.091","article-title":"Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis","volume":"35","author":"Bajpayee","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib56","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/jmre.2000.2216","article-title":"Diffusion of paramagnetically labeled proteins in cartilage: enhancement of the 1-D NMR imaging technique","volume":"148","author":"Foy","year":"2001","journal-title":"J Magn Reson"},{"key":"10.1016\/j.apsb.2022.11.021_bib57","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.drudis.2018.05.023","article-title":"Recent advances in intra-articular drug delivery systems for osteoarthritis therapy","volume":"23","author":"Maudens","year":"2018","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.apsb.2022.11.021_bib58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2015.12.015","article-title":"Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice","volume":"498","author":"Pradal","year":"2016","journal-title":"Int J Pharm"},{"key":"10.1016\/j.apsb.2022.11.021_bib59","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1023\/A:1014260513728","article-title":"Size-dependency of DL-lactide\/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium","volume":"19","author":"Horisawa","year":"2002","journal-title":"Pharm Res (NY)"},{"key":"10.1016\/j.apsb.2022.11.021_bib60","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11095-008-9562-y","article-title":"Role of particle size in phagocytosis of polymeric microspheres","volume":"25","author":"Champion","year":"2008","journal-title":"Pharm Res (NY)"},{"key":"10.1016\/j.apsb.2022.11.021_bib61","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/08982100701557129","article-title":"Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic marker","volume":"17","author":"Edwards","year":"2007","journal-title":"J Liposome Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib62","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/jbm.a.37074","article-title":"Biomaterial strategies for improved intra-articular drug delivery","volume":"109","author":"Mancipe Castro","year":"2021","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.apsb.2022.11.021_bib63","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.apsb.2021.05.002","article-title":"A review of existing strategies for designing long-acting parenteral formulations: focus on underlying mechanisms, and future perspectives","volume":"11","author":"Shi","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2022.11.021_bib64","article-title":"Drug solubility: importance and enhancement techniques","volume":"2012","author":"Savjani","year":"2012","journal-title":"ISRN Pharm"},{"key":"10.1016\/j.apsb.2022.11.021_bib65","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.apsb.2015.07.003","article-title":"Insoluble drug delivery strategies: review of recent advances and business prospects","volume":"5","author":"Kalepu","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2022.11.021_bib66","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00441-016-2403-0","article-title":"BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells","volume":"366","author":"Zhou","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib67","doi-asserted-by":"crossref","first-page":"219","DOI":"10.15283\/ijsc.2015.8.2.219","article-title":"Fibrin scaffolds designing in order to human adipose-derived mesenchymal stem cells differentiation to chondrocytes in the presence of TGF-\u03b23","volume":"8","author":"Sheykhhasan","year":"2015","journal-title":"Int J Stem Cell"},{"key":"10.1016\/j.apsb.2022.11.021_bib68","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.joca.2007.04.019","article-title":"The short-term therapeutic effect of recombinant human bone morphogenetic protein-2 on collagenase-induced lumbar facet joint osteoarthritis in rats","volume":"15","author":"Yeh","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.apsb.2022.11.021_bib69","doi-asserted-by":"crossref","first-page":"19225","DOI":"10.3390\/ijms160819225","article-title":"The Regulatory role of signaling crosstalk in hypertrophy of MSCs and human articular chondrocytes","volume":"16","author":"Zhong","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib70","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/s41467-021-23005-2","article-title":"TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration","volume":"12","author":"Qiao","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2022.11.021_bib71","doi-asserted-by":"crossref","first-page":"59772","DOI":"10.1021\/acsami.1c20565","article-title":"Anti-inflammatory and prochondrogenic in situ-formed injectable hydrogel crosslinked by strontium-doped bioglass for cartilage regeneration","volume":"13","author":"Cai","year":"2021","journal-title":"ACS Appl Mater Inter"},{"key":"10.1016\/j.apsb.2022.11.021_bib72","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10561-014-9472-7","article-title":"Alternative protocols to induce chondrogenic differentiation: transforming growth factor-\u03b2 superfamily","volume":"16","author":"Cicione","year":"2015","journal-title":"Cell Tissue Bank"},{"key":"10.1016\/j.apsb.2022.11.021_bib73","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jbm.a.32980","article-title":"Biomimeticity in tissue engineering scaffolds through synthetic peptide modifications-altering chemistry for enhanced biological response","volume":"96","author":"Sreejalekshmi","year":"2011","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.apsb.2022.11.021_bib74","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-3-319-66095-0_7","article-title":"Peptide-based materials for cartilage tissue regeneration","volume":"1030","author":"Hastar","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.apsb.2022.11.021_bib75","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1359\/JBMR.041104","article-title":"Multidomain synthetic peptide B2A2 synergistically enhances BMP-2 in\u00a0vitro","volume":"20","author":"Lin","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib76","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.bpj.2010.04.070","article-title":"Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling","volume":"99","author":"Bragdon","year":"2010","journal-title":"Biophys J"},{"key":"10.1016\/j.apsb.2022.11.021_bib77","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.actbio.2011.01.019","article-title":"Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients","volume":"7","author":"Moore","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib78","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biomaterials.2017.08.031","article-title":"Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt\/\u03b2\u03b2-catenin signaling","volume":"145","author":"Li","year":"2017","journal-title":"Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib79","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1016\/j.biomaterials.2009.07.064","article-title":"The promotion of chondrogenesis in adipose-derived adult stem cells by an RGD-chimeric protein in 3D alginate culture","volume":"30","author":"Chang","year":"2009","journal-title":"Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib80","doi-asserted-by":"crossref","first-page":"7298","DOI":"10.1016\/j.biomaterials.2010.06.001","article-title":"Biomimetic hydrogels for chondrogenic differentiation of human mesenchymal stem cells to neocartilage","volume":"31","author":"Liu","year":"2010","journal-title":"Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib81","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2217\/nnm-2017-0335","article-title":"Chondrocyte affinity peptide modified PAMAM conjugate as a nanoplatform for targeting and retention in cartilage","volume":"13","author":"Hu","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.apsb.2022.11.021_bib82","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/(SICI)1097-4636(199802)39:2<266::AID-JBM14>3.0.CO;2-B","article-title":"Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing","volume":"39","author":"Hern","year":"1998","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib83","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1016\/S0142-9612(03)00339-9","article-title":"Biomimetic materials for tissue engineering","volume":"24","author":"Shin","year":"2003","journal-title":"Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib84","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.biomaterials.2004.02.012","article-title":"The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides","volume":"26","author":"Fittkau","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib85","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/bit.10625","article-title":"RGD-grafted poly-L-lysine-graft-(polyethylene glycol) copolymers block non-specific protein adsorption while promoting cell adhesion","volume":"82","author":"VandeVondele","year":"2003","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.apsb.2022.11.021_bib86","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12951-021-01230-7","article-title":"Hydrogel composite scaffolds achieve recruitment and chondrogenesis in cartilage tissue engineering applications","volume":"20","author":"Huang","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.apsb.2022.11.021_bib87","doi-asserted-by":"crossref","first-page":"38715","DOI":"10.1021\/acsami.8b11687","article-title":"In Situ articular cartilage regeneration through endogenous reparative cell homing using a functional bone marrow-specific scaffolding system","volume":"10","author":"Sun","year":"2018","journal-title":"ACS Appl Mater Inter"},{"key":"10.1016\/j.apsb.2022.11.021_bib88","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1016\/j.biomaterials.2011.05.017","article-title":"Targeted delivery of non-viral vectors to cartilage in\u00a0vivo using a chondrocyte-homing peptide identified by phage display","volume":"32","author":"Pi","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib89","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/gt.2015.16","article-title":"Intra-articular delivery of anti-Hif-2\u03b1 siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice","volume":"22","author":"Pi","year":"2015","journal-title":"Gene Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib90","first-page":"2372","article-title":"Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy","volume":"6","author":"Xue","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119277","article-title":"Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: from development to application in tissue engineering","volume":"216","author":"Raftery","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib92","article-title":"Controlled non-viral gene delivery in cartilage and bone repair: current strategies and future directions","volume":"1","author":"Gonzalez-Fernandez","year":"2018","journal-title":"Adv Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib93","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrd837","article-title":"Nucleic-acid therapeutics: basic principles and recent applications","volume":"1","author":"Opalinska","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2022.11.021_bib94","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/art.38614","article-title":"Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial","volume":"66","author":"Lohmander","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib95","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/jor.24321","article-title":"Scaffold-based delivery of nucleic acid therapeutics for enhanced bone and cartilage repair","volume":"37","author":"Kelly","year":"2019","journal-title":"J Orthop Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib96","first-page":"411","article-title":"Tetrahedral framework nucleic acids promote the biological functions and related mechanism of synovium-derived mesenchymal stem cells and show improved articular cartilage regeneration activity in situ","volume":"9","author":"Fu","year":"2022","journal-title":"Bioact Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121131","article-title":"Chitosan hydrogel\/3D-printed poly(\u03b5-caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on tetrahedral framework nucleic acid recruitment","volume":"278","author":"Li","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib98","doi-asserted-by":"crossref","first-page":"1605235","DOI":"10.1002\/adma.201605235","article-title":"A Difunctional regeneration scaffold for knee repair based on aptamer-directed cell recruitment","volume":"29","author":"Hu","year":"2017","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib99","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fcell.2017.00006","article-title":"How do mesenchymal stem cells influence or are influenced by microenvironment through extracellular vesicles communication?","volume":"5","author":"Dostert","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.apsb.2022.11.021_bib100","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/cells9040991","article-title":"Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications","volume":"9","author":"Tsiapalis","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2022.11.021_bib101","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J Extracell Vesicl"},{"key":"10.1016\/j.apsb.2022.11.021_bib102","article-title":"Is Extracellular vesicle-based therapy the next answer for cartilage regeneration?","volume":"9","author":"Velot","year":"2021","journal-title":"Front Bio Eng Biotechnol"},{"key":"10.1016\/j.apsb.2022.11.021_bib103","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biomaterials.2004.02.018","article-title":"Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds","volume":"26","author":"Leach","year":"2005","journal-title":"Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib104","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1002\/adma.200900241","article-title":"Controlled growth factor delivery for tissue engineering","volume":"21","author":"Tayalia","year":"2009","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(01)00483-7","article-title":"Release of recombinant human interleukin-2 from dextran-based hydrogels","volume":"78","author":"Cad\u00e9e","year":"2002","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib106","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jconrel.2004.12.019","article-title":"PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release","volume":"103","author":"Bhattarai","year":"2005","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib107","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1163\/156856200744101","article-title":"Controlled release of vascular endothelial growth factor by use of collagen hydrogels","volume":"11","author":"Tabata","year":"2000","journal-title":"J Biomater Sci Polym Ed"},{"key":"10.1016\/j.apsb.2022.11.021_bib108","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/app.23613","article-title":"Preparation and properties of crosslinked chitosan thermosensitive hydrogel for injectable drug delivery systems","volume":"101","author":"Zan","year":"2006","journal-title":"J Appl Polym Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib109","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0142-9612(00)00258-1","article-title":"Release of protein from highly cross-linked hydrogels of poly (ethylene glycol) diacrylate fabricated by UV polymerization","volume":"22","author":"Mellott","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib110","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/jbm.1259","article-title":"Effect of poly (ethylene glycol) molecular weight on tensile and swelling properties of oligo (poly (ethylene glycol) fumarate) hydrogels for cartilage tissue engineering","volume":"59","author":"Temenoff","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib111","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0142-9612(02)00227-2","article-title":"A hydrogel prepared by in situ cross-linking of a thiol-containing poly (ethylene glycol)-based copolymer: a new biomaterial for protein drug delivery","volume":"24","author":"Qiu","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib112","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1538-7836.2007.02386.x","article-title":"Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis","volume":"5","author":"Silva","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.apsb.2022.11.021_bib113","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-3659(03)00197-4","article-title":"In\u00a0vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents","volume":"90","author":"Kushibiki","year":"2003","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib114","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jconrel.2004.05.009","article-title":"Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties","volume":"98","author":"Leonard","year":"2004","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib115","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/jbm.a.34776","article-title":"In\u00a0vitro response to alkaline phosphatase coatings immobilized onto titanium implants using electrospray deposition or polydopamine-assisted deposition","volume":"102","author":"Nijhuis","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.apsb.2022.11.021_bib116","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/adma.200801222","article-title":"Facile conjugation of biomolecules onto surfaces via mussel adhesive protein inspired coatings","volume":"21","author":"Lee","year":"2009","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib117","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jbm.1251","article-title":"Drug-releasing scaffolds fabricated from drug-loaded microspheres","volume":"59","author":"Nof","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib118","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/jbm.a.30771","article-title":"Temporally regulated delivery of VEGF in\u00a0vitro and in\u00a0vivo","volume":"79","author":"Ennett","year":"2006","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.apsb.2022.11.021_bib119","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0169-409X(02)00228-4","article-title":"Biodegradable nanoparticles for drug and gene delivery to cells and tissue","volume":"55","author":"Panyam","year":"2003","journal-title":"Adv Drug Deliver Rev"},{"key":"10.1016\/j.apsb.2022.11.021_bib120","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0168-3659(02)00136-0","article-title":"Precise control of PLG microsphere size provides enhanced control of drug release rate","volume":"82","author":"Berkland","year":"2002","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib121","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.addr.2006.03.005","article-title":"Gene delivery strategies for cartilage tissue engineering","volume":"58","author":"Saraf","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2022.11.021_bib122","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrg3763","article-title":"Non-viral vectors for gene-based therapy","volume":"15","author":"Yin","year":"2014","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.apsb.2022.11.021_bib123","doi-asserted-by":"crossref","first-page":"636","DOI":"10.5966\/sctm.2013-0206","article-title":"Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases","volume":"3","author":"Williams","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib124","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/scrt113","article-title":"SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells","volume":"3","author":"Venkatesan","year":"2012","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib125","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1111\/jcmm.13190","article-title":"Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes","volume":"21","author":"Frisch","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib126","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/sj.gt.3301960","article-title":"Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes","volume":"10","author":"Park","year":"2003","journal-title":"Gene Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib127","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2019.05.028","article-title":"Growth factor delivery: Defining the next generation platforms for tissue engineering","volume":"306","author":"Aguilar","year":"2019","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib128","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.polymer.2008.01.027","article-title":"Hydrogels in drug delivery: progress and challenges","volume":"49","author":"Hoare","year":"2008","journal-title":"Polymer"},{"key":"10.1016\/j.apsb.2022.11.021_bib129","first-page":"1","article-title":"Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings","volume":"8","author":"Feng","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2022.11.021_bib130","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1359\/jbmr.090801","article-title":"Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration","volume":"24","author":"Guldberg","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib131","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tips.2007.10.010","article-title":"Delivering growth factors for therapeutics","volume":"29","author":"Anitua","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib132","doi-asserted-by":"crossref","first-page":"14608","DOI":"10.1021\/acsami.9b01532","article-title":"Sustained release SDF-1\u03b1\/TGF-\u03b21-loaded silk fibroin-porous gelatin scaffold promotes cartilage repair","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl Mater Inter"},{"key":"10.1016\/j.apsb.2022.11.021_bib133","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejpb.2016.12.021","article-title":"New scaffolds encapsulating TGF-\u03b23\/BMP-7 combinations driving strong chondrogenic differentiation","volume":"114","author":"Crecente-Campo","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.apsb.2022.11.021_bib134","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk0011","article-title":"Stem cell\u2013homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model","volume":"8","author":"Zhu","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2022.11.021_bib135","doi-asserted-by":"crossref","first-page":"23369","DOI":"10.1021\/acsami.1c01844","article-title":"3D-Bioprinted difunctional scaffold for in situ cartilage regeneration based on aptamer-directed cell recruitment and growth factor-enhanced cell chondrogenesis","volume":"13","author":"Yang","year":"2021","journal-title":"ACS Appl Mater Inter"},{"key":"10.1016\/j.apsb.2022.11.021_bib136","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biomaterials.2019.04.031","article-title":"Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules","volume":"210","author":"Xu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms7295","article-title":"Self-assembled hydrogels utilizing polymer\u2013nanoparticle interactions","volume":"6","author":"Appel","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2022.11.021_bib138","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.colsurfb.2018.05.039","article-title":"Potential of rhBMP-2 and dexamethasone-loaded Zein\/PLLA scaffolds for enhanced in\u00a0vitro osteogenesis of mesenchymal stem cells","volume":"169","author":"Li","year":"2018","journal-title":"Colloid Surface B"},{"key":"10.1016\/j.apsb.2022.11.021_bib139","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1177\/0885328219894001","article-title":"A multifunctional coaxial fiber membrane loaded with dual drugs for guided tissue regeneration","volume":"34","author":"He","year":"2020","journal-title":"J Biomater Appl"},{"key":"10.1016\/j.apsb.2022.11.021_bib140","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.7150\/thno.47909","article-title":"Preparation of high precision multilayer scaffolds based on melt electro-writing to repair cartilage injury","volume":"10","author":"Han","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2022.11.021_bib141","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2008.10.021","article-title":"Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering","volume":"134","author":"Wang","year":"2009","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib142","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijpharm.2016.09.027","article-title":"Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs","volume":"514","author":"Joshi","year":"2016","journal-title":"Int J Pharm"},{"key":"10.1016\/j.apsb.2022.11.021_bib143","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.2174\/138161206779026245","article-title":"Polymeric micelles for drug delivery","volume":"12","author":"Croy","year":"2006","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.apsb.2022.11.021_bib144","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.reactfunctpolym.2010.10.009","article-title":"Polymeric micelles for nano-scale drug delivery","volume":"71","author":"Miyata","year":"2011","journal-title":"React Funct Polym"},{"key":"10.1016\/j.apsb.2022.11.021_bib145","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.progpolymsci.2007.05.009","article-title":"Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery","volume":"32","author":"Rapoport","year":"2007","journal-title":"Prog Polym Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib146","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1517\/17425240903380446","article-title":"Overcoming the barriers in micellar drug delivery: loading efficiency, in\u00a0vivo stability, and micelle-cell interaction","volume":"7","author":"Kim","year":"2010","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.apsb.2022.11.021_bib147","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.actbio.2016.05.005","article-title":"Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis","volume":"39","author":"Kang","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib148","first-page":"832","article-title":"An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration","volume":"5","author":"Zhang","year":"2020","journal-title":"Bioact Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2021.05.007","article-title":"Multi-functional silica-based mesoporous materials for simultaneous delivery of biologically active ions and therapeutic biomolecules","volume":"129","author":"Zhu","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib150","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jconrel.2006.05.014","article-title":"Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres","volume":"114","author":"Chen","year":"2006","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib151","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jconrel.2004.07.004","article-title":"Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering","volume":"101","author":"Holland","year":"2005","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2022.11.021_bib152","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.joca.2006.07.006","article-title":"Degradable hydrogel scaffolds for in\u00a0vivo delivery of single and dual growth factors in cartilage repair","volume":"15","author":"Holland","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.apsb.2022.11.021_bib153","first-page":"1361","article-title":"Construction of PLGA nanoparticles coated with polycistronic SOX5, SOX6, and SOX9 genes for chondrogenesis of human mesenchymal stem cells","volume":"9","author":"Park","year":"2017","journal-title":"JAAM"},{"key":"10.1016\/j.apsb.2022.11.021_bib154","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1093\/emboj\/17.19.5718","article-title":"A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene","volume":"17","author":"Lefebvre","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2022.11.021_bib155","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.joca.2011.01.005","article-title":"Electroporation-mediated gene transfer of SOX trio to enhance chondrogenesis in adipose stem cells","volume":"19","author":"Im","year":"2011","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.apsb.2022.11.021_bib156","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1053\/joca.2000.0382","article-title":"High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects","volume":"9","author":"Goomer","year":"2001","journal-title":"Osteoarthr Cartilage"},{"key":"10.1016\/j.apsb.2022.11.021_bib157","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3727\/096368912X647261","article-title":"Cartilage tissue formation from dedifferentiated chondrocytes by codelivery of BMP-2 and SOX-9 genes encoding bicistronic vector","volume":"22","author":"Cha","year":"2013","journal-title":"Cell Transplant"},{"key":"10.1016\/j.apsb.2022.11.021_bib158","article-title":"Sox9 potentiates BMP2-induced chondrogenic differentiation and inhibits BMP2-induced osteogenic differentiation","volume":"9","author":"Liao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2022.11.021_bib159","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1111\/j.1582-4934.2008.00474.x","article-title":"Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer","volume":"13","author":"Cucchiarini","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib160","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/284873","article-title":"The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis","volume":"2013","author":"Maldonado","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.apsb.2022.11.021_bib161","article-title":"Smart \u03bc-fiber hydrogels with macro-porous structure for sequentially promoting multiple phases of articular cartilage regeneration","author":"Ma","year":"2022","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib162","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1002\/jcp.30006","article-title":"Cartilage regeneration with dual-drug-releasing injectable hydrogel\/microparticle system: in\u00a0vitro and in\u00a0vivo study","volume":"236","author":"Naghizadeh","year":"2021","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.apsb.2022.11.021_bib163","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1177\/0363546518765098","article-title":"Posttraumatic osteoarthritis development and progression in an ovine model of partial anterior cruciate ligament transection and effect of repeated intra-articular methylprednisolone acetate injections on early disease","volume":"46","author":"Barton","year":"2018","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib164","first-page":"2065","article-title":"Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique","volume":"8","author":"Tobar-Grande","year":"2013","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.apsb.2022.11.021_bib165","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-079X.2008.00646.x","article-title":"Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes","volume":"46","author":"Pei","year":"2009","journal-title":"J Pineal Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib166","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13287-018-0892-3","article-title":"Melatonin rescued interleukin 1\u03b2-impaired chondrogenesis of human mesenchymal stem cells","volume":"9","author":"Gao","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib167","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13287-020-01797-2","article-title":"Dual functional construct containing kartogenin releasing microtissues and curcumin for cartilage regeneration","volume":"11","author":"Asgari","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib168","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3109\/03009742.2015.1009942","article-title":"Exogenous expression of IL-1Ra and TGF-\u03b21 promotes in\u00a0vivo repair in experimental rabbit osteoarthritis","volume":"44","author":"Zhang","year":"2015","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib169","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.actbio.2020.07.008","article-title":"Endogenous cell recruitment strategy for articular cartilage regeneration","volume":"114","author":"Yang","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib170","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201605235","article-title":"A difunctional regeneration scaffold for knee repair based on aptamer-directed cell recruitment","volume":"29","author":"Hu","year":"2017","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib171","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.biomaterials.2016.01.019","article-title":"Water-based polyurethane 3D printed scaffolds with controlled release function for customized cartilage tissue engineering","volume":"83","author":"Hung","year":"2016","journal-title":"Biomater"},{"key":"10.1016\/j.apsb.2022.11.021_bib172","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/art.39049","article-title":"Use of recombinant human stromal cell-derived factor 1\u03b1-loaded fibrin\/hyaluronic acid hydrogel networks to achieve functional repair of full-thickness bovine articular cartilage via homing of chondrogenic progenitor cells","volume":"67","author":"Yu","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib173","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1089\/ten.tea.2012.0441","article-title":"A transduced living hyaline cartilage graft releasing transgenic stromal cell-derived factor-1 inducing endogenous stem cell homing in\u00a0vivo","volume":"19","author":"Zhang","year":"2013","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.apsb.2022.11.021_bib174","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1089\/ten.tea.2011.0380","article-title":"Repair of rabbit osteochondral defects by an acellular technique with an ultrapurified alginate gel containing stromal cell-derived factor-1","volume":"18","author":"Sukegawa","year":"2012","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.apsb.2022.11.021_bib175","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1189\/jlb.0503206","article-title":"Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways","volume":"74","author":"Lee","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.apsb.2022.11.021_bib176","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2796.2009.02153.x","article-title":"Mesenchymal stem cells and cartilage in situ regeneration","volume":"266","author":"Richter","year":"2009","journal-title":"J Intern Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib177","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/ar4025","article-title":"Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair","volume":"14","author":"Zhang","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.apsb.2022.11.021_bib178","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1002\/adfm.201504070","article-title":"Nanocarrier-mediated codelivery of small molecular drugs and siRNA to enhance chondrogenic differentiation and suppress hypertrophy of human mesenchymal stem cells","volume":"26","author":"Xu","year":"2016","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib179","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/s41591-020-1013-2","article-title":"Articular cartilage regeneration by activated skeletal stem cells","volume":"26","author":"Murphy","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib180","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/ijms22020665","article-title":"Hyaluronan-loaded liposomal dexamethasone\u2013diclofenac nanoparticles for local osteoarthritis treatment","volume":"22","author":"Chang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib181","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007126","article-title":"The efficiency and safety of dexamethasone for pain control in total joint arthroplasty: a meta-analysis of randomized controlled trials","volume":"96","author":"Meng","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.apsb.2022.11.021_bib182","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/anae.14610","article-title":"Adverse side-effects of dexamethasone in surgical patients\u2014an abridged cochrane systematic review","volume":"74","author":"Polderman","year":"2019","journal-title":"Anaesthesia"},{"key":"10.1016\/j.apsb.2022.11.021_bib183","first-page":"113","article-title":"Oral versus topical diclofenac sodium in the treatment of osteoarthritis","volume":"31","author":"Tieppo Francio","year":"2017","journal-title":"J Pain Palliat Care"},{"key":"10.1016\/j.apsb.2022.11.021_bib184","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1039\/C8NR10013F","article-title":"A photothermal-triggered nitric oxide nanogenerator combined with siRNA for precise therapy of osteoarthritis by suppressing macrophage inflammation","volume":"11","author":"Chen","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.apsb.2022.11.021_bib185","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.143959","article-title":"Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis","volume":"712","author":"Liu","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.apsb.2022.11.021_bib186","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrrheum.2015.145","article-title":"Osteoarthritis: autophagy prevents age-related OA","volume":"11","author":"Duarte","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.apsb.2022.11.021_bib187","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.biopha.2017.07.032","article-title":"Mesenchymal stem cells with IGF-1 and TGF-\u03b21 in laminin gel for osteochondral defects in rabbits","volume":"93","author":"Gugjoo","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2022.11.021_bib188","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.3892\/etm.2021.10717","article-title":"Sequential growth factor exposure of human Ad-MSCs improves chondrogenic differentiation in an osteochondral biphasic implant","volume":"22","author":"Garcia-Ruiz","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib189","article-title":"Specific clearance of senescent synoviocytes suppresses the development of osteoarthritis based on aptamer-functionalized targeted drug delivery system","author":"Chen","year":"2022","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib190","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.joca.2005.03.008","article-title":"Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts","volume":"13","author":"Sanchez","year":"2005","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.apsb.2022.11.021_bib191","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.joca.2005.07.012","article-title":"Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes","volume":"13","author":"Sanchez","year":"2005","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.apsb.2022.11.021_bib192","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072714","article-title":"Are bisphosphonates effective in the treatment of osteoarthritis pain? a meta-analysis and systematic review","volume":"8","author":"Davis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2022.11.021_bib193","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1136\/ard.2008.089912","article-title":"Bisphosphonates for osteoarthritis prevention: \"Holy Grail\" or not?","volume":"67","author":"Saag","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.apsb.2022.11.021_bib194","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1002\/art.22160","volume":"54","author":"Bingham","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.apsb.2022.11.021_bib195","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/art.23638","article-title":"Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis","volume":"58","author":"Kadri","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.apsb.2022.11.021_bib196","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.bone.2012.03.025","article-title":"Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis","volume":"50","author":"Hayami","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.apsb.2022.11.021_bib197","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.joca.2011.07.003","article-title":"Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis","volume":"19","author":"Bellido","year":"2011","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.apsb.2022.11.021_bib198","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nm.3143","article-title":"Inhibition of TGF-\u03b2 signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis","volume":"19","author":"Zhen","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib199","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tips.2014.03.005","article-title":"Targeting TGF\u03b2 signaling in subchondral bone and articular cartilage homeostasis","volume":"35","author":"Zhen","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib200","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav7756","article-title":"Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration","volume":"11","author":"McDermott","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.apsb.2022.11.021_bib201","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/jor.20329","article-title":"Increased accumulation of superficial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein-7 and growth factors","volume":"25","author":"Khalafi","year":"2007","journal-title":"J Orthop Res"},{"key":"10.1016\/j.apsb.2022.11.021_bib202","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/abd1ba","article-title":"Gradient scaffold with spatial growth factor profile for osteochondral interface engineering","volume":"16","author":"Dorcemus","year":"2021","journal-title":"Biomed Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120385","article-title":"Bioinspired stratified electrowritten fiber-reinforced hydrogel constructs with layer-specific induction capacity for functional osteochondral regeneration","volume":"266","author":"Qiao","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2022.11.021_bib204","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103525","article-title":"Directed regeneration of osteochondral tissue by hierarchical assembly of spatially organized composite spheroids","volume":"9","author":"Lee","year":"2022","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2022.11.021_bib205","first-page":"317","article-title":"Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions","volume":"11","author":"Wang","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.apsb.2022.11.021_bib206","first-page":"257","article-title":"Microfluidic electrospray photo-crosslinkable \u03ba-Carrageenan microparticles for wound healing","volume":"2","author":"Luo","year":"2021","journal-title":"Eng Regener"},{"key":"10.1016\/j.apsb.2022.11.021_bib207","first-page":"96","article-title":"Living materials for regenerative medicine","volume":"2","author":"Yu","year":"2021","journal-title":"Eng Regener"},{"key":"10.1016\/j.apsb.2022.11.021_bib208","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.apsb.2020.08.008","article-title":"Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2022.11.021_bib209","first-page":"109","article-title":"Designing bioactive micro-\/nanomotors for engineered regeneration","volume":"2","author":"Cai","year":"2021","journal-title":"Eng Regener"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522004889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383522004889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:05:20Z","timestamp":1761930320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383522004889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":209,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S2211383522004889"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2022.11.021","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing drug delivery to articular cartilage: From single to multiple strategies","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2022.11.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}