{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:17:13Z","timestamp":1792588633180,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.apsb.2024.06.006","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T17:26:17Z","timestamp":1725470777000},"page":"4577-4590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Simultaneous enhancement of cellular and humoral immunity by the lymph node-targeted cholesterolized TLR7 agonist liposomes"],"prefix":"10.1016","volume":"14","author":[{"given":"Dandan","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxia","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuquan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-6422","authenticated-orcid":false,"given":"Xiawei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2024.06.006_bib1","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1021\/acs.nanolett.0c01230","article-title":"Mimetic heat shock protein mediated immune process to enhance cancer immunotherapy","volume":"20","author":"Li","year":"2020","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2024.06.006_bib2","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1021\/acsnano.3c10117","article-title":"Mitochondrial disruption nanosystem simultaneously depressed programmed death ligand-1 and transforming growth factor-\u03b2 to overcome photodynamic immunotherapy resistance","volume":"18","author":"Jiang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2024.06.006_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202304328","article-title":"A Hybrid nanoadjuvant simultaneously depresses PD-L1\/TGF-\u03b21 and activates cGAS-STING pathway to overcome radio-immunotherapy resistance","volume":"36","author":"Yi","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2024.06.006_bib4","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1016\/j.apsb.2022.05.028","article-title":"Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development","volume":"12","author":"Yang","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.06.006_bib5","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1021\/nn305466z","article-title":"pH-Responsive nanoparticle vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides","volume":"7","author":"Wilson","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2024.06.006_bib6","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1021\/nl500618u","article-title":"Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery","volume":"14","author":"Fang","year":"2014","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2024.06.006_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/nn5062029","article-title":"Nanoparticle-based immunotherapy for cancer","volume":"9","author":"Shao","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2024.06.006_bib8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nri2510","article-title":"Towards an understanding of the adjuvant action of aluminium","volume":"9","author":"Marrack","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib10","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1021\/nn5066793","article-title":"pH-Responsive poly(D,L-lactic-co-glycolic acid) nanoparticles with rapid antigen release behavior promote immune response","volume":"9","author":"Liu","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2024.06.006_bib11","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","article-title":"Cell biology of antigen processing in\u00a0vitro and in\u00a0vivo","volume":"23","author":"Trombetta","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.immuni.2008.05.016","article-title":"Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms","volume":"29","author":"Hou","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2024.06.006_bib13","doi-asserted-by":"crossref","first-page":"pe48","DOI":"10.1126\/stke.4022007pe48","article-title":"T cell activation by TLRs: a role for TLRs in the adaptive immune response","volume":"2007","author":"Macleod","year":"2007","journal-title":"Sci STKE"},{"key":"10.1016\/j.apsb.2024.06.006_bib14","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/j.vaccine.2014.07.081","article-title":"Lymphatic-targeted cationic liposomes: a robust vaccine adjuvant for promoting long-term immunological memory","volume":"32","author":"Wang","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.apsb.2024.06.006_bib15","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.biomaterials.2014.04.022","article-title":"Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2024.06.006_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1166\/jbn.2019.2669","article-title":"Real-time imaging tracking of a dual fluorescent vaccine delivery system based on ovalbumin loaded zinc phthalocyanine-incorporated copolymer nanoparticles","volume":"15","author":"Wei","year":"2019","journal-title":"J Biomed Nanotechnol"},{"key":"10.1016\/j.apsb.2024.06.006_bib17","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1021\/acsnano.7b00978","article-title":"Efficient nanovaccine delivery in cancer immunotherapy","volume":"11","author":"Zhu","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2024.06.006_bib18","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key roles of adjuvants in modern vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2024.06.006_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-6445-1_1","article-title":"Overview of vaccine adjuvants: introduction, history, and current status","volume":"1494","author":"Shah","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.apsb.2024.06.006_bib20","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1182\/blood-2008-07-019307","article-title":"TLRs and innate immunity","volume":"113","author":"Beutler","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.apsb.2024.06.006_bib21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1586\/erv.09.160","article-title":"Advances in the design and delivery of peptide subunit vaccines with a focus on toll-like receptor agonists","volume":"9","author":"Black","year":"2010","journal-title":"Expert Rev Vaccin"},{"key":"10.1016\/j.apsb.2024.06.006_bib24","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1021\/acs.nanolett.7b03218","article-title":"Immunogenic cell death amplified by co-localized adjuvant delivery for cancer immunotherapy","volume":"17","author":"Fan","year":"2017","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2024.06.006_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.actbio.2018.08.002","article-title":"Synergistic effect of dual targeting vaccine adjuvant with aminated \u03b2-glucan and CpG-oligodeoxynucleotides for both humoral and cellular immune responses","volume":"78","author":"Jin","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2024.06.006_bib26","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1166\/jbn.2018.2605","article-title":"Functionalized multi-walled carbon nanotubes for targeting delivery of immunostimulatory CpG oligonucleotides against prostate cancer","volume":"14","author":"Xia","year":"2018","journal-title":"J Biomed Nanotechnol"},{"key":"10.1016\/j.apsb.2024.06.006_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2008-04-151712","article-title":"Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology","volume":"113","author":"Baenziger","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.apsb.2024.06.006_bib28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood-2012-05-432393","article-title":"Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma","volume":"121","author":"Dovedi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.apsb.2024.06.006_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2016.22","article-title":"Toll-like receptors: the swiss army knife of immunity and vaccine development","volume":"5","author":"Dowling","year":"2016","journal-title":"Clin Transl Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib30","doi-asserted-by":"crossref","first-page":"7960","DOI":"10.1021\/acs.nanolett.1c01968","article-title":"Lymph-node-targeted cholesterolized TLR7 agonist liposomes provoke a safe and durable antitumor response","volume":"21","author":"Wan","year":"2021","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2024.06.006_bib31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nature08604","article-title":"Materials engineering for immunomodulation","volume":"462","author":"Hubbell","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2024.06.006_bib32","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1039\/c1nr10166h","article-title":"The role of surface charge density in cationic liposome-promoted dendritic cell maturation and vaccine-induced immune responses","volume":"3","author":"Ma","year":"2011","journal-title":"Nanoscale"},{"key":"10.1016\/j.apsb.2024.06.006_bib33","article-title":"Killing three birds with one stone: multi-stage metabolic regulation mediated by clinically useable berberine liposome to overcome photodynamic immunotherapy resistance","volume":"454","author":"Zheng","year":"2022","journal-title":"Chem Eng J"},{"key":"10.1016\/j.apsb.2024.06.006_bib34","article-title":"Metabolic intervention liposome boosted lung cancer radio-immunotherapy via hypoxia amelioration and PD-L1 restraint","volume":"10","author":"Wang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.apsb.2024.06.006_bib35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00262-007-0390-4","article-title":"A simple but effective cancer vaccine consisting of an antigen and a cationic lipid","volume":"57","author":"Chen","year":"2008","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.apsb.2024.06.006_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/09687860600790537","article-title":"Immunostimulation of dendritic cells by cationic liposomes","volume":"23","author":"Vangasseri","year":"2006","journal-title":"Mol Membr Biol"},{"key":"10.1016\/j.apsb.2024.06.006_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.immunol.19.1.47","article-title":"Cross-presentation, dendritic cells, tolerance and immunity","volume":"19","author":"Heath","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jconrel.2009.10.022","article-title":"Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance\u00a0immunogenicity of soluble antigen","volume":"142","author":"Henriksen-Lacey","year":"2010","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2024.06.006_bib39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1021\/mp100208f","volume":"8","author":"Henriksen-Lacey","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1016\/j.apsb.2024.06.006_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg7836","article-title":"A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response","volume":"6","author":"Connolly","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature19330","article-title":"Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy","volume":"537","author":"Im","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2024.06.006_bib42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.immuni.2018.12.021","article-title":"Intratumoral Tcf1+PD-1+CD8+T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy","volume":"50","author":"Siddiqui","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2024.06.006_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abb1025","article-title":"3M-052, a synthetic TLR-7\/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates","volume":"5","author":"Kasturi","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abf8891","article-title":"Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence","volume":"5","author":"Hartley","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1016\/j.apsb.2024.06.006_bib45","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191393","article-title":"Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival","volume":"218","author":"M\u00fcller-Winkler","year":"2021","journal-title":"J Exp Med"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524002375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524002375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T15:09:54Z","timestamp":1729696194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383524002375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S2211383524002375"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2024.06.006","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous enhancement of cellular and humoral immunity by the lymph node-targeted cholesterolized TLR7 agonist liposomes","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2024.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}