{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:55:23Z","timestamp":1792094123633,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.apsb.2024.02.005","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T22:16:19Z","timestamp":1707516979000},"page":"2210-2227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ER\u03b1 signaling"],"prefix":"10.1016","volume":"14","author":[{"given":"Qing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-3231","authenticated-orcid":false,"given":"Junjie","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-3196","authenticated-orcid":false,"given":"Jiali","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-6991","authenticated-orcid":false,"given":"Guilong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-5295","authenticated-orcid":false,"given":"Kewei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2024.02.005_bib1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tem.2012.03.008","article-title":"Estrogen and the skeleton","volume":"23","author":"Khosla","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.apsb.2024.02.005_bib2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1089\/jwh.2017.6706","article-title":"Postmenopausal osteoporosis: a clinical review","volume":"27","author":"Watts","year":"2018","journal-title":"J Womens Health (Larchmt)"},{"key":"10.1016\/j.apsb.2024.02.005_bib3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35046196","article-title":"Bone versus immune system","volume":"408","author":"Arron","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2024.02.005_bib4","first-page":"1325","article-title":"Interaction between osteoblast and osteoclast: impact in bone disease","volume":"19","author":"Phan","year":"2004","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.apsb.2024.02.005_bib5","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.joms.2017.01.008","article-title":"Bisphosphonate-related osteonecrosis and metastasis within the same site of the jaw","volume":"75","author":"Corsi","year":"2017","journal-title":"J Oral Maxillofacl Surg"},{"key":"10.1016\/j.apsb.2024.02.005_bib6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2016.02.053","article-title":"Treatments for post-menopausal osteoporotic women, what's new? how can we manage long-term treatment?","volume":"779","author":"Herrero","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.apsb.2024.02.005_bib7","first-page":"213","article-title":"Hormone replacement therapy and the prevention of postmenopausal osteoporosis","volume":"4","author":"Gambacciani","year":"2014","journal-title":"Prz Menopauzalny"},{"key":"10.1016\/j.apsb.2024.02.005_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.apsb.2024.02.005_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.apsb.2024.02.005_bib10","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2024.02.005_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"EL Andaloussi","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2024.02.005_bib12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biomaterials.2018.05.048","article-title":"Development and MPI tracking of novel hypoxia-targeted theranostic exosomes","volume":"177","author":"Jung","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2024.02.005_bib13","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1021\/acsami.7b17620","article-title":"Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration","volume":"10","author":"Li","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.apsb.2024.02.005_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.biomaterials.2016.06.018","article-title":"Edible ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer","volume":"101","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2024.02.005_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymthe.2020.11.030","article-title":"Plant exosome-like nanovesicles: emerging therapeutics and drug delivery nanoplatforms","volume":"29","author":"Dad","year":"2021","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2024.02.005_bib16","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1104\/pp.16.01253","article-title":"Extracellular vesicles isolated from the leaf apoplast carry stress-response proteins","volume":"173","author":"Rutter","year":"2017","journal-title":"Plant Physiol"},{"key":"10.1016\/j.apsb.2024.02.005_bib17","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.aar4142","article-title":"Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes","volume":"360","author":"Cai","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.apsb.2024.02.005_bib18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.chom.2018.10.001","article-title":"Plant-derived exosomal microRNAs shape the gut microbiota","volume":"24","author":"Teng","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.apsb.2024.02.005_bib19","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.28713","article-title":"Ginger-derived nanoparticles protect against alcohol-induced liver damage","volume":"4","author":"Zhuang","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.apsb.2024.02.005_bib20","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1158\/0008-5472.CAN-14-3095","article-title":"Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2024.02.005_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2009.01.035","article-title":"Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell","volume":"607","author":"Zhang","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.apsb.2024.02.005_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22071033","article-title":"Total flavonoids of Drynariae rhizoma prevent bone loss induced by hindlimb unloading in rats","volume":"22","author":"Song","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.apsb.2024.02.005_bib23","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.2147\/IJN.S213229","article-title":"Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review","volume":"14","author":"Abdifetah","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.apsb.2024.02.005_bib24","first-page":"447","article-title":"Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors","volume":"26","author":"Wan","year":"2010","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.apsb.2024.02.005_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s40425-019-0817-4","article-title":"Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth","volume":"7","author":"Cao","year":"2019","journal-title":"J Immunotherapy Cancer"},{"key":"10.1016\/j.apsb.2024.02.005_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/15592324.2022.2129290","article-title":"Drug value of Drynariae Rhizoma root-derived extracellular vesicles for neurodegenerative diseases based on proteomics and bioinformatics","volume":"17","author":"Cao","year":"2022","journal-title":"Plant Signal Behav"},{"key":"10.1016\/j.apsb.2024.02.005_bib27","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.apsb.2021.08.016","article-title":"Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation","volume":"12","author":"Chen","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.02.005_bib28","first-page":"1","article-title":"Quercetin stimulates bone marrow mesenchymal stem cell differentiation through an estrogen receptor-mediated pathway","volume":"15","author":"Pang","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.apsb.2024.02.005_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/scrt493","article-title":"Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal\/stem cells through estrogen receptor dependent and independent mechanisms","volume":"5","author":"Strong","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.apsb.2024.02.005_bib30","article-title":"Biomaterials and nanomedicine for bone regeneration: progress and future prospects","volume":"1","author":"Zhou","year":"2021","journal-title":"Exploration"},{"key":"10.1016\/j.apsb.2024.02.005_bib31","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.2174\/092986709788186093","article-title":"Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels","volume":"16","author":"Smiley","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.apsb.2024.02.005_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121509","article-title":"Biofabrication of cell-derived nanovesicles: a potential alternative to extracellular vesicles for regenerative medicine","volume":"8","author":"Ilahibaks","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2024.02.005_bib33","article-title":"Extracellular vesicle in\u00a0vivo biodistribution is determined by cell source, route of administration and targeting","volume":"20","author":"Wiklander","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.apsb.2024.02.005_bib34","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.2147\/IJN.S263756","article-title":"Bone-targeted extracellular vesicles from mesenchymal stem cells\u00a0for osteoporosis therapy","volume":"15","author":"Wang","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.apsb.2024.02.005_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01421-w","article-title":"Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy","volume":"20","author":"Liu","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.apsb.2024.02.005_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2016.05.025","article-title":"Traditional Chinese medicine formulas for the treatment of osteoporosis: implication for antiosteoporotic drug discovery","volume":"189","author":"Zhang","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.apsb.2024.02.005_bib37","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mce.2010.05.004","article-title":"Estrogen and glucocorticoid regulate osteoblast differentiation through the interaction of bone morphogenetic protein-2 and tumor necrosis factor-alpha in C2C12 cells","volume":"325","author":"Matsumoto","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.apsb.2024.02.005_bib38","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s12011-020-02309-2","article-title":"Osteogenesis promotion of selenium-doped hydroxyapatite for application as bone scaffold","volume":"199","author":"Zakhireh","year":"2021","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.apsb.2024.02.005_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75023","article-title":"Transcriptional regulation of cyclophilin D by BMP\/Smad signaling and its role in osteogenic differentiation","volume":"11","author":"Sautchuk","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.apsb.2024.02.005_bib40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00441-016-2403-0","article-title":"BMP2 induces\u00a0chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells","volume":"366","author":"Zhou","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.apsb.2024.02.005_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00223-016-0138-2","article-title":"Icariin stimulates differentiation and suppresses adipocytic transdifferentiation of primary osteoblasts through estrogen receptor-mediated pathway","volume":"99","author":"Zhang","year":"2016","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.apsb.2024.02.005_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800890","article-title":"Bioinstructive naringin-loaded micelles for guiding stem cell osteodifferentiation","volume":"7","author":"Lavrador","year":"2018","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.apsb.2024.02.005_bib43","first-page":"408","article-title":"Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells","volume":"20","author":"Wang","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.apsb.2024.02.005_bib44","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.drudis.2018.05.012","article-title":"Bioinspired bone therapies using naringin: applications and advances","volume":"23","author":"Lavrador","year":"2018","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.apsb.2024.02.005_bib45","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1021\/acsami.0c20268","article-title":"Tumor microenvironment-responsive nanococktails for synergistic enhancement of cancer treatment via cascade reactions","volume":"13","author":"Chen","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.apsb.2024.02.005_bib46","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jconrel.2020.08.066","article-title":"Inhibition of growth and lung metastasis of breast cancer by tumor-homing triple-bioresponsive nanotherapeutics","volume":"328","author":"Zhang","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2024.02.005_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax3931","article-title":"Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer","volume":"6","author":"Dancy","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2024.02.005_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119791","article-title":"Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis","volume":"240","author":"Landgraf","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2024.02.005_bib49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41565-017-0012-z","article-title":"Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression","volume":"13","author":"Pi","year":"2018","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.apsb.2024.02.005_bib50","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1021\/acsnano.6b05630","article-title":"Magnetic and folate functionalization enables rapid isolation and enhanced tumor-targeting of cell-derived microvesicles","volume":"11","author":"Zhang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2024.02.005_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3358","article-title":"Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids","volume":"4","author":"Wang","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2024.02.005_bib52","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153365","article-title":"Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR\/COPS8 pathway","volume":"23","author":"Sriwastva","year":"2022","journal-title":"EMBO Rep"},{"key":"10.1016\/j.apsb.2024.02.005_bib53","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.12659\/MSM.915170","article-title":"Network pharmacology-based pharmacological mechanism of the Chinese medicine Rhizoma drynariae against osteoporosis","volume":"25","author":"Gan","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.apsb.2024.02.005_bib54","doi-asserted-by":"crossref","first-page":"496","DOI":"10.5582\/bst.2017.01216","article-title":"Chinese single herbs and active ingredients for postmenopausal osteoporosis: from preclinical evidence to action mechanism","volume":"11","author":"Lin","year":"2017","journal-title":"Biosci Trends"},{"key":"10.1016\/j.apsb.2024.02.005_bib55","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1002\/jcb.23287","article-title":"Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation","volume":"112","author":"Lin","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.apsb.2024.02.005_bib56","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.ymthe.2017.01.025","article-title":"Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase","volume":"25","author":"Deng","year":"2017","journal-title":"Molr Ther"},{"key":"10.1016\/j.apsb.2024.02.005_bib57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chmed.2023.11.002","article-title":"Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles (2023 edition)","volume":"16","author":"Zhao","year":"2024","journal-title":"Chinese Herb Med"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524000431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524000431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T05:15:34Z","timestamp":1728882934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383524000431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S2211383524000431"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2024.02.005","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ER\u03b1 signaling","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2024.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}